Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黎永祥教授 (病理解剖及细胞学系) |
| 雷兆辉教授 (赛马会公共卫生及基层医疗学院) |
| 邓亮生教授 (化学病理学系) |
| 李锦滔教授 |
| 司徒卓俊教授 (内科及药物治疗学系) |
| 杜家辉教授 (病理解剖及细胞学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/S0272-6386(00)70191-0 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/49WOS source URL
其它资讯
摘要This prognostic study of primary immunoglobulin A (IgA) nephropathy focused on chronic irreversible glomerular sclerosis and interstitial fibrosis, based on the premise that this disease is characterized by a protracted and, for many, progressive course. We used a chronicity-based histological grading system to assess the biopsy specimens of 126 adults with IgA nephropathy over a median follow-up of 10 years. Our grading system included a glomerular grading (GG) of 1 to 3 based on the extent of glomerular sclerosis, a tubulointerstitial grading (TIG) of 1 to 3 based on the degree of tubular loss or interstitial fibrosis, and the evaluation of hyaline arteriolosclerosis (HA). These three histological parameters were correlated with each other and with serum creatinine level, degree of proteinuria, and blood pressure at the time of renal biopsy. Univariate analysis showed that these three histological and three clinical parameters were significantly correlated with renal survival. By multivariate analysis using the Cox regression model, GG, serum creatinine level, and degree of proteinuria represented independent prognostic factors of renal survival. For a subset of patients at a relatively early stage of disease with a serum creatinine level less than 130 mu mol/L at the time of biopsy, all three histological features and degree of proteinuria were significantly correlated with renal survival, and GG was the only independent prognostic factor for renal outcome. This study shows that glomerular sclerosis represents the most important prognostic factor in adult patients with primary IgA nephropathy and has a strong predictive value, Our chronicity-based histological grading system not only correlates well with the natural history of IgA nephropathy but is also reproducible and relatively simple to apply. (C) 2000 by the National Kidney Foundation, Inc.
着者To KF, Choi PCL, Szeto CC, Li PKT, Tang NLS, Leung CB, Wang AYM, Ho KKL, Wong TYH, Lui SF, Lai FMM
期刊名称American Journal of Kidney Diseases
出版年份2000
月份3
日期1
卷号35
期次3
出版社W B SAUNDERS CO
页次392 - 400
国际标準期刊号0272-6386
电子国际标準期刊号1523-6838
语言英式英语
关键词Berger's disease; chronicity; histological grading; immunoglobulin A (IgA) nephropathy; prognosis
Web of Science 学科类别Urology & Nephrology; UROLOGY & NEPHROLOGY
