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生物光子学研究院
研究员/博士生导师
研究方向:分子生物医学
zhouxm@scnu.edu.cn

2005/9–2010/7， 华南师范大学， 生物物理学， 博士学位
2001/9–2005/7， 湖南文理学院， 生物科学， 学士学位
2010/7-2012/12，华南师范大学，生物光子学研究院，讲师
2012/12-2014/12，华南师范大学，生物光子学研究院，副研究员
2014/9-2015/7，武汉大学，化学与分子科学学院，访问****
2014/12-2018/4，华南师范大学，生物光子学研究院，特聘研究员
2018/4-至今，华南师范大学，生命科学学院，研究员
分子生物学与基因工程
国家自然科学基金重大研究计划培育（肿瘤演进与诊疗的分子功能可视化研究）：基于CRISPR/Cas识别原理的纸芯片研究及其在肿瘤基因突变、甲基化可视化检测的应用，2020.01-2022.12，主持
国家自然科学基金面上项目：具有聚合活性三联吡啶钌探针的构建及其在体外与原位分子诊断中的应用, 2019.1-2022.12，主持
国家自然科学基金面上项目：适配体靶向与转运的功能化核酸探针构建及端粒酶活性调控与分析，2015.1-2018.12，主持
国家自然科学基金青年项目：基于单分子荧光光谱与核酸探针的均相生物传感新方法与技术研究，2012.1-2014.12，主持
广东省自然科学****基金：重要病原微生物的核酸分子诊断新策略及新技术研究，2014.10-2018.10，主持
广东省特支计划：科技创新青年拔尖人才项目，2015.10-2018.10，主持
广东省高等学校优秀青年教师培养对象，2015.1-2017.12，主持
广州市珠江科技新星：纳米探针在人端粒酶生物学上的基础研究：功能调控及活性检测，2013.5-2016.6，主持
广东省自然科学基金：基于荧光相关光谱与适配体的均相生物传感新方法与技术研究，2011.10-2013.10，主持
Chun Wu,Ke-Jia Wu,Jin-Biao Liu,Xiaoming Zhou,Chung-Hang Leung* andDik-Lung Ma*, A dual-functional molecular strategy forin situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes, Chemical Communications, 2019, 55(45): 6353-6356.
Yuanyue Shan, Xiaoming Zhou, Ru Huang, and Da Xing*, High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity, Analytical Chemistry, 2019, 91, 5278−5285.
Erhu Xiong, Deshuai Zhen, Ling Jiang*, and Xiaoming Zhou*, Binding-Induced 3D-Bipedal DNA Walker for Cascade Signal Amplification Detection of Thrombin Combined with Catalytic Hairpin Assembly Strategy, Analytical Chemistry, 2019, 91, 15317−15324.
Qian Chen, Tian Tian, Erhu Xiong, Po Wang*, and Xiaoming Zhou*, CRISPR/Cas13a Signal Amplification Linked Immunosorbent Assay for Femtomolar Protein Detection, Analytical Chemistry, 2019, DOI: 10.1021/acs.analchem.9b04403.
Jinjin Shen, Xiaoming Zhou, Yuanyue Shan, Huahua Yue, Ru Huang, Jiaming Hu*, and Da Xing*, Sensitive detection of a bacterial pathogen using allosteric probe-initiated catalysis and CRISPR-Cas13a amplification reaction, Nature Communications, 2019, accepted.
Tian Tian, Bowen Shu*, Lei Liu, Zhonghui Guo, Zeping Han and Xiaoming Zhou*, Droplet-digital CRISPR/Cas13a assay enables one-step, amplification-free and absolute single-molecule quantification of microRNA, PNAS, 2019, Under review.
Xusheng Wang, Erhu Xiong, Tian Tian, Meng Cheng, Wei Lin, Heng Wang, Guihong Zhang, Jian Sun*, and Xiaoming Zhou*, CASLFA: CRISPR/Cas9-mediated lateral flow nucleic acid assay, ACS Nano, 2019, In revision.
Chaoqun Yuan, Tian Tian , Jian Sun, Menglu Hu, Xusheng Wang, Erhu Xiong, Meng Cheng, Yijuan Bao, Wei Lin, Jieming Jiang, Chengwei Yang, Qian Chen, Huang Zhang, Heng Wang, Xiran Wang, Xianbo Deng, Xiaoping Liao, Yahong Liu, Zhang Wang*, Guihong Zhang*, Xiaoming Zhou*, Universal and Naked-Eye Gene Detection Platform Based on CRISPR/Cas12a/13a System, Analytical Chemistry, 2019, In revision.
