简单介绍1987年毕业于四川大学化学系，1992年于华西医科大学药学院获硕士学位，1997年于中国科学院化学研究所获博士学位。1997-2000年在香港理工大学应用生物及化学科技系作博士后研究，2001-2003年在美国亚利桑纳大学 (University of Arizona)化学系作访问****，2003年回国工作。现为中山大学药物化学研究室教授，博士生导师，中山大学“****”引进人才，2006年入选教育部新世纪优秀人才，2011年入选“千百十工程”省级培养人才计划。研究领域为不对称合成反应、药物合成新反应、手性药物的合成工艺、新型抗菌药物的设计、合成和筛选。先后主持国家自然科学基金项目、广州市科技攻关项目、珠海市科技攻关项目、广东省教育厅工程技术研究中心、中山大学启动基金项目、教育部优秀人才项目。至今已在J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; Org. Lett.; J. Org. Chem; Chem.Commun.; Adv. Synth. Catal.; Org.Biomol.Chem.;Tetrahedron; Tetrahedron Lett.; Tetrahdron:Asymmetry.等国内外核心专业期刊上发表研究论文100余篇，获得国内外专利11项。
研究方向1. 手性技术与不对称合成反应
2. 新型抗菌药物
3. 药物的绿色合成工艺
教学情况1.《药物化学》 54学时
本课程讲授化学小分子新药的发明和研究方法、药物的结构与活性的关系、结构修饰的技巧和药物性质的调控方法、化学药物的制备方法、常用药物的物理化学性质、药物分子与机体的相互作用。在新药物的研究中，药物化学处于整个研究链条的最前端，需要高度的创新能力, 涉及化学、生物学、生理学、细胞和分子生物学、免疫学等很多相关的学科知识。《药物化学》是药学专业本科生必修课程。
2.《手性药物与不对称合成》54 学时
本课程讲授手性药物的体内吸收、代谢、治疗活性的差异和手性药物的合成方法。重点介绍催化不对称合成的基本思想、研究方法、各类最重要的反应类型、催化剂的设计和优化、国内外研究现状。帮助学生了解不对称合成方法在现代药物、香料、农药等工业中的应用价值，已取得的成就和面临的问题，此外也启发学生结合个人具体的研究课题产生新的想法和思路。本课程为有机化学和药物化学方向的研究生选修课程。
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科研项目1. 国家自然科学基金项目
“烯基硫鎓盐参与的不对称串联反应”（项目号：**）
2018-2021,64 万元
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2. 国家自然科学基金项目
“t-BuOK/DMF促进的自由基反应研究”（项目号：**）
2015-2018,85 万元
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3. 广州市科技计划项目
“有机催化法合成氨基丁酸类手性药物研究” （项目号：0）
2017-2020，20万元
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4. 广东省科技计划项目
“抗前列腺增生药物西洛多辛的合成新工艺研究”（项目号：2017A）
2017-2018,30万元
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5. 国家自然科学基金项目
“基于α－硝基酮的有机催化串联反应研究”（项目号：**）
2012-2015,60 万元
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论著专利?近期发表论文：
Hua‐ju Liang, Ya‐juan Cheng, Lu‐xia Wang,Bao‐qin Huang, Niu‐niu Zhang, Jie Liang, Ming Yan*, Exploration of (3‐benzyl‐5-hydroxyphenyl) carbamates as new antibacterial agents against Gram‐positive bacteria, Arch. Pharm. Chem. Life Sci. 2020,353, e**.
Zhen-Yu Chen,Bi-Zhen Lin,Lei Chen,Yong Zou,Ming Yan* and Xue-Jing Zhang*, Perfluorobutyl Iodide Mediated [1,2] and [2,3] Stevens Rearrangement for the Synthesis of Indolin-3-Ones, Adv. Synth. Catal. 2020,362,4368-437
Jie Chen, Bao-qin Huang, Zeng-qing Wang, Xue-jing Zhang, and Ming Yan*, Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3?Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams, Org. Lett. 2019,21,9742-9746.
Zhen-Yu Chen, Hua-Ju Liang, Ri-Xing Chen, Lei Chen, Xiang-Zheng Tang, Ming Yan* and Xue-Jing Zhang*, Cross-Dehygrogenative C-O Coupling of Oximes with Acetonitrile, Ketones and Esters, Adv. Synth. Catal. 2019,361,3324-3330.
