职　　称：教授、博士、国家优秀青年基金获得者
　　　　　Professor, PhD
学科专业：微生物学/病毒学
研究方向：病毒感染及其防治
实验室位置：生命科学学院大楼5114房间
联系电话/Tel： 86-(Lab)
Email: zjcao@whu.edu.cn

教育经历/Education：
1999/09-2004/06，武汉大学，博士/Wuhan University, PhD
1994/09-1998/07，武汉大学，学士/Wuhan University, Bachelor's Degree

工作经历/Professional Experience：
2004/07-至今：武汉大学生命科学学院/College of Life Sciences, Wuhan University
2014/02-2015/01：美国梅哈里医学院/Meharry Medical College, USA
1998/07-1999/08： 湖南省畜牧兽医研究所/Animal husbandry and veterinary institute of Hunan province

研究方向/Research Fields：
1) 病毒感染及其防治/Viral infection, prevention and cure
2) 抗病原微生物多肽的药用基础/Medicinal basis of peptides against pathogen viruses and bacteria
3) 毒素多肽生物学/Toxic peptide biology

基金资助/Fund support：
1) 国家优秀青年基金：蝎毒素遗传资源的保护、认识与利用研究
2) 湖北省****基金：靶向抗肿瘤蝎氯毒素的药用基础研究
3) 中央高校基本科研基金：蝎毒素多肽的药用基础研究

研究概述/Research Description：
我过去以蝎为代表开展毒素多肽生物学研究，创建了蝎毒素多肽资源库，发现了蝎毒素多肽的分子多样性，首绘了蝎全基因组图谱，揭示了蝎毒素多肽分子多样性的产生机制，发掘了蝎毒素多肽的抗肿瘤、抗菌、抗病毒功能及作用机制，开拓了蝎毒素多肽研究和药用新领域。现在主要开展离子通道在病毒感染中作用以及在此基础上抗病毒多肽的筛选与设计研究。/ Before, I focused on the biology of toxin peptides (e.g. scorpion), involving in the library construction, diversity and its mechanism, pharmacological roles and their mechanisms of scorpion toxins. Today, I am interesting in the functions of ion channels in the infections of viruses, and then the discovery of antiviral peptides.

发表的代表性论文：
1) Li X, Yang H, Han Y, Yin S, Shen B, Wu Y, Li W, Cao Z*. Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors. J Allergy Clin Immunol. 2020 Dec 22:S0091-6749(20)32413-1. (IF=11.592; 1区)
2) Cheng Y, Sun F, Wang L, Gao M, Xie Y, Sun Y, Liu H, Yuan Y, Yi W, Huang Z, Yan H, Peng K, Wu Y, Cao Z*. Virus-induced p38 MAPK activation facilitates viral infection. Theranostics. 2020, 10(26):12223-12240. (IF=8.579; 1区)
3) Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y*, Cao Z*. Histidine-rich modification of a scorpion-derived peptide improves bioavailability and inhibitory activity against HSV-1. Theranostics. 2018, 8(1):199-211. (IF=8.579; 1区)
4) Cao Z^#, Yu Y^#, Wu Y^#, Hao P^#, Di Z^#, He Y^#, Chen Z, Yang W, Shen Z, He X, Sheng J, Xu X, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H, Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X, Zhao G, Li X, Li Y, Li W. The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun. 2013, 4:2602. (IF=12.121; 1区)
5) Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z*. Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. Biomaterials. 2013, 34(13):3511-3522. (IF=10.317; 1区)
6) Yu XF, Sun Z, Li M, Xiang Y, Wang QQ*, Tang F, Wu Y, Cao Z*, Li W*. Neurotoxin-conjugated upconversion nanoprobes for direct visualization of tumors under near-infrared irradiation. Biomaterials. 2010, 31(33): 8724-8731. (IF=10.317; 1区)

7) Fan S, Sun Z, Jiang D, Dai C, Ma Y, Zhao Z, Liu H, Wu Y, Cao Z*, Li W*. BmKCT toxin inhibits glioma proliferation and tumor metastasis. Cancer Lett. 2010, 291(2):158-166. (IF= 7.360; 2区)
8) Zeng Z, Han S, Hong W, Lang Y, Li F, Liu Y, Li Z, Wu Y, Li W, Zhang X*, Cao Z*. A tat-conjugated peptide nucleic acid Tat-PNA-DR inhibits hepatitis B virus replication in vitro and in vivo by targeting LTR direct repeats of HBV RNA. Mol Ther Nucleic Acids. 2016, 5(3):e295. (IF=7.032; 2区)

9) Chen B, Li F, Zhu XK, Xie W, Hu X, Zan MH, Li X, Li QY, Guo SS, Zhao XZ, Jiang YA*, Cao Z*, Liu W*. Highly biocompatible and recyclable biomimetic nanoparticles for antibiotic-resistant bacteria infection. Biomater Sci. 2021, 9(3):826-834. (IF=6.183; 2区)
10) Lang Y, Li F, Liu Q, Xia Z, Ji Z, Hu J, Cheng Y, Gao M, Sun F, Shen B, Xie C, Yi W, Wu Y, Yao J*, Cao Z*. The Kv1.3 ion channel acts as a host factor restricting viral entry. FASEB J. 2021, 35(2):e20995. (IF=4.966; 2区)
11) Fan Z, Cao L, He Y, Hu J, Di Z, Wu Y, Li W*, Cao Z*. Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus. Antimicrob Agents Chemother. 2011, 55(11):5220-5229. (IF=4.904; 2区)
12) Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y, Cao Z*, Li W*. Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates. Antimicrob Agents Chemother. 2009, 83:3472-3477. (IF=4.904; 2区)
13) Dai C, Ma Y, Zhao Z, Zhao R, Wang Q, Wu Y, Cao Z*, Li W*. Mucroporin, the first cationic host defence peptide from the venom of Lychas mucronatus. Antimicrob Agents Chemother. 2008, 52(11): 3967-3972. (IF=4.904; 2区)
14) Li F, Lang Y, Ji Z, Xia Z, Han Y, Cheng Y, Liu G, Sun F, Zhao Y, Gao M, Chen Z, Wu Y, Li W, Cao Z*. A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles. J Biol Chem. 2019, 294(1):182-194. (IF=4.238; 2区)
15) Meng L, Xie Z, Zhang Q, Li Y, Yang F, Chen Z, Li W, Cao Z*, Wu Y*. Scorpion potassium channel-blocking defensin highlights a functional link with neurotoxin. J Biol Chem. 2016, 291(13):7097-106. (IF=4.238; 2区)
16) Hong W, Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W, Cao Z*. A p7 ion channel-derived peptide inhibits hepatitis C virus infection in vitro. J Biol Chem. 2015, 290(38):23254-23263. (IF=4.238; 2区)
17) Song Y, Gong K, Yan H, Hong W, Wang L, Wu Y, Li W*, Li W*, Cao Z*. Sj7170, a unique dual-functional peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor activating effect from scorpion venom. J Biol Chem. 2014, 289(17):11667-11680. (IF=4.238; 2区)
18) Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W*, Cao Z*. Mucroporin-M1 inhibits Hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) Pathway and down-regulating HNF4α in vitro and in vivo. J Biol Chem. 2012, 287(36):30181-30190. (IF=4.238; 2区)
19) Liu G, Yang F, Li F, Li Z, Lang Y, Shen B, Wu Y, Li W, Harrison PL, Strong PN, Xie Y, Miller K*, Cao Z*. Therapeutic potential of a scorpion venom-derived antimicrobial peptide and its homologs against antibiotic-resistant gram-positive bacteria. Front Microbiol. 2018, 9:1159. (IF=4.235; 2区)
20) Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, Miao L*, Cao Z*. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020, 182:104922. (IF=4.101; 2区)
21) Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z*. Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1. Antiviral Res. 2014, 102:1-10. (IF=4.101; 2区)
22) Zhang C, Xie Z, Li X, Chen J, Feng J, Lang Y, Yang W, Li W, Chen Z, Yao J, Cao Z*, Wu Y*. Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1. Biochem J. 2016, 473(9):1257-1266. (IF=4.097; 2区)
23) Di Z, Yu Y, Wu Y, Hao P, He Y, Zhao H, Li Y, Zhao G, Li X*, Li W*, Cao Z*. Genome-wide analysis of homeobox genes from Mesobuthus martensii reveals Hox gene duplication in scorpions. Insect Biochem Mol Biol. 2015, 61:25-33. (IF=3.827; 2区)
24) Sun F, Xia Z, Han Y, Gao M, Wang L, Wu Y, Sabatier JM, Miao L, Cao Z*. Topology, antiviral functional residues and mechnism of IFITM1. Viruses. 2020, 12:295. (IF=3.816; 2区)
25) Annweiler C*, Cao Z*, Sabatier JM. Point of view: Should COVID-19 patients be supplemented with vitamin D? Maturitas. 2020, 140:24-26. (IF=3.630; 2区)
26) Zhao R, Ma Y, He Y, Di Z, Wu Y, Cao Z*, Li W*. Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components. BMC Genomics. 2010, 11: 452. (IF=3,594; 2区)
27) Ma Y, Zhao R, He Y, Li S, Liu J, Wu Y, Cao Z*, Li W*. Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal. BMC Genomics. 2009, 10: 290. (IF=3.594; 2区)
28) Zeng Z, Zhang Q, Hong W, Xie Y, Liu Y, Li W, Wu Y, Cao Z*. A scorpion defensin BmKDfsin4 inhibits hepatitis B virus replication in vitro. Toxins (Basel). 2016, 8(5). (IF=3.531; 2区)
29) Cao Z^#, Di Z^#, Wu Y, Li W. Overview of scorpion species from China and their toxins. Toxins (Basel). 2014, 6(3):796-815. (IF=3.531; 2区)
30) Li Z, Liu G, Meng L, Yu W, Xu X, Li W, Wu Y*, Cao Z*. K1K8: an Hp1404-derived antibacterial peptide. Appl Microbiol Biotechnol. 2016, 100(11):5069-5077. (IF=3.530; 2区)
31) He Y, Zhao R, Di Z, Li Z, Xu X, Hong W, Wu Y, Zhao H, Li W, Cao Z*. Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-Buthidae. J Proteomics. 2013, 89:1-14. (IF=3.509; 2区)
32) Ma Y, He Y, Zhao R, Wu Y, Li W*, Cao Z*. Extreme diversity of scorpion venom peptides and proteins revealed by transcriptomic analysis: Implication for proteome evolution of scorpion venom arsenal. J Proteomics. 2012, 75(5):1563-1576. (IF=3.509; 2区)
33) Ma Y, Zhao Y, Zhao R, Zhang W, He Y, Wu Y, Cao Z*, Guo L*, Li W*. Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis. Proteomics. 2010, 10(13):2471-2485. ( IF=3.254; 2区)
34) Cheng Y, Sun F, Li S, Gao M, Wang L, Sarhan M, Abdel-Rahman MA, Li W, Kwok HF, Wu Y, Cao Z*. Inhibitory activity of a scorpion defensin BmKDfsin3 against hepatitis C virus. Antibiotics (Basel). 2020, 9(1).
35) Ji Z, Li F, Xia Z, Guo X, Gao M, Sun F, Cheng Y, Wu Y, Li W, Ali SA, Cao Z*. The scorpion venom peptide Smp76 inhibits viral infection by regulating type-I interferon response. Virol Sin. 2018, 33(6):545-556.