职称职务：研究员、博导
　学科专业：病毒学

　研究方向：病原微生物感染与抗体药物研究

　实验室位置：武汉大学生命科学学院

　联系电话：
　Email: haiyzhao@whu.edu.cn


学习经历

2009/09-2014/07 中国农业大学，微生物，博士学位
2005/09-2009/06 河北科技大学，生物技术，学士学位


主要工作经历与任职情况：
2021/03-至今　　　 武汉大学生命科学学院，病毒学国家重点实验室，研究员
2020/01-2021/02　　美国圣路易斯华盛顿大学医学院，讲师
2015/02-2019/12　　美国圣路易斯华盛顿大学医学院，博士后



主要研究领域及兴趣：
　　病毒感染导致的传染性疾病严重影响了人们的生活和国民经济的发展，B细胞介导的体液免疫反应是机体对抗病毒感染的重要手段之一，也是病毒疫苗发挥作用的重要因素。课题组主要以虫媒病毒以及各种新发与再发传染性病毒为研究对象，结合分子病毒学、细胞生物学、动物免疫学、生物化学和结构生物学等多种技术手段，研究病毒感染诱导的体液免疫应答特点和机制，开发高效保护性抗体药物，并进行抗原的优化设计和疫苗的研发。

发表的论文（*通讯作者）：


1. Zhao H^#, Fernandez E^#, Dowd KA, Speer SD, Platt DJ, Gorman MJ, Govero J, Nelson CA, Pierson TC, Diamond MS*, Fremont DH*. Structural Basis of Zika Virus-Specific Antibody Protection. Cell. 2016; 166:1016-1027. ^#Co-first authors.

2. Zhao H, Xu L, Bombardi R, Nargi R, Deng Z, Errico JM, Nelson CA, Dowd KA, Pierson TC, Crowe JE, Diamond MS, Fremont DH. Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge. J Exp Med. 2020; 217:e**.

3. Alsoussi WB^#, Turner JS^#, Case JB^#, Zhao H^#, Schmitz AJ^#, Zhou JQ^#, Chen RE, Lei T, Rizk AA, McIntire KM, Winkler ES, Fox JM, Kafai NM, Thackray LB, Hassan AO, Amanat F, Krammer F, Watson CT, Kleinstein SH, Fremont DH, Diamond MS, Ellebedy AH. A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. J Immunol. 2020;ji**. ^#Co-first authors.

4. Zhao H, Guo XK, Bi Y, Zhu Y, Feng WH*. PKCδ is required for porcine reproductive and respiratory syndrome virus replication. Virology. 2014;468-470:96-103.

5. Zhao H, Wang Y, Ma Z, Wang Y, Feng WH*. Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus GP5 elicits mucosal and cell-mediated immune responses in mice. J Vet Sci. 2014;15:199-208.

6. Chapman NS, Zhao H, Kose N, Westover JB, Kalveram B, Bombardi R, Rodriguez J, Sutton R, Genualdi J, Desiree LaBeaud D, Mutuku FM, Pittman PR, Freiberg AN, Gowen BB, Fremont DH, Crowe JE*. Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition. Proc Natl Acad Sci USA. 2021. (In press)

7. Hassan AO, Feldmann F, Zhao H, Curiel DT, Okumura A, Tang-Huau TL, Case JB, White KM, Callison J, Chen RE, Lovaglio J, Hanley PW, Scott DP, Fremont DH, Feldmann H*, Diamond MS*. A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques. Cell Reports Med. 2021. (In press)

8. Wong R, Belk JA, Govero J, Uhrlaub JL, Reinartz D, Zhao H, Errico JM, D'Souza L, Ripperger TJ, Nikolich-Zugich J, Shlomchik MJ, Satpathy AT, Fremont DH, Diamond MS, Bhattacharya D*. Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. Immunity. 2020; 53:1078-1094.e7.

9. Case JB^#, Rothlauf PW^#, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS*, Whelan SPJ*. Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2. Cell Host and Microbe. 2020; 28:475-485. ^#Co-first authors.

