Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林伟基教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.2332/allergolint.47.23 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/9Scopus source URL
其它资讯
摘要In a 1http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/93 survey, allergic rhinitis was identified as the most common allergic disease in Hong Kong, affecting 2http://aims.cuhk.edu.hk/converis/portal/Publication/9.1% of schoolchildren. Recently (1http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/95), the International Study of Asthma and Allergies in Childhood (ISAAC) also reported 44.5% current rhinitis among Hong Kong teenagers. Our objective was to study the aetiology of allergic rhinitis in Hong Kong using serological tests of allergen sensitization. In 57 allergic rhinitis patients and in the same number of age- and sex-matched controls the following were measured: serum total IgE, mixed aeroallergen IgE (Phadiatop(TM)) and specific IgE versus house dust mite (HDM), cockroach, cat and dog dander, mould mixture (Penicillium, Cladosporium, Aspergillus and Alternaria species) and four local pollens (Bermuda grass, Timothy, ragweed and mugwort). Compared with controls, allergic rhinitis patients (26 males, 31 females; mean (± SD) age 25 ± 11 years) had a significantly elevated serum total IgE concentration (mean ± SEM: 4http://aims.cuhk.edu.hk/converis/portal/Publication/96 ± 88 vs 17http://aims.cuhk.edu.hk/converis/portal/Publication/9 ± 38 kU/L) and an increased proportion of positive Phadiatop (http://aims.cuhk.edu.hk/converis/portal/Publication/95 vs 33%) and specific IgE tests versus HDM (http://aims.cuhk.edu.hk/converis/portal/Publication/90 vs 44%) and cockroach (42 vs http://aims.cuhk.edu.hk/converis/portal/Publication/9%; Mann-Whitney U-test and X2 tests all P < 0.005). There was no significant difference in sensitization to other allergens tested. House dust mite and cockroach are ubiquitous in Hong Kong with a warm, humid climate and crowded living conditions. Their identification as aetiological agents of allergic rhinitis should help in the development of environmental strategies for reducing the inhalant allergen load to prevent and control this prevalent and costly health problem in our community.
着者Lam C.W.K., Fung H.K., Vrijmoed L.L.P., Lit L.C.W., Wong M.C., Woo J.K.S., Hjelm N.M.
期刊名称Allergology International
出版年份1http://aims.cuhk.edu.hk/converis/portal/Publication/9http://aims.cuhk.edu.hk/converis/portal/Publication/98
月份6
日期4
卷号47
期次1
出版社Elsevier BV
出版地Netherlands
页次23 - 28
国际标準期刊号1323-8http://aims.cuhk.edu.hk/converis/portal/Publication/930
语言英式英语
关键词Allergic rhinitis, Cockroach, Hong Kong, House dust mite, In vitro allergy tests, Inhalant allergens
