2021年入学研究生招生计划
课题组尚有药物化学硕士（学术型）名额1名，欢迎同学们报考！
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简单介绍
谭嘉恒，男，1980年11月生，博士，教授，博士生导师。研究方向为核酸化学生物学与核酸药物化学。
作为负责人先后主持4项国家自然科学基金，获广东省自然科学****基金及广东特支计划科技青年拔尖人才项目，共发表高水平论文100余篇，他引2000多次，获授权专利20余项。其中，作为通讯作者在J. Am. Chem. Soc.、Angew. Chem., Int. Ed.、Nucleic Acids Res.、Chem. Sci.、J. Med. Chem.、Chem. Commun.、Biosens. Bioelectron.、Anal. Chem.等知名学术期刊发表论文20多篇，研究结果多次被Chem. Rev.、Chem. Soc. Rev.、J. Am. Chem. Soc.、Angew. Chem., Int. Ed.等期刊论文正面引用，部分探针被国际同行应用。在国内外重要学术会议上做学术报告10余次，现任Sci. Rep.杂志化学领域编委会成员，2017年获第二十届中国药学会-施维雅青年药物化学奖，2019年入选教育部国家级高层次青年人才。
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教育经历
1999.09-2003.07?中山大学化学与化学工程学院，应用化学专业，获学士学位
2003.09-2008.07?中山大学药学院，药物化学专业，获博士学位
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工作经历
2008年7月-至今?中山大学药学院
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教学情况
生物有机化学；药物化学实验；药物发现中的关键技术
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社会/学术任职
Scientific Reports杂志化学领域编委会成员；广东省药学会第十届药物化学专业委员会委员
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科研项目（项目负责人）
1. G-四链体RNA在癌细胞内介导“相分离”过程的分子机制与生物学意义探究，**，国家自然科学基金—面上项目，2020-2023，66万元
2.?靶向G-四链体新型荧光原位杂交探针的设计合成及其在RNA结构与功能研究中的应用，**，国家自然科学基金—面上项目，2017-2020，65万元
3.?应用多芳基取代咪唑类荧光探针研究癌基因启动子G-四链体作为转录调控元件的分子机制，**，国家自然科学基金—面上项目，2013-2016，80万元
4. rDNA G-四链体荧光探针在靶向抗肿瘤药物研发中的应用，2015A，广东省自然科学基金项目—****科学基金，2015-2019，100万元
5.?特异性靶向识别端粒G-四链体DNA?的Isaidigotone衍生物：结构，结合模式与生物活性的关系，**,?国家自然科学基金—青年基金项目，2011-2013, 20万元
6. “广东特支计划”科技青年拔尖人才，2015TQ01R342，2016-2019，30万元
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奖励情况
“****奖励计划”青年****，2019-2022
第二十届中国药学会-施维雅青年药物化学奖，2017
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代表性论著
1.?? Lyu, K.; Chen, S.-B.; Chan, C.-Y.; Tan, J.-H.*; Kwok, C. K.*?Structural analysis and cellular visualization of APP RNA G-quadruplex.?Chemical Science?2019, https://doi.org/10.1039/C9SC02768H
2.?? Hu, M.-H.; Zhou, J.; Luo, W.-H.; Chen, S.-B.; Huang, Z.-S.; Wu, R.*;?Tan, J.-H.*?Development of a smart fluorescent sensor that specifically recognizes the c-MYC G-quadruplex.?Analytical Chemistry?2019, 91, 2480-2487.
3.?? Chen, X.-C.; Chen, S.-B.; Dai, J.; Yuan, J.-H.; Ou, T.-M.; Huang, Z.-S.;?Tan, J.-H.*?Tracking the dynamic folding and unfolding of RNA G-quadruplexes in live cells.?Angewandte Chemie, International Edition?2018, 57, 4702-4706.
