导师姓名：黄永棋
导师类型：硕士生导师
出生日期：1983/4/26
职称：副教授
个人简介：
2012年7月在北京大学院物理化学专业获博士学位，2012年9月至2015年9在美国St.JudeChildren’sResearchHospital结构生物学专业从事博士后研究，现为湖北工业大学生物工程专业副教授，入选2015年湖北省省级****。
所在学院：生物工程与食品学院
专业：生物工程
研究方向：蛋白质工程、分子动力学模拟
主讲硕士生课程：蛋白质工程
主讲博士生课程：蛋白质工程
科研项目：
1.国家自然科学基金青年项目，天然无序蛋白质“序列—结构—功能”关系的比较研究，2017/01-2019/12，20万。
2.北京分子科学国家实验室基金项目，蛋白质折叠与结合耦合机理的研究，2017/03-2019/03，5万。
3.湖北省自然科学基金项目，靶向MdmX为靶标的小分子抑制剂设计，2019/09-2011/09，3万。
科研成果：
2020
1.Electrostaticinteractionsinmolecularrecognitionofintrinsicallydisorderedproteins.JYang,YZeng,YLiu,MGao,SLiu,ZSu,YHuang*.JournalofBiomolecularStructureandDynamicsInpress

2019
2.IntrinsicallydisorderedtransactivationdomainsbindtoTAZ1domainofCBPviadiversemechanisms.MGao,JYang,SLiu,ZSu,YHuang*.BiophysicalJournal**(7),1301-1310
3.14-3-3/Tauinteractionandtauamyloidogenesis.YChen,XChen,ZYao,YShi,JXiong,JZhou,ZSu*,YHuang*.JournalofMolecularNeuroscience201968,620-630
4.Featuresofmolecularrecognitionofintrinsicallydisorderedproteinsviacoupledfoldingandbinding.JYang,MGao,JXiong,ZSu*,YHuang*.ProteinScience201928,1952-1965
5.Theinfluenceofintrinsicfoldingmechanismofanunfoldedproteinonthecoupledfolding-bindingprocessduringtargetrecognition.JXiong,MGao,JZhou,SLiu,ZSu*,ZLiu,YHuang*.Proteins201987,265-275

2018
6.Exploringthesequence-structure-functionrelationshipfortheintrinsicallydisorderedβγ-crystallinHahellin.MGao,FYang,LZhang,ZSu*,YHuang*.JournalofBiomolecularStructureandDynamics201836(5),1171-1181
7.ExploringtheRolesofProlineinThree-DimensionalDomainSwappingfromStructureAnalysisandMolecularDynamicsSimulations.YHuang*,MGao,ZSu*.Theproteinjournal201837(1),13-20

2017
8.Bacterialcupredoxinazurinhijackscellularsignalingnetworks:Protein–proteininteractionsandcancertherapy.MGao,JZhou,ZSu*,YHuang*.ProteinScience201726(12),2334-2341
9.Anovelstrategytopreparetheprecursorpeptideofliraglutide.NCheng,LYang,NDai,ZHu,FYang,RChen,XCheng,JZhou,YHuang*,ZSu*.ProcessBiochemistry201762,10-15
10.DecipheringthepromiscuousinteractionsbetweenintrinsicallydisorderedtransactivationdomainsandtheKIXdomain.YHuang*,MGao,FYang,LZhang,ZSu*.Proteins:Structure,Function,andBioinformatics201785(11),2088-2095
11.EffectoftheFlexibleRegionsoftheOncoproteinMouseDoubleMinuteXonInhibitorBindingAffinity.LQin,HLiu,RChen,JZhou,XCheng,YChen,YHuang*,ZSu*.Biochemistry201756(44),5943-5954
12.Afusionproteinofthep53transactiondomainandthep53-bindingdomainoftheoncoproteinMdmXasanefficientsystemforhigh-throughputscreeningofMdmXinhibitors.RChen,JZhou,LQin,YChen,YHuang*,HLiu*,ZSu*.Biochemistry201756(25),3273-3282
13.ComprehensiveinvestigationofaberrantmicroRNAsexpressionincellsculturemodelofMnCl2-inducedneurodegenerativedisease.RHe,XXie,LLv,YHuang,XXia,XChen,LZhang.Biochemicalandbiophysicalresearchcommunications**(2),342-348

