职称职务：副教授、硕士生导师
学　位：博士
研究方向：癌症细胞信号传导及病毒病理
实验室位置：生命科学学院5102室
联系方式：
Email:　biochem@whu.edu.cn



教育经历：

1995年－1999年，湖北工业大学，发酵工程系，本科/学士
2000年－2005年，武汉大学，生命科学学院/生化与分子生物学系，研究生/硕博连读

工作经历：
2005年－2012年，武汉大学生命科学学院/生化与分子生物学系，讲师
2005年－至今，武汉大学生命科学学院/生化与分子生物学系，副教授
2008年3月－2011年7月，美国匹兹堡大学医学院病理系，博士后

教学工作：
2005年－至今，主讲本科选修课《酶工程》
2011年－至今，主讲研究生选修课《高级分子生物学及生物化学》

主持课题：
国家自然科学基金项目《腺病毒介导精氨酸脱亚氨基酶靶向性基因治疗肝癌的机制》，(2014.01-2017.12),(NO. **).
国家自然科学基金项目《精氨酸脱亚氨基酶催化机理及结构与功能的研究》，(2009.01-2011.12),(NO. **).
湖北省自然科学基金项目《新型可口服微生物溶血栓药物的分子结构的设计与改造》(2007.01-2009.12)年.
湖北省攻关项目《液态深层发酵法生产番茄红素的中试研究》（2007.01-2009.12）.

研究方向：
1、 中国人手足口病病毒（EV71）侵染人体的细胞途径和病理机制。主要解决EV71经口腔进入人体肠道后，通过什么样的细胞机制和体液机制实现增殖、转运及潜伏的科学问题。
2、 抗肿瘤药物在癌症细胞信号传导过程中的作用。主要利用腺病毒、慢病毒等载体介导抗肿瘤基因靶向性治疗癌症的分子机制的科学问题。
3、 蛋白产品及免疫型诊断试剂的开发

代表性论文:

1. Jieyuan Wu, W. c., Yan Yin, Zhongliang Zheng*, Guolin Zou (2014). "Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex." Biometals: Published online.
2. Yu-Chen Han, Zhong-Liang Zheng (co-author), Yan-Ping. Yu, Rui Chen, George C. Tseng, Joel B. Nelson and Jian-Hua Luo (2013). "Metallothionein 1h Tumor Suppressor Activity in Prostate Cancer Is Mediated By Euchromatin Methyltransferase 1." The Journal of Pathology 230: 184-193.

3. Zhongliang Zheng, LangZhu Tan, Yan P. Yu, George Michalopoulos, Jianhua Luo (2012). "Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell death." America Journal of Pathology 181(2): 463-471.

4. Michael Nalesnik, George Tseng, George Michalopoulos, Guo-Sheng Xiang, Zhong-liang Zheng, Yanping Yu and Jianhua Luo. (2012). "Gene Deletions and Amplifications in Human Hepatocellular Carcinomas: Correlation with Hepatocyte Growth Regulation." America Journal of Pathology 180(4): 1495-1508.

5. Hanjing Ding, Hui Liu, Y an Yin, Ying Ding, Yan Jia, Qingming Chen, Guolin Zou* and Zhongliang Zheng* (2012). "Insights into the modulation of optimum pH by a single histidine residue in arginine deiminase from Pseudomonas aeruginosa." Biol. Chem. 393: 1013-1024.

6. Ze-Hua Zhu, Yan-P. Yu, Zhong-Liang Zheng, Yang Song, Guo-Sheng Xiang, Joel Nelson, George Michalopoulos, Jian-Hua Luo. (2010). "Integrin Alpha 7 Interacts with High Temperature Requirement A2 (HtrA2) to Induce Prostate Cancer Cell Death." American Journal of Pathology. 177: 1176-1186.

7. Yan Jia, Hui Liu, Wei Bao, Meizhi Weng, Wei Chen, Yongjun Cai, Zhongliang Zheng, Guolin Zou. (2010). "Functional analysis of propeptide as an intramolecular chaperone for in vivo folding of subtilisin nattokinase." FEBS Letters 584: 4789-4796.

8. MeiZhi Weng, ZhongLiang Zheng, Wei Bao, YongJun Cai, Yan Yin, GouLin Zou. (2009). "Enhancement of oxidative stability of the subtilisin nattokinase by site-directed mutagenesis expressed in Escherichia coli." Biochimica et Biophysica Acta 1794: 1566-1572.

9. Jinsong Wang, Zhongliang Zheng, Jing Lei, Jicheng Pan, Guolin Zou. (2009). "Cloning, expression, characterization and phylogenetic analysis of arginine kinase from greasyback shrimp (Metapenaeus ensis)." Comparative biochemistry and physiology, part B 153: 268-274.

10. HanDong Fan, Jing Liu, WenDan Ren, ZhongLiang Zheng, YuYing Zhang, Xi Yang, HuaPing Li, XiaoYan Wang, GuoLin Zou (2008). "pH Induces Thermal Unfolding of UTI: An Implication of Reversible and Irreversible Mechanism Based on the Analysis of Thermal Stability, Thermodynamic, Conformational Characterization." J Fluoresc 18: 305-317.

11. Zhenyu Zuo, Zhongliang Zheng, Zhigang Liu, Qingming Yi, Guolin Zou* (2007). "Cloning, DNA shuffling and expression of serine hydroxymethyltransferase gene from Escherichia coli strain AB90054." Enzyme and Microbial Technology 40: 569-577. .

12. Xiwen Li, Zhongliang Zheng, Mingyue Han, Zhangping Chen, Guolin Zou* (2007). "Tuning J-Aggregates of Tetra(p-hydroxyphenyl)porphyrin by the Headgroups of Ionic Surfactants in Acidic Nonionic Micellar Solution." J. Phys. Chem. B 111: 4342-4348 .

13. Zhongliang Zheng, Maoqing Ye, Zhenyu Zuo, Zhigang Liu, Kengchang Tsai, Guolin Zou. (2006). "Probing the Importance of Hydrogen Bonds around the Active Center of Nattokinase by Site-directed Mutagenesis and Molecular Dynamics Simulation." Biochemical J. 395(3): 509-515. .

14. Zhigang Liu, Zhongliang Zheng, Zhenyu Zuo, Yingliang Wu, Aifu Liu, Qingming Yi, Wenxin Li. (2006). "Probing the Catalytic Center of Porcine Aminoacylase 1 by Site-Directed Mutagenesis, Homology Modeling and Substrate Docking." J Biochem (Tokyo). 139: 421-430. .

15. Zhongliang Zheng, Zhenyu Zuo, Zhigang Liu, Kengchang Tsai, Aifu Liu,1, Guolin Zou (2005). "Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto—A novel nucleaphilic catalytic mechanism for nattokinase." J. Mo.l Graph. Mod. 23(4): 373-381.