Ya-Juan Cheng, Zhi-Yong Liu, Hua-Ju Liang, Cui-Ting Fang, Niu-Niu Zhang, Tian-Yu Zhang,* and Ming Yan*, Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as New Antitubercular Agents with Potent In Vitro and In Vivo Efficacy, Molecules 2019,24,2021.
Niu-niu Zhang, Bai-jiao An, Yan Zhou, Xing-shu Li* and Ming Yan *, Synthesis, Evaluation, and Mechanism Study of New Tepotinib Derivatives as Antiproliferative Agents, Molecules 2019,24,1173.
Niu-niu Zhang, Yun-xiang Tang, Lu Qian, Ya-min Gao, Zhi-yong Liu, Zhi-liang Zou, Tian-yu Zhang*, Ming Yan*, Design, synthesis, and antitubercular activity of 3-amidophenols with 5-heteroatomic substitutions, Arch Pharm Chem Life Sci. 2019,352,e180027
Xiang-Zheng Tang, Jie Liang, Xue-Jing Zhang, Raymond Wai-Yin Sun, Ming Yan*, Albert S. C. Chan, Synthesis of multisubstituted arylsulfones via a one-pot, three-component [3 + 3] benzannulation reaction, Org. Biomol. Chem. 2019,17, 4753-4760.
Lei Chen, Jie Liang, Zhen-yu Chen, Jie Chen, Ming Yan*, Xue-jing Zhang*, A Convenient Synthesis of Sulfones via Light Promoted Coupling of Sodium Sulfinates and Aryl Halides, Adv. Synth. Catal. 2019,361,956-960.
Shenquan Guo, Niuniu Zhang, Xiangzheng Tang, Zhifeng Mao, Xuejing Zhang, Ming Yan,* Yining Xuan*, Cyclopropanation of active methylene compounds withβ-alkoxycarbonyl vinylsulfonium salts, Chin. Chem. Lett. 2019,30,406-408.
Lang Tong, Zhi-feng Mao, Xiang-zheng Tang, Xue-jing Zhang*, Ming Yan*, Cycloaddition of hydrazones and 1, 2-diarylalkynes promoted by t-BuOK/DMF: A convenient synthesis of tetraarylpyrazoles, Chin. Chem. Lett. 2019,30,395-397.
Xiang-zheng Tang, Jing-xuan zhou, Hua-ju Liang, Xue-jing Zhang, Ming Yan*, Albert S. C. Chan,A practical synthesis of functionalized isoindolinones via [3 + 3] benzannulation of 1,3-bissulfonylpropenes and 4-arylmethylene-2,3-dioxopyrrolidines, Tetrahedron Lett. 2019,60, 147-149.
Jie Liang, Yun-xiang Tang, Xiang-zheng Tang, Hua-jv Liang, Yamin Gao, Cuiting Fang, Tian-yu Zhang*, Ming Yan*, Discovery of meta-amido bromophenols as new antitubercular agents, Chem. Pharm. Bull. 2019,67,372-381.
Zi-cong Chen, Lang Tong, Zhi-bo Du, Zhi-feng Mao,* Xue-jing Zhang, Yong Zou and Ming Yan*，Annulation of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts: synthesis of dihydrofuran derivatives, Org. Biomol. Chem.2018,16,2634-2638.
Xiang-zheng Tang, Lang Tong, Hua-ju Liang, Jie Liang, Yong Zou, Xue-jing Zhang,* Ming Yan * and Albert S. C. Chan, Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy, Org. Biomol. Chem.2018,16,3560-3563.
Niu-niu Zhang, Zhi-yong Liu, Jie Liang, Yun-xiang Tang, Lu Qian, Ya-min Gao, Tian-yu Zhang * and Ming Yan *, Design, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents, Med. Chem. Commun. 2018,9,1293-1304.
Zhen-yu Chen, Liang-yu Wu, Hai-sheng Fang, Ting Zhang, Zhi-feng Mao, Yong Zou, Xue-jing Zhang,* and Ming Yan,* Intramolecular hydroamidation of ortho-vinyl benzamides promoted by potassium tert-butoxide, Adv. Synth. Catal. 2017, 359, 3894-3899.
Lin-Miao Ye, Lu Qian, Yan-Yan Chen, Xue-Jing Zhang and Ming Yan*，A practical synthesis of benzothiophenes via visible-light-promoted cyclization of disulfides and alkynes, Org. Biomol. Chem. 2017,15, 550-554.
Ri-long Liu, Xiang-zheng Tang, Xue-jing Zhang, Ming Yan* and Albert S. C. Chan, Organocatalytic asymmetric conjugate addition of t-butyl nitroacetate to o-quinone methides: synthesis of optically active a-nitro-b,b-diaryl-propionates, RSC Adv. 2017, 7, 6660–6663.
