基本信息科学研究教育教学论文著作
基本信息


李惠静，女，汉族，1975年生。教授，博士生导师。现主持威海市科技攻关重点项目、山东省科技攻关和国家自然科学基金等项目。

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新闻标题课题组现状

发表时间2015-09-01

课题组成立于2012年，现有实验室面积150平方米，拥有15个先进的通风柜系统，HPLC 分离分析/提纯系统，零下120度超低温合成反应浴系统，无污染合成反应铁浴加热系统，溶剂蒸馏提纯系统等现代化实验室设备设施，目前拥有2000 个不同的化学试剂，为科研项目实施提供了有力保障。

2013 年秋，课题组所在学院的核磁共振波谱仪、高分辨质谱仪、红外光谱仪、高精度旋光仪等设备陆续到位，课题组各类科研项目得以顺利开展。课题组对进入课题组做科研的研究生和本科生进行生活补贴。

初进实验室的本科生需和研究生联合组成合作共赢的科研小组，待能力提高后根据意愿可以从科研小组中独立出来做课题。学生可以根据科研能力、科研经验和科研意愿等从事天然产物（药物）合成、绿色化学和有机合成等领域的研究。应用化学系、生物工程系和环境工程系本科生均可进入课题组，在传帮带形式下短期内可以上手课题研究。

欢迎本科生来课题组从事科研锻炼或进行本科毕业设计！欢迎同学报考或免试推荐到我们课题组做硕士生和博士生！让我们携手为理想而奋斗！


新闻标题吴彦超教授的个人主页

发表时间2014-12-08

http://homepage.hit.edu.cn/pages/wuyanchao


新闻标题本科生科研成果

发表时间2015-09-02

邓凯等。《苯并吡喃、三苯基苯等功能化合物的绿色制备》。2015年, 第八届全国大学生节能减排社会实践与科技竞赛科技类作品全国三等奖。邓凯，崔同旭，朱帅，蒋官赞，王晓彤。《基于绿色化学理念合成三苯基苯、苯并吡喃和喹啉类化合物》。2015年, 第十四届“挑战杯”·鲁信山东省大学生课外学术科技作品竞赛一等奖。邓凯，朱帅，崔同旭，蒋官赞，王晓彤，刘晨。“功能化合物的绿色合成”。2015年, 第十四届“挑战杯”大学生课外学术科技作品竞赛校内竞赛特等奖。Kai Deng (邓凯), Qi-Yong Huai, Zhi-Lun Shen, Hui-Jing Li*, Chen Liu (刘晨) and Yan-Chao Wu*. "Rearrangement of dypnones to 1,3,5-triarylbenzenes." Org. Lett. 2015, 17(6), 1473-1476. (SCI, IF = 6.364)Hui-Jing Li*, Chen-Chao Wang, Shuai Zhu (朱帅), Chun-Yang Dai and Yan-Chao Wu*. "Ru(II)-catalyzed hydrogen transfer/annulation cascade processes between alcohols and 2-nitrobenzaldehydes." Adv. Synth. Catal. 2015, 357(2-3), 583-588. (SCI, IF = 5.663)Hui-Jing Li*, Rui Wang, Jing Gao (高晶), Yuan-Yuan Wang, Dong-Hui Luo and Yan-Chao Wu*. "Bismuth(III) bromide-catalyzed substitution of benzyl alcohols with arylsulfonylmethyl isocyanides: an unexpected access to sulfinates." Adv. Synth. Catal. 2015, 357(7), 1393-1397. (SCI, IF = 5.663)Hui-Jing Li*, Kai Deng (邓凯), Dong-Hui Luo, De-Hui Liu(刘德辉), Jun-Li Wang, Chun-Hua Lin (林春华) and Yan-Chao Wu*. "Synthesis of functional 4H-chromenes from phenols and acetophenones under solvent- and metal-free conditions." RSC Adv. 2014, 4 (50), 26316-26324. (SCI, IF = 3.840)Hui-Jing Li,* Ying-Ying Wu (吴莹莹), Qin-Xi Wu（武芹席）, Rui Wang, Chun-Yang Dai, Zhi-Lun Shen, Cheng-Long Xie (谢成龙) and Yan-Chao Wu*. "Water-promoted ortho-selective monohydroxymethylation of phenols in NaBO2 system." Org. Biomol. Chem. 2014, 12 (19), 3100-3107. (SCI, IF = 3.567)邓凯等，"一种以β-甲基查尔酮为原料制备1,3,5-三苯基苯的方法. " 2015, 中国发明专利，申请号为**6.5朱帅等，"一种喹啉类化合物的制备方法." 2015, 中国发明专利，申请号为**9.2高晶等，"一种以苯磺酰甲基异腈为原料制备亚磺酸酯的方法." 2015, 中国发明专利，申请号为**1.1朱帅等，Iron-catalysed triple hydrogen transfer processes among 2-nitrobenzyl alcohols, alcohols, and formic acid: a new access to quinolines, in preparation.邓凯等，Cyclotrimerization of acetophenones in the KOH/18-crown-6 system: Synthesis of 1,3,5-triarylbenzenes under acid-free conditions, in preparation



