Dr. CHEN, Chia-Hung
B.S. (NTU), M.S. (Harvard), Ph.D. (Cambridge)
Associate Professor
Research Interest Microfluidic functional assays for precision medicine
Quantitative single-cell biology via intelligent Drop-Screen
Smart hydrogel- based technology
Single cell drug screen for personalized therapeutics.
Platform engineering for synthetic biology


Phone: +852 3442-9547
Email: chiachen@cityu.edu.hk

Address: YEUNG-G5355
Web: https://imb-cch.net/



BIOGRAPHY
Dr. Chen is focused on developing integrative platforms for biomedical applications. Compared with most platforms using gene sequence for quantitative biology, integrative functional assay offers unique advantages for the rapid characterization of biological samples for diagnosis and timely precision medicine. With the possibility of high-throughput biological sample screening and cell sorting using the integrative platform, statistically information could be obtained for effective quantitative biological analysis. For example, an intelligent system that integrated imaging technology, multiplexed chemical sensors and a computational data-analysis method was previously developed to analyze small amounts of physiological samples to determine the disease progression of individual patients with cancer. Before joining City University of Hong Kong, Dr. Chen worked at National University of Singapore and Massachusetts Institute of Technology. He received his Ph.D. degree at University of Cambridge. He earned his M.S. degree at Harvard University, and earned his B.S. degree at National Taiwan University.



EDUCATION
2010 Ph.D. Physics University of Cambridge
2006 M.S. Applied Physics Harvard University
2004 B.S. Physics National Taiwan University




AWARDS
Lab on a Chip Emerging Investigator, 2018
MicroTAS Presentation Award, 2010
Cambridge Overseas Trust 2006-2009
Overseas Research Studentship (Cambridge) 2006-2009
Harvard Alumni Scholarship 2005



SELECTED PUBLICATIONS
Plasmonic Droplet-Screen for Single-Cell Secretion Analysis, S. C. Wei, M. N. Hsu, and C. H. Chen, Biosensors and Bioelectronics, 144, 111639, 2019
Upconversion Amplification through Dielectric Superlensing Modulation, L. Liang, D. Teh, N. C. Dinh et al C. H. Chen, A. All, N. V. Thakor and X. Liu, Nature Communications, 10, 1391, 2019
Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions, H. Tan, S. Guo, N. Dinh, R. Luo, J. Lin and C. H. Chen, Nature Communications, 8, 663, 2017
Single Cell Multiplexed Assay for Proteolytic Activity Using Droplet Microfluidics, E. X. Ng, M. A. Miller, T. Jing, and C. H. Chen, Biosensors and Bioelectronics, 81, 408-414, 2016
Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array. E. X. Ng, M. A. Miller, T. Jing, D. A. Lauffenburger and C. H. Chen, Lab on a Chip, 15, 1153-1159, 2015
Gradient Porous Elastic Hydrogels with Shape-memory Property and Anisotropic Responses for Programmable Locomotion. R. Luo, J. Wu, N. Dinh, and C. H. Chen, Advanced Functional Materials, 25, 7272-7279, 2015.
ADAM-10 regulates cell migration via Jnk/p38 and opposing feedback through dual ligand and receptor shedding in invasive disease. M. A. Miller, A. S. Meyer, M. T. Beste, Z. Lasisi, S. Reddy, K. W. Jeng, C. H. Chen, J. Han, K. Isaacson, L. G. Griffith, and D. A. Lauffenburger, PNAS, 2013, 110, E2074–E2083
Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis. C. H. Chen, M. A. Miller, A. Sarkar, M. T. Beste, K. B. Isaacson, D. A. Lauffenburger, L. G. Griffith, and J. Han. JACS, 2013, 135, 1645-1648
Enhancing protease activity assay in droplet-based microfluidics Using a Biomolecule Concentrator. C. H. Chen, A. Sarkar, Y. Song, M. A. Miller, S. J. Kim, L. G. Griffith, D. A. Lauffenburer and J. Han, JACS, 2011, 133, 10368-10371
Microfluidic assembly of magnetic hydrogel particles with uniformly anisotropic structure. C. H. Chen, A. R. Abate, D. Lee, E. M. Terentjev and D. A. Weitz, Advanced Materials, 2009, 21, 3201-3204




Last modified on 9 August, 2020