莫德林

Submitted on 周一, 10/30/2017 - 21:03


性别
男

工作电话


电子邮件
modelin@mail.sysu.edu.cn

职称
教授

导师类型
博士生导师

学历
博士

学科方向
0710生物学-08发育生物学


研究方向
常年招聘国内外博士后，从事肌肉与脂肪发育分子调控机理、动物基因编辑等研究1、肌肉发育差异的遗传与分子调控机制
2、脂肪时空分布以及肌内脂肪含量差异的遗传与分子调控机制

个人经历
1、1996.09-2000.06，华中农业大学，本科/学士，畜牧学（A+学科）
2、2001.09-2006.06，华中农业大学，研究生/博士，动物遗传育种与繁殖
3、2014.02-2015.02，Cornell University/美国，访问****，动物科学
4、2006.09-2009.06，中山大学，博士后
5、2009.06-至今， ? ? ? 中山大学，讲师、副教授、教授
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讲授课程
《生命科学引论》（课程负责人）；必修课《普通生物学》（课程负责人）；《细胞生物学》
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学术成就
首次提出胚胎早期成肌基因起始表达时间差异及其所导致的初级肌纤维形成时间是影响动物产肉量的关键因素。
获得奖励
1、刘小红、陈瑶生、李加琪、王希斌、张哲、陈赞谋、袁金锋、莫德林、张从林、宋德清、陈清森、唐凡、曾检华、谢水华、罗艳凤, 2016，数字化种猪育种关键技术研发与产业化应用，广东省科技进步奖二等奖
2、王翀、莫德林、张豪、陈瑶生、李加琪、杨慧荣、吴珍芳、张哲、邱志鹏、覃立立、李莉、余丽明、邓振强、张育乔、李岩、吴同山、潘炎均、邓春武、巩振华，现代猪分子育种技术的应用与推广，2013，广东省农业技术推广一等奖，广东省农业厅。
3、陈瑶生、李加琪、张勤、刘小红、王翀、刘海良、王志刚、张豪、吴秋豪、薛明、莫德林、丁向东、罗旭芳、余丽明、郑华，国家和区域性种猪遗传评估系统关键技术研发与应用，2011年，广东省科学技术进步一等奖，广东省科技厅。
4、莫德林，中山大学-广东温氏食品集团有限公司奖励基金温氏杰出产业服务奖教金，2015年，中山大学
5、莫德林，李宝健遗传学研究基金，2017年，中山大学
6、莫德林，校级优秀本科毕业论文指导老师，中山大学

承担课题
1、国家重点研发计划课题，不同区域地方猪杂交利用关键技术研究与示范，2018YFD**，莫德林（主持人），2018.1-2020.12
2、国家自然科学基金面上项目，代谢参与调控不同品种猪肌肉发育差异的研究，**，莫德林（主持人），2021.1-2024.12
3、国家自然科学基金面上项目，myoD表达时间对肌纤维数量的影响及其在猪品种间表达时间差异的分子机制，**，莫德林（主持人），2018.1-2021.12；
4、国家自然科学基金面上项目，初级肌纤维形成时间对猪瘦肉量的影响及其调控机制，**，莫德林（主持人），2013.1-2016.12
5、国家自然科学基金青年项目，猪caveolin基因家族相互作用蛋白鉴定以及对脂肪与肌细胞胆固醇转运机理的研究，**，莫德林（主持人），2008.1-2010.12
6? ?国家自然科学基金委（NSFC）-广东联合基金项目，蓝塘猪背最长肌脂肪含量与脂肪酸组成形成的分子机制，U**，陈瑶生（主持人）、莫德林（核心），2013.01-2016.12
7、国家自然科学基金委（NSFC）-广东联合基金项目，不同猪种肌肉生长发育差异的分子机制与调控研究，U**，陈瑶生（主持人）、莫德林（核心），2013.01-2016.12

