简单介绍吴一诺?博士，副教授，博士研究生导师。2006年本科毕业于中山大学化学与化学工程学院应用化学专业。2011年毕业于中山大学药学院药物化学专业，获理学博士学位。2011年至2013年于香港理工大学应用生物与化学科技系进行博士后研究。2013年加入中山大学药学院。主要从事磷酸二酯酶抑制剂的发现 及其在肺部、神经系统疾病中的应用。目前已在 J. Med.Chem, Org. Lett., Chem.Commun.,E.? J. Med.Chem, Chem.Eur. J., Adv. Synth. Catal.等国际权威杂志发表高水平收录论文30余篇。共主持国家自然科学基金等项目8项，并作为课题骨干参与国家科技部重点研发计划。
教育经历2006/09 - 2011/06，中山大学，药学院，药物化学，博士
2002/09 - 2006/06，中山大学，化学与化学工程学院，应用化学系，学士
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工作经历?
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2018/04- 至今，中山大学，药学院，副教授
2013/07 - 2018/04，中山大学，药学院，讲师
2011/07 - 2013/06，香港理工大学，应用生物与化学科技系，博士后
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教学情况《现代分析技术与应用》
《大学化学实验》
科研项目1.?国家自然科学基金面上项目，高选择性磷酸二酯酶9型抑制剂的成药性优化及抗肺纤维化作用研究，项目编号：**；2020.01 - 2023.12; 66万元
2. 国家自然科学基金青年项目，钯催化下甲苯类酰化试剂参与的邻位和间位C-H酰基化反应，项目编号：**；2015.01 - 2017.12; 25万元
3.?国家重点研发计划，课题骨干，基于E 级高性能计算生物医药应用软件系统研制及应用。课题四：癌症、糖尿病与感染性疾病新药研究与软件应用验证, 课题编号：2017YFB**; 2017.07 - 2020.12; 749万元。
4. 广州市科技计划项目珠江科技新星专题，新型萘内酰亚胺类磷酸二酯酶二型抑制剂的合理化设计、合成及其抗阿尔茨海默症药效研究，2018.01 - 2020.12；30万元。
5. 广东省医学科研基金，C-H键磷酯方法高效构建HIV-1非核苷类逆转录酶抑制剂，项目编号：B**；2014.06 - 2016.06；1万元。
6. 广东省中医药局面上项目，透骨草中天然磷酸二酯酶4型抑制剂的发现及结构改造，项目编号：**；2017.01 - 2018.12；0.5万元。
7. 中山大学青年教师培育基金，C-H键磷酯方法高效构建苯（杂）环类有机磷化合物新型方法研究，项目编号：13ykpy10；2013.11 - 2016.12；15万元。
8. 中山大学青年教师起步基金，钯催化C-H酰基化反应在芳（杂）环酮类物质制备中的应用，项目编号：**；2013.11 - 2014.12；2万元。
9. 国家自然科学基金青年项目，合作单位负责人，可支配经费10万元；吡喃并吡唑类AKR1C3选择性抑制剂的设计、优化和分子机制研究，项目编号：**；2017.01 - 2019.12
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论著专利??????? 近年来共发表论文35篇，其中第一作者或共同通讯作者论文23篇，8篇属于中科院JCR分区一区论文；总引用次数884次，单篇最高他引次数为125次。以第二发明人申请中国专利3项，授权1项，第三发明人申请欧洲专利1项。
部分第一或通讯作者发表论文列表如下：
Wu, Y.;? Tian, Y. J.;? Le, M. L.;? Zhang, S. R.;? Zhang, C.;? Huang, M. X.;? Jiang, M. Y.;? Zhang, B.; Luo, H. B., Discovery of Novel Selective and Orally Bioavailable Phosphodiesterase-1 Inhibitors for the Efficient Treatment of Idiopathic Pulmonary Fibrosis. Journal of medicinal chemistry 2020, 63 (14), 7867-7879.（IF:6.253 )
Wu, Yinuo#; Zhou, Q.#; Zhang, T.#; Li, Z.; Chen, Y. P.; Zhang, P.; Yu, Y. F.; Geng, H.; Tian, Y. J.; Zhang, C.; Wang, Y.; Chen, J. W. *; Chen, Y. *; Luo, H. B. *, Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. J. Med. Chem. 2019, 62 (8), 4218-4224. （IF:6.253 )
Huang, Y. Y.; Yu, Y. F.; Zhang, C.; Chen, Y.; Zhou, Q.; Li, Z.; Zhou, S.; Li, Z.; Guo, L.; Wu, D. *; Wu, Yinuo;*; Luo, H. B. *, Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors. J. Med. Chem.? 2019, 62 (7), 3707-3721. （IF:6.253 )
Wu, Yinuo; Li, Z.; Huang, Y.-Y.; Wu, D.; Luo, H.-B. *, Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer's Disease. J. Med. Chem. 2018, 61 (13), 5467-5483.（IF:6.253)
Wu, X. N.; Huang, Y. D.;?Li, J.; Yu, Y.-F.;Zhou, Q.;?Zhang, C.;?Wu, Yinuo*?and Luo, H.-B.*?Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors.?Acta Pharmaceutica Sinica B.?2017,?2018, 8 (4), 615-628.（IF:6.014)
