教育背景
教授课程
专利与奖励
出版信息
科研活动
指导学生
基本信息
秦岭男博导其他
电子邮件： qin@ort.cuhk.edu.hk
通信地址： 深圳市南山区西丽大学城学苑大道1068号
邮政编码： 518055
招生信息
招生专业
071010-生物化学与分子生物学086000-生物与医药083100-生物医学工程招生方向
骨质疏松和骨坏死等骨科疾患的病因、病生理、诊断与防治方向骨缺血性坏死的病生理和中西医物与非药物防治的机理和临床转化研究基于骨病基础研究的可降解骨科活性生物材料在骨质疏松骨折和骨坏死修复中的开发与应用教育背景
1987-09--1992-07德国科隆体育大学骨科运动医学与康复理疗 博士1985-09--1987-07北京体育大学运动解剖学 硕士1978-09--1982-07北京体育大学运动解剖学 学士教授课程
骨科生物力学骨科医学影像学和骨密度仪的应用专利与奖励
奖励信息
（1） 抗骨质疏松传统中药现代化研究及其应用, 二等奖, 部委级, 2013（2） 学术论坛优秀论文奖, , 国家级, 2007（3） 中医药研究突出贡献奖, , 其他, 2007（4） 中国药学发展奖, 三等奖, 部委级, 2001（5） 运动解剖学学科研究贡献奖, , 其他, 1998专利成果
（ 1 ） Nanoparticles, methods of making same and cell labeling using same, 发明, 2009, 第 3 作者, 专利号: US2009/**（ 2 ） 生物复合材料及其制备方法和用途, 发明, 2010, 第 1 作者, 专利号: CNA（ 3 ） 一种预防激素性骨坏死作用机制新颖的草药淫羊藿来源的黄酮馏分, 发明, 2008, 第 1 作者, 专利号: WO2008/089669（ 4 ） 一种仙灵骨葆的提取方法,分离提取物及制剂, 实用新型, 2013, 第 4 作者, 专利号: 9.3（ 5 ） 一种新型淫羊藿素骨靶向给药系统的制备, 实用新型, 2012, 第 2 作者, 专利号: PCT/CN2012/081355（ 6 ） 用于预防类骨醇性骨坏死的得自淫羊藿的类黄铜馏分的新型组合, 发明, 2013, 第 1 作者, 专利号: zl3.x（ 7 ） 淫羊藿素在制备防治阿尔之海默病药物中的应用, 发明, 2013, 第 2 作者, 专利号: 1（ 8 ） 一种用于检测仙灵骨葆胶囊的质量的方法, 实用新型, 2013, 第 5 作者, 专利号: 3.9（ 9 ） 骨修复材料及其制备方法, 发明, 2014, 第 2 作者, 专利号: ZL1.2（ 10 ） 3D打印设备和基于3D打印的物料供给搅拌系统, 实用新型, 2016, 第 3 作者, 专利号: ZL8.7（ 11 ） 多孔性骨支架, 实用新型, 2013, 第 4 作者, 专利号: ZL4.2（ 12 ） 补骨脂定在抑制脂肪细胞分化、形成及其功能中的应用, 发明, 2018, 第 4 作者, 专利号: 3.0出版信息
发表论文
（1）Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model.,Biomaterials,2020,通讯作者（2）Revolutionary Magnesium-based Implants for Treating Challenging Bone Diseases – A General Review and Perspectives,Advanced Science,2020,通讯作者（3）Orbital ?oor repair using patient speci?c osteoinductive implant made by stereolithography,Biomaterials,2020,其他（合作组作者）（4）Corrigendum to "Anti-infective efficacy, cytocompatibility and biocompatibility ofa 3D-printed osteoconductive composite scaffold functionalized with quaternized chitosan"[ Acta Biomater.46(2016)112-128],Acta Biomater,2019,其他（合作组作者）（5）Development of a novel biodegradable and anti-bacterial polyurethane coating for biomedical magnesium rods,MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,其他（合作组作者）（6）NOD2 negatively regulated titanium particle-induced osteolysis in mice.,iomaterials science,2019,第3作者（7）Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect,BIOMATERIALS,2019,其他（合作组作者）（8）Quantitative determination of residual 1,4-dioxane in three-dimensional printed bone scaffold,JOURNAL OF ORTHOPAEDIC TRANSLATION,2018,第7作者（9）Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head-A first multicentre, randomised, double-blind, placebo-controlled clinical trial,JOURNAL OF ORTHOPAEDIC TRANSLATION,2018,通讯作者（10）Steroid-associated osteonecrosis animal model in rats,JOURNAL OF ORTHOPAEDIC TRANSLATION,2018,通讯作者（11）Fracture Healing in a Collagen-Induced Arthritis Rat Model： Radiology and Histology Evidence,Journal of Orthopaedic