Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3109/07853899908995896 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/25WOS source URL
其它资讯
摘要The prenatal diagnosis of fetal rhesus D (RhD) status is useful for the management of RhD-negative women with partners heterozygous for the RHD gene. Conventional methods for prenatal fetal RhD status determination involve invasive procedures such as fetal blood sampling and amniocentesis. The recent demonstration of the existence of cell-free fetal DNA in maternal plasma and serum opens up the possibility of determining fetal RhD status by analysis of maternal plasma or serum DNA. This possibility has recently been realized by three independent groups of investigators. This development: represents an important step towards the routine application of noninvasive fetal blood group diagnosis in sensitized, pregnancies and may become a model for developing safer noninvasive prenatal tests for other single-gene disorders.
着者Lo YMD
期刊名称Annals of Medicine
出版年份1999
月份10
日期1
卷号31
期次5
出版社ROYAL SOC MEDICINE PRESS LTD
页次308 - 312
国际标準期刊号0785-3890
语言英式英语
关键词blood grouping; DNA; polymerase chain reaction; pregnancy; prenatal diagnosis
Web of Science 学科类别General & Internal Medicine; Medicine, General & Internal; MEDICINE, GENERAL & INTERNAL
