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电子邮箱：bihchang@mail.sysu.edu.cn
办公地址：广州市大学城外环东路132号 中山大学药学院，邮编：510006
?简单介绍毕惠嫦?博士，中山大学药学院教授/博导、副院长，美国匹兹堡大学药学院兼职教授。2007年毕业于中山大学获博士学位并留任药学院，2011年至2012年于美国国立卫生研究院、国家癌症研究所（NCI/NIH）作博士后/访问****。研究方向为代谢调控，专注于核受体/代谢酶/转运体影响下内/外源物代谢与调控对疾病及合理用药的研究。
目前目前担任中国药理学会分析药理学专业委员会副主任委员兼青委会主任委员、中国药理学会临床药理学专业委员会副主任委员、中国药理学会药物代谢专业委员会青委会主任委员、广东省药理学会常务理事、广东省药理学会药物代谢专业委员会主任委员、治疗药物监测专业委员会副主任委员。担任高水平期刊《Drug Metabolism and Disposition》、《Journal of Biochemical and Molecular Toxicology》、《Acta Pharmaceutica Sinica B》、《Chinese Medicine》、《Chinese Journal of Natural Medicines》、《药学学报》、《药学进展》编委。
主持国家自然科学基金、国家重点研发计划等国家及省部级科研基金近20项。已出版专著4部（主编、副主编），参编专著7部，在国内外期刊发表研究论文130多篇，其中高水平期刊收录100多篇，以通讯作者或第一作者在Hepatology, Cell Death & Differentiation, Cell Death & Disease, British Journal of Pharmacology, Carcinogenesis, Drug Metabolism and Disposition等发表高水平论文70多篇。申请专利多项。获2014年中国药理学会-Servier优秀药理学工作者奖、2015年国家自然科学优秀青年科学基金、2018年国际代谢学会（ISSX）亚太青年****奖（2018 ISSX Asia Pacific New Investigator Award）、2019年获广东省药理学会科技成果奖一等奖、2020年国家自然科学****基金、2021年美国药理与实验治疗学会（ASPET）Richard Okita Early Career Award in Drug Metabolism and Disposition。
?研究方向代谢调控与疾病及临床合理用药。
?教育经历1993.09 ~ 1997.06：中国药科大学，获英语药学学士学位
2002.09 ~ 2007.06：中山大学药学院，获药理学博士学位
?工作经历2007.07 ~ 至今：中山大学药学院药物代谢与药代动力学实验室、中山大学临床药理研究所
2011.10 ~ 2012.11：美国国立卫生研究院、国家癌症研究所（NCI/NIH）
?科研项目国家自然科学****基金，2021.01～2025.12。
国家重点研发计划重点专项，2018.07～2022.06。
国家自然科学优秀青年基金，2016.01～2018.12。
国家自然科学基金（面上项目），2020.01～2023.12。
国家自然科学基金（面上项目），2016.01～2019.12。
国家自然科学基金（面上项目），2014.01～2017.12。
国家自然科学基金（青年基金），2011.01～2013.12。
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近年发表的部分论文Gao Yue, Fan Shicheng, Li Hua, Jiang Yiming, Yao Xinpeng, Zhu Shuguang, Yang Xiao, Wang Ruimin, Tian Jianing, Gonzalez Frank J, Huang Min*, Bi Huichang*. Constitutive androstane receptor induced-hepatomegaly is partially via yes-associated protein activation. Acta Pharm Sin B. 2020 September; accepted.
Chen Yixin, Zhou Yanying, Han Fangwei, Zhao Yingyuan, Tu Meijuan, Wang Yongtao, Huang Can, Fan Shicheng, Chen Panpan, Yao Xinpeng, Guang Lihuan, Yu Ai-ming, Gonzalez J Frank, Huang Min, Bi Huichang*. A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis. Theranostics. 2020; 10(16): 7193-7210.
Zhou Yanying#, Fan Xiaomei#, Jiao Tingying, Li Wenzhou, Chen Panpan, Jiang Yiming, Sun Jiahong, Chen Yixin, Chen Pan, Guan Lihuan, Wen Yajie, Huang Min, Bi Huichang*. SIRT6 as a key event linking p53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation. Acta Pharm Sin B. 2020 June; accepted.
Jiao Tingying^#, Yao Xinpeng^#, Zhao Yingyuan, Zhou Yanying, Gao Yue, Fan Shicheng, Chen Panpan, Li Xuan, Jiang Yiming, Yang Xiao, Gonzalez Frank J, Huang Min, Bi Huichang*. Dexamethasone-induced liver enlargement is related to PXR/YAP activation and lipid accumulation but not hepatocyte proliferation. Drug Metabolism and Disposition. 2020; 48(9): 830-839.
Chen Panpan, Zhang Qianbin, Zhang Huizhen, Gao Yue, Zhou Yanying, Chen Yixin, Guan Lihuan, Jiao Tingying, Zhao Yingyuan, Huang Min, Bi Huichang*. Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.??J Cell Physiol. 2020 Jul 6. doi: 10.1002/jcp.29906.
