彭博

Submitted on 周一, 10/30/2017 - 20:34


性别
男

电子邮件
pengb26@mail.sysu.edu.cn

职称
教授

导师类型
博士生导师

学科方向
0710生物学-05微生物学
0710生物学-10生物化学与分子生物学


研究方向
细菌耐药性及其代谢调控

学术成就
长期以来从事细菌耐药及其代谢调控方面的研究。近年来，通过功能代谢组学发现，耐药菌的代谢状态决定耐药性。通过关键代谢物将细菌的耐药代谢状态逆转为敏感代谢状态，从而提高耐药菌对抗生素的敏感性，促进胞外抗生素进入胞内，提高胞内抗生素浓度，高效杀死细菌。细菌耐药代谢组的发现和关键代谢物逆转耐药性新概念的提出，对建立控制细菌耐药的新策略具有十分重要的价值。此外，从宿主中发现抗耐药菌代谢状态生物标志物作为调节物，使宿主从对病原菌敏感代谢状态转为对病原菌抵抗状态，增强宿主抗感染能力，减轻和消除病原菌对宿主的侵染作用。并在研究细菌耐药性的过程中，发现在一个新的产能循环，丙酮酸循环而不是三羧酸循环为细菌提供能量。

承担课题
1. 优秀青年科学基金，2019
2.面上项目两项（2016，2018）
3. 重点研发子课题一项（2016）

论文专著
1. Peng B, Su YB, Li H, Han Y, Guo C, Tian YM, Peng XX. Exogenous alanine and or/glucose plus kanamycin kills antibiotic-resistant bacteria. Cell Metabolism, 2015, 21(2):249-261
2. Su YB, Peng B, Li H, Cheng ZX, Zhang TT, Zhu JX, Li D, Li MY, Ye JZ, Du CC, Zhang S, Zhao XL, Yang MJ, Peng XX. Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria. Proc. Natl. Acad. Sci, 2018, 115 (7) E1578-E1587（co-corresponding author）
3. Ye JZ, Su YB, Lin XM, Lai SS, Li WX, Ali F, Zheng J, Peng B. Alanine enhances aminoglycosides-induced ROS production as revealed by proteomic analysis. Frontiers in Microbiology, 2018, 9：29(corresponding author)
4. Xie RQ, Zhang XH, Zhao Q, Peng B, Zheng J. Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries. Emerging Microbes & Infections, 2018, 7:31
5. Ye JZ, Lin XM, Cheng ZX, Su YB, Li WX, Ali F, Zheng J, Peng B. Identification and efficacy of glycine serine and threonine metabolism in potentiating kanamycin-mediated killing of Edwardsiella piscicida Journal of Proteomics, 2018, 183:34-44 (corresponding author)
6. Cheng ZX, Gong QY, Wang Z, Chen ZG, Ye JZ, Li J, Wang J, Yang MJ, Ling XP, Peng B. Edwardsiella tarda tunes tricarboxylic acid cycle to evade complement-mediated killing, Frontiers in Immunology, 2017, 8:1706 (corresponding author)
7. Li H, Zhu QF, Peng XX, Peng B. (2017) Interactome of E.piscicida and grouper liver proteins reveals strategies of bacterial infection and host immune response. Scientific reports, 7, 39284 (corresponding author)
8. Zeng ZH, Du CC, Liu SR, Li H, Peng XX, Peng B. (2017) Glucose enhances tilapia against Edwardsiella tarda infection through metabolome reprogramming. Fish & Shellfish Immunology, 61, 34-43 (corresponding author)
9. Peng B, Wang C, Li H, Su YB, Ye JZ, Yang MJ, Jiang M, Peng XX. (2017) Outer membrane proteins form specific patterns in antibiotic-resistant Edwardsiella tarda. Front. Microbiol, 8, 69
10. Zhang YL, Peng B, Li H, Yan F, Wu HK, Zhao XL, Lin XM, Min SY, Gao YY, Wang SY, Li YY, Peng XX (2017) C-terminal domain of hemocyanin, a major antimicrobial protein from Litopenaeus vannamei: structural homology with immunoglobulins and molecular diversity. Front. Immunol, 8, 611
11. Chen XH, Liu SR, Peng B, Li D, Cheng ZX, Zhu JX, Zhang S, Peng YM, Li H, Zhang TT, Peng XX. (2017) Exogenous L-valine promotes phagocytosis to kill multidrug-resistant bacterial pathogens. Frontiers in Immunol, 2017, 8:207
12. Du CC, Yang MJ, Li MY, Yang J, Peng B, Li H, Peng XX. (2017) Metabolic mechanism for L-Leucine-induced metabolome to eliminate Streptococcus iniae. J Proteome Res.16(5):1880-1889
13. Li H, Chu X, Peng B, Peng XX (2016) DNA shuffling approach for recombinant polyvalent OmpAs against V. alginolyticus and E.tarda infections. Fish Shellfish Immunol. 58:508-513
14. Wu CW, Wu X, Wen C, Peng B, Peng XX, Chen XH, Li H. (2016) Fructose promotes growth and antifugal activity of Penicillium citrinum. Protein Cell. 7, (7), 527-533
15. Wang Z, Li MY, Peng B, Cheng ZX, Li H, Peng XX. (2016) GC-MS-based metabolome and metabolite regulation in serum-resistant Streptococcus agalactiae. J Proteome Res. 15, (7), 2246-2253.
16. Peng B, Ye JZ, Han Y, Zeng L, Zhang JY, Li H. (2016) Identification of polyvalent protective immunogens from outer membrane proteins in Vibrio paraheamolyticus to protect fish against bacterial infection. Fish & Shellfish Immunology, 54, 204-210
17. Li H, Huang X, Zeng Z, Peng XX, Peng B. (2016) Identification of the interactome between fish plasma proteins and Edwardsiella tarda reveals tissue-specific strategies against bacterial infection. International Journal of Biochemistry and Cell Biology. 78: 260-267 (corresponding author)
18. Wang C, Peng B, Li H, Peng XX. (2016) TolC plays a crucial role in immune protection conferred by Edwardsiella tarda whole-cell vaccines. Scientific Report, 6 : 29488
19. Peng B, Liu F, Han R, Luo G, Cathopoulis T, Lu K, Li X, Yang L, Liu GY, Cai JC, Shi SL. (2015) Dyanmic metabolic change is indicative of inflammation-induced transformation of hepatic cells. International Journal of Biochemistry & Cell Biology. 66: 45-58
20. Peng B, Li H, Peng XX. (2015) Functional metabolomics: from biomarker discovery to metabolome reprogramming. Protein & Cell 6(9), 628-637.
21. Peng B, Ma YM, Zhang JY, Li H. (2015) Metabolome strategy against Edwardesiella tarda infection through glucose-enhanced metabolic modulation in talapias. Fish & Shellfish Immunology 45 (2),869-876
22. Su YB*, Peng B*, Han Y, Li H, Peng XX. (2015) Fructose restores susceptibility of multidrug-resistant Edwardesilla tarda to kanamycin. Journal of Proteome Research. 14, 1612-1620. (*Co-first author)
23. Guo C*, Peng B*, Song M, Wu CW, Yang MJ, Zhang JY. Li H. (2015) Live Edwardsiella tarda vaccine enhances innate immunity by metabolic modulation in Zebrafish. Fish & Shellfish Immunology
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