研究领域
招生信息
教育背景
专利与奖励
出版信息
科研活动
基本信息
王言男中国科学院深圳先进技术研究院
电子邮件： yan.wang@siat.ac.cn
通信地址： 深圳南山区学苑大道1068号
邮政编码：
研究领域
主要研究计算机筛选药物的新方法和新型体外药物筛选平台的建立，结合这两种技术，开展了天然产物的活性筛选研究，以及现有药物的二次开发研究。建立了中药高丰度物质化合物库，并开发出第一个用于天然产物筛选的程序Herbalog，极大的提高了天然产物筛选效率。在药物筛选方法开发方面，建立了针对人源乙酰胆碱酯酶(AChE)，淀粉样蛋白(β-amyloid)和脂肪酸结合蛋白4(FABP4)的体外高通量筛选模型，以及针对HIV integrase/p75和CXCR4/SDF-1进行Protein-Protein Interaction抑制剂筛选的细胞模型。开发了首个针对HCMV terminase的抑制剂定量筛选方法，以及首个针对其的高通量筛选方法，获得NIH的认可，在此基础上资助200万美元开发HCMV terminase抑制剂。王言博士共开发药物筛选平台十余个，其中全新平台五个，为针对新靶点的药物设计和开发打下基础，其亦利用计算机筛选和体外筛选平台，进行药物二次开发研究。发现levofloxacin和pimozide作为新的FABP4抑制剂，具有治疗代谢类疾病的潜质，该发明获得美国专利授权，多家海外公司和科研院所表达合作意向，被Nature Reviews Endocrinology等权威杂志引用。在药物筛选领域发表SCI文章30余篇。招生信息
招生专业
071010-生物化学与分子生物学招生方向
药物筛选教育背景
2010-08--2014-12香港中文大学博士2007-09--2010-06中国药科大学硕士2003-09--2007-06南京中医药大学学士学位
博士 香港中文大学专利与奖励
深圳市海外高层次人才“孔雀计划”C类引进人才，2019年专利成果
（ 1 ） Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening, 发明, 2018, 第 2 作者, 专利号: US**B2出版信息
发表论文
（1）Lung tissue distribution of drugs as a key factor for COVID‐19 treatment,British Journal of Pharmacology,2020,通讯作者（2）Development of an enzyme-linked Immunosorbent Assay for Keap1-Nrf2 interaction inhibitors identification,Redox Biology,2020,通讯作者（3）Ganoderma cochlear Metabolites as Probes to Identify a COX-2 Active Site and as in Vitro and in Vivo Anti-Inflammatory Agents,Organic Letters,2020,其他（合作组作者）（4）(+/?)-Lucidumone, a COX-2 Inhibitory Caged Fungal Meroterpenoid from Ganoderma lucidum,Organic Letters,2019,其他（合作组作者）（5）Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway,Journal of Orthopaedic Translation,2019,其他（合作组作者）（6）FRET-based assay using a three-way junction DNA substrate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity,European Journal of Pharmaceutical Sciences,2019,第1作者（7）Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells,Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,2018,第2作者（8）Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease,ChemMedChem,2018,其他（合作组作者）（9）Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication,Antiviral Research,2018,第1作者（10）Synthesis, β-catenin Translocation Capability and ALP Activation Activity of 7H-thiazolo [3, 2-b]-1, 2, 4-triazin-7-one Derivatives,Medicinal Chemistry,2018,其他（合作组作者）（11）A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity,Biochemical and Biophysical Research Communications,2017,其他（合作组作者）（12）Inhibition of human cytomegalovirus pUL89 terminase subunit blocks virus replication and genome cleavage,Journal of Virology,2017,第1作者（13）The novel targets of DL-3-n-butylphthalide predicted by similarity ensemble approach in combination with molecular docking study,Quantitative imaging in medicine and surgery,2017,第1作者（14）Discovery of a novel HIV-1 integrase/p75 interacting inhibitor by docking screening, biochemical assay, and in vitro studies,Journal of chemical information and modeling,2017,第1作者（15）Bovine Lactoferrampin, Human Lactoferricin, and Lactoferrin 1-11 Inhibit Nuclear Translocation of HIV Integrase,Applied Biochemistry and Biotechnology,2016,第1作者（16）Herbalog: a tool for target-based identification of herbal drug efficacy through molecular docking,Phytomedicine,2016,第1作者（17）Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database,Journal of Functional Foods,2016,第1作者（18）MiR‐25 Suppresses 3T3‐L1 Adipogenesis by Directly Targeting KLF4 and C/EBPα,Journal of cellular biochemistry,2015,其他（合作组作者）（19）The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer,Oncotarget,2015,其他（合作组作者）（20）Antiviral activities of whey proteins,Applied microbiology and biotechnology,2015,其他（合作组作者）（21）Pimozide, a novel fatty acid binding protein 4 inhibitor, promotes adipogenesis of 3T3-L1 cells by activating PPARγ,ACS chemical neuroscience,2015,第1作者（22）Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening,Journal of chemical information and modeling,2014,第1作者（23）Silibinin, a novel chemokine receptor type 4 antagonist, inhibits chemokine ligand 12-induced migration in breast cancer cells,Phytomedicine,2014,第1作者（24）Identification of miRNAs that specifically target tumor suppressive KLF6-FL rather than oncogenic KLF6-SV1 isoform,RNA biology,2014,其他（合作组作者）（25）Differential regulation of lipid metabolism genes in the brain of acetylcholinesterase knockout mice,Journal of Molecular Neuroscience,2014,其他（合作组作者）（26）1, 4-Bis (5-(naphthalen-1-yl) thiophen-2-yl) naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor,Chemico-biological interactions,2014,其他（合作组作者）（27）Characterization of mi R‐210 in 3 T 3‐L 1 adipogenesis,Journal of cellular biochemistry,2013,其他（合作组作者）（28）Synthesis, characterization and biological activity of 3-aryl-6-(4-fluorobenzyl)-7H-thiazolo [3, 2-b]-1, 2, 4-triazin-7-one derivatives as novel acetylcholinesterase inhibitors,Latin American Journal of Pharmacy,2013,其他（合作组作者）（29）Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes,Phytomedicine,2013,其他（合作组作者）（30）Acetylshikonin, a novel AChE inhibitor, inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells,Evidence-Based Complementary and Alternative Medicine,2013,第1作者（31）Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes,Phytomedicine,2012,其他（合作组作者）科研活动
科研项目
（ 1 ） 黄芪甲苷通过抑制CXCR4/SDF1信号轴对抗骨关节炎的作用机制研究, 主持,国家级,2020-01--2022-12（ 2 ） 脂肪酸结合蛋白4诱导软骨基质降解的机制研究, 主持,省级,2019-10--2022-09（ 3 ） 天然小分子FABP4抑制剂的发现及其对抗骨关节炎的机制研究, 主持,省级,2020-05--2023-042013 © 中国科学院大学，网络信息中心.