10. Case JB^#, Rothlauf PW^#, Chen RE, Kafai NM, Fox JM, Smith BK, Shrihari S, McCune BT, Harvey IB, Keeler SP, Bloyet LM, Zhao H, Ma M, Adams LJ, Winkler ES, Holtzman MJ, Fremont DH, Whelan SPJ*, Diamond MS*. Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice. Cell Host Microbe. 2020; 28:465-474. ^#Co-first authors.

11. Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S*. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proc Natl Acad Sci USA. 2020; 117:32105-32113.

12. Liu Z^#, VanBlargan LA^#, Bloyet LM, Rothlauf PW, Chen RE, Stumpf S, Zhao H, Errico JM, Theel ES, Liebeskind MJ, Alford B, Buchser WJ, Ellebedy AH, Fremont DH, Diamond MS*, Whelan SPJ*. Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization. Cell Host & Microbe. 2021; 29:1-12.

13. Hassan AO, Kafai NM, Dmitriev IP, Fox JM, Smith BK, Harvey IB, Chen RE, Winkler ES, Wessel AW, Case JB, Kashentseva E, McCune BT, Bailey AL, Zhao H, VanBlargan LA, Dai YN, Ma M, Adams LJ, Shrihari S, Danis JE, Gralinski LE, Hou YJ, Sch?fer A, Kim AS, Keeler SP, Weiskopf D, Baric RS, Holtzman MJ, Fremont DH, Curiel DT*, Diamond MS*. A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2. Cell. 2020; 183:169-184.

14. Deng Z, Zhao Y, Feng J, Zhang J, Zhao H, Rau MJ, James A. J. Fitzpatrick JAJ, Hu H, Yuan P*. Cryo-EM structure of a proton-activated chloride channel TMEM206. Sci Adv. ?2021; 7:eabe5983

15. Smith BK, Janowski AB, Danis JE, Harvey IB, Zhao H, Dai YN, Farnsworth CW, Gronowski AM, Roper S, Daved H. Fremont DH*, Wang D*. ?Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA. mSphere. 2021; 6:1-7

16. ?Adhikari J, Zhao H, Estefania Fernandez E, Huang Y, Diamond MS, Fremont DH, Gross ML*. ?Hydrogen–deuterium exchange mass spectrometry identifies spatially distinct antibody epitopes on domain III of the Zika virus envelope protein. ?J Mass Spectrom. 2021; 56:e4685

17. Hassan AO, Dmitriev IP, Kashentseva EA, Zhao H, Brough DE, Fremont DH, Curiel DT, Diamond MS*. A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy. Cell Rep. 2019; 28:2634-2646.

18. Tai W^#, He L^#, Wang Y^#, Sun S, Zhao G, Luo C, Li P, Zhao H, Fremont DH, Li F, Jiang S*, Zhou Y*, Du L*. Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses. Emerg Microbes Infect. 2018; 7:7. ^#Co-first authors.

19. Scott JM, Lebratti TJ, Richner JM, Jiang X, Fernandez E, Zhao H, Fremont DH, Diamond MS, Shin H*. Cellular and humoral immunity protect against vaginal infection of Zika virus in mice. J Virol. 2018; 92.pii: e00038-18.

20. Sapparapu G^#, Fernandez E^#, Kose N, Bin Cao, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS*, Crowe JE*. Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature. 2016; 540:443-447. ^#Co-first authors.

21. Bi Y, Guo XK, Zhao H, Gao L, Wang L, Tang J, Feng WH*. Highly pathogenic porcine reproductive and respiratory syndrome virus induces prostaglandin E2 production through cyclooxygenase 1, which is dependent on the ERK1/2-p-C/EBP-β pathway. J Virol. 2014; 88:2810-20.

22. Wang Y, Zhao H, Ma Z, Wang Y, Feng WH*. CTLA4 mediated targeting enhances immunogenicity against PRRSV in a DNA prime/killed virus boost strategy. Vet Immunol Immunopathol. 2013; 154:121-128.

23. Ma Z, Wang Y, Zhao H, Xu AT, Wang Y, Tang J, Feng WH*. Porcine reproductive and respiratory syndrome virus nonstructural protein 4 induces apoptosis dependent on its 3C-like serine protease activity. PLoS One. 2013; 8:e69387.