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东北农业大学博士生导师简介-李一经

本站小编 Free考研网/2020-03-07

 李一经
性 别: 男 出生年月: 1960-11-08
职 称: 教授 工作单位: 动物医学学院
招生学科1: 预防兽医学 招生学科2:
办公电话: ** E-mail: yijingli@163.com;liyijing@neau.edu.cn

 开设研究生课程情况
课程编号 课程名称 课程级别 学时
微生物病原学72
兽医细菌学专题72
高级兽医微生物学72
 近五年主持科研项目概况
1. 牵头主持“十三五”国家重点研发计划“畜禽重大疫病防控与高效安全养殖综合技术研发”重点专项“动物重大疫病新概念防控产品研发”项目,2178万元,2017.7-2020.12。
2. 主持国家自然科学基金“表达猪腹泻冠状病毒保护性抗原转基因乳酸菌诱导黏膜免疫的研究,60万,2018.1-2021.12。
3. 主持国家自然科学基金“乳酸菌表达与传递猪流行性腹泻病毒保护性抗原靶向融合肽诱导黏膜免疫的研究”,88万,2015.1-2019.12。
4. 主持国家自然科学基金“PEDV保护性抗原树突细胞靶向融合肽诱导黏膜免疫的分子机制
”,57万,2020.1-2023.12。
5. 主持科技部中国农村技术开发中心子课题(哈尔滨兽医研究所),新型肠道黏膜靶向免疫抗感染机制研究,140万,2016.7-2020.12 。
5. 主持哈药集团生物疫苗有限公司课题“表达猪流行性腹泻病毒ps1蛋白的干酪乳杆菌口服疫苗的研制”2014.1-。
6. 主持“十二五”863项目子课题,猪腹泻性疫病新型分子诊断技术研究与产品开发/2012AA101304, 143.3万元,2012.1.1-2015.12.30。
7. 主持“十二五”863项目子课题,动物梭菌类疾病安全级重组乳酸菌活菌载体疫苗创制及工艺创新/2011AA10A213, 80.8万元。 2011.1.1-2015.12.30。
8. 主持“十一五” 国家科技支撑计划,李斯特菌快速检测技术研究/2010BAD04B02,40万元,2010.1.1-2012.12.31。
9. 主持黑龙江省十二五攻关项目,猪腹泻相关疾病新型疫苗与诊断试剂工艺创新及其应用/GC12B303,2012.1.1-2015-12-31,30万。
10.黑龙江省高等学校科技创新团队,猪重要腹泻性疾病致病机制及其防治关键技术研究,2011-2015,100万。
11、主持国家自然科学基金“转基因乳酸菌表面展示猪轮状病毒保护性抗原及诱导黏膜免疫的研究”,2003年1-2016年12月,81万。


 近五年项目获奖概况
1.国家科学技术进步二等奖,获奖名称:民猪优异种质特性遗传机制、新品种培育及产业化,获奖人员:刘娣、张树敏、刘忠华、李一经、李娜、杨秀芹、马红、尹志、刘春龙,2017.12
获黑龙江科技发明二等奖,获奖名称:猪传染性胃肠炎快速检测试剂的研制及其应用,获奖人员:李一经、唐丽杰、师东方、葛俊伟、任晓峰、姜骞,刘玉芬、王新生,2007.8
2. 获黑龙江高校科学技术一等奖,获奖名称:猪腹泻病毒重要基因及其结构蛋白免疫相关功能的研究,获奖人员:李一经、任晓峰、刘敏、尹杰超、葛俊伟、唐丽杰、乔薪瑗、姜艳平、崔文,2010.4.9