Lin-miao Ye, Jie Chen, Peng Mao, Zhi-feng Mao, Xue-jing Zhang, and Ming Yan**, Visible-light-promoted synthesis of benzothiazoles from 2-aminothiophenols and aldehydes, Tetrahedron Lett. 2017, 58, 874-876.
Lin-miao Ye, Jie Chen, Peng Mao, Xue-jing Zhang, and Ming Yan*, Visible-light promoted synthesis of 3-arylthioindoles from indoles and diaryl disulfides, Tetrahedron Lett. 2017, 58, 2743-2746.
Wang, Wei-juan; Chen, Jia-hua; Zhen, Zi-cong; Zeng, Yu-feng; Zhang, Xue-jing; Yan, M.; Chan, Albert S. C. A Convenient Synthesis of 1-Aryl- and 2-Aryl-Substituted Indazolones via Intramolecular C-N Coupling Promoted by KOt-Bu, Synthesis 2016, 48, 3551-3558.
Yan-yan Chen, Zhen-yu Chen, Niu-niu Zhang, Jia-hua Chen, Xue-jing Zhang, Ming Yan*, Intramolecular Addition of Triarylmethanes to Alkynes Promoted by KOtBu/DMF: A Synthetic Approach to Indene Derivatives, Eur. J. Org. Chem. 2016, 3, 599-606.
Chen, Jia-hua; Chen, Zi-cong; Zhao, Hong; Ting Zhang, Wei-juan Wang, Yong Zou, Xue-jing Zhang*, Ming Yan, Intramolecular addition of diarylmethanols to imines promoted by KOt-Bu/DMF: a new synthetic approach to indole derivatives, Org. Biomol. Chem. 2016, 14, 4071-4076.
Jia-hua Chen, Zi-cong Chen, Hong Zhao, Yong Zou, Xue-jing Zhang* and Ming Yan*, Intramolecular cyclization of diarylmethanols to α,β-unsaturated amides promoted by KOt-Bu/DMF: a metal-free approach towards 3,4-disubstituted quinolinones, Org. Biomol. Chem. 2016, 11148-11153.
Wei-juan Wang, Ting Zhang, Li-jun Duan, Xue-jing Zhang *, Ming Yan *, KOt-Bu promoted homocoupling and decomposition of N￠-aryl-acylhydrazines: synthesis of unsymmetric N,N-diarylacylhydrazines, Tetrahedron 2015, 71, 9073-9080.
Ri-long Liu, Yun-yun Yan, Ting Zhang, Xue-jing Zhang, Ming Yan*, A practical synthesis of optically active d-nitro-a-ketoesters and 4-cyclohexyl-proline catalyzed by chiral squamides, Tetrahedron: Asymmetry 2015, 26, 1416-1422.
Wen-Tao Wei, Ya-Juan Cheng, Yu Hu, Yan-Yan Chen, Xue-Jing Zhang, Yong Zou, and Ming Yan*, Concise Synthesis of 4-Arylquinolines via Intramolecular Cyclization of Allylamines and Ketones，Adv. Synth. Catal. 2015, 357, 3474-3478.
Xiang Sun, Ming Yan*, Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling，Org. Biomol. Chem. 2015, 13, 7381-7383.
Yan-yan Chen, Niu-niu Zhang, Lin-miao Ye, Jia-hua Chen, Xiang Sun, Xue-jing Zhang, Ming Yan*, KOt-Bu/DMF promoted intramolecular cyclization of 1,1′-biphenyl aldehydes and ketones: an efficient synthesis of phenanthrenes, RSC Adv. 2015, 5, 48046-48049.
Yu Hu，Liang Liang，Wen-tao Wei，Xiang Sun，Xue-jing Zhang*, Ming Yan*, A convenient synthesis of deuterium labeled amines and nitrogen heterocycles with KOt-Bu/DMSO-d6, Tetrahedron 2015, 71, 1425-1430.
Wen-Tao Wei, Yu Liu, Lin-Miao Ye, Rong-Hui Lei, Xue-Jing Zhang and Ming Yan*，An expedite synthesis of isoquinolinones by intramolecular coupling of amides and ketones, Org. Biomol. Chem. 2015, 13, 817–824.
Yan-yan Chen, Jia-hua Chen, Niu-niu Zhang, Lin-miao Ye, Xue-Jing Zhang, Ming Yan*, A new synthesis of indoles via intramolecular cyclization of o-alkynyl N,N-dialkylanilines promoted by KOt-Bu/DMSO, Tetrahedron Lett. 2015, 56, 478-481.
