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王成华
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广西南宁市大学东路100号轻工与食品工程学院408室
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博士后合作导师, 博士研究生导师, 硕士研究生导师
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2017.01-至今，广西大学轻工与食品工程学院，教师2014.01-2016.12，清华大学化学工程系，博士后2008.09-2013.12，南京工业大学生物与制药工程学院，工业生物催化专业，博士研究生2007.09-2008.01，中国动物卫生与流行病学中心，访学2007.07-2008.09，南宁邦尔克生物技术有限责任公司，南宁市发酵与酶工程技术研究中心2004.09-2007.07，广西大学生命科学与技术学院，发酵工程专业，硕士研究生2000.09-2004.07，河南农业大学生物工程学院，生物技术专业，本科生
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国家自然科学基金委评议专家；南宁市特聘专家
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《食品生物技术》《蛋白质化学》
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食品酶学、分子食品、生物催化
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1. 国家自然科学基金面上项目，**，2020/01-2023/12，在研，主持。2. 国家自然科学基金地区基金项目，**，2019/01-2022/12，在研，主持。3. 广西科技基地和人才专项项目，桂科AD**，2018/09-2021/08，在研，主持。4. 广西自然科学基金面上项目，2017GXNSFAA198265，2017/09-2020/09，在研，主持。5. 国家自然科学基金青年基金项目，**，2015/01-2017/12，结题，主持。6. 中国博士后科学基金特别资助项目，2015T80094，2015/07-2016/12，结题，主持。7. 中国博士后科学基金面上项目，2014M550743，2014/05-2016/12，结题，主持。8. 中国博士后科学基金国际交流计划学术交流项目（第二批），结题，主持。9. 国家自然科学基金重大科研仪器研制项目，**，2017/01-2021/12，在研，参与（第七完成人）。10. 广西科技重大专项，桂科AA**，2017/09-2020/12，在研，参与（第二完成人）。11. 入选“第六批南宁市特聘专家”，2018.05-2021.05，在岗，主持。12. 入选“博世科青年教师创新人才培养奖励资助计划”，2018.01-2020.12，在研，主持。13. 2017年南宁市人才小高地专项资金资助项目，2018.01-2019.12，在研，主持。
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发表SCI收录论文19篇，授权专利3项。[1] Ran Zhang#, Shi-Jue Gao, Chun-Yan Zhu, Yu Sun, Xiao-Ling Liu, Mou-Ming Zhao, Cheng-Hua Wang*. Characterization of a novel alkaline Arxula adeninivorans urate oxidase expressed in Escherichia coli and its application in reducing uric acid content of food. Food Chemistry, 2019, 293:254-262.[2] Yu Sun#, Yixin Xiao, Ran Zhang, Chenghua Wang*, Xiaoling Liu, Mouming Zhao. Screening, Identification and Characterization of Selenium-Enriched Bacillus pumilus D1-019. Food Science, 2019, 40(14):130-137.[3] Cheng-Hua Wang#,*, Xiao-Ling Liu, Ri-Bo Huang*, Bing-Fang He, Mou-Ming Zhao. Enhanced acidic adaptation of Bacillus subtilis Ca-independent alpha-amylase by rational engineering of pKa values. Biochemical Engineering Journal, 2018, 139:146–153. [4] Chenghua Wang#, Chong Zhang, Xinhui Xing*. Metabolic engineering of Escherichia coli cell factory for highly active xanthine dehydrogenase production. Bioresource Technology. 2017, 245:1782-1789. [5] Chenghua Wang#, Gang Li, Chong Zhang, Xinhui Xing*. Enhanced Catalytic Properties of Novel (αβγ)2 Heterohexameric Rhodobacter capsulatus Xanthine Dehydrogenase by Separate Expression of the Redox Domains in Escherichia coli. Biochemical Engineering Journal, 2017,119:1-8. [6] Chenghua Wang#, Chong Zhang, Xinhui Xing*. Xanthine dehydrogenase: an old enzyme with new knowledge and prospects. Bioengineered. 2016, 7(6):395-405. [7] Chenghua Wang#, Tongxin Zhao, Mei Li, Chong Zhang, Xinhui Xing*. Characterization of a novel Acinetobacter baumannii xanthine dehydrogenase expressed in Escherichia coli. Biotechnology Letters. 