论文专著
2020年
42. Yaping Nie#, Shufang Cai#, Renqiang Yuan, Suying Ding, Xumeng Zhang, Luxi Chen, Yaosheng Chen, Delin Mo*.?Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.?Cell Death & Differentiation, 2020,?27(5):1644-1659. (IF：10.7,中科院一区)
41.?Ying Fang,?Feng Liang,?Renqiang Yuan,?Qi Zhu,?Shufang Cai, Keren Chen,Junyan Zhang,?Xiaorong Luo, Yaosheng Chen, Delin Mo*. High mobility group box 2 regulates skeletal muscle development through ribosomal protein S6 kinase 1.?The FASEB Journal, 2020,;34:12367–12378.?(IF=5.39)
40. Shufang Cai. Qi Zhu, Cilin Guo, Renqiang Yuan, Xumeng Zhang, Yaping Nie, Luxi Chen, Ying Fang, Keren Chen, Junyan Zhang,?Delin Mo*, Yaosheng Chen*. MLL1 promotes myogenesis by epigenetically regulating Myf5,?Cell Proliferation, 2020;53:e12744.?(IF：5.75)?Q1
2019年
39. Xumeng Zhang#,?Yaping Nie#, Shufang Cai#, Suying Ding, Bingqiang Fu, Hong Wei, Luxi Chen, Xiaohong Liu, Minggui Liu, Renqiang Yuan, Boqing Qiu, Zuyong He, Peiqing Cong, Yaosheng Chen,?Delin Mo*. Earlier demethylation of myogenic genes contributes to embryonic precocious terminal differentiation of myoblast in miniature pigs.?The FASEB Journal, 2019, 33 (8) :9638-9655. (IF=5.595) Q1
38. Suying?Ding, Yaping?Nie, Xumeng?Zhang, Xiaohong?Liu, Chen?Wang, Renqiang?Yuan, Keren?Chen, Qi?Zhu, Shufang?Cai, Ying?Fang, Yaosheng?Chen,?Delin Mo*. The SNPs in myoD gene from normal muscle developing individuals have no effect on muscle mass.?BMC Genetics, 2019,?20:72 (IF:2.55)?
37. Xumeng Zhang,?Shufang Cai, Luxi Chen, Renqiang Yuan, Yaping Nie, Suying Ding, Ying Fang, Qi Zhu, Keren Chen, Hong Wei, Yaosheng Chen,?Delin Mo*. Integrated miRNA-mRNA transcriptomic analysis reveals epigenetic mediated embryonic muscle growth differences between Wuzhishan and Landrace pigs.?Journal of Animal Science，2019，97:1967–1978. (IF:1.714) Q1
36. Luxi Chen, Yue Zhang, Hu Chen, Xumeng Zhang, Xiaohong Liu, Zuyong He, Peiqing Cong, Yaosheng Chen, and?Delin Mo*. Comparative transcriptome analysis reveals more complicated adipogenic process in intramuscular stem cells than that of subcutaneous vascular stem cells.?Journal of Agricultural and Food Chemistry, 2019，67, 16, 4700-4708. （IF=3.412. 中科院一区）Q1
2018年
35. RenqiangYuan, Xumeng Zhang, Ying Fang, Yaping Nie, Shufang Cai, Yaosheng Chen,?Delin Mo*. Mir-127-3p inhibits the proliferation of myocytes by targeting KMT5a.?Biochem Biophys Res Commun. 2018, 503(2):970-976. Q3
2017年
34. Zhuning Yuan, Yaosheng Chen, Xumeng Zhang, Xingyu Zhou, Mingsen Li, Hu Chen, Ming Wu, Ying Zhang,?Delin Mo*. Silencing myotubularin related protein 7 enhances proliferation and early differentiation of C2C12 myoblast.?Biochemical and Biophysical Research Communications, 2017, 484: 592-597 Q3
33.?Delin Mo#, Kaifan Yu#, Hu Chen, Luxi Chen, Xiaohong Liu, Zuyong He, Peiqing Cong, Yaosheng Chen *. Transcriptome Landscape of Porcine Intramuscular Adipocytes during Differentiation.?J Agric Food Chem.?2017, 65(30):6317-6328?（3.15，中科院一区）Q1
