牛锋锋 生物医药研究院 研究助理教授 niuff@sustech.edu.cn 个人主页



教育经历
2009-2015 中国科学院生物物理研究所 生物化学与分子生物学 博士
2005-2009 南开大学 生命科学 学士


工作经历
2019-至今 南方科技大学 前沿与交叉科学研究院 研究助理教授
2016-2019 南方科技大学 生物系 博士后


交叉研究领域
1. 利用结构生物学手段（X-射线晶体学和冷冻电镜），解析人和病原体内重要蛋白或蛋白质复合物结构，为相关疾病防治及药物设计提供结构基础
2. 结合生物化学，结构生物学，细胞生物学等手段，阐释细胞内分子马达蛋白介导的物质运输的分子机制及生命功能


代表文章
1. Niu, F.*, Shaw, N*., Wang, Y. E.*, Jiao, L.*, Ding, W., Li, X., ... & Liu, Z. J. (2013). Structure of the Leanyer orthobunyavirus nucleoprotein–RNA complex reveals unique architecture for RNA encapsidation. Proceedings of the National Academy of Sciences, 110(22), 9054-9059.
2. Jiao, L.*, Ouyang, S.*, Liang, M.*, Niu, F.*, Shaw, N., Wu, W., ... & Liu, Z. J. (2013). Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential. Journal of virology, 87(12), 6829-6839.
3. Niu, F., Ru, H., Ding, W., Ouyang, S., & Liu, Z. J. (2013). Structural biology study of human TNF receptor associated factor 4 TRAF domain. Protein & cell, 4(9), 687-694.
4. Li, J. *, Rodriguez, J. P. *, Niu, F., Pu, M., Wang, J., Hung, L. W., ... & Ouyang, S. (2016). Structural basis for DNA recognition by STAT6. Proceedings of the National Academy of Sciences, 113(46), 13015-13020.
5. Ouyang, S.*, Song, X.*, Wang, Y.*, Ru, H.*, Shaw, N., Jiang, Y., Niu, F., ... & Liu, Z. J. (2012). Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity, 36(6), 1073-1086.
6. Jiao, L.*, Ouyang, S.*, Shaw, N., Song, G., Feng, Y., Niu, F., ... & Liu, Z. J. (2014). Mechanism of the Rpn13-induced activation of Uch37. Protein & Cell, 1-15.
7. Gu, J., Feng, Y., Feng, X., Sun, C., Lei, L., Ding, W., Niu, F., ... & Han, W. (2014). Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin. PLoS pathogens, 10(5), e**.
8. Burakova, L. P., Natashin, P. V., Malikova, N. P., Niu, F., Pu, M., Vysotski, E. S., & Liu, Z. J. (2016). All Ca 2+-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg2+-loaded apo-berovin. Journal of Photochemistry and Photobiology B: Biology, 154, 57-66.


联系方式
niuff@sustech.edu.cn