Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 潘力行教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1054/mehy.2000.1058 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要The award of the Nobel Prize in Physiology and Medicine for 1998 bears witness to the 'explosive' field of nitric oxide (NO), and who would have thought the explosive nitroglycerin owed its therapeutic effectiveness to this little molecule? NO is also involved in causing penile erection, which has brought sildenafil to the aid of patients with erectile dysfunction. However, emerging evidence in animals and in vitro studies indicates that NO also inhibits steroidogenesis, which may have repercussions in humans. The decrease in androgen secretion may impact on secondary sexual characteristics, including penile size. The tolerance to the nitrate therapy in angina, characterized by volume expansion and not due to sodium retention, may also be related to steroid hormone deficiency. Decreased cortisol secretion may impair water excretion, resulting in volume expansion. Impaired aldosterone secretion would cause hyponatraemia with resultant raised renin. I hypothesize that continuous therapy with nitrates and sildenafil will result in diminished levels of steroid hormones with predicted sequelae. (C) 2000 Harcourt Publishers Ltd
着者Panesar NS
期刊名称MEDICAL HYPOTHESES
出版年份2000
月份10
日期1
卷号55
期次4
出版社CHURCHILL LIVINGSTONE
页次310 - 313
国际标準期刊号030http://aims.cuhk.edu.hk/converis/portal/Publication/6-9877
语言英式英语
Web of Science 学科类别Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine
