职称职务：教授、博导
研究方向：抗病毒天然免疫、炎症反应与肿瘤发生
实验室位置：武汉大学生命科学学院2101室

电话：
Email:　zhongbo@whu.edu.cn





学习经历：
2001.9－2005.6 中国地质大学外国语学院 英语专业 学士
2003.2－2005.6 武汉大学生命科学学院 生物科学专业 学士
2005.9－2010.6 武汉大学生命科学学院 细胞生物学 博士
导师：舒红兵 院士
工作经历：
2010.7－2013.2 The University of Texas MD Anderson Cancer Center 博士后 导师：董晨 教授
2013.3－现在 武汉大学生命科学学院
病毒学国家重点实验室
武汉大学医学研究院 教授、博导

获奖与荣誉
2017 中国细胞生物学学会青年研究员奖
2017 湖北省细胞生物学学会优秀青年****奖
2016 武汉大学朱裕璧医学奖
2015 国家自然科学二等奖（第二完成人）
2015 武汉大学十大****
2012 “全国百篇优秀博士论文”获得者，中国
2012 美国免疫学家学会“Abstract Award”，美国
2011 Odyssey Fellowship, MD Anderson Cancer Center
2010 应邀参加第60届“诺贝尔获奖者大会”，德国
2009 吴瑞奖，吴瑞基金会，美国

主要社会兼职：
中国细胞生物学会青年委员会委员
中国免疫学会青年委员会委员
Virologica Sinica编委
Sci Rep, JBC，Acta Biochim Biophys Sin，Immunologic Research等杂志应邀审稿人

研究兴趣：
本 实验室主要从事抗病毒天然免疫信号转导、炎性细胞因子介导的炎症反应与肿瘤发生的分子机理的研究。我们主要以表达克隆、酵母双杂交以及蛋白质组学等多种手段，筛选参与调控抗病毒天然免疫以及炎症反应过程的蛋白，并通过基因敲除、转基因小鼠以及动物疾病模型研究这些蛋白在调控病毒感染、自身免疫性疾病以及肿瘤发生等过程中的功能与机制。

主持课题项目：
1. 国家自然科学基金面上项目(**,**): 2014.01-2017.12, 2017.01-2020.12
2. 自然科学基金委优秀青年科学基金(**): 2017.01-2019.12
3. 国家重大基础研究计划子项目（973）(2014CB542601): 2014.01-2018.12
4. 教育部优秀博士论文获得者基金(201427): 2014.01-2017.12
5. 病毒学国家重点实验室研究骨干: 2014.01-
6. 家畜疫病病原生物学国家重点实验室开放基金: 2015.01-2016.12，2017.01-2018.12

代表性论文（*corresponding author）

1. Lu B#, Ren Y#, Sun X#, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL,Du HN, Zhong B*, Huang Z*. Induction of INKIT by viral infection negatively regulates antiviral responses through inhibiting phosphorylation of p65 and IRF3. Cell Host Microbe, 2017, 22(1):86-98.e4. (Cover story)

2. Sun H#, Zhang Q#, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B*. USP13 negatively regulates antiviral responses by deubiquitinating STING. Nat Commun. 2017, May 23; 8:15534. 10.1038/NCOMMS15534.

3. Zhang M#, Zhang MX#, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu QY, Yao J, Shu HB, Zhong B*. USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. Cell Res. 2016, 26(12): 1302-1319.

4. Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB, Zhong B*. The type I IFN-IRF7 mediates virus-triggered upregulation of Usp25. J Biol Chem. 2016, 291(25): 13206-13215.

5. Lin D, Zhang M, Zhang MX, Ren YJ, Zhao Q, Jin J, Pan Z, Wu M, Shu HB, Dong C, Zhong B*. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 112(36):11324-329.

6. Lin D, Zhong B*. Regulation of cellular innate antiviral signaling by ubiquitin modification. Acta Biochim Biophys Sin. 2015 47(3):149-155.

7. Peng Q, Lan X, Wang C, Ren Y, Yue N, Wang J, Zhong B, Zhu Q. Kobuvirus VP3 protein restricts the IFN-β-triggered signaling pathway by inhibiting STAT2-IRF9 and STAT2-STAT2 complex formation. Virology. 2017 Apr 22; 507:161-169.

8. Wang A, Ding X, Demarque M, Liu X, Pan D, Xin H, Zhong B, Wang X, Dejean A, Jin W, Dong C. Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes. J Immunol. 2017 May 1; 198(9):3461-3470.

9. Gao SF, Zhong B, Lin D*. Regulation of T helper cell differentiation by E3 ubiquitin ligases and deubiquitinating enzymes. Int Immunopharmacol. 2017, 42:150-156.

10. Wang J, Lei CQ, Ji Y, Zhou H, Ren Y, Peng Q, Zeng Y, Jia Y, Ge J, Zhong B, Li Y, Wei J, Shu HB, Zhu Q. Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA. J Immunol. 2016, 197(12):4704-4713.