Yuhui Liao, Xiaoming Zhou*, Yu Fu, and Da Xing*, Graphene Oxide as a Bifunctional Material Towards Superior RNA Protection and Extraction, ACS Appl. Mater. Interfaces 2018, 10, 30227-30234.
Hongxing Liu, Xiaoming Zhou*, Qi Shen, and Da Xing*, Paper-based electrochemiluminescence sensor for highly sensitive detection amyloid?β oligomerization: Toward potential diagnosis of Alzheimer’s disease, Theranostics 2018, 8, 2289-2299.
Huahua Yue,Xiaoming Zhou*,Da Xing*, Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing,Nanoscale2018, 10, 1063-1071.
Mengqi Huang, Xiaoming Zhou*, Huiying Wang, and Da Xing*, Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Triggered Isothermal Amplification for Site-Specific Nucleic Acid Detection, Analytical Chemistry 2018, 90, 2193-2200.
Bofan Li, Xiaoming Zhou*, Hongxing Liu, Huaping Deng, Ru Huang, Da Xing*, Simultaneous Detection of Antibiotic Resistance Genes on Paper-Based Chip Using [Ru(phen)2dppz]2+Turn-on Fluorescence Probe, ACS Appl. Mater. Interfaces 2018, 10, 4494-4501.
Yu Fu, Xiaoming Zhou* and Da Xing*, Integrated Paper-based Detection Chip with Nucleic Acid Extraction and Amplification for Automatic and Sensitive Pathogen Detection, Sensors & Actuators: B. Chemical 2018, 261, 288-296.
Ru Huang, Xiaoming Zhou*, Chunsun Zhang, Da Xing*, High-specific microRNA detection based on dual-recycling cascadereaction and nicking endonuclease signal amplification, Sensors & Actuators: B. Chemical 2018, 264, 169-176.
Meng Cheng, Xiaoming Zhou* and Da Xing*, Peptide cleavage induced assembly enables highly sensitive electrochemiluminescence detection of protease activity, Sensors & Actuators: B. Chemical 2018, 262, 516-521.
Yu Fu, Xiaoming Zhou* and Da Xing*, Lab-on-capillary: a rapid, simple and quantitative genetic analysis platform integrating nucleic acid extraction, amplification and detection, Lab on a Chip 2017, 17, 4334-4341.
Yuhui Liao, Xiaoming Zhou*, Yu Fu, and Da Xing*, Linear Ru(bpy)32+−Polymer as a Universal Probe for Sensitive Detection of Biomarkers with Controllable Electrochemiluminescence Signal-Amplifying Ratio, Analytical Chemistry 2017, 89, 13016−13023.
Huaping Deng, Xiaoming Zhou*, Qianwen Liu, Bofan Li, Hongxing Liu, Ru Huang, and Da Xing*, Paperfluidic Chip Device for Small RNA Extraction, Amplification, and Multiplexed Analysis, ACS Appl. Mater. Interfaces 2017, 9, 41151−41158.
Xiaoke Yang, Xiaoming Zhou*, Minjun Zhu, Da Xing*, Sensitive detection of Listeria monocytogenes based on highly efficient enrichment with vancomycin-conjugated brush-like magnetic nano-platforms, Biosensors and Bioelectronics 2017, 91, 238-245.
Huaping Deng, Qianwen Liu, Xin Wang, Ru Huang, Hongxing Liu, Qiumei Lin, Xiaoming Zhou* and Da Xing*, Quantum Dots-Labeled Strip Biosensor for Rapidand Sensitive Detection of MicroRNA Based on Target-Recycled Nonenzymatic Amplification Strategy, Biosensors and Bioelectronics 2017, 87, 931–940.
Ru Huang, Yuhui Liao, Xiaoming Zhou*, Yu Fu, Da Xing*, Multiplexed detection of microRNA biomarkers from tumor cells andtissues with a homogeneous nano-photon switch, Sensors & Actuators: B. Chemical 2017, 247, 505–513.
Hongxing Liu, Xiaoming Zhou*, Jinjin Shen, and Da Xing*, Sensitive Detection of Hg2+ with Switchable Electrochemiluminescence Luminophore and Disposable Bipolar Electrode, ChemElectroChem 2017, 4, 1681–1685.
Weipeng Liu, Minjun Zhu, Hongxing Liu, Jitao Wei, Xiaoming Zhou* and Da Xing*, Invading stacking primer: a trigger for high-efficiency isothermal amplification reaction with superior selectivity for detecting microRNA variants, Biosensors and Bioelectronics 2016, 81, 309–316.