Research,2018,通讯作者（12）Angiogenesis Assays for the Evaluation of Angiogenic Properties of Orthopaedic Biomaterials - A General Review.,Advanced Healthcare Materials,2017,通讯作者（13）Biodegradable Magnesium Screws Accelerate Fibrous Tissue Mineralization at the Tendon-Bone Insertion in Anterior Cruciate Ligament Reconstruction Model of Rabbit.,Scientific Reports,2017,通讯作者（14）Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats.,Nature Medicine,2016,通讯作者（15）Biodegradable Magnesium (Mg) Implantation Does Not Impose Related Metabolic Disorders in Rats with Chronic Renal Failure,Scientific Reports,2016,通讯作者（16）Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model,BONE,2016,通讯作者（17） In vivo Screening for Anti-osteoporotic Fraction from Extract of Herbal Formula Xianlinggubao in Ovariectomized Mice.,PlosOne,2015,通讯作者（18）Src blockage prevents destructive repair in steroid-associated osteonecrosis. ,JBMR,2015,通讯作者（19）The RAPIDOS projectdEuropean and Chinese collaborative research on biomaterials.,Journal of Orthopaedic Translation ,2015,通讯作者（20）Phytomolecule Icaritin Incorporated PLGA/TCP Scaffold for Steroid-Associated Osteonecrosis: Proof-of-Concept for Prevention of Hip Joint Collapse in Bipedal Emus and Mechanistic Study in Quadrupedal Rabbits. ,Biomaterials,2015,第1作者（21）Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials,Acta biomaterialia,2015,通讯作者（22）Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats.,J Orthop Res. ,2014,通讯作者（23）Metabolites profile of Xian-Ling-Gu-Bao capsule, a traditional Chinese medicine prescription, in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis.,J Pharm Biomed Anal. ,2014,通讯作者（24）Extracorporeal shockwave enhanced regeneration of fibrocartilage in a delayed tendon-bone insertion repair model.,J Orthop Res. ,2014,通讯作者（25）Bone structural and mechanical indices in Adolescent Idiopathic Scoliosis evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT),BONE,2014,通讯作者（26）Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation,BONE,2014,通讯作者（27）Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. ,Bone,2014,通讯作者（28）Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model.,J Tissue Eng Regen Med. ,2013,通讯作者（29）Steroid-associated hip joint collapse in bipedal emus.,PLoS One,2013,通讯作者（30）Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: A drill-hole defect model,Bone,2011,通讯作者（31）Biodegradable CaMgZn bulk metallic glass for potential skeletal application,Acta Biomaterialia,2011,通讯作者（32）Osteogenic effects of flavonoid aglycones from an osteoprotective fraction of Drynaria forthunei - An in vitro efficacy study, Phytomedicine ,2011,通讯作者（33）Impaired bone healing in rabbits with steroid-associated osteonecrosis,Journal of Bone and Joint Surgery-British Volume,2011,通讯作者（34）A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy,Nature