4.?? ?Hu, M.-H.; Wang, Y.-Q.; Yu, Z.-Y.; Hu, L.-N.; Ou, T.-M.; Chen, S.-B.*; Huang, Z.-S.;?Tan, J.-H.*?Discovery of a new four-leaf clover-like ligand as a potent c-MYC transcription inhibitor specifically targeting the promoter G-quadruplex.?Journal of Medicinal Chemistry?2018, 61, 2447-2459.
5.?? ?Wang, Y.-Q.; Hu, M.-H.; Guo, R.-J.; Chen, S.-B.*; Huang, Z.-S.;?Tan, J.-H.*?Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA.?Sensors and Actuators, B: Chemical?2018, 266, 187-194.
6.?? ?Che, T.; Chen, S.-B.; Tu, J.-L.; Wang, B.; Wang, Y.-Q.; Zhang, Y.; Wang, J.; Wang, Z.-Q.; Zhang, Z.-P.; Ou, T.-M.; Zhao, Y.;?Tan, J.-H.*; Huang, Z.-S.* Discovery of novel schizocommunin derivatives as telomeric G-quadruplex ligands that trigger telomere dysfunction and the deoxyribonucleic acid (DNA) damage response.?Journal of Medicinal Chemistry?2018, 61, 3436-3453.
7.?? ?Chen, S.-B.; Liu, G.-C.; Gu, L.-Q.; Huang, Z.-S.;?Tan, J.-H.*?Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex.?Journal of Molecular Structure?2018, 1154, 1-7.
8.?? ?Hu, M.-H.; Chen, S.-B.; Wang, B.; Ou, T.-M.; Gu, L.-Q.;?Tan, J.-H.*; Huang, Z.-S.* Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.?Nucleic Acids Research?2017, 45, 1606-1618.
9.?? ?Wang, Y.-Q.; Huang, Z.-L.; Chen, S.-B.; Wang, C.-X.; Shan, C.; Yin, Q.-K.; Ou, T.-M.; Li, D.; Gu, L.-Q.;?Tan, J.-H.*; Huang, Z.-S.* Design, synthesis, and evaluation of new selective NM23-H2 binders as c-MYC transcription inhibitors via disruption of the NM23-H2/G-quadruplex interaction.?Journal of Medicinal Chemistry?2017, 60, 6924-6941.
10.?? ?Hu, M.-H.; Guo, R.-J.; Chen, S.-B.; Huang, Z.-S.;?Tan, J.-H.*?Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes.Dyes and Pigments?2017, 137, 191-199.
11.?? ?Chen, S.-B.; Hu, M.-H.; Liu, G.-C.; Wang, J.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.*;?Tan, J.-H.*?Visualization of NRAS RNA G-quadruplex structures in cells with an engineered fluorogenic hybridization probe.?Journal of the American Chemical Society?2016, 138, 10382-10385.
12.?? ?Hu, M.-H.; Chen, S.-B.; Wang, Y.-Q.; Zeng, Y.-M.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.;?Tan, J.-H.*?Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole.?Biosensors & Bioelectronics?2016, 83, 77-84.
13.?? ?Guo, R.-J.; Yan, J.-W.; Chen, S.-B.; Gu, L.-Q.; Huang, Z.-S.;?Tan, J.-H.*?A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes.?Dyes and Pigments?2016, 126, 76-85.
14.?? ?Xiong, Y.-X.; Huang, Z.-S.;?Tan, J.-H.*?Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives.?European Journal of Medicinal Chemistry?2015, 97, 538-551.
15.?? ?Hu, M.-H.; Chen, X.; Chen, S.-B.; Ou, T.-M.; Yao, M.; Gu, L.-Q.; Huang, Z.-S.;?Tan, J.-H.*?A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology.?Scientific Reports?2015, 5, 17202.
16.?? ?Hu, M.-H.; Chen, S.-B.; Guo, R.-J.; Ou, T.-M.; Huang, Z.-S.;?Tan, J.-H.*?Development of a highly sensitive fluorescent light-up probe for G-quadruplexes.Analyst?2015, 140, 4616-4625.
17.?? ?Hou, J.-Q.; Chen, S.-B.; Zan, L.-P.; Ou, T.-M.;?Tan, J.-H.*; Luyt, L. G.; Huang, Z.-S.* Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach.?Chemical Communications?2015, 51, 198-201.
