职称职务：教授、博士生导师
学　　历：理学博士
专　　业：病毒学、免疫学
实验室位置：生科院大楼5012
联系电话：(办公室)；(实验室)
Email： zspan@whu.edu.cn




教育经历
1988－1991 卫生部兰州生物制品研究所 医学硕士
1997－2001 武汉大学 理学博士
2003－2005 美国加州大学(UCI) 博士后


研究方向
抗病毒免疫和病毒基因工程疫苗
病毒基因组复制及其调控

承担课程
本科生：生物技术制药
研究生：高级微生物学

获资助项目
国家重点研发计划、国家973、国家863计划、国家自然科学基金、回国留学人员基金、湖北省和武汉市科技攻关等。

代表性论文
1. Fengwei Zheng, Guoliang Lu, Ling Li, Peng Gong*, Zishu Pan* (2017). The uncoupling of protease trans-cleavage and helicase activities in the pestivirus NS3. Journal of Virology doi: 10.1128/JVI.01094-17.

2. Chunlin Huo, Jie Yang, Lei Lei, Lei Qiao, Jiantao Xin, Zishu Pan* (2017). Hepatitis B virus core particles containing multiple epitopes confer protection against enterovirus 71 and coxsackievirus A16 infection in mice. Vaccine 35(52):7322-7330.

3. Cheng Zhao, Xiaofang Sheng, Rui Wu, Ling Li, Zishu Pan* (2017). Classical swine fever virus nonstructural protein p7 modulates infectious virus production. Scientific Reports doi: 10.1038/s41598-017-13352.

4. Rui Wu,Ling Li,Lei Lei,Cheng Zhao,Xiaofang Shen,Haizhong Zhao,Zishu Pan*(2017). Synergistic roles of the E2 glycoprotein and 3' untranslated region in the increased genomic stability of chimeric classical swine fever virus?with attenuated phenotypes. Archieves of Virology 162(9):2667-2678.

5. Yuang Zhang,Lei Qiao,Xiao Hu,Kang Zhao,Yanwen Zhang,Feng Chai,Zishu Pan* (2016) Baculovirus vectors expressing F proteins in combination with virus-induced signaling adaptor (VISA) molecules confer protection against respiratory syncytial virus infection. Vaccine 34: 252-260.

6. Lei Qiao, Yuan Zhang, Feng Chai, Yiluo Tan, Chunlin Huo, Zishu Pan*(2016). Chimeric?virus-like?particles?containing a conserved region of the G protein in combination with a single peptide of the M2 protein confer protection against respiratory syncytial virus infection. Antiviral Research 131,131-140.

7. Rui Wu, Ling Li, Yu Zhao, Jun Tu, Zishu Pan* (2016) Identification of two amino acids within E2 important for the pathogenicity of chimeric classical swine fever virus. Virus Research 211 (1): 79-85.

8. Yuanyuan Li, Suoqin Jin, Lei Lei, Zishu Pan*, Xiufen Zou*(2015). Deciphering deterioration mechanisms of complex diseases based on the construction of dynamic networks and systems analysis. Scientific Reports 5, 9283.

9. Xiao Qu Longfei Ding, Zhenqiao Qin, Jianguo Wu, Zishu Pan* (2015) Additional Evidence That the Polymerase Subunits Contribute to the Viral Replication and the Virulence of H5N1 Avian Influenza Virus Isolates in Mice. PloS one 10(5), e**

10. Ling Li,Rui Wu,Fengwei Zheng,Cheng Zhao,Zishu Pan* (2015) The N-terminus of classical swine fever virus (CSFV) nonstructural protein 2 modulates viral genome RNA replication. Virus Research 210, 90-99.

11. Ling Wu, Longfei Ding, Zenglin Pei, Xixiang Huo, Guoyuan Wen, Zishu Pan* (2013). A multiplex reverse transcription-PCR assay for the detection of influenza A virus and differentiation of the H1, H3, H5 and H9 subtypes. Journal of Virological Methods 188, 47-50.

12. Junying Tan, Ruangang Pan, Lei Qiao, Xiufen Zou*, Zishu Pan* (2012). Modeling and Dynamical Analysis of Virus-Triggered Innate Immune Signaling Pathways. Plos One 7, e48114.

13. Zhenhu Yang, Rui Wu, Robert W. Li, Ling Li, Zhongliang Xiong, Haizhong Zhao, Deyin Guo, Zishu Pan* (2012). Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections. Virus Research 165, 61-70.

14. Mengcheng Luo, Xiao Qu, Ruangang Pan, Dandan Zhu, Yuan Zhang, Jianguo Wu, Zishu Pan* (2011). The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice. Vaccine 29, 2561-2567.

15. Chao Wan, Li Yi, Zhenhua Yang, Jun Yang, Huabin Shao, Chuyu Zhang, Zishu Pan*. (2010). The Toll-like receptor adaptor molecule TRIF enhances DNA vaccination against classical swine fever. Veterinary Immunology and Immunopathology 137, 47-53.

16. Xiufen Zou, Xueshuang Xiang, Yan Chen, Tao Peng, Xuelian Luo, Zishu Pan* (2010). Understanding inhibition of viral proteins on type I IFN signaling pathways with modeling and optimization. Journal of Theoretical Biology 265, 691-703.

17. Pan Tao, Mengcheng Luo, Ruangang Pan, Dawei Ling, Siyu Zhou, Po Tien, Zishu Pan* (2009). Enhanced protective immunity against H5N1 influenza virus challenge by vaccination with DNA expressing a chimeric hemagglutinin in combination with an MHC class I-restricted epitope of nucleoprotein in mice. Antiviral Research 81, 253-260.

18. Xuelian Luo, Ruangang Pan, Chao Wan, Xinfeng Liu, Jianguo Wu, Zishu Pan* (2009). Glycosylation of classical swine fever virus E(rns) is essential for binding double-stranded RNA and preventing interferon-beta induction. Virus Research 146,135-139.

19. 6.Guoyuan Wen, Jinnuo Xue, Yanping Shen, Chuyu Zhang, Zishu Pan* (2009). Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase. Virus Research 141, 63-70.

20. Pan Tao, Mengcheng Luo, Dandan Zhu, Sanfu Qu, Zhenhua Yang, Meng Gao, Deyin Guo, Zishu Pan* (2009).Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice. Viral Immunology 22,273-281.

21. Mengcheng Luo, Pan Tao, Junwei Li, Siyu Zhou, Deyin Guo, Zishu Pan* (2008). Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice. Journal of Virological Methods 154,121-127.

22. Xiufen Zou, Tao Peng, Zishu Pan* (2008). Modeling specificity in the yeast MAPK signaling networks. Journal of Theoretical Biology 250,139-155.