2016
14.Model-GuidedInterfaceProbeArrangementforSensitiveProteinDetection.XXu,LWang,YHuang,WGao,KLi,WJiang.AnalyticalChemistry201688(20),9885-9889
15.Interplaybetweenbindingaffinityandkineticsinprotein–proteininteractions.HCao,YHuang*,ZLiu*.Proteins:Structure,Function,andBioinformatics201684(7),920-933
16.Crypticsequencefeatureswithinthedisorderedproteinp27Kip1regulatecellcyclesignalingRKDas#,YHuang#,AHPhillips#,RWKriwacki*,RVPappu*.ProceedingsoftheNationalAcademyofSciences**(20),5616-5621

2015
17.TheActivityandStabilityoftheIntrinsicallyDisorderedCip/KipProteinFamilyAreRegulatedbyNon-ReceptorTyrosineKinases.YHuang#,MKYoon#,SOtieno,MLelli,RWKriwacki*.Journalofmolecularbiology**(2),371-386

2014
18.Advantagesofproteinsbeingdisordered.ZLiu*,YHuang.ProteinScience201423(5),539-550

2013
19.Dointrinsicallydisorderedproteinspossesshighspecificityinprotein–proteininteractions?YHuang,ZLiu*.Chemistry–AEuropeanJournal201319(14),4462-4467
20.Evidencesfortheunfoldingmechanismofthree-dimensionaldomainswapping.ZLiu*,YHuang.ProteinScience201322(3),280-286

2012
21.Mechanismof3DDomainSwappingforMpro-C:CluesfromMolecularSimulations.YHuang,XKang,BXia,ZLiu*.ActaPhysico-ChimicaSinica201228(10),2411-2417
22.Bindingoftwointrinsicallydisorderedpeptidestoamulti-specificprotein:acombinedMonteCarloandmoleculardynamicsstudy.IStaneva,YHuang,ZLiu,SWallin*.PLoScomputationalbiology20128(9),e**
23.Three-dimensionaldomainswappingintheproteinstructurespace.YHuang,HCao,ZLiu*.Proteins:Structure,Function,andBioinformatics201280(6),1610-1619

2011
24.Anchoringintrinsicallydisorderedproteinstomultipletargets:lessonsfromN-terminusofthep53protein.YHuang,ZLiu*.Internationaljournalofmolecularsciences201112(2),1410-1430

2010
25.Smoothingmolecularinteractions:The“kineticbuffer”effectofintrinsicallydisorderedproteins.YHuang,ZLiu*.Proteins:Structure,Function,andBioinformatics201078(16),3251-3259
26.Nonnativeinteractionsincoupledfoldingandbindingprocessesofintrinsicallydisorderedproteins.YHuang,ZLiu*.PLoSOne20105(11),e15375
27.Intrinsicallydisorderedproteins:thenewsequence-structure-functionrelations.YHuang,ZLiu*.ActaPhysico-ChimicaSinica201026(8),2061-2072
28.Foldingsimulationsofadenovodesignedproteinwithaβαβfold.YQi#,YHuang#,HLiang,ZLiu*,LLai*.Biophysicaljournal201098(2),321-329

2009
29.Kineticadvantageofintrinsicallydisorderedproteinsincoupledfolding-bindingprocess:acriticalassessmentofthe“fly-casting”mechanism.YHuang,ZLiu*.Journalofmolecularbiology**(5),1143-1159
30.MoleculardynamicssimulationexplorationofcooperativemigrationmechanismofcalciumionsinsarcoplasmicreticulumCa2+-ATPase.YHuang,HLi,YBu*.Journalofcomputationalchemistry200930(13),2136-2145