Dr. CHAN, W. Y., Kannie
BSc(HKU), PhD(HKU)
Associate Professor
Research Interest MRI, CEST-MRI
Biomaterials
Nanosensors for cellular imaging
Hydrogel and its neural applications


Phone: +852 3442-9141
Email: KannieW.Y.C@cityu.edu.hk

Address: YEUNG-Y6709



BIOGRAPHY
Dr. Chan's research focuses on the development of biomaterials and imaging approaches to facilitate the clinical translation of cancer therapy and cell therapy, and early diagnosis of neurodegenerative diseases. She received her BSc and PhD degrees from The University of Hong Kong. She completed post-doctoral fellowships in magnetic resonance imaging (MRI) at Department of Radiology, Johns Hopkins University School of Medicine, and became an Assistant Professor in 2014. She joined City University of Hong Kong in 2016. She is a leading researcher in applying a frontier molecular MRI contrast mechanism to address clinical needs, which is known as chemical exchange saturation transfer (CEST). She has pioneered the imaging of glucose utilization in the brain using CEST-MRI. The way how our brain uses glucose could have implications on diagnosis and therapy in many neurological disorders, including Alzheimer’s disease and stroke. Her team is developing various techniques to effectively image and deliver drugs/cells in the brain non-invasively. She published over 60 peer-reviewed articles, including a cover article in Nature Materials, Science Advances and Nature Communications.



