Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林伟基教授 (化学病理学系) |
| 司徒卓俊教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1159/000013488 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/28WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/28Scopus source URL
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摘要Recent studies reveal conflicting results on the change of solute transfer with time on continuous ambulatory peritoneal dialysis (CAPD) and recurrent peritonitis. Herein, we performed a cross-sectional study of 76 patients on CAPD to examine their peritoneal permeability by measuring the dialysate to serum ratio of creatinine (D/P) and the mass transfer area coefficients of creatinine (MTACCr) or glucose (MTACGlu). Transforming growth factor-β1 (TGF-β1), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF) were measured in the dialysate by ELISA. TGF-β1 mRNA in peritoneal macrophages were determined by a quantitative polymerase chain reaction. We failed to observe any correlation between the duration on dialysis and the peritoneal permeability in those patients with no previous peritonitis. Frequency of peritonitis episode did not affect the MTACCr, MTACGlu, or D/P. The MTACCr correlated well with MTACGlu (r = 0.78, p = 0.001) and with D/P (r = 0.98, p < 0.0001). No inverse correlation was demonstrated between dialysate PDGF or EGF and the peritoneal permeability. A positive correlation was demonstrated between the dialysate TGF-β1 and MTACCr, MTACGlu or D/P (r = 0.64, 0.54, and 0.64 respectively, p < 0.001). The dialysate TGF-β1 levels in patients with low D/P (≤ 0.5) were only half of that in patients with normal or high DIP (p = 0.0002). The dialysate levels of TGF-β1 did not correlate with PDGF or EGF. These findings raise the possibility that, other than diffusion across the peritoneal membrane from circulation, there could also be an intrinsic production of TGF-β1 by peritoneal cells in these CAPD patients. Our findings raise the speculation that TGF-β1 in dialysate from stable CAPD patients may exert an inhibitory action to fibroblast. Such action of TGF-β1 could reduce the risk of peritoneal sclerosis and hence, maintains a satisfactory peritoneal permeability to small solutes.
着者Lai K.N., Lai K.B., Szeto C.C., Lam C.W.K., Leung J.C.K.
期刊名称American Journal of Nephrology
出版年份1999
月份5
日期1
卷号19
期次3
出版社S. Karger AG
出版地Switzerland
页次416 - 422
国际标準期刊号0250-8095
电子国际标準期刊号1421-9670
语言英式英语
关键词Continuous ambulatory peritoneal dialysis, Macrophages, Mesothelial cells, Peritoneal transport, Peritonitis, Transforming growth factor-beta
