简单介绍
雷金平，中山大学药学院“****”副教授，兼任青年教师专职辅导员。研究领域为计算药物化学及计算化学生物学，研究方向包括：计算机辅助小分子药物设计及靶标筛选、药物合成的量子化学计算、药物作用机制的量子力学/分子力学多尺度模拟、药物性质计算预测等。近些年在Proc. Natl. Acad. Sci. USA.、J. Am. Chem. Soc.和Angew. Chem. Int. Ed.等国际著名学术杂志发表相关多篇。在抗肿瘤药物、阿司匹林药物、抗生素类药物、基因编辑治疗等相关领域研究中有着丰富经验。
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教育经历
2005-2009，四川大学，化学，学士
2009-2014，南京大学，化学，博士
工作经历
2014，南方科技大学，化学系，助理工程师
2015-2019，香港科技大学，化学系，副研究员
2019至今，中山大学，药学院，副教授
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科研项目
国家自然科学基金青年项目，含“苯并[4,5]咪唑并[1,2-a]吡嗪-1-胺”骨架的腺苷A_2A受体选择性拮抗剂的设计、合成及抗肿瘤活性研究，2020年，主持，在研
国家自然科学基金重大研究项目，不对称多组分反应高效构建手性分子及活性评价，2020年，主要参与者，在研
中山大学2020年度“三大”建设超算培育专项，抗肿瘤活性小分子化合物数据库及相关虚拟筛选云平台的建设与应用，2020年，主持，在研
高校基本科研业务费-中山大学青年教师培育项目，新型含咪唑环的腺苷A_2A受体拮抗剂的计算机辅助设计，2020年，主持，在研
清远高新区特色载体建设项目，计算机辅助药物研发设计平台的建设与应用，2019年，主持+参与，在研
中山大学“****”启动项目，2019年，主持，在研
代表性论著（近三年）
G. Lakshma Reddy, Rupam Sarma, Shuhao Liu,^?Weifeng Huang,^?Jinping Lei,* Jiasheng Fu,* Wenhao Hu,*?Design, synthesis and biological evaluation of novel scaffold benzo[4,5]imidazo [1,2-a]pyrazin-1-amine: towards adenosine A_2A?receptor (A_2A AR) antagonist, Eur. J. Med.?Chem., 2021, 210, 113040.
Jing Zhang^#, Hang Zou^#, Jinping Lei^#, Benzhao He, Xuewen He, Herman H. Y. Sung, Ryan T. K. Kwok, Jacky W. Y. Lam, Lei Zheng*, Ben Zhong Tang*, Multifunctional Au(I)-based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics, Angew. Chem. Int. Ed., 2020, 59, 7097-7105.
Yunjiao He^#, Jinping Lei^#, Xuehua Pan, Xuhui Huang*,?Yanxiang Zhao*.?The hydrolytic water molecule of Class A β-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis.?Sci. Rep., 2020, 10, 10205.
Kostiantyn O. Marichev,?Kan?Wang,?Nicole?Greco,?Kuiyong?Dong,?Jinzhou?Chen,?Jinping?Lei*,?Michael P. Doyle*,?Strain-Induced?Nucleophilic?Ring?Opening?of?Donor-Acceptor?Cyclopropenes?for?Synthesis?of?Monosubstituted?Succinic?Acid?Derivatives, Chemistry-A European Journal, 2020, 26, 1-9.
Jianwei Zheng, Junfeng Wang, Qian Wang, Hongye Zou, Hong?Wang, Zhenhua Zhang, Jianghe Chen, Qianqian Wang, Yueshan Zhao, Jing Lu, Xiaolei Zhang, Songtao Xiang, Haibin Wang, Jinping Lei, Hong-Wu Chen, Peiqing Liu^*, Yonghong Liu^*, Fanhai Han^*, Junjian Wang^*. Targeting castration-resistant?prostate?cancer with a novel RORg?antagonist elaiophylin. Acta?Pharmaceutica Sinica B. 2020, 10, 2313-2322.
Jinzhou?Chen,?Shuhao Liu, Xinxin Lv, Kemiao Hong, Jinping?Lei,?Xinfang Xu*,?Wenhao Hu*,?Blue Light-Promoted Formal [4+1]-Annulation of Diazoacetates with o-Aminoacetophenones: Synthesis of Polysubstituted Indolines and Computational Study, J. Org. Chem, 2020, 85, 13920-13928.
Sifan Yu, Jinzhou Chen, Gengxin Liu, Jinping Lei, Wenhao Hu*,?Huang Qiu*. A gold(I)-catalysed chemoselective three-component reaction between phenols, α-diazocarbonyl compounds and allenamides, Chem. Commun., 2020, 56, 1649-1652?
Zefeng Zhu; Chun Chen; Jingxing Jiang; Qianzhong Zhang; Zhibo Du; Shuxian Wei; Xianheng Song; Jie Tang; Jinping Lei; Zhuofeng Ke; Yong Zou*. Synthesis and biological evaluation of Suffrutines A, B and their N-fused analogues, ORG. CHEM. FRONT., 2020, 7, 1122
Jinping Lei, Gang Sheng, Peter Pak-Hang Cheung, Shenglong Wang, Yu Li, Xin Gao, Yingkai Zhang*, Yanli Wang*, Xuhui Huang*, Two Symmetric Arginine Residues Play Distinct Roles in Thermus thermophilus Argonaute DNA Guide Strand-mediated DNA Target Cleavage, Proc. Natl. Acad. Sci. USA, 2019, 116(3): 845-853
Jinping Lei, Yanzi Zhou*, Daiqian Xie, Yingkai Zhang*, Mechanistic Insights into a Classic Wonder Drug-Aspirin, J. Am. Chem. Soc, 2015, 137(1): 70-73
Xuehua Pan, Yunjiao He, Jinping Lei, Xuhui Huang, Yanxiang Zhao*. Crystallographic snapshots of Class A β-lactamase catalysis reveal structural changes that facilitate β-lactam hydrolysis, J. Biol. Chem., 2017, 292(10), 4022-4033
Quinn, Taylor;?Haines, Brandon;?Lei, Jinping;?Jiang, Hanlun;?Huang, Xuhui;?Helquist, Paul;?Wiest, Olaf. Microsecond molecular dynamic simulations on the second hydride transfer transition state of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl reductase using Q2MM, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, 2017, 253 (242)
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