32. Shuihua Xie,?Luxi Chen,?Xumeng Zhang,?Xiaohong Liu,?Yaosheng Chen,?Delin Mo*. An integrated analysis revealed different microRNA-mRNA profiles during skeletal muscle development between Landrace and Lantang pigs.?Sci Rep.?2017, 7(1):2516 Q1
31. Yaping Nie, Hu Chen, Cilin Guo, Zhuning Yuan, Xingyu Zhou, Ying Zhang, Xumeng Zhang, Delin Mo* & Yaosheng Chen*. Palmdelphin promotes myoblast differentiation and muscle regeneration.?Sci Rep.?2017, 7:41608. Q1
2016年
30. Xingyu Zhou#, Mingsen Li#, Huaxing Huang, Keren Chen, Zhuning Yuan, Ying Zhang, Yaping Nie, Hu Chen, Xumeng Zhang, Luxi Chen, Yaosheng Chen*, and?Delin Mo*. HMGB2 regulates satellite cell-mediated skeletal muscle regeneration via IGF2BP2.?Journal of Cell Science,?2016, 129(22):4305-4316. (IF: 5.5) Q2
29. Hu Chen, Renqiang Yuan, Ying Zhang, Xumeng Zhang, Luxi Chen, Xingyu Zhou, Zhuning Yuan, Yaping Nie, Ming Li,?Delin Mo*, Yaosheng Chen*. ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation.?Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016, 1859(11):1459-1469. (IF: 5.55) Q1
28. Xumeng Zhang, Yaosheng Chen, Jinchun Pan, Xiaohong Liu, Hu Chen, Xingyu Zhou, Zhuning Yuan, Xilong Wang and?Delin Mo*. iTRAQ-based quantitative proteomicanalysis reveals the distinct early embryomyofiber type characteristics involved in Landrace and miniature pig.?BMC Genomics, 2016, 17:137 Q1
27. Ming Li,?Hu Chen,?Luxi Chen,?Yaosheng Chen,?Xiaohong Liu,?Delin Mo*. miR-709 modulates LPS-induced inflammatory response through targeting GSK-3β.?International Immunopharmacology, 2016, 36: 333–338 (IF: 2.65)
2015年
26. Mingsen Li#, Xingyu Zhou#, Yaosheng Chen, YapingNie, Huaxing Huang, Hu Chen and?Delin Mo*. Not all the number of skeletal muscle fibers is determined prenatally.BMC Developmental Biology, 2015, 15:42(IF: 2.45)
25.?Ming Wu, Gongshe Yang, Yaosheng Chen, Xingyu Zhou, Hu Chen, Mingsen Li, Kaifan Yu, Xumeng Zhang, ShuihuaXie, Ying Zhang, Guiyan Chu,?Delin Mo*. Cep2 attenuates myoblast differentiation but does not affect proliferation.?International journal of biological sciences,?2015, 11(1): 99-108. (IF: 4.37) Q2
2014年
24. Hu Chen,?Delin Mo, Ming Li, Yun Zhang, Luxi Chen, Xumeng Zhang, Mingsen Li, Xingyu Zhou, Yaosheng Chen.miR-709 inhibits 3T3-L1 cell differentiation by targeting GSK3βof Wnt/β-catenin signaling.?Cellular Signaling. 2014, 26(11): 2583-2589. (IF: 4.47)
23. Kaifan Yu#,?Delin Mo#（并列第一作者）, Ming Wu, Hu Chen, Luxi Chen, Mingsen Li, Yaosheng Chen. Activating transcription factor 4 regulates adipocyte differentiation via altering the coordinate expression of CCATT/enhancer binding protein β and peroxisome proliferator-activated receptorγ.?FEBS Journal. 2014, 281(10):2399-2409.(IF:3.99)
22. Hu Chen,?Siqi Wang,?Luxi Chen,?Yaosheng Chen,?Ming Wu,?Yun Zhang,?Kaifan Yu,?Zheng Huang,?Lijun Qin,?Delin Mo*. MicroRNA-344 inhibits 3T3-L1 cell differentiation via targeting GSK3β.?FEBS Letter.?2014, 588(3):429-435.(IF:3.54)
