李术
性 别： 女 出生年月： 1970-10-01
职 称： 教授 工作单位： 动物医学学院
招生学科1： 基础兽医学 招生学科2：
办公电话： E-mail： lishu@neau.edu.cn

 开设研究生课程情况
课程编号 课程名称 课程级别 学时
206305 动物生理学专题 硕士课 32
106119 动物生理学与生物化学研究进展 博士课 48
106312 动物生理学研究技术 博士课 48
 近五年主持科研项目概况
主持国家自然科学基金5项，十三五重点研发项目、博士后科学基金、省教育厅科学基金、哈尔滨市科技局基金等10余项。
近五年主持的课题如下：
1. 国家自然科学基金面上项目，基于硒蛋白调控中性粒细胞外捕网形成探讨鸡缺硒性动脉炎的发生机制，2019/01-2022/12，主持。
2. 环境有害气体因子对肉鸡免疫损伤的影响及机制，国家重点研发计划，2016/07-2020/12，子课题负责人。
3. 国家自然科学基金面上项目，microRNA-155在鸡缺硒性脾淋巴细胞凋亡中的作用机制研究， 2015/01-2018/12， 主持。
4. 哈尔滨市科技创新人才研究专项资金项目， 谷氨酰胺在冷应激雏鸡肺损伤中保护作用的研究， 2010/05-2013/04，主持。
5. α-突触核蛋白在阿维菌素致鸽神经元线粒体损伤中的作用，高等学校博士学科点专项科研基金联合资助课题（博导类联合），2011/01-2013/12，主持。