荣誉称号
2015年 全国大学生节能减排社会实践与科技竞赛科技类作品全国三等奖指导老师

2015年 山东省大学生课外学术科技作品竞赛一等奖指导老师

1998年 中国大学生跨世纪发展基金

1997年 中国化学工业部科技兴化奖

工作经历


时间

工作经历
2004年

美国奥勒冈州立大学，天然产物分离分析/质谱学，博士后
2009年

法国巴黎大学，金属有机化学/有机合成，博士后
2011年

哈尔滨工业大学威海校区海洋学院，天然产物合成化学/精细化学品，副教授
2014年

哈尔滨工业大学博士生导师，化学工程与技术/应用化学，教授





教育经历
2004年，中国科学院化学研究所，分子识别与功能重点实验室，有机化学，理学博士

研究领域
天然产物与活性化合物合成海产品活性物质提取与串联质谱分析材料改性与功能材料制备 主要研究方向: 课题组从事天然产物与活性化合物合成，海产品活性物质提取与串联质谱分析，材料改性和制备等。随着课题组海洋天然药物、高活性海洋天然防污化合物合成的不断实现，课题组2015年开始在海藻酸钠、壳聚糖等聚合物材料上接枝功能天然产物，制备功能材料，用于海水养殖水净化、船舶压载水处理、海洋防污、杀菌消炎等领域。

团队成员
李惠静教授博导、吴彦超教授、刘颖讲师、王军利博士(在读）、王洪双博士(在读）、黄登明博士（在读）、吉元昭博士、南祥博士、王琦硕士 (在读）、张振国硕士 (在读）、戴春阳硕士（在读）、沈志仑硕士（在读）、穆婉露硕士 (在读）、王龙飞硕士 (在读）、李肖微硕士 (在读）、陈永硕士 (在读）、邓凯学士（在读）、朱帅学士（在读）等。

科研项目
国家自然科学基金面上项目**，镓催化的环异构化反应研究及其在几种天然产物合成中的应用，负责，201401?201712国家自然科学基金青年科学基金**，具有重要生物活性的啤酒花多酚类天然产物的全合成与结构修饰研究，负责，201301?201512山东省科技攻关2013GGA10075，活性构象导向的海洋天然抗癌药物apratoxin的研制，负责，201308?201508北京分子科学国家实验室开放基金，啤酒花A型原花色素类化合物的合成研究，负责，201210?201409中国科学院分子识别与功能重点实验室开放基金2012LMRF003，A型原花色素类天然产物全合成研究，负责，201301?201412威海市科技攻关重点项目2012DXGJ02，海洋船舶防污导向的天然产物全合成与结构修饰，负责，201301?201412哈尔滨工业大学创新基金HIT. NSRIF. **，苯并吡喃类（海洋）天然产物分离分析与合成，负责，201201?201312哈尔滨工业大学威海校区科研启动基金HIT (WH) 201106，吡喃稠环类（海洋）天然产物分离分析与合成，负责，201101?201312国家自然科学基金面上项目**，基于有机SOMO活化串联环化反应的几种多环萜类天然产物的不对称全合成研究，参与，201301?201612山东省自然科学基金面上项目ZR2012BM002，Puupehenone类海洋天然产物的全合成，参与，201207?201507威海市科技攻关重点项目2011DXGJ13，若干具有高生物活性海洋天然产物全合成，参与，201201?201412天然药物及仿生药物国家重点实验室开放基金K**，嘌酮菌素天然产物全合成研究，参与，201206?201306