2013年
21. Lijun Qin,?Yaosheng Chen,?Xiaohong Liu,?Sanxing Ye,?KaifanYu,Zheng Huang,?Jingwei Yu,?Xingyu Zhou,?Hu Chen,?Delin Mo*. Integrative Analysis of Porcine microRNAome during Skeletal Muscle Development.?PLoS ONE, 2013, 8(9): e72418.(IF: 3.73)
20.?Xiao Zhao,?Zheng Huang,?Xiaohong Liu,?Yaosheng Chen,?Wen Gong,?Kaifan Yu,?Lijun Qin,?Hu Chen,?Delin Mo*. The switch role of the Tmod4 in the regulation of balanced development between myogenesis and adipogenesis.?Gene.?2013,532(2):263-71.(IF: 2.2)
19.?Anning Li#,?Delin Mo#（并列第一作者）,?Xiao Zhao,?Wei Jiang,?Peiqing Cong,?Zuyong He,?Shuqi Xiao,?Xiaohong Liu,?Yaosheng Chen. ?Comparison of the longissimus muscle proteome between obese and lean pigs at 180 days.?Mamm Genome.?2013, 24(1-2):72-9 (IF: 2.5)
2012年
18. Yunxue Guo,?Yaosheng Chen,?Yun Zhang,?Yue Zhang,?Luxi Chen,?Delin Mo. Up-regulated miR-145 Expression Inhibits Porcine Preadipocytes Differentiation by Targeting IRS1.?Int J Biol Sci.?2012;8(10):1408-17. (IF: 3.17)
17. Yunxue Guo#,Delin Mo#（并列第一作者）, Yue Zhang, Yun Zhang, Peiqing Cong, Shuqi Xiao, Zuyong He, Xiaohong Liu, Yaosheng Chen*. MicroRNAome Comparison between Intramuscular and Subcutaneous Vascular Stem Cell Adipogenesis.?PLoS ONE. 2012,7(9): e45410.(IF: 3.73)
16. Qin LL, Li XK, Xu J,?Mo DL, Tong X, Pan ZC, Li JQ, Chen YS, Zhang Z, Wang C, Long QM. Mechano growth factor (MGF) promotes proliferation and inhibits differentiation of porcine satellite cells (PSCs) by down-regulation of key myogenic transcriptional factors.?Mol Cell Biochem. 2012, 370(1-2):221-30.?
2011年
15.?Xiao Zhao#,Delin Mo#（并列第一作者）, Anning Li, Wen Gong, Shuqi Xiao, Yue Zhang, Limei Qin, YunaNiu, YunxueGuo, Xiaohong Liu, Peiqing Cong, Zuyong He, Chong Wang, Jiaqi Li, Yaosheng Chen*. Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness.?PLoS ONE,2011, 6(5): e19774.（IF: 4.35，被Nature genetics等他引84次）
14. Yuna Niu,?Delin Mo, Limei Qin, Chong Wang, Chunyan Zhou, Anning Li, Xiao Zhao, Shuqi Xiao, Qiwei Wang, Ying Xie, Jing Li, Zuyong He, Peiqing Cong, Yaosheng Chen. LPS-induced miR-1224 negatively regulates tumor necrosis factor-alpha gene expression by modulating Sp1.?Immunology, 2011,133(1):8-20.（IF:3.7）
13. Weiquan Chen, Yaosheng Chen, Limei Qin, Anning Li, Xiao Zhao, Xiaoying Wang, ShuqiXiao,?Delin Mo*. Transcription Factor Sp1 is Essential for the Regulation of the Porcine Caveolin-1 Gene.?DNA and Cell Biology,?2011, 30(7):491-7,?（IF: 2.28）
2010年
12. Limei?Qin, Yaosheng?Chen, Yuna?Niu, Weiquan?Chen, Qiwei?Wang, Shuqi?Xiao, Anning?Li, Ying?Xie, Jing?Li, Xiao?Zhao, Zuyong?He?and?Delin?Mo*. A deep investigation into the adipogenesis mechanism: profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway.?BMC Genomics. 2010, 11:320.?（被Genome biology等他引139次，IF: 4.2）
