Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林伟基教授 (化学病理学系) |
| 庄立信教授 (肿瘤学系) |
| 潘全威教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1258/0004563001899942 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/5WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/9Scopus source URL
其它资讯
摘要We describe a 6-year-old boy with histologically confirmed pancreatoblastoma and a markedly elevated serum α-fetoprotein (AFP) concentration. Due to local tumour invasion, cytotoxic chemotherapy was given to debulk the tumour before attempting surgical resection. Serial serum AFP concentrations were measured on this patient. During chemotherapy there was a > http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/5% fall in total AFP. Tumour-specific variants of AFP, detected by isoelectric focusing, also disappeared during chemotherapy but recurred when chemotherapy was withdrawn. It is suggested that although there was no change in overall size of the tumour, as assessed by various imaging techniques, the changes in serological markers may indicate that the treatment did in fact cause considerable tumour necrosis. AFP and its variants may be useful markers of tumour response in patients with pancreatoblastoma. The expression of AFP and its variants in pancreatoblastoma may be related to the embryonic origin of the pancreas.
着者Chan M.H.M., Shing M.M.K., Poon T.C.W., Johnson P.J., Lam C.W.K.
期刊名称Annals of Clinical Biochemistry
出版年份2000
月份http://aims.cuhk.edu.hk/converis/portal/Publication/9
日期28
卷号37
期次http://aims.cuhk.edu.hk/converis/portal/Publication/5
出版社Royal Society of Medicine
出版地United Kingdom
页次681 - 68http://aims.cuhk.edu.hk/converis/portal/Publication/5
国际标準期刊号0004-http://aims.cuhk.edu.hk/converis/portal/Publication/5632
电子国际标準期刊号17http://aims.cuhk.edu.hk/converis/portal/Publication/58-1001
语言英式英语