18.?? ?Yan, J.-W.; Chen, S.-B.; Liu, H.-Y.; Ye, W.-J.; Ou, T.-M.;?Tan, J.-H.*; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids.?Chemical Communications?2014, 50, 6927-6930.
19.?? ?Chen, S.-B.; Wu, W.-B.; Hu, M.-H.; Ou, T.-M.; Gu, L.-Q.;?Tan, J.-H.*; Huang, Z.-S.* Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes.?Chemical Communications?2014, 50, 12173-12176.
20.?? ?Wang, X.; Zhou, C.-X.; Yan, J.-W.; Hou, J.-Q.; Chen, S.-B.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.;?Tan, J.-H.*?Synthesis and evaluation of quinazolone derivatives as a new class of c-KIT G-quadruplex binding ligands.?ACS Medicinal Chemistry Letters?2013, 4, 909-914.
21.?? ?Chen, S.-B.; Shi, Q.-X.; Peng, D.; Huang, S.-Y.; Ou, T.-M.; Li, D.;?Tan, J.-H.*; Gu, L.-Q.; Huang, Z.-S. The role of positive charges on G-quadruplex binding small molecules: Learning from bisaryldiketene derivatives.?Biochimica et Biophysica Acta, General Subjects?2013, 1830, 5006-5013.
22.?? ?Yan, J.-W.; Ye, W.-J.; Chen, S.-B.; Wu, W.-B.; Hou, J.-Q.; Ou, T.-M.;?Tan, J.-H.*; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Development of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.?Analytical Chemistry?2012, 84, 6288-6292.
23.?? ?Yan, J.-W.; Li, Y.-P.; Ye, W.-J.; Chen, S.-B.; Hou, J.-Q.; Tan, J.-H.*; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.?Bioorganic & Medicinal Chemistry?2012, 20, 2527-2534.
24.?? ?Chen, S.-Y.; Chen, Y.; Li, Y.-P.; Chen, S.-H.;?Tan, J.-H.*; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.* Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease.?Bioorganic & Medicinal Chemistry?2011, 19, 5596-5604.
25.?? ?Chen, S.-B.;?Tan, J.-H.*; Ou, T.-M.; Huang, S.-L.; An, L.-K.; Luo, H.-B.; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand.?Bioorganic & Medicinal Chemistry Letters?2011, 21, 1004-1009.
26.?? ?An, Z.-Y.; Yan, Y.-Y.; Peng, D.; Ou, T.-M.;?Tan, J.-H.*; Huang, S.-L.; An, L.-K.; Gu, L.-Q.; Huang, Z.-S.* Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.?European Journal of Medicinal Chemistry?2010, 45, 3895-3903.
27.?? ?Tan, J.-H.; Ou, T.-M.; Hou, J.-Q.; Lu, Y.-J.; Huang, S.-L.; Luo, H.-B.; Wu, J.-Y.; Huang, Z.-S.*; Wong, K.-Y.; Gu, L.-Q.* Isaindigotone derivatives: A new class of highly selective ligands for telomeric G-quadruplex DNA.?Journal of Medicinal Chemistry?2009, 52, 2825-2835.
28.?? ?Tan, J.-H.; Gu, L.-Q.; Wu, J.-Y.* Design of selective G-quadruplex ligands as potential anticancer agents.?Mini-Reviews in Medicinal Chemistry?2008, 8, 1163-1178.
29.?? ?Tan, J.-H.; Lu, Y.-j.; Huang, Z.-S.; Gu, L.-Q.*; Wu, J.-Y.* Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin.?European Journal of Medicinal Chemistry?2007, 42, 1169-1175.
30.?? ?Tan, J. H.; Zhang, Q. X.; Huang, Z. S.; Chen, Y.; Wang, X. D.; Gu, L. Q.*; Wu, J. Y.* Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives.?European Journal of Medicinal Chemistry?2006, 41, 1041-1047.
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