 近五年代表性著作、论文
1.论文目录:
(1) Ge JW, Liu DQ, Li YJ*,Construction of recombinant lactobacilli expressing the core neutralizing epitope (COE) of porcine epidemic diarrhea virus and a fusion protein consisting of COE and Escherichia coli heat-labile enterotoxin B, and comparison of the immune responses by orogastric immunization,Can. J. Microbiol. 58: 1258–1267 (2012)
(2) Zhao LL, Liu M, Ge JW, Qiao XY, Li YJ*, Liu DQ*. Expression of infectious pancreatic necrosis virus (IPNV) VP2-VP3 fusion protein in Lactobacillus casei and immunogenicity in rainbow trouts. Vaccine. 2012 Feb 27;30(10):1823-9.
(3)Luo JG, Ge JW, Tang LJ, Qiao XY, Jiang YP, Cui W, Liu M, Li YJ*,Development of a loop-mediated isothermal amplification assay for rapid detection of parvovirus. J Virol Methods. 2013 Aug;191(2):155-61(4)Liu DQ, Ge JW, Qiao XY, Jiang YP, Liu SM, Li YJ*. High-level mucosal and systemic immune responses induced by oral administration with Lactobacillus-expressed porcine epidemic diarrhea virus (PEDV) S1 region combined with Lactobacillus-expressed N protein. Appl Microbiol Biotechnol. 2012 Mar;93(6):2437-46.
(5)Min L, Li-Li Z, Jun-Wei G, Xin-Yuan Q, Yi-Jing L*, Di-Qiu L*, Immunogenicity of Lactobacillus-expressing VP2 and VP3 of the infectious pancreatic necrosis virus (IPNV) in rainbow trout. Fish Shellfish Immunol. 2012 Jan;32(1):196-203
(6) Song BF, Ju LZ, Li YJ*, Tang LJ. Chromosomal insertions in the Lactobacillus casei upp gene that are useful for vaccine expression.Appl Environ Microbiol. 2014 Jun;80(11):3321-6
(7)Jiang X, Yu M, Qiao X, Liu M, Tang L, Jiang Y, Cui W, Li Y*.,Up-regulation of MDP and tuftsin gene expression in Th1 and Th17 cells as an adjuvant for an oral Lactobacillus casei vaccine against anti-transmissible gastroenteritis virus.,Appl Microbiol Biotechnol. 2014 Oct;98(19):8301-12
(8)Song L, Cui H, Tang L, Qiao X, Liu M, Jiang Y, Cui W, Li Y*.Construction of upp deletion mutant strains of Lactobacillus casei and Lactococcus lactis based on counterselective system using temperature-sensitive plasmid.J Microbiol Methods. 2014 Jul;102:37-44
(9)Jing Wen, Dan Jiao, Jian-hua Wang, De-hai Yao, Zhi-xiang Liu, Gang Zhao, Wen-dong Ju, Cheng Cheng, Yi-jing Li*, Yi Sun* ,Rickettsia raoultii, the predominant Rickettsia found in Dermacentor silvarum ticks in China–Russia border areas, Experimental and Applied Acarology ,2014,63,(4)579-585
(10)Zanyu Wang, Yin Jiyuan, Chen Su, Qiao Xinyuan, Tang Lijie, and Li Yijing*, Development of an Antigen Capture Enzyme-Linked Immunosorbent Assay for Virus Detection Based on Porcine Epidemic Diarrhea Virus Monoclonal Antibodies, VIRAL IMMUNOLOGY, 28(3), 2015, 184–189
(11) Zhifu Shan,3 Jiyuan Yin,3 Zongying Wang, Peipei Chen, Yijing Li* and Lijie Tang*, Identification of the functional domain of the porcine epidemic diarrhea virus receptor, Journal of General Virology (2015), 00, 1–5 DOI 10.1099/vir.0.000211
(12)Xinpeng Jiang, Xingyu Hou, Lijie Tang, Yanping Jiang, Guangpeng Ma*,, Yijing Li*, A phase trial of the oral Lactobacillus casei vaccine polarizes Th2 cell immunity against transmissible gastroenteritis coronavirus infection, Appl Microbiol Biotechnol.
(13)Ji-Yuan Yin, Chao-Qun Guo, Zi Wang, Mei-Ling Yu, Shuai Gao, Syed M. Bukhari, Li-Jie Tang, Yi-Gang Xu*, Yi-Jing Li*, Directed chromosomal integration and expression of porcine rotavirus outer capsid protein VP4 in rotavirus outer capsid protein VP4 in Lactobacillus casei ATCC393, Appl Microbiol Biotechnol. 2016 Nov;100(22):9593-9604
