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?简单介绍黄河清，男，湖北十堰人，生于1965年1月，医学博士，教 授/主任医师，博士生导师；
研究方向?
? ? ? ?研究方向主要为内分泌代谢性疾病药理与中西医结合防治研究。近几年来负责承担国家自然科学基金、国家重大新药创制专项、粤港关健领域重点突破招标项目、广东省重大新药创制专项项目、广东省自然科学基金、广东省科技计划重点与面上项目、广州市科技计划重大专项项目等纵向研究课题16项（其中国家重大新药创制专项项目1项，国家自然科学基金面上项目6项），承担多项重大横向合作研究课题；累积在国内外期刊发表学术论文百余篇，其中近几年来在糖尿病（肾病）、血管硬化性疾病研究中发表与本项目相关研究论文近80篇(高水平收录期刊通讯作者论文余60篇，其中9篇IF＞5.0，29篇IF＞3.0)；研制的具有独立自主知识产权、治疗2型糖尿病合并高脂血症的疗效独特的中药新药--糖脉交泰胶囊获得国家食品药品监督管理局临床试验批文，正开展3期临床增补试验；目前在研和即将启动2个具有独立自主知识产权、治疗高血压合并胰岛素抵抗等代谢综合症的中药新药临床前研究。获得中国发明专利授权多项，获得6项省部科研成果奖励。
?工作经历1991年7月　　　　　　　毕业于湖北中医学院硕士研究生。
1991年8月-1995年8月　　在湖北省十堰市人民医院（三甲医院）从事中西医结合内科临床工作。
1995年9月-1998年8月　　在成都中医药大学攻读中医内科(血管疾病方向)博士学位，其间在四川省人民医院内科临床工作一年。
1998年9月-2000年7月　　在原中山医科大学（现中山大学中山医学院）从事动脉粥样硬化病理生理学（中西医结合）博士后研究工作。
2000年8月-2002年9月　　在广东省中医研究所、广东省第二中医院从事中西医结合防治糖尿病、心脑血管病临床工作。
2002年10月至今　　　　在中山大学药学院、中山大学实验动物中心等单位从事药理学、中西医结合教、研、医工作。
?社会/学术任职中国药理学会中药与天然药物药理专业委员会常务委员，中华中医药学会中药实验药理专业委员会常务委员，中国药理学会表观遗传药理专业委员会常务委员，中国医师协会中西医结合高血压血管病专家委员会常务委员，广东省药理学会中药药理专业委员会副主任委员, 广东省中西医结合学会代谢性肾病专业委员会副主任委员，广东省中医药学会中药贴敷专业委员会副主任委员。
?科研项目1.科技部国家重大新药创制专项课题
2014.01—2016.12，糖脉交泰胶囊治疗2型糖尿病合并高脂血症的新药研发与产业化，编号：2014ZX**-008, 经费：522万元，已结题。
2.国家自然科学基金课题
1）2020.01—2023.12，国家自然科学基金项目，基于氧化应激炎性反应Cx32调控糖尿病肾脏纤维化的研究，编号：**，直接经费：54万元，进行中。
2）2018.01--2021.12，CKIP-1在Cx43调控糖尿病肾脏纤维化中的作用及其抗氧化应激分子机制，编号：**，直接经费：56万元，进行中。。
3）2016.01—2019.12， 蛋白激酶CK2介导SphK-1/S1P信号通路调节糖尿病肾脏纤维化的研究，编号：**，直接经费：64.8万元，进行中。
4）2014.01—2017.12， TGR5对糖尿病肾脏纤维化的影响及其相关分子机制研究，编号：**，经费：80万元，已结题。
5）2012.01—2015.12, Sphk-1/S1p信号通路调节糖尿病肾脏纤维化的作用与机制，编号：**，经费：50万元，已结题。。
6）2009.01—2011.12, 大黄素调节p38MAPK信号通路抗糖尿病肾病的研究，编号：**，经费：30万元，已结题。
3.广东省自然科学基金重点项目
1）2017.05 – 2020.05，蛋白激酶 CK2介导SphK-1/S1P通路调节糖尿病肾脏纤维化的研究，编号：2017A，经费：50万元，进行中。
2）2012.10—2015.10，基于SphK-1/S1P信号通路小檗碱改善糖尿病肾脏纤维化的分子机制，编号：S91，经费：30万元，已结题。
4.广东省重大专项课题
1）2020.1—2024.12.31，“心宝丸”精准治疗心肾阳虚型慢性心衰的作用机制解析及新标志物发现，广东省重点领域研发计划项目，编号：2020B，经费：166万元，进行中。
2）2011.10—2014.10，糖脉交泰胶囊治疗2型糖尿病合并高脂血症的Ⅲ期临床研究，广东省重大新药创制专项项目，编号：2011A，经费：150万元，已结题。
3）2009.1—2012.1，糖脉交泰治疗糖尿病合并高血脂等慢性血管并发症的新药研发，粤港关健领域重点突破招标项目，编号：2008A**，经费：100万元，已结题。
近几年主要论著1.Xiaohong Sun # , Kaipeng Huang# , Xiao Haiming , Zeyuan Lin? , Yan Yang? , Meng Zhang? , Peiqing Liu? and Heqing Huang* . Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway. Clinical Science. 2020, 134(13):1573–1592?2.Haiming Xiao,XiaohongSun, RenbinLiu, ZhiquanChen, ZeyuanLin, YanYang, MengZhang, PeiqingLiu, ShijianQuan*, HeqingHuang* . Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy. pharmacological research .2020,151:104559?3. Zhiquan Chen, Xiaohong Sun, Qiuhong Chen , Tian Lan,*, Kaipeng Huang , Haiming Xiao , Zeyuan Lin , Yan Yang , Peiqing Liu , Heqing Huang*. Connexin32 ameliorated renal fibrosis in diabetic mice by promoting K48-linked Nox4 polyubiquitination and degradation via inhibition of Smurf1 expression. British Journal of Pharmacology. 2020;177:145~160