国家自然科学基金面上项目**，环境友好介质中有机反应的研究，参与，200401?200712

讲授课程
《药物化学》：本科生专业基础课《有机化学》：本科生专业基础课《绿色化学》：本科生专业选修课《天然产物化学》：研究生专业基础课《有机合成化学》：研究生专业基础课


招生信息
硕士招生:
海洋科学/应用化学：2～4 名/年
从事天然产物合成，精细化学品合成，有机合成方法学研究


博士招生:
化学工程与技术/应用化学：1～2 名/年

从事天然产物合成，精细化学品合成，有机合成方法学研究


论文期刊
[40] Deng Kai, Huai Qi-Yong, Shen Zhi-Lun, Li Hui-Jing,* Liu Chen and Wu Yan-Chao. "Rearrangement of dypnones to 1,3,5-triarylbenzenes." Org. Lett. 2015, 17(6), 1473-1476.

[39] Li Hui-Jing, Wang Rui, Gao Jing, Wang Yuan-Yuan, Luo Dong-Hui and Wu Yan-Chao. "Bismuth(III) bromide-catalyzed substitution of benzyl alcohols with arylsulfonylmethyl isocyanides: an unexpected access to sulfinates." Adv. Synth. Catal. 2015, 357(7), 1393-1397.

[38] Li Hui-Jing,* Wang Chen-Chao, Zhu Shuai, Dai Chun-Yang and Wu Yan-Chao. "Ru(II)-catalyzed hydrogen transfer/annulation cascade processes between alcohols and 2-nitrobenzaldehydes." Adv. Synth. Catal. 2015, 357(2-3), 583-588.

[37] Wu Qin-Xi, Li Hui-Jing,* Wang Hong-Shuang, Zhang Zhen-Guo, Wang Chen-Chao and Wu Yan-Chao. "Catalyst-free synthesis of spiropyrazolines from chalcones and cyclic-ketone N-tosylhydrazones." Synlett 2015, 26(2), 243-249.

[36] Feng Ling, Li Yang, Song Zhi-fang, Li Hui-Jing* and Huai Qi-yong, "Synthesis and biological evaluation of curcuminoid derivatives." Chem. Pharm. Bull. 2015, 63 (11), 873-881.

[35] Li Hui-Jing,* Wu Ying-Ying, Wu Qin-Xi, Wang Rui, Dai Chun-Yang, Shen Zhi-Lun, Xie Cheng-Long and Wu Yan-Chao. "Water-promoted ortho-selective monohydroxymethylation of phenols in NaBO₂ system." Org. Biomol. Chem. 2014, 12 (19), 3100-3107.

[34] Li Hui-Jing,* Deng Kai, Luo Dong-Hui, Liu De-Hui, Wang Jun-Li, Lin Chun-Hua and Wu Yan-Chao. "Synthesis of functional 4H-chromenes from phenols and acetophenones under solvent- and metal-free conditions." RSC Adv. 2014, 4 (50), 26316-26324.

[33] Li Hui-Jing, Wu, Yan-Chao,* Dai Jian-Hong, Song Yan,* Cheng Runjiao and Qiao Yuanyuan. "An "ortho effect" in electrophilic aromatic nitrations: Theoretical analysis and experimental validation." J. Chin. Chem. Soc. 2014, 61(12), 1307-1312.

[32] Li Hui-Jing,* Luo Dong-Hui, Wu Qin-Xi, Dai Chun-Yang, Shen Zhi-Lun and Wu Yan-Chao. "Bi(OTf)₃-catalyzed tandem reaction of naphthols with β,γ-unsaturated α-ketoesters. Efficient synthesis of functionalized 4H-chromenes." Chin. Chem. Lett. 2014, 25 (9), 1235-1239.

[31] Cao Ya-Kun, Li Hui-Jing, Song Zhi-Fang, Li Yang and Huai Qi-Yong. "Synthesis and biological evaluation of novel curcuminoid derivatives." Molecules 2014, 19 (10), 16349-16372.

[30] Li Hui-Jing, Song Zhi-Fang, Yu Junqiang, Li Yang, Feng Ling and Huai Qi-Yong. "Synthesis and performance of ferrocene-bonded chiral stationary phase for RP-HPLC." Asian J. Chem. 2014, 26 (14), 4465-4468.