2016, 38(2):337-344. [8] Tong-Xin Zhao, Mei Li, Xiang Zheng, Cheng-Hua Wang, Chong Zhang*, Xin-Hui Xing. Improved production of trans-4-hydroxy-l-proline by chromosomal integration of the Vitreoscilla hemoglobin gene into recombinant Escherichia coli with expression of proline-4-hydroxylase. Journal of Bioscience and Bioengineering, 2016, 103(1):109-115. [9] Jiaxing Xu*, Bingfang He, Bin Wu, Bin Wang, Chenghua Wang, Lei Hu. An ionic liquid tolerant cellulase derived from chemically polluted microhabitats and its application in in situ saccharification of rice straw. Bioresource Technology. 2014,157:166-173. [10] Chenghua Wang#, Qingyan Wang, Siming Liao, Bingfang He, Ribo Huang*. Thermal stability and activity improvements of a Ca-independent alpha-amylase from Bacillus subtilis CN7 by C-terminal truncation and hexahistidine-tag fusion. Biotechnology and Applied Biochemistry. 2014, 61(2):93-100. [11] Chenghua Wang#, Ribo Huang*, Bingfang He, Qishi Du. Improving the thermostability of alpha-amylase by combinatorial coevolving-site saturation mutagenesis. BMC Bioinformatics. 2012, 13:263. [12] Qishi Du*, Jianzong Meng, Chenghua Wang, Siyu Long, Ribo Huang. Structural Position Correlation Analysis (Spca) for Protein Family. PLoS One. 2011, 6 (12): e28206. [13] Qishi Du*, Xianwei Fan, Chenghua Wang, Ribo Huang. A possible CO2 conducting and concentrating mechanism in plant stomata Slac1 Channel. PLoS One. 2011, 6 (9): e24264. [14] Ribo Huang, Qishi Du*, Chenghua Wang, Siming Liao, Kouchen Chou. A fast and accurate method for predicting pka of residues in proteins. Protein Engineering Design & Selection. 2010, 23 (1): 35-42. [15] Qishi Du*, Chenghua Wang, Siming Liao, Ribo Huang. Correlation analysis for protein evolutionary family based on amino acid position mutations and application in PDZ domain. PloS One. 2010, 5(10):e13207.[16] Qishi Du*, Chenghua Wang, Yuting Wang, Ribo Huang. Empirical and accurate method for the three-dimensional electrostatic potential (Em-Esp) of biomolecules. Journal of Physical Chemistry B. 2010, 114 (12): 4351-7. [17] Hang Wei, Chenghua Wang, Qishi Du*, Jianzong Meng, Kouchen Chou. Investigation into adamantane-based M2 inhibitors with Fb-Qsar. Medicinal Chemistry. 2009, 5 (4): 305-17. [18] Qishi Du*, Ribo Huang, Chenghua Wang, Xiaoming Li, Kouchen Chou. Energetic analysis of the two controversial drug binding sites of the M2 proton channel in influenza A virus. Journal of Theoretical Biology. 2009, 259 (1): 159-64. [19] Ribo Huang, Qishi Du, Chenghua Wang, Kuochen Chou. An in-depth analysis of the biological functional studies based on the NMR M2 channel structure of influenza A virus. Biochemical and Biophysical Research Communications. 2008, 377:1243–1247. [20] Qishi Du*, Ribo Huang, Yutuo Wei, Chenghua Wang, Kuochen Chou. Peptide reagent design based on physical and chemical properties of amino acid residues. Journal of Computational Chemistry. 2007, 28: 2043–2050. [21] 粱莲华, 王成华，蒙健宗，李晓明，韦航. 一种耐酸性高温β-淀粉酶的突变体TBA-H2及其应用.中国, ZL5.2. 2015.[22] 王成华，蒙健宗，粱莲华，李晓明，韦航，陈发忠，杜奇石，周礼芹. 一种耐酸性高温β-淀粉酶突变体及其应用.中国, ZL9.8. 2015.[23] 王成华,黄日波,王青艳,申乃坤,陈东,黎贞崇,黄志民. α-淀粉酶截断体及其应用. 授权专利号:ZL6.9. 2014.
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