Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/24WOS source URL
其它资讯
摘要The prenatal determination of fetal rhesus D (RhD) status is useful for the management of sensitized RhD-negative women. Conventional methods for prenatal RhD status determination involve invasive methods such as amniocentesis.' The discovery of circulating cell-free fetal DNA in maternal plasma and serum opens up a new source of fetal genetic material for prenatal RhD status determination.(2) Indeed, this possibility has recently been realized by three groups who demonstrated the presence of fetal-derived RHD gene sequences in RhD-negative women bearing RhD-positive fetuses.(3-5) The detection system used by our group is a homogenous assay based on real-time PCR analysis(3,6) using exon 10 of the RHD gene. However, as it has been advocated that at least two independent PCR systems should be used for the clinical diagnosis of fetal RhD status, we describe, in this communication, a second real-time PCR assay for RhD status determination using sequences derived from exon 7 of the RHD gene.
着者Zhang J, Fidler C, Murphy MF, Chamberlain PF, Sargent IL, Redman CWG, Hjelm NM, Wainscoat JS, Lo YMD
会议名称1st International Symposium on Circulating Nucleic Acids in Plasma/Serum
会议开始日18.08.1999
会议完结日20.08.1999
会议地点MENTHON ST BERNARD
期刊名称Annals of the New York Academy of Sciences
出版年份2000
月份1
日期1
卷号906
出版社NEW YORK ACAD SCIENCES
页次153 - 155
国际标準书号1-57331-269-X
国际标準期刊号0077-8923
电子国际标準期刊号1749-6632
语言英式英语
Web of Science 学科类别Medical Laboratory Technology; Multidisciplinary Sciences; Oncology; Science & Technology - Other Topics