Li, J.; Chen, J.-Y.; Deng, Y.-L.; Zhou, Q.; Wu, Yinuo*; Wu, D. *; Luo, H.-B., Structure-based design, synthesis, biological evaluation, and molecular docking of novel PDE10 inhibitors with antioxidant activities. Front. Chem. 2018, 6, 167/1-167/12.（IF: 4.155 )
Zhang, C.; Zhou, Q.; Wu, X. N.; Huang, Y. D.; Zhou, J.; Lai, Z.;?Wu, Yinuo*; Luo, H.-B.?Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease.?J. Enzym. Inhib. Med. Chem. 2018, 33 (1), 260-270.（IF:3.638)
Yu, Y. F.; Huang, Y. D.; Zhang, C; Wu, X. N.; Zhou, Q; Wu, D. Y.;?Wu, Yinuo*; ?Luo, H. B. * Discovery of Novel Pyrazolopyrimidinone Derivatives as ?Phosphodiesterase 9A Inhibitors Capable of Inhibiting ?Butyrylcholinesterase for Treatment of Alzheimer's Disease.?ACS Chem. Neurosci.?2017, 8, 2522.?（IF:4.211)
.Zhang, C; Feng, L. J.; Huang, Y. Y.; Wu, D. Y.; Li, Z.; Zhou, Q.;?Wu, Yinuo*;??Luo, ?H. B.* Discovery of Novel Phosphodiesterase-2A Inhibitors by ?Structure-Based Virtual Screening, Structural Optimization, and ?Bioassay.?J. Chem. Inf. Model.?2017, 57, 355. （IF: 3.804).
Zheng, X. H.; Zhou, S. Y.;?Zhang, C.; Wu, D. Y.; Luo, H. B.;?Wu, Yinuo*?Docking-assisted 3D-QSAR studies on xanthones as alpha-glucosidase inhibitors.?J. Mol. Model.?2017,?23, DOI: 10.1007/s00894-017-3438-1.
Tan, B.X.; Yang, L.; Huang, Y. Y.; Chen, Y. Y.; Peng, G. T.; Yu, S.;?Wu, Yinuo*; Luo, H. B.; He, X. X. Bioactive triterpenoids from the leaves of Eriobotrya japonica as the natural PDE4 inhibitors. Natural Product Research,?2017,?31, 2836.
Zheng, X.; Wu, X. N.; Chen, J. Y.; Luo, H. B.; Wu, D.*;?Wu, Yinuo*.?Transitional Metal-free catalyzed C-H arylation of unactivated arenes with 8-hydroxyquinoline as a promoter.Synthesis?2017，Just Accepted.
Wu, Yinuo;??Jiang, C.; Wu, D.; Gu, Q.; Luo, Z. Y.; Luo, H. B.*.?Palladium-catalyzed ?C–H bond carboxylation of acetanilides: an efficient usage of N, ?N-dimethyloxamic acid as the carboxylate source.?Chem. Commun.?2016,?52,?1286.
Wu, Yinuo;?Sun, L.; Chen, Y.; Zhou, Q.; Huang, J. W.; Miao, H.; Luo, H. B.*?Palladium-catalyzed decarboxylative acylation of N-nitrosoanilines with α-oxocarboxylic acids.?J. Org. Chem.?2016,?81, 1244.
Cai, Y. H.; Guo, Y.; Li, Z.;Wu, D.; Li, X.; Zhang, H.; Yang, J.; Lu, H.; Sun. Z.; Luo, H. B.; Yin, S.*;??Wu, Yinuo*. Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4.?Eur. J. Med. Chem.?2016,?114,?134.
Yang, Q. J.; Choy, P. Y.;?Wu, Yinuo*;?Fan, B. M.*; Kwong, F. Y.* Oxidative coupling between C(sp(2))-H and C(sp(3))-H bonds of indoles and cyclic ethers/cycloalkanes.?Org. Biomo. Chem.?2016,?14, 2608.?
Li, Z.; Lu, X.; Feng, L.-J.; Gu, Y.; Li, X.;?Wu, Yinuo*; Luo, H.-B.*?Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds.?Mol. BioSyst.?2015,?11,?115.
