张秀英
性 别： 女 出生年月： 1963-05-01
职 称： 教授 工作单位： 东北农业大学动物医学学院
招生学科1： 基础兽医学 招生学科2：
办公电话： E-mail： zhangxiuying@neau.edu.cn

 开设研究生课程情况
课程编号 课程名称 课程级别 学时
6.022 药理学与毒理学专题 博士课 72
6.021 分子药理学 博士课 54
6.574 高级药理学 硕士课 54
26.5 兽医药理学与毒理学专题 硕士课 54
6.024 药理毒理研究生班讨论 博士课 36
 近五年主持科研项目概况
1.《非酒精性脂肪肝增量表达CYP2A5的作用机制及其发病机制》2011-2015,国家自然基金,**。
2.哈尔滨市科技局科技创新人才：blaNDM-1基因引起猪源大肠杆菌耐药与其适应性代价和毒力的研究,2013-2015,RFXXJ035 3黑龙江省自然基金重点项目：Nrf2信号通路对NAFLD小鼠药物代谢酶基因表达的调控，2014-2016，ZD201405
4.国家十三五重点研发计划专项：“畜禽重要耐药病原菌耐药耐药性检测与控制技术”子项目“畜禽病原菌耐药性检测标准研究”201601-202012,59,2016YFD**
5.加米霉素注射液的靶动物安全实验及临床试验，冀中生物科技有限公司，2017.01-2017.12,横向合作项目。
6.多西环素生物等效性和残留研究，青岛蔚蓝生物，2018-2019，横向合作项目。
7. 国家十三五重点研发计划专项：“畜禽药物的代谢转归和耐药性形成机制研究”子项目“畜禽重要病原菌关键耐药蛋白机制确证和抑制剂筛选”2018-2020, 2018YFD**





 近五年项目获奖概况
1.张秀英，抗鸡新城疫病毒复方中药制剂的研制与应用，黑龙江省，省科技进步奖，二等奖，第一名
2.张秀英，抗鸡新城疫病毒复方中药制剂的研制与应用，省畜牧局，科技进步奖，一等奖，第一名
3.张秀英，中草药添加剂及其防治疾病作用研究，黑龙江省，省科技进步奖，三等奖，第一名
4. 张秀英，奶牛重要疫病防治技术研究与产业化开发，省畜牧局，科技进步奖，一等奖，第二名