Medicine ,2011,通讯作者（35）A delayed bone-tendon junction healing model established for potential treatment of related sports injuries,British Journal of Sports Medicine,2010,通讯作者（36）Osteogenesis Induced by Extracorporeal Shockwave in Treatment of Delayed Osteotendinous Junction Healing,Journal of Orthopaedic Research,2010,通讯作者（37）Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone ,Bone,2009,通讯作者（38）A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner ,Bone,2009,通讯作者（39）Continuous Occurrence of Both Insufficient Neovascularization and Elevated Vascular Permeability in Rabbit Proximal Femur During Inadequate Repair of Steroid-Associated Osteonecrotic Lesions,Arthritis Rheum ,2009,通讯作者（40）Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing progress of postmenopausal osteoporosis: A 24-month randomized, double-blind and placebo-controlled trial,Journal of Bone and Mineral Research,2007,通讯作者发表著作
（1）骨科基础学,Orthopaedic Basic Science,人民卫生出版社,2001-07,第3作者（2）骨矿与临床,Bone Mineral and Clinical Research,中国科学技术出版社,2006-03,第2作者（3）体育生物医学基础研究与进展,Fundamental Research and Development of Sporrts Biomedicine,人民体育出版社,2006-05,第1作者（4）中药防治骨质疏松症及其骨折的临床前和临床评价指导原则,Guidelines of evaluation for the prevention of osteoporosis and fractures in pre-clinical and clinical cases with Chinese Medicine ,人民卫生出版社,2006-08,第1作者（5）高端影像技术评估骨及支架材料的性能,Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials,Springer,2007-07,第1作者（6）骨骼肌研究实用手册,A Practical Manual for Musculoskeletal Research ,World Scientific,2008-08,第4作者（7）骨质疏松症药效研究方法与技术,Methods And Techniques Pharmacodynamics Research Osteoporosis,人民卫生出版社,2009-09,第2作者（8）《骨质疏松诊断》(708页),中国现代文艺出版社(ISBN978-988-19792-3-0),2011-06,第2作者（9）骨内科学,Medicine of Bone,人民卫生出版社,2013-11,第1作者（10）《可降解金属(上册)》(880页),科学出版社（ISBN：978-7-03-050394-7）,2016-02,第2作者（11）《可降解金属(下册)》 (877页),科学出版社（ISBN: 978-7-03-050393-0）,2016-08,第2作者（12）《中华骨科学－骨科总论卷》(1833页),人民卫生出版社 (ISBN：85),2017-07,第5作者科研活动
科研项目
（ 1 ） PLGA/TCP/Icarilin复合骨生物材料制备及生物性能评估, 主持,省级,2011-01--2012-12（ 2 ） Epimedium-derived Flavonoids Reduce Risk of Steroi, 主持,国家级,2008-12--2011-12（ 3 ） An innovative approach for treatment of bone defec, 主持,研究所（学校）,2009-12--2011-12（ 4 ） 深圳市创新药物和生物治疗临床前试验和检测公共技术服务平台, 主持,省级,2011-01--2013-12（ 5 ） 防治骨质疏松中药"仙灵骨葆胶囊"的二次开发, 主持,国家级,2011-01--2013-12（ 6 ） 生物可降解镁合金及相关植入器件创新研发与产业化, 参与,省级,2011-01--2015-12（ 7 ） 医疗器械转化, 参与,省级,2011-01--2013-12（ 8 ） 生物材料装备技术转化, 参与,省级,2011-01--2013-12（ 9 ） 深圳创新药物和生物治疗临床前试验和检测公共技术服务, 主持,省级,2011-01--2013-12（ 10 ） VEGF-Src信号阻断预防激素性骨坏死破坏性骨修复的基础研究, 主持,国家级,2012-01--2015-12（ 11 ） 基于新型快速成型技术构建的活性骨修复材料修复难治愈性骨缺损的研究, 主持,国家级,2012-01--2016-12（ 12 ） 生物活性节段骨缺损修复体的研制, 主持,国家级,2016-07--2020-12（ 13 ） 深港生物材料联合实验室, 主持,部委级,2018-10--2023-09（ 14 ） 骨科转化医学研究平台, 主持,省级,2019-12--2021-12指导学生
已指导学生虎义平博士研究生071010-生物化学与分子生物学
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