罗欢乐

中山大学公共卫生学院（深圳） 副教授



电子邮件
luohle@mail.sysu.edu.cn



硕士生导师
研究方向1. 病毒与宿主相互作用
2. 疫苗研发
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工作经历2019/05 - 至今??? 中山大学公共卫生学院（深圳），副教授
2017/10-2019/04?? 德克萨斯大学免疫&微生物系，研究专员??
2013/09-2017/09?? 德克萨斯大学免疫&微生物系，博士后
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教育经历2008/09-2013/07?? 中国科学院武汉病毒所，生物化学与分子生物，理学博士
2004/09-2008/07?? 河南师范大学，生命科学，理学学士
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人才项目中山大学****，2019
发表论文Huanle Luo#, Tingting Jia#, Jiamin Chen, Shike Zeng, Zengzhao Qiu, Shu Wu, Xu Li, Yuxuan Lei, Xin Wang, Weihua Wu, Renli Zhang, Xuan Zou, Tiejian Feng, Ruxia Ding, Yue Zhang, Yao-Qing Chen, Caijun Sun, Tian Wang*, Shisong Fang*, Yuelong Shu*. The characterization of disease severity associated IgG subclasses response in COVID-19 patients, Front. Immunol, 2021, 12(460).
Huanle Luo#, Guangyu Li#, Binbin Wang, Bing Tian, Junling Gao, Jing Zou, Shuizhen Shi, Shuang Zhu, Bi-Hung Peng, Awadalkareem Adam, Ariza Martinez, Kimberly Hein, Evandro R Winkelmann; Yoseph Mahmoud, Xiaofei Zhou, Chao Shan, Shannan Rossi, Scott Weaver, Alan D T Barrett, Alan D T Barrett, Wenbo Zhang, Pei-Yong Shi, Ping Wu, Tian Wang*. Peli1 signaling blockade attenuates congenital zika syndrome, PLoS Pathog, 2020, 16(6).
Lu Zhao#, Huanle Luo#, Doudou Huang, Ping Yu, ?Qiannan Dong, Caroline Mwaliko, Evans Atoni,?Raphael Nyaruaba, Jiangling Yuan,?Guilin Zhang,?Dennis Bente, Zhiming Yuan,*?and?Han Xia*. Pathogenesis and Immune Response of Ebinur Lake Virus: A Newly Identified?Orthobunyavirus?That Exhibited Strong Virulence in Mice. Front Microbiol.?2020; 11: 625661.
Awadalkareem Adama#, Huanle Luo#, Samantha R. Osmana, Binbin Wanga, Christopher M. Roundya,? AlbertJ. Augustea,b,c, Kenneth S. Planted, Bi-Hung Penge, Saravanan Thangamanif, Elena I. Frolovag, Ilya Frolovg, Scott C. Weavera, and Tian Wang*. Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models. Emerging Microbes & Infections. 2021, VOL. 10.
Huanle Luo#, Evandro R Winkelmann#, Shuang Zhu, Wenjuan Ru, Elizabeth Mays, Jesus A Silvas, Lauren L Vollmer, Junling Gao, Bi-Hung Peng, Nathen E Bopp, Courtney Cromer, Chao Shan, Guorui Xie, Guangyu Li, Robert Tesh, Vsevolod L Popov, Pei-Yong Shi, Shao-Cong Sun, Ping Wu , Robyn S Klein, Shao-Jun Tang, Wenbo Zhang, Patricia V. Aguilar and Tian Wang. Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection. (#Authors contributed equally to this work) JCI, 2018 Nov 1;128(11):4980-4991.
Huanle Luo, Evandro R.Winkelmann, Ildefonso Fernandez-Salas, LiLi, Sandra V. Mayer, Rogelio Danis-Lozano, Rosa MaSanchez-Casas, NikosVasilakis, Robert Tesh, Alan D. Barrett, Scott C. Weaver and Tian Wang. Zika, dengue and yellow fever viruses induce differential anti-viral immune responses in human monocytic and first trimester trophoblast cells. Antiviral Res, 2018 Mar;151:55-62.?
Huanle Luo, Evandro Winkelmann, Guorui Xie, Rong Fang,? Bi-Hung Peng,? Li Li,? Helen M. Lazear, Slobodan Paessler, Michael S. Diamond, Michael Gale, Jr., Alan D. Barrett and Tian Wang. MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection.?JVI, 2017 Feb 28;91(6).
Shuang Zhua#, Huanle Luo#, Hua Liu, Yonju Ha, Elizabeth R.Mays, Ryan E.Lawrence, Evandro Winkelmann, Alan D.Barrett, Sylvia B.Smith, MinWang, Tian Wang and Wenbo Zhang. p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection. (#Authors contributed equally to this work) Antiviral Res, 2017 Sep;145:70-81.?