 近五年代表性著作、论文
1. Li Rui, Wang YuanYuan, Zhang Xiu Ying*.Expression of Cytochrome P450 2A5 in C57BL/6J mouse model of nonalcoholic fatty liver disease，J. Pharmacology, 2013;92(1-2):26-31.
2. R. Ll, Y. Z. Cao, Y. Y.  Wang, F. P.  Liu,G. F. G. Guo& X. Y. Z. ZHang。Expression of P450 2A5 in a mouse model of NAFLD: the identification of another pathological condition of regulation CYP2A5 expression。J. Vet. Pharamcol. Therap. 35(Suppl.3)137-138.2012
3.Guofeng Xu1, WeiAn2, HongdongWang1 and XiuyingZhang1* Prevalence and characteristics of extended-spectrumb-lactamase genes in Escherichia coli isolated from piglets with post-weaningdiarrhea in Heilongjiang province, China.Frontiers in Microbiology,2015,6(10):1-8
4.Guofeng Xu1  Yue Jiang1 Wei An2 Hongdong Wang1 Xiuying Zhang1 Emergence of KPC-2- producing Escherichia coli isolates in an urban river in Harbin, China. World J Microbiol Biotechnol (2015) 31:1443–1450
5. Yizhe Cui1,2 Qiuju Wang2 Xing Yi1 Xiuying Zhang1*   Effects of Fatty Acids on CYP2A5 and Nrf2 Expression in Mouse Primary Hepatocytes. Biochem Genet (2016) 54:29–40
6. Yizhe Cuia, Qiuju Wang, Xiaochong Lia, Xiuying Zhang*. Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation. Redox Biology, 1 (2013) 433–440.
7. Chunhua Wang, Yizhe Cui, Chunyan Li, Yanhua Zhang, Shang Xu, Xiaochong Li, Hong Li and Xiuying Zhang*. Nrf2 deletion causes “benign” simple steatosis to develope into nonalcoholic steatohepatitis in mice  fed a high-fat diet. Lipids in Health and Disease, 2013, 12:165.
8.Xinghe Wang, Chunyan Li, Shang Xu, Ishfaq Muhammad, Xiuying Zhang*，NF-E2-related factor 2 deletion facilitates hepatic fatty acids metabolism disorder induced by high-fat diet via regulating related genes in mice.，Food Chem. Toxicol.2016, 94:186-96。
9.Xinghe Wang, Chunyan Li, Ishfaq Muhammad, Xiuying Zhang*。Fatty acid composition in serum correlates with that in the liver and non-alcoholic fatty liver disease activity scores in mice fed a high-fat diet.Environ. Toxicol. Phar.2016, 44:140-150。
10.Chunhua Wang1, Qimeng Tao2, Xinghe Wang1, Xiurong Wang2, Xiuying Zhang1*。Impact of High-Fat Diet on Liver Genes Expression Profiles in Mice Model of Nonalcoholic Fatty Liver Disease.Environ. Toxicol. Phar.2016, 45:52-62。
11.Ping Cheng, Tong Wang, Wei Li, Ishfaq Muhammad, He Wang, Xiaoqi Sun, Yuqi Yang,Jiarui Li, Tianshi Xiao and Xiuying Zhang*Baicalin Alleviates Lipopoly saccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-kB Pathway.Frontiers in Pharamcology. 2017.08,VolumeB,article 547.
12.Ishfaq Muhammad, Xiaoqi Sun, He Wang, Wei Li, Xinghe Wang, Ping Cheng, Sihong Li, Xiuying Zhang* and Sattar HamidCurcumin Successfully Inhibited theComputationally Identified CYP2A6Enzyme- Mediated Bioactivation of Aflatoxin B1 in Arbor Acres broiler. Frontiers in Pharamcology. 2017.03, VolumeB,article 143.
13Xiaoxu Cui 1†, Ishfaq Muhammad1†, Rui Li 2, Huiran Jin2, Zhaolin Guo2, Yuqi Yang1,Sattar Hamid1, Jiarui Li 1, Ping Cheng1 and Xiuying Zhang1*Development of a UPLC-FLD Method for Detection of Aflatoxin B1 and M1 in Animal Tissue to Study the Effectof Curcumin on Mycotoxin Clearance Rates Frontiers in Pharamcology.  2017.09, VolumeB,article 650.
14.Xing-he Wang, Xiao-xu Cui, Xiao-qi Sun, Xing-hui Wang, Xiao-chong Li, Yue Qi, Wei Li, Mei-yu Han, Ishfaq Muhammad and Xiu-ying Zhang* High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids AccumulationUp-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. 2017.05, VolumeB,article 233.
15.QIU‑JU WANG1,2*, YI‑ZHE CUI2*, XIU‑YING ZHANG1 and JING SU3. Effect of early weaning on the expression of excitatory amino acid transporter 1 in the jejunum and ileum of piglets.  MOLECULAR MEDICINE REPORTS 16: 6518-6525, 2017
16. Jin-ming Zhang Xing-he Wang Li-hong Hao He Wang Xiu-ying Zhang Ishfaq Muhammad Yue Qi Guang-liang Li Xiao-qi Sun Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells. Environmental Toxicology and Pharmacology, 52 (2017) 21–26 
   17. Muhammad I, Wang H, Sun X, Wang X, Han M, Lu Z, Cheng P, Hussain MA and Zhang X (2018). Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification. Front. Pharmacol. 9:554. doi: 10.3389/fphar.2018.00554
.18Wang H, Muhammad I, Li W, Sun X, Cheng P, Zhang X, Sensitivity of Arbor Acres broilers and Chemoprevention of Aflatoxin B1-induced liver injury by Curcumin, a natural potent inducer of Phase-II enzymes and Nrf2, Environmental Toxicology and Pharmacology 2018, 59:94-104,
 19. He Wang, Wei Li, Ishfaq Muhammad, Xiaoqi Sun, Xiaoxu Cui, Ping Cheng, Abdul Qayum & Xiuying Zhang (2018): Biochemical basis for the age-related sensitivity of broilers to aflatoxin B1, Toxicology Mechanisms and Methods, 2018;28(5):361-368  (IF-1.5, 四区).  2018.05
20. Xing-he Wang,∗,† Wei Li,† Xing-hui Wang,† Mei-yu Han,† Ishfaq Muhammad,† Xiu-ying Zhang,†,1Xiao-qi Sun,† and Xiao-xu Cui  Water-soluble substances of wheat: a potential preventer of aflatoxin B1-induced liver damage in broilers. poultry science,2018
21. Ishfaq Muhammad1 · Xinghe Wang2 · Sihong Li1 · Rui Li1 · Xiuying Zhang1 Curcumin confers hepatoprotection against AFB1-induced toxicity via activating autophagy andameliorating inflammation involving Nrf2/HO-1 signaling pathway. Molecular Biology Reports. 2018. https://doi.org/10.1007/s11033-018-4323-4
22.Xinghe Wang2 · Ishfaq Muhammad1 · Xiaoqi Sun1 · Meiyu Han1 · Sattar Hamid1 · Xiuying Zhang1,3.Protective role of curcumin in ameliorating AFB1-induced apoptosis via mitochondrial pathway in liver cells. Molecular Biology Reports,2018. https://doi.org/10.1007/s11033-018-4234-4
23 张秀英  副主译，《Veterinary Pharmacology and Therapertics》. 国家“十二五”重点著作项目。中国农业出版社。2012年六月出版
24.张秀英，编委，中华人民共和国兽药典（2015版）：兽药使用指南（化学药品卷），中国农业出版社，2016年4月出版
25. 张秀英，主编，动物药物分析，面向21世纪高等农业院校统编教材，中国农业出版社，2018.04

 


 近五年授权的专利等情况
1张秀英，治疗奶牛乳腺炎中药透皮软膏及其制备方法，2011.09,中国，ZL4.2
2同时检测小鼠血液和肝脏组织中脂肪酸含量的气相色谱方法，发明专利，中国，ZL0.0，张秀英  李睿  李春艳
 


 其他获奖及荣誉称号
东北农业大学优秀硕士研究生导师