4. Jia Mi,?Wenda He,?Jiawei Lv,?Kai Zhuang,?Heqing Huang*,Shijian Quan*.
Effect of berberine on the HPA-axis pathway and skeletal muscle GLUT4 in type 2 diabetes mellitus rats. Diabetes Metab Syndr Obes. 2019 Sep 3; 12:1717-1725?
5.Futian Xu, Haiming Xiao , Renbin Liu , Yan Yang , Meng Zhang, Lihao Chen , Zhiquan Chen , Peiqing Liu and Heqing Huang *.Paeonol Ameliorates Glucose and
Lipid Metabolism in Experimental Diabetes by Activating Akt. Frontiers in Pharmacology, 2019 Mar 19;10:261?
6.Lihao Chen , Xiaohong Sun , Haiming Xiao , Futian Xu , Yan Yang , Zeyuan Lin ,
Zhiquan Chen , Shijian Quan* , Heqing Huang*. PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway. Experimental Cell Research , 2019 Aug 15;381(2):301-310
7.Yanhui Deng , Wenyan Gong , Qiang Li , Xian Wu , Liyao Wu , Xiaoxia Zheng ,
Wenying Chen* , Heqing Huang *. Resveratrol inhibits high glucose-induced activation of AP-1 and NF-κB via SphK1/S1P2 pathway to attenuate mesangial cells proliferation and inflammation. Journal of Functional Foods.2019;(55):86-94
8. Yan Yang#, Wenyan Gong#, Chenxi Jin, Zhiquan Chen, Lei Zhang, Yezi Zou,Shijian Quan*, Heqing Huang*. Naringin ameliorates experimental diabetic renal fibrosis by inhibiting the ERK1/2 and JNK MAPK signaling pathways. Journal of Functional Foods.2018; 50:53-62?
9.Yezi Zou#, Zhiquan Chen#, Jie Li#, Wenyan Gong, Lei Zhang, Futian Xu,
Lihao Chen, Peiqing Liu and Heqing Huang*. Progestin and adipoQ receptor 3 Upregulates Fibronectin and intercellular adhesion Molecule-1 in glomerular Mesangial cells via activating nF-κB signaling Pathway Under high glucose conditions. Front Endocrinol (Lausanne). 2018 Jun 7;9:275
10.Lei Zhang#, Zhiquan Chen#, Wenyan Gong, Yezi Zou, Futian Xu, Lihao Chen and Heqing Huang*. Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1. Front Pharmacol. 2018 May 18;9:512.?
11. Jie Hao, Kaipeng Huang,Cheng Chen,Yan Liang,Yu Wang,Xiaojian Zhang,*and Heqing Huang*.Polydatin Improves Glucose and Lipid Metabolisms in Insulin-Resistant HepG2 Cells through the AMPK Pathway. Biol Pharm Bull. 2018;41(6):891-898
12.Wenyan Gong, Zhiquan Chen, Yezi Zou, Lei Zhang, Junying Huang , Peiqing Liu , Heqing Huang*, CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys. Free Radic Biol Med. 2018 Feb 1;115:338-350
13. Zhiquan Chen#, Qiuhong Chen# , Junying Huang , Wenyan Gong, Yezi Zou , Lei Zhang , Peiqing Liu ,Heqing Huang* , CK2a promotes advanced glycation end products-induced expressions of fibronectin and intercellular adhesion molecule-1 via activating MRTF-A in glomerular mesangial cells. Biochem Pharmacol. 2018 Feb;148:41-51?
14. Qiuhong Chen , Junying Huang , Wenyan Gong , Zhiquan Chen , Jiani Huang ,
Peiqing Liu , Heqing Huang* , MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5. Mol Cell Endocrinol. 2018 Jan 15;460:123-133.
15.Wenyan Gong# , Jie Li#, Zhiquan Chen , Junying Huang , Qiuhong Chen , Weibin Cai , Peiqing Liu , Heqing Huang*. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys. Free Radical Biology and Medicine. 2017 May;106:393-405?