SELECTED PUBLICATIONS
X. Han, J. H. C. Lai, J. Huang, S. W. Park, Y. Liu, K. W. Y. Chan*. Imaging self-healing hydrogels and chemotherapeutics using CEST MRI at 3T. ACS Applied Bio Materials 2021(Supp. Cover Article)
J. Huang, L. Chen, X. Xu, P. C. M. van Zijl, J. Xu, K. W. Y. Chan*. Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3T. Magn. Reson. Med. 2021, 85, 254.
J. Huang, P. C. M. van Zijl, X. Han, C. M. Dong, G. W. Y. Cheng, K. H. Tse, L. Knutsson, L. Chen, J. H. C. Lai, E. X. Wu, J. Xu*, K. W. Y. Chan*. Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose enhanced MRI. Science Advances 2020:6:eaba3884.
A. Thakur, G. Qiu, X. Han, K. W. Y. Chan*, L. C. Wu, Y. Lee. Label-free sensing of exosomal. MCT1 and CD147 for tracking metabolic reprogramming and malignant progression in glioma. Science Advances 2020:6:eaaz6119.
L. Chen, M. Schar, K. W. Y. Chan*, J. Huang, Z. Wei, H. Lu, Q. Qin, R. G. Weiss, P. C. M. van Zijl, J. Xu. In vivo imaging of phosphocreatine with artificial neural networks. Nature Communications 2020:11:1071.
L. Chen, Z. Wei, K. W. Y. Chan*, Y. Li, K. Suchal, S. Bi, J. Huang, X. Xu, P. C. Wong, H. Lu, P. C. M. van Zijl, T. Li, J. Xu. D-glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI. J. Cereb. Blood Flow Metab. 2020 In Press.
Z. Mao, K. Zhu, L. Pan, G. Liu, T. Tang, Y. He, J. Huang, J. Hu*, K. W. Y. Chan*, J. Lu*. Direct-Ink written shape-morphing film with rapid and programmable multimotion. Adv. Mater. Tech. 2020:5:1900974.
X. Han, J. H. A. K.W. To, J. H.C. Lai, P. Xiao, E. X. Wu, J. Xu, K. W. Y. Chan*. CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T. Theranostics 2020:10:2215-2228.
J. Huang, L. Chen, K. W. Y. Chan*, C. Cai, S. Cai, Z. Chen. Super-resolved water/fat image reconstruction based on single-shot spatiotemporally encoded MRI. J. Magn Reson. 2020:106736.
J. Huang, J. Xu, C. M. Dong, L. Chen, X. Han, E. X. Wu, P. C.M. van Zijl, K. W. Y. Chan*. Impaired glucose uptake in mouse brain with Alzheimer’s disease detected by dynamic glucose enhanced (DGE) MRI at 3T. Journal of Alzheimer’s & Dementia 2019, 15:747.
J. Ren, J, Li, P. Xiao, Y. Liu, C. M. Tsang, S. W. Tsao, D. Lau, K. W. Y. Chan*, R. H. W. Lam*. Elasticity-modulated microbeads for classification of normal and cancer cells using confining microchannels. ACS Biomaterials Science & Engineering. 2019:5:3889-3898.
X. Xu, J. Xu, L. Knutsson, J. Liu, H. Liu, Y. Li, B. Lal, J. Laterra, D. Artemov, G. Liu, P. C. M. van Zijl*, K. W. Y. Chan*. The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma. Magn. Reson. Med. 2019:81:3798-3807.
T. Yu*, K. W. Y. Chan*, A. Anonuevo, X. Song, B. S. Schuster, S. Chattopadhyay, Q. Xu, N. Oskolkov, H. Patel, L. M. Ensign, P. C. M. van Zjil, M. T. McMahon, J. Hanes. (*, authors contributed equally) Liposomal mucus-penetrating particles (MPP) for efficient mucosal delivery and intravaginal diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI). Nanomedicine: Nanotechnology, Biology and Medicine 2015:11:401-405.
K. W. Y. Chan*, G. Liu, P. C. M. van Zijl, J. W. M. Bulte, M. T. McMahon. Magnetization transfer contrast MRI for non-invasive assessment of innate and adaptive immune responses against alginate-encapsulated cells. Biomaterials 2014:53:7811-7818.
K. W. Y. Chan*, T. Yu, Y. Qiao, Q. Liu, M. Yang, H. Patel, G. Liu, K. W. Kinzler, B. Vogelstein, J. W. Bulte, P. C. M. van Zijl, J. Hanes, S. Zhou, M. T. McMahon. A diaCEST MRI approach for monitoring liposomal accumulation in tumors. J Control. Release 2014:180:51-59.
K. W. Y. Chan*, J. W. M. Bulte, M. T. McMahon. Diamagnetic chemical exchange saturation transfer (diaCEST) liposomes: physicochemical properties and imaging applications. WIREs Nanomed. Nanobiotech. 2014:6:111-124.
K. W. Y. Chan*, G. Liu, X. Song, H. Kim, T. Yu, D. R. Arifin, A. A. Assaf, J. Hanes, P. Walczak, P. C. M. van Zijl, J. W. M. Bulte, M. T. McMahon. MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted cell viability. Nature Materials 2013:12:268-275. (Cover Article; ISI Citation: 94; Highly Citation Award, Web of Science in 2015)
G. Liu, X. Song, K. W. Y. Chan*, M. T. McMahon. Nuts and bolts of chemical exchange saturation transfer MRI. NMR Biomed. 2013:26:810-828.
D. R. Arifin, D. A. Kedziorek, Y. Fu, K. W. Y. Chan*, M. T. McMahon, C. R. Weiss, D. L. Kraitchman, J. W. M. Bulte. Microencapsulated cell tracking. NMR Biomed. 2013:26:850-859.
K. W. Y. Chan*, M. T. McMahon, Y. Kato, G. Liu, J. W. M. Bulte, Z. M. Bhujwalla, D. Artemov, P. C. M. van Zijl. Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer. Magn. Reson. Med. 2012:68:1764-1773.





NICE-Lab recruitment Our lab is looking for passionate and talented graduate students, research assistants and senior research assistants. If you are interested in our research, please send your CV to KannieW.Y.C@cityu.edu.hk
Lab website: https://sites.google.com/site/kannienicelab

Last modified on 6 September, 2021