(14) Yu M, Qi R, Chen C, Yin J, Ma S, Shi W, Wu Y, Ge J, Jiang Y, Tang L, Xu Y*, Li Y*,Immunogenicity of recombinant Lactobacillus casei-expressing F4 (K88) fimbrial adhesin FaeG in conjunction with a heat-labile enterotoxin A (LTAK63) and heat-labile enterotoxin B (LTB) of enterotoxigenic Escherichia coli as an oral adjuvant in mice. See comment in PubMed Commons belowJ Appl Microbiol. 2016 Nov 17. doi: 10.1111/jam.13352
(15) C. Wang, G.H. Lian, L.L. Zhao, Y. Wu, Y.J. Li, L.J. Tang, X.Y. Qiao, Y.P. Jiang, M. Liu, Virulence and serological studies of recombinant infectioushematopoietic necrosis virus (IHNV) in rainbow trout, Virus Research 220 (2016) 193–202
(16) C. Wang,  L. L. Zhao, Y. J. Li#,  L. J. Tang,  X. Y. Qiao, Y. P. Jian, M. Liu#,  Analysis of the genome sequence of infectious hematopoietic necrosis virus HLJ-09 in China, Virus Genes (2016) 52:29–37
(17)Shi W, Fan W, Bai J, Tang Y, Wang L, Jiang Y, Tang L, Liu M, Cui W, Xu Y, Li Y. TMPRSS2 and MSPL Facilitate Trypsin-Independent Porcine Epidemic Diarrhea Virus Replication in Vero Cells. Viruses. 2017 May 18;9(5). pii: E114. doi: 10.3390/v**.
(18)Wu Y, Guo M, Hua X, Duan K, Lian G, Sun L, Tang L, Xu Y, Liu M, Li Y. The role of infectious hematopoietic necrosis virus (IHNV) proteins in the modulation of NF-κB pathway during IHNV infection.Fish Shellfish Immunol. 2017 Apr;63:500-506. doi: 10.1016/j.fsi.2017.02.041. Epub 2017 Feb 27.
(19)Yang Wu, Li Wang, Tiantian Guo, Yanping Jiang, Xinyuan Qiao, Li Sun, Min Liu, Lijie Tang, Yigang Xu, Yijing Li, Identification of amino acid residues in infectious hematopoietic necrosis virus (IHNV) NV protein necessary for viral replication and pathogenicity;Fish and Shellfish Immunology 79 (2018) 294–302
(20)Sunting Ma, Li Wang, Xuewei Huang, Xiaona Wang, Su Chen, Wen Shi, Xinyuan Qiao, Yanping Jiang, Lijie Tang, Yigang Xu and Yijing Li, Oral recombinant Lactobacillus vaccine targeting the intestinal microfold cells and dendritic cells for delivering the core neutralizing epitope of porcine epidemic diarrhea virus, Microb Cell Fact. 2018  9;17(1):20.  
(21)Xingyu Hou, Xinpeng Jiang, Yanping Jiang, Lijie Tang, Yigang Xu, Xinyuan Qiao, Liu Min, Cui Wen, Guangpeng Ma and Yijing Li, Oral Immunization against PEDV with Recombinant Lactobacillus casei Expressing Dendritic Cell-Targeting Peptide Fusing COE Protein of PEDV in Piglets, Viruses 2018, 10, 106;
(22)Shuo Jia, Guojie Ding, Chao Wang, Baohua Feng, Zhuo Wang, Li Wang, Yanping Jiang, Wen Cui, Xinyuan Qiao, Lijie Tang, Yijing Li*, Yigang Xu*,N-linked glycosylation sites in G protein of infectious hematopoietic necrosis virus (IHNV) affect its virulence and immunogenicity in rainbow trout, Fish and Shellfish Immunology, 2019,89: 537–547
(23)Sunting Ma, Xinyuan Qiao, Yigang Xu, Li Wang, Han Zhou, Yanping Jiang, Wen Cui, Xuewei Huang, Xiaona Wang, Lijie Tang* and Yijing Li*, Screening and Identification of a Chicken Dendritic Cell Binding Peptide by Using a Phage Display Library,Frontiers in Immunology,2019,Aug 6 10:1853.doi:10.3389/fimmu.2019.0853.eCollection 2019
(24) Yanan Wang, Aoying Sun, Yu Sun,Sijia Zhang, Tian Xia, Tiantian Guo,Yanping Jiang, Xinyuan Qiao, Wen Cui, Lijie Tang, Yigang Xu, Yijing Li* and Li Wang*,Porcine transmissible gastroenteritis virus inhibits NF-κB activity via nonstructural protein 3 to evade host immune system,Virology Journal (2019) 16:97.

2.论著
主编国家级规划教材:兽医微生物学,高等教育出版社



 近五年授权的专利等情况
1、表达猪传染性胃肠炎病毒S蛋白的重组乳酸球菌及制法,国家发明专利,唐丽杰、李一经、葛俊伟、欧笛,专利号:ZL1.1,2009年12月9日
2、无选择标记残留的乳酸菌基因组基因操作系统及其应用,发明专利,第一,专利号:ZL1,2014年7月9日
3、用于同时检测猪流行性腹泻病毒、猪传染性胃肠炎病毒以及猪轮状病毒的多重PCR引物组,发明专利,第一,专利号:ZL2.1,2016年3年30日
4、一种用于检测猪流行性腹泻病毒的免疫胶体金试纸条及其制备方法和应用,发明专利,第一,专利号:ZL3.6,2015年3月25日
5、抗魏氏梭菌病转基因植物疫苗及其制作方法,发明专利,第二,专利号:ZL2,2015年2月25日
6、一种作为断乳仔猪饲料添加剂的表达乳铁蛋白重组乳酸菌组合物,发明专利,第二,专利号:ZL9.1,2015年9月30日



 其他获奖及荣誉称号
相关话题/免疫 病毒 发明专利 动物 兽医

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