Wu, Yinuo;?Feng, L. J.; Lu, X.; Kwong, F. Y.*; Luo, H. -B.*.?Palladium-catalyzed oxidative C–H bond acylation of?N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize?N-alkyl-2-aminobenzophenones.?Chem. Commun.?2014,?50,?15352.
Wu, Yinuo*;?Choy, P. Y.; Kwong, F. Y.?Direct intermolecular C–H arylation of unactivated arenes with aryl bromides catalysed by 2-pyridyl carbinol.?Org. Biomo. Chem.?2014,?12, 6820.
Wu, Yinuo;?Choy, P. Y.; Kwong, F. Y.* A Direct C-H Arylation of Unactivated Arenes Promoted by Mixed Potassium Alkoxides.?Asian J. Org. Chem.?2014,?3, 1262.
Wu, Yinuo;?Choy P. Y., Mao F., Kwong F. Y.* Toluene Derivatives as Simple Coupling Precursors for Cascade Palladium-Catalyzed Oxidative C-H bond Acylation of Acetanilides. Chem. Commun.?2013,?49, 689.
Wu, Yinuo; Kwong, F. Y.; Li, P. ; Chan, A. S. C.??An?Efficient Oxidative Cross-Coupling Reaction between CH and NH Bonds; A Transition-Metal-Free Protocol at Room Temperature.?Synlett,?2013,?24, 2009.
Wu, Yinuo;?Wong, S. M.; Mao, F.; Chan, T. L.; Kwong, F. Y. *?Intramolecular Direct C-H Bond Arylation from Aryl Chlorides: A Transition-Metal-Free Approach for Facile Access of Phenanthridines.?Org. Lett.?2012,?14,?5306. （IF: 6.290)
Wu, Yinuo;?Wang, J.; Li, P. *; Kwong, F. Y.*?Catalyst-free efficient aza-michael addition of azoles to nitroalkenes,?Synlett,?2012,?23, 788
Wu, Yinuo;?Li, B.; Mao, F.; Li, X.;* Kwong, F. Y.*?Palladium -Catalyzed Oxidative C-H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilide.?Org. Lett.?2011,?13, 3258.
Wu, Yinuo;?Mao, F.; Meng, F.; Li. X.*?Enantioselective Vanadium-Catalyzed Oxidation of 1,3-Dithianes from Aldehydes and Ketones using beta-Amino Alcohol Derived Schiff Base Ligands.?Adv. Synth.Catal.?2011,?353,?1707.
Wu, Yinuo;?Wang, J. *; Mao, F.; Kwong F. Y.*Palladium-catalyzed cross-dehydrogenative functionalization of C (sp (2))-H Bonds.?综述，Chem. Asian J.?2014,?9, 26.
Chan T. L.;?Wu, Yinuo*;?Choy P. Y.; Kwong F. Y.* A Radical Process towards the Development of Transition Metal-Free Aromatic Carbon-Carbon Bond-Forming Reactions.?综述，Chem. Eur. J.?2013,?19,?15802
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专利：
1.???? 罗海彬；吴一诺；张佩；周倩；陈仪萍；张天华；于艳发；吴旭年。一种N-取代吡唑并[3 ,4-d ]嘧啶酮类化合物及其制备方法和应用. 专利申请号：CN5.9，2018年7月
2.?? 罗海彬；吴一诺；吴旭年；黄雅丹；周倩。一种N-取代吡唑并[3 ,4-d ]嘧啶酮类化合物及其制备方法和应用. 专利申请号：CN1.5， 2017年12月
2.???????Luo, Haibin;?Wu, Yinuo; Deng, Yalin; Huang, Yiyou; Wu, Xunian .Preparation of quinazoline compounds as inhibitors of phosphodiesterase type 10。专利号：CN ；专利申请日：2016年9月4日，专利类型：A，公开日期：2017年5月10日
3.??????Luo, H. B.;?Wu, Yinuo; Wu, X.; Huang, Y.; Zhou, Q.? N-Substituted pyrazolo[3,4-d]pyrimidinone compound, preparation method and application thereof。专利号：CN ；专利申请日：2017年3月6日，专利类型：A，公开日期：2017年7月25日
4.??????Kwong, Fuk Yee; Choy, Pui Ying;?Wu, Yinuo; Yang, Qingjing Synthesis of phosphine ligands bearing tunable linkage and methods of their use in catalysis，专利号：WO；专利申请日：2016年5月10日，专利类型：A1，公开日期：2017年9月16日
5.????Wu, Yinuo;?Wang, J.；Kwong F. Y. C-C Cross-Coupling Reactions of Acidic C-H Nucleophiles with Two Activating Groups,?Science of synthesis,?Cross Coupling and Heck-Type Reactions 2. 2.7.2. 2012年11月21日