 近五年项目获奖概况


 近五年代表性著作、论文
近五年在国际学术期刊上发表SCI论文60余篇（第一作者或通讯作者），代表性论文如下：
1 Zhepeng Sun, Zhe Xu, Dongxu Wang, Haidong Yao, Shu Li*,Selenium Deficiency Inhibits Dendritic Cells Differentiation and Immune Function, Imbalance the Th1/Th2 of Dendritic Cells, Metallomics, 2018, 10: 759—767 ( 通讯作者 )
2 Tingru Pan, Xueyuan Hu, Tianqi Liu, Zhe Xu, Na Wan, Yiming Zhang, Shu Li*, miR-128-1-5p regulates tight junction induced by Se deficiency via targeting CADM1 in broilers vein endothelial cells,Journal of Cellular Physiology,DOI: 10.1002/jcp.26794 ( 通讯作者 )
3 Tianqi Liu, Tianshu Yang, Zhe Xu, Siran Tan, Tingru Pan, Na Wan, Shu Li*,microRNA-193b-3p regulates hepatocyte apoptosis in selenium-deficient broilers by targeting MAML1,Journal of Inorganic Biochemistry, 2018,186: 235–245 ( 通讯作者 )
4 Qianru Chi,Xin Chi, Xueyuan Hu, Shuang Wang, Hongfu Zhang*, Shu Li*,The effects of atmospheric hydrogen sulfide on peripheral blood lymphocytes of chickens: Perspectives on inflammation, oxidative stress and energy metabolism, Environmental Research, 2018, 167 : 1–6 ( 通讯作者 )
5 Xueyuan Hu, Qianru Chi, Dongxu Wang, Xin Chi, Xiaohua Teng*, Shu Li*, Hydrogen sulfide inhalation-induced immune damage is involved in oxidative stress, inflammation, apoptosis and the Th1/Th2 imbalance in broiler bursa of Fabricius, Ecotoxicology and Environmental Safety, 2018, 164: 201–209 ( 通讯作者 )
6 Jianqiao Chen, Tingru Pan, Na Wan, Zhepeng Sun, Ziwei Zhang, Shu Li*, Cadmium-Induced Endoplasmic Reticulum Stress in Chicken Neutrophils is Alleviated by Selenium, Journal of Inorganic Biochemistry. 2017, 170: 169–177 ( 通讯作者 )
7 Ci Liu, Zhepeng Sun, Zhe Xu, Tianqi Liu, Tingru Pan, Shu Li*, Down-regulation of microRNA-155 promotes selenium deficiency-induced apoptosis by tumor necrosis factor receptor superfamily member 1B in the broiler spleen, Oncotarget. 2017,8(35): 58513–58525. ( 通讯作者 )
8 Zhepeng Sun, Ci Liu, Tingru Pan, Haidong Yao, Shu Li*, Selenium Accelerates Chicken Dendritic Cells Differentiation and affects Selenoproteins Expression, Developmental and Comparative Immunology,2017, 77: 30-37 ( 通讯作者 )
9 Ming Li, Shuo Zhou, Xian-Song Wang, Ci Liu, Shu Li*. Effects of in vitro, and in vivo, avermectin exposure on alpha synuclein expression and proteasomal activity in pigeons. Ecotoxicology Environmental Safety, 2017, 135: 24-31. ( 通讯作者 )
10 Jianping Qu, Ming Li, Fuqing Zhao, Ci Liu, Ziwei Zhang, Shiwen Xu, Shu Li*. Autophagy is upregulated in brain tissues of pigeons exposed to avermectin, Ecotoxicology and Environmental Safety, 2015, 113, 159–168. ( 通讯作者 )
11 Liu, C. P., Fu, J., Xu, F. P., Wang, X. S., Li, S*. The role of heat shock proteins in oxidative stress damage induced by se deficiency in chicken livers. BioMetals, 2015, 28(1), 163-173. ( 通讯作者 )
12 Houjuan Xing, Zhilei Wang, Xuejiao Gao, Dechun Chen, Liangliang Wang, Shu Li*, Shiwen Xu*. Atrazine and chlorpyrifos exposure induces liver autophagic response in common carp. Ecotoxicology Environmental Safety, 2014, 113: 52-58. ( 通讯作者 )
13 Houjuan Xing, Ziwei Zhang, Haidong Yao, Tao Liu, Liangliang Wang, Shiwen Xu*, Shu Li*. Effects of Atrazine and Chlorpyrifos on cytochrome P450 in common carp liver. Chemosphere, 2014, 104(3): 244. ( 通讯作者 )
14 Zi-wei Zhang, Ming-yu Bi, Hai-dong Yao, Jing Fu, Shu Li*, Shi-wen Xu*. Effect of cold stress on expression of AMPKalpha-PPARalpha pathway and inflammation genes. Avian Diseases, 2014, 58(3):415-26. ( 通讯作者 )
15 Ming Li, Xian-Song Wang, Feng-Ping Xu, Shuang Liu, Shi-Wen Xu, Shu Li*. The change in heat shock protein expression in avermectin induced neurotoxicity of the pigeon (Columba livia) both in vivo and in vitro. Ecotoxicology Environmental Safety, 2014, 110:95-102. ( 通讯作者 )
16 Yao Fu, Ming Li, Ci Liu, Jian-Ping Qu, Wen-Jun Zhu, Hou-Juan Xing, Shi-Wen Xu, Shu Li*. Effect of atrazine and chlorpyrifos exposure on cytochrome P450 contents and enzyme activities in common carp gills. Ecotoxicology & Environmental Safety, 2013, 94(1):28. ( 通讯作者 )
17 Shu Li*, Ming Li, Yali Cui, Xiansong Wang. Avermectin exposure induces apoptosis in King pigeon brain neurons. Pesticide Biochemistry & Physiology, 2013, 107(2):177-187. ( 第一作者 )
18 Ming Li, Tian-Zi You, Wen-Jun Zhu, Jian-Ping Qu, Ci Liu, Bing Zhao, Shi-Wen Xu, Shu Li*. Antioxidant response and histopathological changes in brain tissue of pigeon exposed to avermectin.. Ecotoxicology, 2013, 22(8):1241. ( 通讯作者 )
19 Li-Jie Chen, Bao-Hong Sun, Jian ping Qu, Shiwen Xu, Shu Li*. Avermectin induced inflammation damage in king pigeon brain. Chemosphere, 2013, 93(10):2528. ( 通讯作者 )
20 Wen-Jun Zhu, Ming Li, Ci Liu, Jian-Ping Qu, Ya-Hong Min, Shi-Wen Xu, Shu Li*. Avermectin induced liver injury in pigeon: mechanisms of apoptosis and oxidative stress. Ecotoxicology & Environmental Safety, 2013, 98(12):74-81. ( 通讯作者 )

 近五年授权的专利等情况
1.发明专利，治疗犬皮肤真菌病的药物组合及其制备方法，第1完成人，国家知识产权局，专利号：ZL5.1，2012年5月。
2.实用新型专利，奶牛酮病快速诊断板，第1完成人，国家知识产权局，专利号：ZL2.2，2010年9月。
3.实用新型专利，细胞爬片培养板，第1完成人，国家知识产权局，专利号：ZL1.8，2010年9月。



 其他获奖及荣誉称号