崔隽

Submitted on 周一, 10/30/2017 - 20:20


性别
男

工作电话


电子邮件
cuij5@mail.sysu.edu.cn

职称
教授

导师类型
博士生导师

学历
博士

学科方向
0710生物学-09细胞生物学
0710生物学-10生物化学与分子生物学


研究方向
主要研究方向为固有免疫系统识别和调控、信号转导机制与疾病相关性，以及系统生物学研究，具体的研究领域包括：
炎症反应
抗病毒免疫
细胞自噬
可逆泛素化及类泛素化修饰
肿瘤免疫
自身免疫性疾病
细胞信号网络的数学模拟和分析

讲授课程
现代分子免疫学进展
生命科学史
新生研讨课
科研技能训练
生命科学引论
现代生命科学进展
免疫学II
专业文献科技阅读和理解

学术成就
崔隽，博士，中山大学教授、博士生导师，生命科学学院副院长，生物化学系主任，广东省免疫学会常务理事，中国免疫学会终身会员。曾获2011年全国百篇优秀博士论文提名奖，并获2013年广东省自然科学****基金项目资助，2014年入选“广东省特支计划”千百万青年工程拔尖人才，2015年入选国家自然科学基金优秀青年基金项目，并入选广东省高等学校优秀青年教师培养计划。主要研究方向为固有免疫系统识别和调控、信号转导机制与疾病相关性，以及系统生物学研究。在实验生物学（特别是分子免疫学）和计算生物学（生物信号传导网络的数学模型建立）领域均取得多项进展，目前已发表学术论文60余篇，在Cell， Immunity （2篇）， Nature Immunology，Nature Communications，Science Advances（3篇），Advanced Science（2篇），JACI（2篇），Cell Research（4篇），EMBO J（3篇），EMBO Reports，Autophagy（5篇），Journal of Cell Biology，Cell Reports（3篇），Molecular Cell（3篇）等顶级杂志发表多篇一作或通讯作者论文，并撰写书目章节4篇， 主编专著一部（Autophagy Regulation of Innate Immunity, Springer-Nature 2020）， 论文影响因子累计600以上，他引累计已达2000余次。