Lisha Zhang, Xiaoming Zhou* and Da Xing*, Rapid and Visual Detection of Listeria monocytogenes Based on Nanoparticle Cluster Catalyzed Signal Amplification, Biosensors and Bioelectronics 2016, 86, 1-7.
Weipeng Liu, Huiheng Yu, Xiaoming Zhou* and Da Xing*, In Vitro Evaluation of CRISPR/Cas9 Function by an Electrochemiluminescent Assay, Analytical Chemistry 2016, 88, 8369-8374.
Hongxing Liu, Xiaoming Zhou*, Weipeng Liu, Xiaoke Yang, and Da Xing*, Paper-Based Bipolar Electrode Electrochemiluminescence Switch for Label-Free and Sensitive Genetic Detection of Pathogenic Bacteria, Analytical Chemistry 2016, 88, 10191-10197.
Qianwen Ding, Qiuqiang Zhan, Xiaoming Zhou, Tao Zhang* and Da Xing*, Theranostic Upconversion Nanobeacons for Tumor mRNA Ratiometric Fluorescence Detection and Imaging-Monitored Drug Delivery, Small 2016, 12, 5944-5953.
Fang Liu, Hongxing Liu,Yuhui Liao,Jitao Wei, Xiaoming Zhou* and Da Xing*, Multiplex detection and genotyping of pathogenic bacteria on paper-based biosensor with a novel universal primer mediated asymmetric PCR, Biosensors and Bioelectronics 2015,74, 778–785.
Minjun Zhu, Weipeng Liu, Hongxing Liu, Yuhui Liao, Jitao Wei, Xiaoming Zhou* and Da Xing* Construction of Fe3O4/Vancomycin/PEG Magnetic Nanocarrier for Highly Efficient Pathogen Enrichment and Gene Sensing, ACS Appl. Mater. Interfaces 2015, 7, 12873−12881.
Yuhui Liao, Yu Fu, Yunxia Wu, Ru Huang, Xiaoming Zhou* and Da Xing*, Ultrasensitive Detection of MicroRNA in Tumor Cells and Tissues via Continuous Assembly of DNA Probe, Biomacromolecules 2015, 16, 3543−3551.
Ru Huang, Yuhui Liao, Xiaoming Zhou*, Da Xing*, Toehold-mediated nonenzymatic amplification circuit on grapheme oxide fluorescence switching platform for sensitive and homogeneous microRNA detection, Analytica Chimica Acta 2015, 888, 162-172.
Xiaoming Zhou, DebinZhu, Yuhui Liao, Weipeng Liu, Hongxing Liu, Zhaokui Ma, Da Xing*, Synthesis, labelling, and bioanalytical applications of a tris (2, 2'-bipyridyl) ruthenium (II) based electrochemiluminescence probe, Nature Protocols 2014, 9, 1146-1159.
Ting Zhou, Xiaoming Zhou*, Da Xing*, Controlled release of doxorubicin from graphene oxide based charge-reversal nanocarrier, Biomaterials 2014, 35, 4185-4194.
Yuhui Liao, Ru Huang, Zhaokui Ma, Yunxia Wu, Xiaoming Zhou*, and Da Xing*, A target-triggered enzyme-free amplification strategy for sensitive detection of microRNA in tumor cells and tissues, Analytical Chemistry 2014, 86, 4596-4604.
Weipeng Liu, Xiaoming Zhou*, Da Xing*, Rapid and reliable microRNA detection by stacking hybridization on electrochemiluminescent chip system, Biosensors and Bioelectronics 2014, 58, 388–394.
Hongxing Liu, Fangfang Zhan, Fang Liu,Minjun Zhu, Xiaoming Zhou* and Da Xing*, Visual and sensitive detection of viable pathogenic bacteria by sensing of RNA markers in gold nanoparticles based paper platform, Biosensors and Bioelectronics 2014, 62, 38–46.
Yuhui Liao, Xiaoming Zhou* and Da Xing*, Quantum Dots and Graphene Oxide Fluorescent Switch Based Multivariate Testing Strategy for Reliable Detection of Listeria monocytogenes, ACS Appl. Mater. Interfaces 2014, 6, 9988−9996.
Jitao Wei, Hongxing Liu, Fang Liu, Minjun Zhu, Xiaoming Zhou*, Da Xing* Miniaturized Paper-Based Gene Sensor for Rapid and Sensitive Identification of Contagious Plant Virus, ACS Appl. Mater. Interfaces 2014, 6, 22577−22584.