Wang Yongtao#, Yu Tao#, Zhou Yanying, Wang Shike, Zhou Xunian, Wang Limin, Ou Tianmiao, Chen Yixin, Zhou Yawen, Zhang Huizhen, Wang Ying, Fan Xiaomei, Chen Pan, Gonzalez J Frank, Yu Aiming, Huang Peng, Huang Min, Bi Huichang^*. Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. Aging. 2020 Apr 14; 12(8): 6733-6755.
Li Yuhua#, Meng Qiang#, Yang Mengbi#, Liu Dongyang#, Hou Xiangyu#, Tang Lan#, Wang Xin#, Lyu Yuanfeng, Chen Xiaoyan*, Liu Kexin*, Yu Ai-Ming*, Zuo Zhong*, Bi Huichang*. Current trends in drug metabolism and pharmacokinetics. Acta Pharm Sin B. 2019 Dec 3; 9(6): 1113-1144.
Fan Shicheng#, Liu Conghui#, Jiang Yiming, Gao Yue, Chen Yixin, Fu Kaili, Yao Xinpeng, Huang Min, Bi Huichang*. Lignans from Schisandra sphenanthera protect against lithocholic acid-induced cholestasis by pregnane X receptor activation in mice. J Ethnopharmacol. 2019 Jul 20;245:112103.
Fu Kaili, Wang Conghui, Gao Yue, Fan Shicheng, Zhang Huizhen, Sun Jiahong, Jiang Yiming, Liu Conghui, Guan Lihuan, Liu Junling*, Huang Min, Bi Huichang*. Metabolomics and lipidomics reveal the effect of hepatic Vps33b deficiency on bile acids and lipids metabolism. Frontiers in Pharmacology. 2019 Mar 22. 10; 276.
Guan Lihuan, Chen Yixin, Wang Yongtao, Zhang Huizheng, Fan Shicheng, Gao Yue, Jiao Tingyin, Fu Kaili, Sun Jiahong, Yu Aiming, Huang Min, Bi Huichang*. Effects of carnitine palmitoyltransferases on cancer cellular senescence. J Cell Physiol. 2019 Feb; 234(2):1707-1719.
Jiang Yiming, Feng Dechun, Ma Xiaochao, Fan Shicheng, Gao Yue, Fu Kaili, Wang Ying, Sun Jiahong, Yao Xinpeng, Liu Conghui, Zhang Huizhen, Xu Leqian, Liu Aiming, Gonzalez J Frank, Yang Yingzi, Gao Bin, Huang Min, Bi Huichang*. Pregnane X receptor regulates liver size and liver cell fate via yes-associated protein activation. Hepatology, 2019 Jan; 69(1):343-358.
Wang Yongtao, Chen Yixin, Guan Lihuan, Zhang Huizheng, Huang Yaoyao, Johnson H Caroline, Wu Zeming, Gonzalez J Frank, Yu Aiming, Huang Peng, Wang Ying, Yang Shouhui, Chen Pan, Fan Xiaomei, Huang Min, Bi Huichang*. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death and Differentiation. 2018 Mar; 25(4):733-746.
Sun Jiahong#, Wen Yajie#, Zhou Yanying#, Jiang Yiming, Chen Yixin, Zhang Huizheng, Guan Lihuan, Yao Xinpeng, Huang Min*, Bi Huichang*. P53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression. Cell Death and Disease. 2018 May, 9(5): 536-547.
Chen Pan#, Li Dongshun#, Chen Yixin#, Sun Jiahong, Fu Kaili, Guan Lihuan, Zhang Huizhen, Jiang Yiming, Li Xi, Zeng Xuezhen, Chen Xiao, Huang Min, Bi Huichang*. p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. British Journal of Pharmacology. 2017 Dec; 174(23):4345-4361.
Zeng X, Li X, Xu C, Jiang F, Mo Y, Fan X, Li Y, Jiang Y, Li D, Huang M, Bi Huichang*. Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice. Acta Pharm Sin B. 2017 Sep; 7(5):583-592.
Chen Yixin, Wang Yongtao, Huang Yaoyao, Zeng Hang, Hu Bingfang, Guan Lihuan, Zhang Huizhen, Yu Aiming, Johnson H Caroline, Gonzalez J Frank, Huang Min, Bi Huichang*. PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis, 2017; 38(4):474-483.
Zeng Hang#, Jiang Yiming#, Chen Pan, Fan Xiaomei, Li Dongshu, Liu Aiming, Ma Xiaochao, Xie Wen, Liu Peiqing, Gonzalez Frank J, Huang Min, Bi Huichang*. Schisandrol B protects against cholestatic liver injury through pregnane X receptor. British Journal of Pharmacology. 2017; 174(8):672-688.
Li Xi, Fan Xiaomei, Li Dongshun, Zeng Xuezhen, Zeng Hang, Wang Yongtao, Zhou Yawen, Chen Yixin, Huang Min*, Bi Huichang*. Schisandra sphenanthera extract facilitates liver regeneration after partial hepatectomy in mice. Drug Metab Dispos. 2016; 44(5):647-652.
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