职称职务：教授、主任
Appointment: Professor, Director
学科专业：病毒学
Department: Virology
研究方向：肿瘤病毒感染与致瘤机制
Research: Mechanisms of Tumor Viral Infection and Pathogenesis
实验室位置：生命科学学院大楼4105房间
Location: College of Life Sciences, Room 4105
联系方式：
Email:　klan@whu.edu.cn



教育经历/Education：
1989-1994 重庆医科大学临床医学专业，获医学学士学位 1995-1998 重庆医科大学病理生理学专业，获医学硕士学位
1998-2001 中南大学湘雅医学院病理生理学专业，获医学博士学位

工作经历与任职/Professional Experience：
1994-1995 四川省屏山县人民医院，住院医师
2002-2006 美国宾夕法尼亚大学医学院，博士后
2006-2016 中国科学院上海巴斯德研究所研究员，博士生导师，肿瘤病毒研究组组长，病原诊断技术研发中心主任
2011-2016 中国科学院上海巴斯德研究所副所长，纪委书记
2017-至今 武汉大学病毒学国家重点实验室主任，武汉大学医学研究院副院长，生命科学学院教授、博士生导师

学术兼职：
中国病理生理学会肿瘤专业委员会常委
中国微生物学会病毒专业委员会理事
Journal of Virology编委
Viruses编委
Journal of Medical Virology副主编
Science Bulletin副主编
Virologica Sinica副主编

获奖及荣誉：
国家****领军人才（2016年）
上海市先进工作者（2015年）
上海领军人才（2015年）
国家创新人才推进计划中青年科技创新领军人才（2015年）
国家****科学基金获得者（2014年）
药明康德生命化学研究奖（2012年）
国务院政府特殊津贴获得者（2011年）
明治乳业生命科学奖（2010年）
中科院朱李月华优秀教师奖（2010年）
新世纪百千****才工程国家级人选（2009年）
上海市浦江人才计划入选者（2008年）
美国白血病和淋巴瘤学会Special Fellow Award（2006年）

研究概述/Research Description：
主要从事肿瘤疱疹病毒感染及致瘤机理研究，在卡波氏肉瘤疱疹病毒(KSHV)潜伏感染与致瘤机理研究方面做出了系统性、原创性的研究工作：曾揭示KSHV关键开关分子RTA的表达调控机机理，提出RTA-LANA负反馈调控工作模型，得到领域内的广泛认可，对阐明KSHV潜伏感染的形成机制有重要的指导意义；曾利用KSHV作为工作模型，率先发现病毒包装自身及宿主miRNA，不仅揭示了病毒粒子一种新的构成成分，也鉴定了胞外游离型miRNA的一种新的存在形式，具有重要的学术价值；曾阐明KSHV通过操控Notch及BMP等重要信号转导通路参与致瘤的新机制，为发展相关肿瘤有效的治疗手段奠定了重要基础。

代表性论文/Publications:
1. Bai L, Dong J, Liu Z, Rao Y, Feng P*, Lan K*. Viperin catalyzes methionine oxidation to promote protein expression and function of helicases. Sci Adv 2019(5): eaax1031

2. Zhang F, Liang D, Lin X, Zou Z, Sun R, Wang X, Liang X, Kaye KM, Lan K*. NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. PLoS Pathog. 2019 Feb 27;15(2):e**


3. Yuan F, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM*, Dong YH*, Lan K*. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function. PLoS Pathog. 2018 Aug 10;14(8):e**

4. Yuan F, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM, Dong YH, Lan K* . The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function. PLoS Pathog. 2018 Aug 10;14(8):e**

5. Li G, Zhu Y, Shao D, Chang H, Zhang X, Zhou D, Gao Y, Lan K*, Deng Q*. Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model. Hepatology. 2018 Jan;67(1):56-70.

6. Wang X, Zou Z, Deng Z, Liang D, Zhou X, Sun R, Lan K*. Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma. PLoS Pathog. 2017 Sep 28;13(9):e**.

7. Zou Z, Meng Z, Ma C, Liang D, Sun R, Lan K*. Guanylate-binding protein 1 inhibits nuclear delivery of Kaposi's sarcoma-associated herpesvirus virions by disrupting formation of actin filament. J Virol. 2017 Jul 27;91(16). pii: e00632-17

8. Lin X, Sun R, Zhang F, Gao Y, Bin L, Lan K*. The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/sentrin Specific Peptidase 6 to Facilitate Latency Establishment. J Virol. 2017 Aug 10;91(17). pii: e00806-17

9. Sun R, Tan X, Wang X, Wang X, Yang L, Robertson ES, Lan K*. Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues. PLoS Pathog. 2017 Jan 24;13(1):e**

10. Li S, Hu H, He Z, Liang D, Sun R, Lan K*. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog. 2016 Oct 19;12(10):e**

11. Hu H, Dong J, Liang D, Gao Z, Bai L, Sun R, Hu H, Zhang H, Dong Y, Lan K*. Genome-wide mapping of the binding sites and structural analysis of KSHV vIRF2 reveal it is a DNA-binding transcription factor. J Virol. 2015 Nov 4;90(3):1158-68

12. Jia B, Guo M, Li G, Yu D, Zhang X, Lan K*, Deng Q*. Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7. J Virol. 2015 Feb 15;89(4):2041-51.


13. Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88. J Virol. 2015 Jan;89(1):415-27

14. Hu H, Zhang H, Gao Z, Wang D, Liu G, Xu J, Lan K*, Dong Y*. Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting. Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2175-85

15. Liang D , Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao S, Lan K*. Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis. PLoS Pathog. 2014 Jul 10;10(7):e**.