11. Luo WW, Li S, Li C, Lian H, Yang Q, Zhong B, Shu HB. iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol. 2016, 17(9): 1057-66.

12. Liu TT, Yang Q, Li M, Zhong B, Ran Y, Liu LL, Yang Y, Wang YY, Shu HB. LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner. J Immunol. 2016 196(12):5101-11.

13. An T, Li S, Pan W, Tien P, Zhong B, Shu HB, Wu S. DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation. PLoS Pathog. 2015 11(9): e**.

14. Wei J, Lian H, Zhong B, Shu HB. Parafibromin is a component of IFNγ-triggered signaling pathways that facilitates JAK1/2-mediated tyrosine phosphorylation of STAT1. J Immunol. 2015 195(6):2870-8.

15. Deng T, Lin D, Zhang M, Zhao Q, Li W, Zhong B, Deng Y, Fu X. Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma. Acta Biochim Biophys Sin. 2015 47(7):557-63.

16. Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature. 2014, 507(7493):513-8.

17. Luo WW, Lian H, Zhong B, Shu HB, Li S. Krüppel-like factor 4 negatively regulates cellular antiviral immune response. Cell Mol Immunol. 2016, 13(1):65-72.

18. Zhou Q, Lin H, Wang S, Wang S, Ran Y, Liu Y, Ye W, Xiong X, Zhong B, Shu HB, Wang YY. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe. 2014, 16(4):450-61.

19. Qin Y, Zhou MT, Hu MM, Hu YH, Zhang J, Guo L, Zhong B, Shu HB. RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 2014, 10(9):e**.

20. Lei CQ, Zhang Y, Li M, Jiang LQ, Zhong B, Kim YH, Shu HB. ECSIT Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral Responses. J Innate Immun. 2015, 7(2):153-64.

21. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB. Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes. J Biol Chem. 2014, 289(18):12876-85.

22. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB. TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014, 111(4):1509-14.

23. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB. FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. (2013). J Biol Chem. 288, 12596-604.

24. Zhong B, Liu XK, Wang XH, Liu XD, Li HX, Darnay BR, Lin X, Sun SC and Dong C. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune response through deubiquitination of TRAF3. (2013). Sci Signal. 6, ra35.

25. Liu XK#, Li HX#, Zhong B#, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X and Dong C. USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. (2013). J Exp Med. 210, 1575-90. (#Co-first authors)

26. Zhong B, Liu XK, Wang XH, Chang SH, Liu XD, Wang AB, Reynolds JM, and Dong C. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. (2012). Nat Immunol. 13, 1110-17.

27. Liu XD, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. (2012). J Exp Med. 209:1841-52.

28. Xu T#, Wang X#, Zhong B, Nurieva RI, Ding S, Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. (2011). J Biol Chem. 286, 22707-10.

29. Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S and Shu HB. Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. (2010). Immunity. 33, 878-89.

30. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY and Shu HB. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. (2010). J Immunol. 184, 6249-6255.

31. Zhong B, Wang YY and Shu HB. Regulation of virus-triggered type I interferon signaling by cellular and viral proteins. (2010). Frontier in Biology 5, 12-31.

32. Zhong B, Zhang L, Lei CQ, Li Y., Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (2009). Immunity 30, 397-407.

33. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB. The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (2008). Immunity 29, 538–550.

34. Zhong B, Tien P and Shu HB. Innate immune responses: crosstalk of signaling and regulation of gene transcription. (2006). Virology 352, 14-21.

35. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P and Shu HB. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. (2010). Proc Natl Acad Sci U S A. 107, 815-820.

36. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q and Shu HB. Virus-triggered ubiquitination of TRAF3 by cIAP1/2 at the mitochondria is essential for induction of IFN-? and cellular antiviral response. (2010). J Biol Chem. 285, 9470-9476.

37. Chen R, Zhang L, Zhong B, Tan B, Liu Y and Shu HB. Ubiquitin-specific protease 17 is involved in virus-triggered type I interferon signaling. (2010). Cell Res. 20: 802-11.

38. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P and Shu HB. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (2010). J Biol Chem. 285, 4291-4297.

39. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang FQ and Shu HB. ISG56 is a negative regulator of virus-triggered signaling and cellular antiviral response. (2009). Proc Natl Acad Sci U S A. 106, 7945-50.

40. Daio FC, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Zhai Z, Zhong B, Tien P and Shu HB. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxya. (2007). Proc Natl Acad Sci U S A. 104, 11706-11711.

41. Tian Y#, Zhang Y#, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai Z and Shu HB. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (2007). J Biol Chem. 282, 16776-11782. (#Co-first authors).

42. 张煜， 钟波，杨艳，舒红兵. TLRs与RLRs介导的细胞抗病毒反应信号转导及其调节机制. (2009). 细胞生物学杂志 31, 453-468.

43. 钟波，舒红兵. 天然免疫模式识别受体与树突状细胞的发现和意义——2011年诺贝尔生理学或医学奖成果和相关研究. 生命科学 (2011). 23, 1147-1161.