[29] Li Hui-Jing, Wu Yan-Chao,* Dai Jian-Hong, Song Yan,* Cheng Runjiao and Qiao Yuanyuan. "Regioselective electrophilic aromatic bromination: theoretical analysis and experimental verification." Molecules 2014, 19 (3), 3401-3416.

[28] Li Hui-Jing,* Wang Jun-Li, Wang Rui, Luo Dong-Hui and Wu Yan-Chao. "Synthetic studies on potent marine drugs: synthesis and the crystal structure of 6-tert- butyl-4-phenyl-4H-chromene-2-carboxylic acid." J. Chem. 2013, Article ID 106908.

[27] Wu Yan-Chao,* Li Hui-Jing, Liu Li, Liu Zhe, Wang Dong, Chen Yong-Jun. "Hafnium triflate as an efficient catalyst for direct Friedel-Crafts reaction of chromene hemiacetals." Adv. Synth. Catal. 2011, 353 (6), 907-912.

[26] Wu Yan-Chao,* Li Hui-Jing, Liu Li, Liu Zhe, Wang Dong and Chen Yong-Jun. "Cascade reaction of β,γ-unsaturated α-ketoesters with phenols in trityl chloride/TFA system. Highly selective synthesis of 4-aryl-2H-chromenes and their applications." Yan-Chao Wu,* Org. Biomol. Chem. 2011, 9 (8), 2868-2877.

[25] Wu Yan-Chao,* Li Hui-Jing, Liu Li, Liu Zhe, Wang Dong and Chen Yong-Jun. "Facile Synthesis of Spiropyrans from Chromene Hemiacetal Esters and Bifunctional Nucleophiles." Synlett 2011, (11), 1573-1578.

[24] Wu Yan-Chao,* Li Hui-Jing and Yang Hua-Zheng. "A sensitive and highly selective fluorescent sensor for In³⁺." Org. Biomol. Chem. 2010, 8 (15), 3394-3397.

[23] Li Hui-Jing, Guillot Regis and Gandon Vincent. "A Gallium-Catalyzed Cycloisomerization/Friedel-Crafts Tandem." J. Org. Chem. 2010, 75 (24), 8435-8449.

[22] Li Hui-Jing, Deinzer Max L. "Chapter 32-Proanthocyanidins in hops" in Beer in Health and Disease Prevention (Editor(s): Preedy, Victor R. Publisher: Elsevier Inc., Burlington, England), 2009, 333–348.

[21] Li Hui-Jing, Deinzer Max L. "Chapter 9-Polyphenolic Compounds in Hops" in Hop Flavor and Aroma (Editor(s): Thomas H. Shellhammer. Publisher: Master Brewers Association of the Americas, Minnesota, USA), 2009, 99–121.

[20] Li Hui-Jing, Deinzer Max L. "The mass spectral analysis of isolated hops A-type proanthocyanidins by electrospray ionization tandem mass spectrometry." J. Mass Spectrom. 2008, 43 (10), 1353-1363.

[19] Wu Yan-Chao,* Li Hui-Jing, Liu Li, Wang Dong, Yang Hua-Zheng, Chen Yong-Jun. "Efficient Construction of Pyrazolo[1,5-a]pyrimidine Scaffold and its Exploration as a New Heterocyclic Fluorescent Platform." J. Fluoresc. 2008, 18 (2), 357-363.

[18] Li Hui-Jing, Deinzer Max L. "Tandem mass spectrometry for sequencing proanthocyanidins." Anal. Chem. 2007, 79 (4), 1739-1748.

[17] Wu Yan-Chao, Chen Yong-Jun, Li Hui-Jing, Zou Xiao-Mao, Hu Fang-Zhong and Yang Hua-Zheng. "Synthesis of trifluoromethyl-promoted functional pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones." J. Fluorine Chem. 2006, 127 (3), 409-416.

[16] Wu Yan-Chao, Liu Li, Li Hui-Jing, Wang Dong and Chen Yong-Jun. "Skraup?Doebner?Von Miller Quinoline Synthesis Revisited: Reversal of the Regiochemistry for γ-aryl-β,γ-unsaturated α-Ketoesters." J. Org. Chem. 2006, 71 (17), 6592-6595.

[15] Li Hui-Jing, Deinzer Max L. "Structural identification and distribution of proanthocyanidins in 13 different hops." J. Agr. Food Chem. 2006, 54 (11), 4048-4056.