16. Junying Huang , Zhiquan Chen , Jie Li , Qiuhong Chen , Jingyan Li , Wenyan Gong , Jiani Huang , Peiqing Liu, Heqing Huang*. Protein kinase CK2 a catalytic subunit ameliorates diabetic renal inflammatory fibrosis via NF- kB signaling pathway. Biochemical Pharmacology. 2017；132：102–117
17.Zhiquan Chen#, Xi Xie^#* , Junying Huang , Wenyan Gong , Xiaoyu Zhu ,Qiuhong Chen ,Jiani Huang , Heqing Huang* . Connexin43 regulates high glucose-induced expression of fibronectin,ICAM-1 and TGF-β1 via Nrf2/ARE pathway in glomerular mesangial cells. Free Radic Biol Med..2017 Jan;102:77-86.
18. Jiani Huang , Wenyan Gong , Zhiquan Chen , Junying Huang , Qiuhong Chen ,
Heqing Huang? , Chunshun Zhao?. Emodin self-emulsifying platform ameliorates the expression of FN,ICAM-1 and TGF-β1 in AGEs-induced glomerular mesangial cells by promoting absorption. European Journal of Pharmaceutical Sciences. 2017;99 :128–136
19. Junying Huang#, Jingyan Li#, Zhiquan Chen1, Jie Li, Qiuhong Chen, Wenyan Gong, Peiqing Liu and Heqing Huang*. Sphingosine kinase 1 mediates diabetic renal fbrosis via NF-kBsignaling pathway: involvement of CK2α. Oncotarget, 2017 Oct 4;8(51):88988-89004.
20. Cheng Chen #, Wenyan Gong# , Changzheng Li , Fengxiao Xiong , Shaogui Wang , Junying Huang , Yu Wang , Zhiquan Chen , Qiuhong Chen , Peiqing Liu ,Tian Lan and Heqing Huang*. Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy. Oncotarget, ?2017 Aug 10;8(45):78660-78676.
21.Fengxiao Xiong# , Xuejuan Li# ,Zhiying Yang ,Yu Wang ,Wenyan Gong ,Junying
Huang , Cheng Chen ,Peiqing Liu , Heqing Huang*. TGR5 suppresses high glucose-induced upregulation of fibronectin and transforming growth factor-β1 in rat glomerular mesangial cells by inhibiting RhoA/ROCK signaling. Endocrine. ?2016 Dec;54(3):657-670.?
22.Wenyan Gong, Cheng Chen, Fengxiao Xiong, Zhiying Yang, Yu Wang, Junying Huang, Peiqing Liu, Heqing Huang*. CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells. Biochemical Pharmacology. 2016 Sep 15;116:140-52.?
23. Shaogui Wang#, Zhiying Yang#, Fengxiao Xiong#, Cheng Chen, Xiaojuan Chao,
Junying Huang, ?Heqing Huang*. Betulinic acid ameliorates experimental
diabetic-induced renal inflammation and fibrosis via inhibiting the activation of NF-κB signaling pathway. Molecular and Cellular Endocrinology. ?2016 Oct 15;434:135-43
24. Zhiying Yang, Fengxiao Xiong, Yu Wang, Wenyan Gong, Junying Huang, Cheng Chen^, , Peiqing Liu, Heqing Huang*. TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. Pharmacological Research. ?2016 Sep;111:226-36?25. Zhiying Yang#,? Jie Li#,? Fengxiao Xiong,?Junying Huang,? Cheng Chen,? Peiqing Liu,? Heqing Huang*. Berberine attenuates high glucose-induced fibrosis by activating the G protein-coupled bile acid receptor TGR5 and repressing the S1P2/MAPK signaling pathway in glomerular mesangial cells. Experimental Cell Research. 2016 Aug 15;346:241-7?26. Cheng Chen# , Kaipeng Huang #, Jie Hao #, Junying Huang , Zhiying Yang ,Fengxiao Xiong , Peiqing Liu , Heqing Huang* . Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. Molecular and Cellular Endocrinology .2016 May 15;427:45-56.?
27. Shaogui Wang , Hong-Min Ni? , Kenneth Dorko , Sean C. Kumer , Timothy M.Schmitt , Atta Nawabi , Masaaki Komatsu? , Heqing Huang* Wen-Xing Ding *.Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury. Oncotarget,: ?2016 Apr 5;7(14):17681-98.
28. Yu Wang, Jiantao Ye, Jie Li, Cheng Chen, Junying Huang, Peiqing Liu, Heqing Huang*. Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9). Cardiovascular Diabetology . ?2016 Feb 1;15：19-32
29. Huang KP,?Chen C,?Hao J,?Huang JY,?Liu PQ,?Huang HQ*. AGEs-RAGE System Downregulates Sirt1 Through the Ubiquitin-Proteasome Pathway to Promote FN and TGF-β1 Expression in Male Rat Glomerular Mesangial Cells. Endocrinology.??2015 Jan;156(1):268-7930. Kaipeng Huang ，Cheng Chen, Jie Hao, Junying Huang ，Peiqing Liu, Heqing Huang*. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin andtransforming growth factor-β1 in rat glomerular messangial cells，Mol Cell Endocrinol.. 399 (2015) ,178–189
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