Huanle Luo, Zhenfeng Zhang, Zhenhua Zheng, Xianliang Ke, Xiaowei Zhang, Qian Li, Yan Liu, Bingke Bai, Panyong Mao, Qinxue Hu and Hanzhong Wang. Human Bocavirus VP2 Up-regulates IFN-b Pathway by Inhibiting RNF125-mediated Ubiquitination of RIG-I. J Immunol. 2013 Jul 15;191(2):660-
Awadalkareem Adam^?,?Camila R Fontes-Garfias^?,?Vanessa V Sarathy^?,?Yang Liu^?,?Huanle Luo^?,?Emily Davis^?,?Wenqian Li^?,?Antonio E Muruato^?,?Binbin Wang^?,?Renat Ahatov^?,?Yoseph Mahmoud^?,?Chao Shan^?,?Samantha R Osman^?,?Steven G Widen^?,?Alan D T Barrett^?,?Pei-Yong Shi^?,?Tian Wang^?A genetically stable Zika virus vaccine candidate protects mice against virus infection and vertical transmission. NPJ Vaccines.?2021 Feb 17;6(1):27.
Jaclyn A. Kaiser,?Huanle Luo,?Steven G. Widen,?Thomas G. Wood, Claire Y.-H. Huang,?Tian Wang?and?Alan D.T. Barrett*. Genotypic and phenotypic characterization of West Nile virus NS5 methyltransferase mutants. Vaccine. 2019 Nov 15; 37(48): 7155–7164.
Chao Shan , Xuping Xie, Huanle Luo, Antonio E. Muruato, Yang Liu, Maki Wakamiya, Jun-Ho La, Jin Mo Chung, Scott C. Weaver, Tian Wang, & Pei-Yong Shi. Maternal vaccination and protective immunity against Zika virus vertical transmission. Nat Commun. (2019) 10:5677.
Emily M Webb,?Sasha R Azar,?Sherry L Haller,?Rose M Langsjoen,?Candace E Cuthbert,?Anushka T Ramjag,?Huanle Luo,?Kenneth Plante,?Tian Wang,?Graham Simmons,?Christine V F Carrington,?Scott C Weaver,?Shannan L Rossi,?Albert J Auguste. Effects of Chikungunya virus immunity on Mayaro virus disease and epidemic potential, Sci Rep.?2019; 9: 20399.
Guangyu Li, Awadalkareem Adam, Huanle Luo, Chao Shan, Zengguo Cao, Camila R. Fontes-Garfias, Vanessa V. Sarathy, Cody Teleki, Evandro R. Winkelmann, Yuejin Liang, Jiaren Sun, Nigel Bourne, Alan D. T. Barrett, Pei-Yong Shi* and Tian Wang*. An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses. NPJ Vaccines.?2019; 4: 48.
Jaclyn A Kaiser,?Huanle Luo,?Steven G Widen,?Thomas G Wood,?Claire Y-H Huang,?Tian Wang,?Alan D T Barrett. Japanese encephalitis vaccine-specific envelope protein E138K mutation does not attenuate virulence of West Nile virus. NPJ Vaccines.?2019; 4: 50.
Huanle Luo and Tian Wang. Recent advances in understanding West Nile virus host immunity and viral pathogenesis. F1000 Research, 2018; 7: 338.
Xuping Xie, Dieudonné B Kum, Hongjie Xia, Huanle Luo, Chao Shan, Jing Zou, Antonio E Muruato, Daniele B A Medeiros, Bruno T D Nunes, Kai Dallmeier, Shannan L Rossi, Scott C Weaver, Johan Neyts, Tian Wang, Pedro F C Vasconcelos, Pei-Yong Shi. A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission. Cell Host Microbe. 2018 Oct 10;24(4):487-499.e5.
Jing Zou, Xuping Xie, Huanle Luo, Chao Shan, Antonio E Muruato, Scott C Weaver, Tian Wang, Pei-Yong Shi. A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity. EBioMedicine. 2018 Oct;36:92-102. 、
Hongjie Xia, Huanle Luo, Chao Shan1, Antonio E. Muruato, Bruno T.D. Nunes, Daniele B.A. Medeiros,Jing Zou, Xuping Xie, Maria Isabel Giraldo, Pedro F.C. Vasconcelos, Scott C. Weaver, Tian Wang, Ricardo Rajsbaum & Pei-Yong Shi. An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction. Nat Commun. 2018 Jan 29;9(1):414.