Jianzhi Liu; Yongjun Hu*; Guichi Zhu;Xiaoming Zhou; Li Jia; Tao Zhang，Highly Sensitive Detection of Zearalenone in Feed Samples Using Competitive Surface-Enhanced Raman Scattering Immunoassay，Journal of Agricultural and Food Chemistry 2014, 62, 8325-8332.
Yi Long, Xiaoming Zhou*, Da Xing*, An isothermal and sensitive nucleic acids assay by target sequence recycled rolling circle amplification, Biosensors and Bioelectronics 2013, 46, 102-107.
Zhongyu Fu, Xiaoming Zhou*, Da Xing*, Sensitive colorimetric detection of Listeria monocytogenes based on isothermal gene ampli?cation and unmodi?ed gold nanoparticles, Methods 2013,64, 260–266.
Zhongyu Fu, Xiaoming Zhou*, Da Xing*, Rapid colorimetric gene-sensing of food pathogenic bacteria using biomodification-free gold nanoparticle, Sensors & Actuators: B. Chemical 2013,182, 633–641.
Xiao Zhu, Xiaoming Zhou, Da Xing*, Label-Free Detection of MicroRNA: Two-Step Signal Enhancement with a Hairpin-Probe-Based Graphene Fluorescence Switch and Isothermal Amplification, Chemistry A European Journal 2013, 19, 5487–5494.
Fangfang Zhan, Xiaoming Zhou, Da Xing*, Rapid and sensitive electrochemiluminescence detection of rotavirus by magnetic primer based reverse transcription-polymerase chain reaction, Analytica Chimica Acta 2013, 761, 71-77.
Xiaoming Zhou, Yuhui Liao, Da Xing*, Sensitive monitoring of RNA transcription levels using a graphene oxide fluorescence switch, Chinese Science bulletin 2013, 21: 2634-2639.
Xiaoming Zhou, and Da Xing*, Assays for human telomerase activity: progress and prospects, Chemical Society Reviews 2012, 41, 4643-4656.
Liyun Xue, Xiaoming Zhou (co-first author), and Da Xing*, Sensitive and Homogeneous Protein Detection Based on Target- Triggered Aptamer Hairpin Switch and Nicking Enzyme Assisted Fluorescence Signal Amplification, Analytical Chemistry 2012, 84, 3507−3513.
Xiaoming Zhou, Qiang Su, Da Xing*, An electrochemiluminescent assay for high sensitive detection of mercury (II) based on isothermal rolling circular amplification，Analytica Chimica Acta 2012, 713, 45–49.
Xiaoming Zhou, Ruixue Duan, and Da Xing*, Highly sensitive detection of protein and small molecules based on aptamer-modified electrochemiluminescence nanoprobe, Analyst 2012, 137, 1963-1969.
Xiaoming Zhou,, Da Xing*, Amplified electrochemiluminescence detection of nucleic acids by hairpin probe based isothermal amplification, Analyst 2012, 137, 4188-4192.
Zhen Zhao, Xiaoming Zhou*, Ultrasensitive electrochemiluminescence detection of mercury ions based on DNA oligonucleotides and cysteamine modified gold nanoparticles probes, Sensors & Actuators: B. Chemical 2012 (171–172) 860– 865.
Zhen Zhao, Xiaoming Zhou, Da Xing*, Highly sensitive protein kinase activity assay based on electrochemiluminescence nanoprobes, Biosensors and Bioelectronics 2012, 31, 299-304.
Xiao Zhu, Xiaoming Zhou, Da Xing*, Nano-magnetic primer based electrochemiluminescence-polymerase chain reaction (NMPE-PCR) assay, Biosensors and Bioelectronics 2012, 31, 463-468.
Xiaoming Zhou, Yonghong Tang, and Da Xing*, One-Step Homogeneous Protein Detection Based on Aptamer Probe and Fluorescence Cross-Correlation Spectroscopy, Analytical Chemistry 2011, 83, 2906–2912.
Yi Long, Xiaoming Zhou, Da Xing*, Sensitive and isothermal electrochemiluminescence gene-sensing of Listeria monocytogenes with hyperbranching rolling circle amplification technology, Biosensors and Bioelectronics 2011, 26, 2897-2904.
Xiao Zhu, Xiaoming Zhou, Da Xing*, Ultrasensitive and Selective Detection of Mercury (Ⅱ) in Aqueous Solution by Polymerase Assisted Fluorescence Amplification, Biosensors and Bioelectronics 2011, 26, 2666-2669.
