刘宽程

中山大学公共卫生学院（深圳） 副教授



电子邮件
liukuanc@mail.sysu.edu.cn



硕士生导师
研究方向1.乙肝病毒感染与复制机制
2.基于病毒衣壳的应用研究
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工作经历2019/02 - 至今??? 中山大学公共卫生学院（深圳），副教授
2015/07-2019/01?? 浙江理工大学，讲师
2015/07-2017/09?? 宾州州立大学医学院，博士后
2012/11-2015/02?? 宾州州立大学医学院，访问****
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教育经历2010/09-2015/06?? 复旦大学，病原生物学，理学博士
2006/09-2010/06?? 南京农业大学，生物技术（国家生命科学与技术基地班），理学学士
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主要承担课题及人才项目1.中山大学****，2019
2.浙江省自然科学基金青年基金项目，LQ19H190003，乙型肝炎病毒衣壳蛋白乙酰化修饰调控病毒颗粒稳定性的机制研究，2019.01-2021.12，在研，主持
3.国家自然科学基金青年科学基金项目，**，干扰素通过肝非实质细胞分泌的外体（exosomes）抑制乙型肝炎病毒在肝细胞中复制的机制研究，2013.01-2015.12，已结题，参与
发表论文1.?Kuancheng Liu*, Jianming Hu. Secretion of Empty or Complete Hepatitis B Virions: Envelopment of Empty Capsids vs. Mature Nucleocapsids.?Future Virology?2019, 14(2): 95~105. (*通讯作者)
2.?Kuancheng Liu, Laurie Luckenbaugh, Xiaojun Ning, Ji Xi, Jianming Hu. Multiple Roles of Core Protein Linker in Hepatitis B Virus Replication.?PLoS Pathogens?2018, 14(5): e**.
3.?Kuancheng Liu, Jianming Hu. Host-regulated Hepatitis B Virus Capsid Assembly in a Mammalian Cell-free System. Bio-protocol 2018, 8(8): e2813. DOI: 10.21769/BioProtoc.2813.
4.?Laurie Ludgate#,?Kuancheng Liu#, Laurie Luckenbaugh, Nicholas Streck, Stacey Eng, Christian Voitenleitner, William E. Delaney IV, Jianming Hu. Cell-free Hepatitis B Virus Capsid Assembly Dependent on Core Protein C-Terminal Domain and Regulated by Phosphorylation.?Journal of Virology?2017, 90(12): 5830–5844. (#共同一作)
5.?Kuancheng Liu, Laurie Ludgate, Zhenghong Yuan, Jianming Hu. Regulation of Multiple Stages of Hepadnavirus Replication by the Carboxyl-Terminal Domain of Viral Core Protein in trans.?Journal of Virology?2015, 89(5): 2918-2930
6.?Jianming Hu,?Kuancheng Liu, Jun Luo. HIV–HBV and HIV–HCV Coinfection and Liver Cancer Development. In: Craig Meyers (Ed.),?HIV/AIDS-Associated Viral Oncogenesis (2nd Edition).?Springer International Publishing, Switzerland, 2019
7.?Xiaojun Ning, Laurie Luckenbaugh,?Kuancheng Liu, Volker Bruss, Camille Sureau, and Jianming Hu. Common and Distinct Capsid and Surface Protein Requirements for Secretion of Complete and Genome-free Hepatitis B Virions.?Journal of Virology?2018, 2018, 92(14): e00272-00218.
8.?Jianming Hu*, Kuancheng Liu. Complete and Incomplete Hepatitis B Virus Particles: Formation, Function, and Application. Viruses 2017, 9(3), 56.
9.?Xiaojun Ning, Suresh H. Basagoudanavar,?Kuancheng Liu, Laurie Luckenbaugh, Duoqian Wei, Chunyan Wang, Bo Wei, Yingren Zhao, Taotao Yan, William Delaney, Jianming Hu. Capsid Phosphorylation State and Hepadnavirus Virion Secretion.?Journal of Virology?2017, 91(9), e00092-17.
10.?Xiuji Cui, Daniel N. Clark,?Kuancheng Liu, Xiao-Dong Xu, Ju-Tao Guo, and Jianming Hu. Viral DNA-dependent Induction of Innate Immune Response to Hepatitis B Virus in Immortalized Mouse Hepatocytes.?Journal of Virology?2015, 90(1): 486-496.
11.?Jieliang Chen, Min Wu,?Kuancheng Liu, Wen Zhang, Yaming Li, Xiaohui Zhou, Lu Bai, Zhenghong Yuan. New insights into hepatitis B virus biology and implications for novel antiviral strategies.?National Science Review?2015, 2 (3): 296-313.
12.?Jianhua Li,?Kuancheng Liu, Yang Liu, Yan Xu, Fei Zhang, Huijuan Yang, Jiangxia Liu, Tingting Pan, Jieliang Chen, Min Wu, Xiaohui Zhou, Zhenghong Yuan. Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity.?Nature Immunology?2013, 14(8): 793-803.
13.?Jianhua Li, Yinghui Liu, Zekun Wang,?Kuancheng Liu, Yaohui Wang, Jiangxia Liu, Huanping Ding, Zhenghong Yuan. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment.?Journal of Virology?2011, 85(13): 6319-6333.
招生信息? ?接收本科生2-3人/年进行科研培训，招收硕士生2人左右/年。欢迎对病毒感染与复制机理、宿主抗病毒机制等方向感兴趣的研究生和本科生加入！
联系人：刘宽程；联系方式：liukuanc@mail.sysu.edu.cn