Refereed conference paper presented and published in conference proceedings
香港中文大学研究人员 ( 现职)
| 邓亮生教授 (化学病理学系) |
| 吴浩强教授 (病理解剖及细胞学系) |
| 潘伟生教授 (外科学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/9WOS source URL
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摘要The effect of experimental acute hyponatraemia on severe traumatic brain injury (TBI) was studied in a modified impact-acceleration model. The cortical contusional volume was quantified by image analysis on serial sections, injured axons were visualized and quantified by beta -Amyloid Precursor Protein (beta -APP) immunohistochemical staining. Regional brain water content was estimated by the wet-dry weight method. The experiment was conducted in Group I (injury only) and Group II (injury followed by acute hyponatraemia). Comparison between the two groups showed that acute hyponatraemia significantly increased contusional volume (3.24 +/- 0.70 mm(3) vs. 1.80 +/- 0.65 mm(3), P = 0.00http://aims.cuhk.edu.hk/converis/portal/Publication/9) and the number of injured axons (128.7 +/- 44.3 vs. 41.7 +/- 50.1, P = 0.04) in the right thalamus & basal ganglia region. Water content of the brain stem region was also significantly increased by acute hyponatraemia (73.71 +/- 0.14% vs. 72.28 +/- 0.http://aims.cuhk.edu.hk/converis/portal/Publication/93%, P = 0.004). These results suggest that acute hyponatraemia potentiates secondary brain damage in severe TBI by augmentation of both focal contusion and diffuse axonal injury. The injured brain stem region is more susceptible to edema formation induced by experimental acute hyponatraemia.
着者Ke C, Poon WS, Ng HK, Tang NLS, Chan Y, Wang JY, Hsiang JNK
会议名称11th International Brain Oedema Symposium
会议开始日06.06.1http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/9
会议完结日10.06.1http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/9
会议地点NEWCASTLE TYNE
会议国家英国
期刊名称Acta Neurochirurgica -Supplementum then Supplement- Wien-
出版年份2000
月份1
日期1
卷号76
出版社SPRINGER-VERLAG WIEN
页次405 - 408
国际标準书号3-211-83561-X
国际标準期刊号0065-141http://aims.cuhk.edu.hk/converis/portal/Publication/9
语言英式英语
关键词Head injury; hyponatraemia; rat
Web of Science 学科类别Clinical Neurology; Neurosciences & Neurology