16. Qi Z, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y, Lan K*, Deng Q*. Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice. J Virol. 2014 Jul;88(14):8045-56

17. Sun R, Liang D, Gao Y, Lan K*. Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency. J Virol. 2014 Jul 1;88(13):7331-7344.

18. Han J, Wang L, Liu J, Jin M, Hao F, Zhang P, Zhang Z, Wen D, Wu X, Liu G, Ji L, Xu D, Zhou D, Leng Q, Lan K*, Zhang C*. Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus. J Virol. 2014 Jun;88(11):6506-11

19. Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H, Lan K*. Latency-Associated Nuclear Antigen of Kaposi Sarcoma-Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1. Cancer Res. 2014 Apr 1;74(7):2026-37.

20. Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML, Lan K*, Deng Q*. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection. J Virol. 2014 Mar;88(5):3004-15.

21. Han J, Jin M, Zhang P, Liu J, Wang L, Wen D, Wu X, Liu G, Zou Y, Lv X, Dong X, Shao B, Gu S, Zhou D, Leng Q, Zhang C, Lan K. Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill. 2013 May 16;18(20). pii: 20481.

22. Han J, Niu F, Jin M, Wang L, Liu J, Zhang P, Xie B, Wu X, Wen D, Ji L, Liu G, Yang Z, Zhang C, Zhou D, Leng Q, Lan K*. Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses. Emerg Microbes Infect. 2013 May;2(5):e23.

23. Xia T, L évy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA, Lan K*, Wei Y*.The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factor β (TGF-β) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia. J Biol Chem. 2013 Jan 18;288(3):1785-94.

24. Yang Y, Xia T, Li N, Zhang J, Yang Y, Cong W, Deng Q, Lan K*, Zhou W*. Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma. Protein Cell. 2013 Jan;4(1):71-81.

25. Lin X, Li X, Liang D, Lan K*. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirusvirions. J Virol. 2012 Dec; 86(23): 12717-30.

26. Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES, Lan K*. Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-J κ and Are Responsible for LANA-Mediated RTA Repression. J Virol. 2012 May;86(9):4956-69

27. Liang D, Lin X, Lan K^*. Looking at Kaposi's Sarcoma-Associated Herpesvirus-Host Interactions from a microRNA Viewpoint. Front Microbiol. 2011;2:271.

28. Liu Y, Sun R, Lin X, Liang D, Deng Q, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5. J Virol. 2012 Feb; 86(3):1372-81.

29. Li X, Liang D, Lin X, Robertson ES, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. J Virol. 2011 Sep;85(17):8606-15.

30. Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L, Lan K*,Wang J*. Penicilliummarneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells. PLoS One. 2011;6(11):e27609

31. Lin X, Liang D, He Z, Deng Q, Robertson ES, Lan K*. miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA. PLoS One. 2011 Jan 20;6(1):e16224.

32. Liang D, Gao Y, Lin X, He Z, Zhao Q, Deng Q, Lan K^*. A human herpesvirusmiRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKK ε. Cell Res. 2011 May;21(5):793-806.

33. Wang X, He B, Zhang Z, Liu T, Wang H, Li X, Zhang Q, Lan K, Lu X, Wen H*. Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors. Virol J. 2010 Mar 17;7:62.

34. He Z, Liu Y, Liang D, Wang Z, Robertson ES, Lan K*. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol. 2010 Feb;84(4):2047-62.

35. Lan K , Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES. Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor. Cancer Biol Ther. 2009 Nov;8(22):2136-43.

36. Liu Y, Cao Y, Liang D, Gao Y, Xia T, Robertson ES, Lan K*. Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element. Virology. 2008 Oct 25;380(2):264-75.

37. Lan K , Verma SC, Murakami M, Bajaj B, Kaul R, Robertson ES. Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16287-92.

38. Lan K , Murakami M, Choudhuri T, Tsai DE, Schuster SJ, Wasik MA, and Robertson E. Detection of Epstein-Barr Virus in T-Cell Prolymphocytic Leukemia cells in vitro. J Clin Virol. 2008;43:260-5.

39. Verma S, Lan K, Choudhuri T, Cotter MA, and Robertson E. An autonomous replicating element within the KSHV genome. Cell Host Microbe. 2007 Aug 16;2(2):106-18.

40. Lan K , Choudhuri T, Murakami M, Kuppers DA, and Robertson E. Intracellular Activated Notch1 Is Critical for Proliferation of KSHV Associated B Lymphoma Cell Lines in vitro. J Virol. 2006, 80(13):6411-6419

41. Lan K , Murakami M, Choudhuri T, Kuppers D, and Robertson E. Intracellular Activated Notch1 Can Reactivate KSHV from Latency. Virology. 2006, 351:393-403.

42. Lan K , Kuppers D, Verma S, Sharma N, Murakami M, and Robertson E. Induction of KSHV Latency Associated Nuclear Antigen by the Lytic Transactivator RTA: A Novel Mechanism for Establishment of Latency. J Virol. 2005;79(12):7453-65

43. Lan K , Kuppers D, and Robertson E. KSHV Reactivation is Regulated by Interaction of LANA with RBP-Jk, the Major Downstream Effector of the Notch Signaling Pathway. J Virol. 2005;79(6):3468-78

44. Lan K , Kuppers DA, Verma SC, and Robertson E. Kaposi ’s Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: a Potential Mechanism for Virus-Mediated Control of Latency. J Virol. 2004;78: 6585-6594