论文专著
[1] Wu Y#, Ma L#, Zhuang Z#, Cai S#, Zhao Z, Zhou L, Zhang J, Wang PH, Zhao J*, Cui J*. Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling. Signal Transduct Target Ther. 2020 Oct 6;5(1):221. doi: 10.1038/s41392-020-00332-2. PMID: ** Free PMC article.
[2] Zhou L#, Liu T#, Huang B#, Luo M, Chen Z, Zhao Z, Wang J, Leung D, Yang X, Chan KW, Liu Y, Xiong L, Chen P, Wang H, Ye L, Liang H, Masters SL, Lew AM, Gong S, Bai F, Yang J, Pui-Wah Lee P, Yang W, Zhang Y, Lau YL*, Geng L*, Zhang Y*, Cui J*. Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development. J Allergy Clin Immunol. 2020 Sep 14:S0091-6749(20)31246-X. doi: 10.1016/j.jaci.2020.09.003. Online ahead of print. PMID: **
[3] Wu Y#, Jin S, Liu Q, Zhang Y, Ma L, Zhao Z, Yang S, Li YP, Cui J*. Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression. Autophagy. 2020 May 31:1-14. doi: 10.1080/**.2020.**.
[4] Tian S#, Jin S#, Wu Y#, Liu T, Luo M, Ou J, Xie W, Cui J*. High-throughput screening of functional deubiquitinating enzymes in autophagy. Autophagy. 2020 May 26:1-12. doi: 10.1080/**.2020.**.
[5] Xie W#, Jin S#, Wu Y, Xian H, Tian S, Liu DA, Guo Z, Cui J*. Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34. Cell Rep. 2020 Feb 25;30(8):2807-2819.e4. doi: 10.1016/j.celrep.2020.01.088
[6] Zhou J#, Sun T, Jin S, Guo Z, Cui J*. Dual Feedforward Loops Modulate Type I Interferon Responses and Induce Selective Gene Expression during TLR4 Activation. iScience. 2020 Feb 21;23(2):100881. doi: 10.1016/j.isci.2020.100881.
[7] Chen M#, Zhao Z#, Meng Q#, Liang P#, Su Z, Wu Y, Huang J, Cui J*.TRIM14 Promotes Noncanonical NF-kB Activation by Modulating p100/p52 Stability via Selective Autophagy. Advanced Science. 2019 Nov 11; DOI: 10.1002/advs.
[8] Zhang CX#, Ye SB#, Ni JJ#, Cai TT, Liu YN, Huang DJ, Mai HQ, Chen QY, He J, Zhang XS, Zeng YX*, Li J*, Cui J*. STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion. Cell Death Differ. 2019 Feb 28. doi: 10.1038/s41418-019-0302-0.
[9] Xian H#, Yang S#, Jin S#*, Zhang Y, Cui J*. LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I. Autophagy. 2019 May 22:1-11. doi: 10.1080/**.2019.**.
[10] Liu T#, Zhou YT#, Wang LQ#, Li LY#, Bao Q, Tian S, Chen MX, Chen HX, Cui J*, Li CW*. NLRP3 contributes to inflammation, pyroptosis, and mucin production in human airway epithelium upon rhinovirus infection. J Allergy Clin Immunol. 2019 May 15. pii: S0091-6749(19)30623-2. doi: 10.1016/j.jaci.2019.05.006.
[11] Liu Q#, Wu Y#, Qin Y#, Hu J, Xie W, Qin FX*, Cui J*. Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses. Sci Adv. 2018 May 2;4(5):eaar2824
[12] Zheng Y#, Liu Q#, Wu Y#, Ma L, Zhang Z, Liu T, Jin S, She Y, Li YP*, Cui J*. Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis. EMBO J. 2018 Sep 14;37(18). pii: e99347. doi: 10.15252/embj.. Epub 2018 Jul 31.
[13 ]Jin S#, Zhang X#, Miao Y#, Liang P, Zhu K, She Y, Wu Y, Liu DA, Huang J, Ren J*, Cui J*. m6A RNA modification controls autophagy through upregulating ULK1 protein abundance. Cell Res. 2018 Sep;28(9):955-957. doi: 10.1038/s41422-018-0069-8. Epub 2018 Jul 25
[14] Liu K#, Zhang C#, Li B#, Xie W, Zhang J, Nie X, Tan P, Zheng L, Wu S*, Qin Y*, Cui J*, Zhi F*. Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression. Cell Rep. 2018 Apr 17;23(3):838-851. doi: 10.1016/j.celrep.2018.03.096.
[15] Du Y#, Duan T#, Feng Y#, Liu Q, Lin M, Cui J*, Wang RF*. LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation. EMBO J. 2018 Feb 1;37(3):351-366. doi: 10.15252/embj.. Epub 2017 Dec 29.
[16] Jin S#, Cui J*. BST2 inhibits type I IFN (interferon) signaling by accelerating MAVS degradation through CALCOCO2-directed autophagy. Autophagy. 2018;14(1):171-172. doi: 10.1080/**.2017.**. Epub 2017 Dec 31.
[17] Wu C#, Su Z, Lin M, Ou J, Zhao W, Cui J*, Wang RF*. NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A. Nat Commun. 2017 Dec 7;8(1):1977. doi: 10.1038/s41467-017-02073-3.
[18] Qin Y#, Su Z#, Wu Y#, Wu C, Jin S, Xie W, Jiang W, Zhou R, Cui J*. NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis. EMBO Rep. 2017 Dec;18(12):2160-2171. doi: 10.15252/embr.. Epub 2017 Nov 2.
[19] Feng Y#, Duan T#, Du Y#, Jin S, Wang M, Cui J*, Wang RF*. LRRC25 Functions as an Inhibitor of NF-κB Signaling Pathway by Promoting p65/RelA for Autophagic Degradation. Sci Rep. 2017 Oct 18;7(1):13448. doi: 10.1038/s41598-017-12573-3.
[20] Jin S#, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J*. Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells. Mol Cell. 2017 Oct 19;68(2):308-322.e4. doi: 10.1016/j.molcel.2017.09.005. Epub 2017 Sep 28.
[21] Xian H#, Xie W, Yang S, Liu Q, Xia X, Jin S, Sun T*, Cui J*. Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression. Sci Adv. 2017 Sep 22;3(9):e**. doi: 10.1126/sciadv.**. eCollection 2017 Sep.
[22] Lin M#, Zhao Z#, Yang Z#, Meng Q, Tan P, Xie W, Qin Y, Wang RF*, Cui J*. USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome. Mol Cell. 2016 Oct 20; 64(2):267-281.
[23] Chen M#, Meng Q#, Qin Y#, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J*, Wang RF*, Cui J*. TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses. Mol Cell. 2016 Oct 6; 64(1):105-119.
[24] Liu T#, Tang Q#, Liu K, Xie W, Liu X, Wang H, Wang RF*, Cui J*. TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy. Cell Rep. 2016 Aug 16; 16(7):1988-2002.
[25] Jin S#, Tian S#, Chen Y#, Zhang C, Xie W, Xia X, Cui J*, Wang RF*. USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1. EMBO J. 2016 Apr 15; 35(8):866-80.
[26] Qin Y#, Liu Q#, Tian S#, Xie W, Cui J*, Wang RF*. TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1. Cell Res. 2016 May;26(5):613-28.
[27] Meng Q#, Cai C#, Sun T#*, Wang Q, Xie W, Wang R*, Cui J*. Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch. J Cell Biol. 2015 Dec 7; 211(5):1025-40.
[28]??Cui J#*, Song Y#, Li Y#, Zhu Q, Tan P, Qin Y, Wang HY, Wang RF*. USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors. Cell Res. 2014 Apr; 24(4):400-16.
[29] Tong Y#, Cui J#, Li Q, Zou J, Wang HY, Wang RF*. Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice. Cell Res. 2012 May; 22(5):822-35.
[30] ?Cui J#, Li Y#, Zhu L, Liu D, Songyang Z, Wang HY, Wang RF*. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat Immunol. 2012 Mar 4; 13(4):387-95.
[31]? Ajibade AA#, Wang Q#, Cui J#, Zou J, Xia X, Wang M, Tong Y, Hui W, Liu D, Su B, Wang HY, Wang RF*. TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils. Immunity. 2012 Jan 27; 36(1):43-54.
[32]? Xia X#, Cui J#, Wang HY, Zhu L, Matsueda S, Wang Q, Yang X, Hong J, Songyang Z, Chen ZJ, Wang RF*. NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. Immunity. 2011 Jun 24; 34(6):843-53.
[33] ?Cui J#, Zhu L#, Xia X#, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ, Wang RF*. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell. 2010 Apr 30; 141(3):483-96.
# 第一作者 ???*通讯作者
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