Yi-ning Xuan*, Zhen-yu Chen, Ming Yan *, An organocatalytic cascade reaction of 2-nitrocyclohexanone and α,β-unsaturated aldehydes with unusual regioselectivity, Chem. Commun. 2014, 50, 10471-10473.
Wei-juan Wang, Xu Zhao, Lang Tong, Jia-hua Chen, Xue-jing Zhang,*and Ming Yan*，Direct Inter- and Intramolecular Addition of Amides to Arylalkenes Promoted by KOt?Bu/DMF, J. Org. Chem. 2014, 79, 8557?8565.
Wen-tao Wei, Xue-jiao Dong, Shao-zhen Nie, Yan-yan Chen, Xue-jing Zhang, Ming Yan*, Intramolecular dehydrative coupling of tertiary amines and ketones promoted by KOt-Bu/DMF: A new synthesis of indole derivatives, Org. Lett. 2013, 15, 6018-6021.
Yan-yan Chen, Xue-jing Zhang, Hui-min Yuan, Wen-tao Wei and Ming Yan*, Efficient cyclization of tertiary amines and alkenes promoted by KOt-Bu–DMF, Chem. Commun. 2013, 49, 10974-76.
Xiang Sun, Yu Hu, Shao-zhen Nie, Yun-yun Yan, Xue-jing Zhang, and Ming Yan,* Efficient Construction of C=N Double Bonds via Acceptorless Dehydrogenative，Adv. Synth. Catal. 2013, 355, 2179-2184.
Shao-zhen Nie, Xiang Sun, Wen-tao Wei, Xue-jing Zhang, Ming Yan*, Jian-liang Xiao*, Unprecedented construction of C=C double bonds via iridium-catalyzed dehydrogenative and dehydrative cross couplings, Org. Lett. 2013, 15, 2394-2397.
Yi-ning Xuan,* Han-Sen Lin and Ming Yan*, Highly efficient asymmetric synthesis of α,β-epoxy esters via one-pot organocatalytic epoxidation and oxidative esterification, Org. Biomol. Chem. 2013, 11, 1815-1817.
Yun-yun Yan, Yan-yan Chen, Ming Yan*, Xing-shu Li , Wei Zeng, Iridium-catalyzed aerobic oxidation of alkylarenes with excellent turnover numbers, Catal. Commun. 2013, 35, 64-67.
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授权发明专利：
1. 鄢明、张天宇、张妞妞、刘志永、钱露、唐运祥、程亚娟、张学景，间二取代苯酚化合物及其制备方法与抗结核菌应用，中国发明专利2.7
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2.? 鄢明、刘玉、张学景，一种合成右旋佐匹克隆的方法，中国发明专利3.5
3.鄢明、董雪娇、张学景, 一种合成氨基丁酸类手性化合物的方法，中国发明专利 8.7
4.鄢明、王卫娟、张学景, 一种合成七元含氮杂环化合物的新方法，中国发明专利 7.8
5.鄢明、孙翔，一种合成环状脒类化合物的新方法，中国发明专利申请 6.5
6.鄢明、陈艳艳、张学景，一种合成含氮杂环化合物的方法，中国发明专利 2.X
7. 鄢明、位文涛、张学景、聂少振、陈艳艳，一种合成吲哚类化合物的方法，中国发明专利申请 1.5
8. 鄢明、严云云、张学景，一种用于芳基烷烃氧化反应的催化体系及其应用，中国发明专利 4.X
9. 鄢明、肖国强、殷霞，一种具有抗菌活性的3-硝基-2H-色烯类化合物及制备方法和用途，中国发明专利 4.5
10. 鄢明，张学景，刘生平，手性磺胺类有机小分子催化剂及其应用，中国发明专利 2.8
???? 专著：
1．Yue-Ming Li,Ming Yan, Albert S. C. Chan "Atropisomeric Partially Hydrogenated 1,1'-Binaphthyl Diphosphines"in Armin Borner Ed. "Phosphorus ligands in asymmetric cataltsis"pp (284-306),Wiley InterScience,2008.
2．鄢明，梁亮，陈新滋，"催化不对称共轭加成反应新进展"，（第17章，292-306 页， 《不对称有机反应》（李月明，范青华，陈新滋 主编），化学工业出版社，2005年1月第1版）。
?? 教材：
《药物化学》，鄢明、成志毅 编著，科学出版社，2018