Ruixue Duan, Xiaoming Zhou (co-first author), Da Xing*, Electrochemiluminescence Biobarcode Method Based on Cysteamine-Gold Nanoparticle Conjugates, Analytical Chemistry 2010, 82, 3099-3103.
Jie Wei, Xiaoming Zhou (co-first author), Da Xing*, Rapid and sensitive detection of vibrio parahaemolyticus in sea foods by electrochemiluminescence polymerase chain reaction method, Food Chemistry 2010, 123, 852-858.
Liyun Xue, Xiaoming Zhou and Da Xing*, Highly sensitive protein detection based on aptamer probe and isothermal nicking enzyme assisted fluorescence signal amplification, Chemical Communications 2010, 46, 7373–7375.
Qiang Li, Xiaoming Zhou, Da Xing*, Rapid and highly sensitive detection of mercury ion (Hg2+) by magnetic beads-based electrochemiluminescence assay, Biosensors and Bioelectronics 2010, 26, 859-862.
Qiang Su, Da Xing*, Xiaoming Zhou, Magnetic beads based rolling circle amplification–electrochemiluminescence assay for highly sensitive detection of point mutation, Biosensors and Bioelectronics 2010, 25, 1615-1621.
Debin Zhu, Xiaoming Zhou, Da Xing*, A new kind of aptamer-based immunomagnetic electrochemiluminescence assay for quantitative detection of protein, Biosensors and Bioelectronics 2010, 26, 285-288.
Xiaoming Zhou, Da Xing*, Debin Zhu, Li Jia, Magnetic bead and nanoparticle based electrochemiluminescence amplification assay for direct and sensitive measuring of telomerase activity, Analytical Chemistry 2009, 81, 255-261.
Xiaoming Zhou, Da Xing*, Yonghong Tang, and Wei R. Chen, PCR-Free Detection of Genetically Modified Organisms Using Magnetic Capture Technology and Fluorescence Cross-Correlation Spectroscopy, PLoS One 2009, 4, e8074.
Huijuan Zhou, Da Xing*, Debin Zhu, and Xiaoming Zhou, Rapid and sensitive detection of point mutation by DNA ligase-based electrochemiluminescence assay, Talanta 2009, 78, 1253-1258.
Xiaoming Zhou, Da Xing*, Debin Zhu and Li Jia, Magnetic beads-based electrochemiluminescence assay for rapid and sensitive detection of telomerase activity, Electrochemistry Communications 2008, 10, 564-567.
Xiaoming Zhou, Da Xing*, Debin Zhu, Yabing Tang, and Li Jia, Development and application of a capillary electrophoresis- electrochemiluminescent method for the analysis of enrofloxacin and its metabolite ciprofloxacin in milk, Talanta 2008, 75, 1300–1306.
Jie Wei, Xiaoming Zhou*, An improved electrochemiluminescence polymerase chain reaction method for the detection of Fusarium wilts, Chinese Chemical Letters 2008, 19, 959–961.
学术兼职包括获聘《激光生物学报》常务编委、《分析测试学报》青年编委、中国光学学会生物医学光子学专委、中国生物医学工程学会生物医学光子学青委、广东省生物医学工程学位专委、《Nucleic Acids Research》， 《Clinical Chemistry》、《Analytical Chemistry》，《Advanced Science》，《Biotechnology and Bioengineering》，《Biosensors and Bioelectronics》，《ACS Applied Materials & Interfaces》，《Nanoscale》，《Environmental Science & Technology》，《ACS Sensors》，《Sensors & Actuators: B. Chemical》，《Journal of Agricultural and Food Chemistry》，《Analytica Chimica Acta》，《Analyst》等生物、化学、材料、环境、医学领域权威刊物审稿人。
在读博士研究生：
程猛（博士研究生），2013年入学
乐花花（博士研究生），2018年入学
黄梦琪（博士研究生），2018年入学
在读硕士研究生：
王徐升（硕士研究生）, 2016年入学
田甜（硕士研究生）, 2017年入学
元超群（硕士研究生）,2017年入学
陈倩（硕士研究生）,2017年入学，联合培养
林薇（硕士研究生）, 2018年入学
胡梦露（硕士研究生）, 2018年入学
廖沣（硕士研究生），2019年入学，联合培养
毕子荣（硕士研究生），2019年入学
林梅（硕士研究生），2019年入学


“新型生物传感技术在功能分子检测和成像中的应用基础研究”，教育部自然科学二等奖，2013年
广东省自然科学****基金，2014年
广东省科技创新拔尖人才，2015年
广东省优秀青年教师培养对象，2014年
广州市珠江科技新星，2013年