简单介绍郭磊 博士、副教授、博士生导师。2017年1月通过中山大学“****”引进入职药学院，现为罗海彬教授团队组成员。主要研究领域：高选择性磷酸二酯酶PDE抑制剂的开发，PDE靶向特异性荧光探针分子的设计，有机荧光小分子用于老年痴呆疾病的诊断和治疗等方面，多光子吸收蓝光有机材料的设计与开发。曾在JACS、Angewante、Adv. Mater.?、Acta Pharm. Sin. B.、Chem. Commun. 等国际高影响力期刊上发表论文多篇。
教育经历2001.09 – 2005.07 ?中国药科大学，制药工程，学士
2005.09 – 2008.07 ?中国药科大学，药物化学，硕士
2006.10 – 2008.06 ?中科院上海有机化学研究所，生命有机国家重点实验室，联合培养
2009.09 – 2013.02 ?香港浸会大学，有机化学，博士
工作经历2008.07 – 2009.08 ?中科院上海有机化学研究所，研究助理
2013.03 – 2016.12 ?香港浸会大学，博士后
2017.01 – 至今 ? ? ? 中山大学药学院，副教授，药物化学
科研项目国自然青年科学基金项目:? 肿瘤细胞靶向、核仁RNA结构选择性染色的红色吲哚半花菁类探针分子：设计、合成和作用机制研究 (2018.01-2020.12)
广东省自然科学基金-面上项目：苯并咪唑类高选择性PDE10抑制剂的结构优化及抗肺动脉高压研究?（2021.01-2023.12）
论著专利
(1) Yuncong Yang#, Sirui Zhang#, Qian Zhou#, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang*, Lei Guo*, Hai-Bin Luo*, Discovery of Highly Selective and Orally Available Benzimidazole-Based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for Treatment of Pulmonary Arterial Hypertension, Acta Pharm. Sin. B. 2020, 10(12), 2339-2347.（共同通讯）
(2) Yan-Fa Yu#, Chen Zhang#, Yi-You Huang#, Sirui Zhang, Qian Zhou, Xiangmin Li, Zengwei Lai, Zhe Li, Yuqi Gao, Yinuo Wu, Lei Guo*, Deyan Wu*, and Hai-Bin Luo, Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors, ACS Chem Neurosci. 2020, 11(7), 1058-1071.（共同通讯）
(3) Lei Guo, Xiao Liu, Tongxin Zhang, Hai-Bin Luo, Hai Hua Fan, Man Shing Wong*, Star-Shaped Triazine-Cored Ladder-Type Ter(p-phenylene)s for High-Performance Multiphoton Absorption and Amplified Spontaneous Blue Emission, J. Mater. Chem. C 2020, 8(5), 1768--1772.
(4) Lei Guo#, Siu Wai Tsang#, Tong-Xin Zhang, Kang-Lun Liu, Yi-Fu Guan, Bo Wang, Han-Dong Sun, Hong-Jie Zhang*, Man Shing Wong*, Efficient Semisynthesis of (-)-Pseudoirroratin A from (-)-Flexicaulin A and Assessment of Their Antitumor Activities, ACS Med. Chem. Lett. 2017, 8(3), 372?376.
(5) Lei Guo, King Fai Li, Xiaoqin Zhang, Kok Wai Cheah, Man Shing Wong, Highly Efficient Multiphoton-Pumped Frequency-Upconversion Stimulated Blue Emission with Ultralow Threshold from Highly Extended Ladder-Type Oligo(p-phenylene)s, Angew. Chem. Int. Ed. 2016, 55(36), 10639-10644.
(6) Lei Guo#, Miu Shan Chan#, Di Xu, Dick Yan Tam, Fre?de?ric Bolze*, Pik Kwan Lo*, Man Shing Wong*, Indole-based Cyanine as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging, ACS Chem. Biol. 2015, 10(5):1171-1175.
(7) Lei. Guo, Man Shing Wong*, Multiphoton Excited Fluorescent Materials for Frequency Upconversion Emission and Fluorescent Probes, Adv. Mater. 2014, 26(31), 5400-5428.
(8) Lei Guo, King Fai Li, Man Shing Wong*, Kok Wai Cheah*, Star-Shaped Ladder-Type Ter(p-phenylene)s for Efficient Multiphoton Absorption, Chem. Commun. 2013, 49(34): 3597-3599.
(9) Hai Hua Fan#, Lei Guo#, King Fai Li, Man Shing Wong*, Kok Wai Cheah*, Exceptionally Strong Multiphoton-Excited Blue Photoluminescence and Lasing from Ladder-Type Oligo(p-phenylene)s, J. Am. Chem. Soc. 2012, 134(17), 7297-7300. (共同一作)
(10) Lei Guo#, Ben Li#, Wenlong Huang, Gang Pei, Dawei Ma*, Elaboration of the Oxazepine Ring System via CuI/L-Proline-Catalyzed Intramolecular Aryl Amination, Synlett, 2008, 12, 1833-1836.
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[1] 黄文成，张卫锋，郭磊，用于太阳能电池应用的低带隙的二氰基乙烯基和三氰基乙烯基低聚噻吩，2015，中国，CN B.
[2] Man Shing Wong, Weifeng Zhang, Lei Guo, Low bandgap dicyanovinyl and tricyanovinyl oligothiophenes for solar cell applications, 2015, USA US** B2.
[3] Lei Guo, Di Xu, See-Lok Ho, Chung-Yan Poon, Olivia T. W. Hung Wing Li, Ken K. L. Yung, Daniel W. J. Kwong, Ricky M. S. Wong, Imaging beta-Amyloid Peptides and Inhibition of beta-Amyloid Peptide Aggregation, 2016, US 9,255,933 B2.