[14] Li Hui-Jing, Tian Hong-Yu, Wu Yan-Chao, Chen Yong-Jun, Liu Li, Wang Dong and Li Chao-Jun. "Aqueous asymmetric mukaiyama aldol reaction catalyzed by chiral gallium lewis acid with trost-type semi-crown ligands." Adv. Synth. Catal. 2005, 347 (9), 1247-1256.

[13] Li Hui-Jing, Zhao Jun-Ling, Chen Yong-Jun, Liu Li, Wang Dong,* Li Chao-Jun.* "Water-promoted direct aerobic oxidation of enol silyl ether to alpha-hydroxyl ketones without catalyst." Green Chem. 2005, 7 (2), 61-63.

[12] Pan Gebo, Li Hui-Jing, Yuan Qunhui, Chen Yongjun,* Wan Lijun,* Bai Chunli. "Ordered arrays of semi-crown ligands on an Au(III) electrode surface: In situ STM study." Science in China, Series B: Chemistry 2004, 47(4), 320–325.

[11] Li Hui-Jing, Tian Hong-Yu, Chen Yong-Jun, Wang Dong,* Li Chao-Jun.* "Chiral anionic surfactants for asymmetric Mukaiyama aldol-type reaction in water." J. Chem. Res. 2003, (3), 153–156.

[10] Li Hui-Jing, Tian Hong-Yu, Chen Yong-Jun, Wang Dong,* Li Chao-Jun.* "Novel chiral gallium Lewis acid catalysts with semi-crown ligands for aqueous asymmetric Mukaiyama aldol reactions." Chem. Commun. 2002, (24), 2994–2995.

[9] Tian Hong-Yu, Li Hui-Jing, Chen Yong-Jun, Wang Dong,* Li Chao-Jun.* "Development of Highly Effective Encapsulating Surfactants for Mukaiyama Aldol Reactions in Water." Ind. Eng. Chem. Res. 2002, 41 (18), 4523-4527.

[8] Xu Liang-Zhong,* Zhang Shu-Sheng,* Li Hui-Jing, Jiao Kui. "Studies on synthesis and biological activities of novel triazole compounds containing 1,3-dioxolane." Chem. Res. Chinese U. 2002, 18(3), 284–286.

[7] Li Hui-Jing, Xu Liang-Zhong,* Zhang Shu-Sheng.* "Synthesis of (N,N-diethylamino)ethyl caproate by using Ti(OBu)₄ catalyst." Journal of Qingdao Institute of Chemical Technology 2001, 22 (2), 147-148.

[6] Xu Liang-Zhong,* Li Hui-Jing, Zhang Shu-Sheng.* "Studies on syntheses and biological activities of novel triazole compounds containing phosphorodithioate groups." Journal of Qingdao Institute of Chemical Technology 2000, 21, 80-82.

[5] Zhang Shu-Sheng,* Jiao, Kui,* Li Hui-Jing, Chen Hong-Yuan. "Spectroscopic and electrochemical studies on the enzyme-catalyzed reaction of PAP-H₂O₂-HRP." Chem. J. Chinese U. 2000, 21 (5), 710–712.

[4] Xu Liang-Zhong,* Li Hui-Jing, Zhang Shu-Sheng.* "Progress of 1,2,4-triazole fungicides." Journal of Qingdao Institute of Chemical Technology 2000, 21 (3), 201-205.

[3] Xu Liang-Zhong,* Li Hui-Jing. "The study of 2% Hypertonic abamectin Bla and alphacypermethrin EC." Journal of Qingdao Institute of Chemical Technology 2000, 21, 75-77.

[2] Xu Liang-Zhong,* Ye Qing-Guo, Li Hui-Jing, Jiao Kui, Zhang Shu-Sheng.* "Structure and characterization of O,O-diethylthiophosphoryl- hydrazine o-vanillin Schiff base nickel(II) complex: NiC₂₄H₃₆N₄O₈P₂S₂." J. Chem. Crystallogr. 2000, 30 (7), 463-467.

[1] Zhang Shu-Sheng,* Jiao Kui,* Chen Hong-Yuan, Li Hui-Jing. "Spectroscopic and electrochemical studies on the MAP-H₂O₂-HRP voltammetric enzyme-linked immunoassay system." Acta Chim. Sinica 1999, 57 (8), 922-930.