Camila R. Fontes-Garfias, Chao Shan, Huanle Luo, Antonio E. Muruato, Daniele B.A. Medeiros, Elizabeth Mays, Xuping Xie, Jing Zou, Christopher M. Roundy, Maki Wakamiya, Shannan L. Rossi, Tian Wang, Scott C. Weaver and Pei-Yong Shi. Functional Analysis of Glycosylation of Zika Virus Envelope Protein. Cell Rep. 2017 Oct 31;21(5):1180-1190.
Justin M. Richner, Brett W. Jagger, Chao Shan, Camila R. Fontes, Kimberly A. Dowd, Bin Cao, Sunny Himansu, Elizabeth A. Caine, Bruno T.D. Nunes, Daniele B.A. Medeiros, Antonio E. Muruato, Bryant M. Foreman, Huanle Luo, Tian Wang, Alan D. Barrett, Scott C. Weaver, Pedro F.C. Vasconcelos, Shannan L. Rossi, Giuseppe Ciaramella, Indira U. Mysorekar, Theodore C. Pierson, Pei-Yong Shi and Michael S. Diamond. Vaccine Mediated Protection Against Zika VirusInduced Congenital Disease. Cell. 2017 Jul 13;170(2):273-283.
Jian Ye,?Yadan Wang,?Xia Liu,?Lingyun Li,?Adeleye Opejin,?Eddy C. Hsueh,?Huanle Luo,?Tian Wang,?Daniel Hawiger?and?Guangyong Peng. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy. J Immunol. 2017 Aug 1;199(3):941-954.
Chao Shan, Antonio E Muruato, Bruno T D Nunes, Huanle Luo, Xuping Xie, Daniele B A Medeiros, Maki Wakamiya, Robert B Tesh, Alan D Barrett, Tian Wang, Scott C Weaver, Pedro F C Vasconcelos, Shannan L Rossi & Pei-Yong Shi. A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models. Nat Med. 2017 Jun;23(6):763-767.
Jesse H Erasmus, Albert J Auguste, Jason T Kaelber, Huanle Luo, Shannan L Rossi, Karla Fenton, Grace Leal, Dal Y Kim, Wah Chiu, Tian Wang, Ilya Frolov, Farooq Nasar & Scott C Weaver. A chikungunya fever vaccine utilizing an insect-specific virus platform. Nat Med. 2017 Feb;23(2):192-199.
Evandro Winkelmann, Huanle Luo and Tian Wang. West Nile Virus Infection in the Central Nervous System. 2016 Jan 26;5:F1000 Faculty Rev-105.
Guorui Xie, Huanle Luo, Lan Pang, Bi-hung Peng, Evandro Winkelmann, Brenna McGruder, Joseph Hesse, Melissa Whiteman, Gerald Campbell, Gregg N. Milligan, Yingzi Cong, Alan D. Barrett and Tian Wang. Dysregulation of TLR7 compromises innate and adaptive T cell responses and host resistance to an attenuated West Nile virus infection in old mice. JVI, 2015 Nov 18;90(3):1333-44.
Guorui Xie, Huanle Luo, Bing Tian, Brian Mann, Xiaoyong Bao, Jere McBride, Robert Tesh, Alan D. Barrett and Tian Wang. A West Nile virus NS4B–P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells. Vaccine. 2015 Feb 11;33(7):869-78.
Qian Li, Zhenfeng Zhang, Zhenhua Zheng, Xianliang Ke, Huanle Luo, Qinxue Hu and Hanzhong Wang. Identification and Characterization of Complex Dual Nuclear Localization Signals in?Human Bocavirus?NP1. J Gen Virol. 2013 Jun;94(Pt 6):1335-42.
Zhenfeng Zhang,?Zhenhua Zheng,?Huanle Luo,?Jin Meng,?Hongxia Li,?Qian Li,?Xiaowei Zhang,?Xianliang Ke,?Bingke Bai,?Panyong Mao,?Qinxue Hu?and?Hanzhong Wang. Human Bocavirus NP1 Inhibits IFN-b Production by Blocking Association of IFN Regulatory Factor 3 with IFNB Promoter. J Immunol. 2012 Aug 1;189(3):1144-53.
Ling Tao, Jianjun Chen, Zhenhua Zheng, Jin Meng, Zhenfeng Zhang, Yao Chen, Huanle Luo, Hongxia Li, Ze Chen, Qinxue Hu and? Hanzhong Wang. H5N1 influenza virus-like particles produced by transient expression in mammalian cells induce humoral and cellular immune responses in mice. Can J Microbiol. 2012 Apr;58(4):391-401.
招生信息?接收本科生2-3人/年进行科研培训，招收硕士生2人左右人/年。欢迎对病毒感染及宿主免疫，疫苗研发感兴趣的研究生和本科生加入！联系人：罗欢乐，联系方式：luohle@mail.sysu.edu.cn，来信请注明申请方向及职位。