11. Anning Li, Yaosheng Chen, Xiao Zhao, Yuna Niu, Peiqing Cong, Zongwu Zhang, Weiquan Chen, Wei Jiang,?Delin Mo?*. Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene.?Mol Genet Genomics. 2010. 284(3):185-95.?（IF: 2.84）
10.?Shuqi?Xiao, Jianyu?Jia,?Delin?Mo, Qiwei?Wang, Limei?Qin,ZuyongHe,XiaoZhao, Yukai?Huang, Anning?Li, Jingwei?Yu, Yuna?Niu, Xiaohong?Liu, Yaosheng?Chen.Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing.PLoS One.?2010,29;5(6):e11377.?
9. Shuqi Xiao,?Delin Mo, Qiwei Wang, JianyuJia, Limei Qin, Xiangchun Yu, YunaNiu, Xiao Zhao, Xiaohong Liu, Yaosheng Chen. Aberrant host immune response induced by highly virulent PRRSV identified by digital gene expression tag profiling.?BMC Genomics, 2010, 11:544.?（IF:4.2）
8.?Zongwu?Zhang#,?Delin?Mo#,FeiLing, Chong?Wang, Anning?Li, Xiao?Zhao, Yanfang?Li, Yaosheng?Chen.Characterization and promoter activity analysis of a new porcine gene: NICE-3.DNA Cell Biol.?2010,?29(3):141-7.?（IF:2.0）
7.?Zhisheng?Zhang#,?Delin?Mo#, Peiqing?Cong, Zuyong?He, Fei?Ling, Anning?Li, Yuna?Niu, Xiao?Zhao, Chunyan?Zhou, Yaosheng?Chen.Molecular cloning, expression patterns and subcellular localization of porcine TMCO1 gene.Mol Biol Rep.?2010,?37(3):1611-8.?
2009年
6. Xiao S, Li S, Zhang J, Zhang S, Dai L, Bao Y, Jiang N, Gao Y, Zhao Z,?Mo D, Chen Y, Zhao Z. Cloning and characterization of class 1 and class 2 insulin-like growth factor-I mRNA in Songliao black pig.?Mol Biol Rep. 2009, 36(2):415-21.?
2008年
5.?Delin Mo, Zhengmao Zhu, Marinus F W te Pas, Xinyun Li, Shulin Yang, Heng Wang, Huanling Wang and Kui Li. Characterization, expression profiles, intracellular distribution and association analysis of porcine PNAS-4 gene with production traits.?BMC Genetics, 2008, 9:40.?（IF: 2.35）
2007年
4. Li X, Zhu Z,?Mo D, Wang H, Yang S, Zhao S, Li K. Comparative molecular characterization of ADSS1 and ADSS2 genes in pig (Sus scrofa).?Comp Biochem Physiol B Biochem Mol Biol. 2007, 147(2):271-7.
2006年
3. Zhu Z, Li Y,?Mo D, Li K, Zhao S. Molecular characterization and expression analysis of the porcine caveolin-3 gene.?Biochem Biophys Res Commun. 2006, 346(1):7-13.?
2. Wang H, Zhu Z, Wang H, Yang S,?Mo D, Li K. Characterization of different expression patterns of calsarcin-1 and calsarcin-2 in porcine muscle.?Gene. 2006, 374:104-11
2003年
1.?Mo DL, Liu B, Wang ZG, Zhao SH, Yu M, Fan B, Li MH, Yang SL, Zhang GX, Xiong TA and Li K. Genetic variation and relationship of seventeen Chinese indigenous pig breeds using ten serum protein loci.?Asian-Australasian Journal of Animal Sciences. 2003, 16(7): 939-944.
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已获授权专利：
1、一种用于猪背膘厚标记辅助选择的分子标记的方法（ZL50.7）发明专利，莫德林，陈瑶生，朱晓萍，王翀，李加琪，李华周，专利权人：中山大学
2、一种评价猪的脂肪沉积性能的方法（ZL63.6），发明专利，陈瑶生，莫德林，朱晓萍，王翀，李加琪，姜增固。专利权人：中山大学
3、抗菌肽Protegrin-1在防治猪蓝耳病中的应用（ZL3.6），刘小红、郭春和、莫德林、陈瑶生、高进涛，专利权人：中山大学
4、氯化血红素在制备抗猪繁殖与呼吸综合征病毒药物上的应用（ZL6.3），刘小红、汪亮亮、高进涛、莫德林、陈瑶生，专利权人：中山大学
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