张文勇医学院副院长、教学教授、博士生导师


zhangwy@sustech.edu.cn
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个人简介张文勇教授为南方科技大学医学院副院长、教授，博士生导师。他毕业于美国Bowdoin College，获生物化学学士学位。之后获得美国国立卫生院医学科学家培养基金，进入著名的“康奈尔医学院、洛克菲勒大学、斯隆凯特琳癌症中心—三校MD-PhD Program”攻读医学博士和生物学博士双学位，于2004年以优异成绩毕业，获得The Herman L. Jacobius 病理学奖。在攻读生物学博士期间，在何大一医学博士实验室，从事HIV DNA疫苗的研发工作，获得Elizabeth Glaser Pediatric AIDS Foundation Student Award。医学院毕业后他在康奈尔大学医学院纽约长老会医院病理系接受了病理学的住院医师培训，并获得了纽约州的行医执照。随后他到休斯顿贝勒医学院、MD安德森癌症研究中心、德州儿童医学中心进行了分子病理学的进修。他分别在西奈山医学院任病理系分子病理实验室副主任，及纽约医学院附属医院病理系任分子病理实验室主任。在分子病理学的研究成果发表在《Journal of Clinical Oncology》、《American Journal of Pathology》、《Modern Pathology》、《Blood》等杂志上。他有丰富的教学经验，在西奈山医学院和纽约医学院分别教授医学院学生、病理系住院医师、分子病理进修医生不同层次的病理学课程，并负责指导分子病理进修医生的科研工作。为深圳市孔雀计划B类人才，国家科技库专家、教育部科技管理信息系统专家库专家、广东省科技厅专家、深圳市科创委重大项目评审专家、北京4P健康研究院理事及专家委员会委员等。
张文勇教授证明了利用融合基因方法，使得抗原靶向进入树突状细胞可以增强HIV DNA疫苗的活性。他在AIDS领域的研究让他获得了Elizabeth Glaser Pediatric AIDS Foundation Student Award，研究发表在Science、Vaccine、JAIDS等杂志上。他研发了针对多个癌症靶向基因的简易、高效、精确的检测方法，包括BRAFV600E, MPLW515L/K, EWSR1/ATF1, EWSR1/CREB1, JAK2V617F等。在分子病理学的研究成果发表在《Journal of Clinical Oncology》、《American Journal of Pathology》、《Modern Pathology》、《Blood》等杂志上。
研究领域1、分子病理学
2、衰老机制及干预手段研究
3、系统生物学与癌症预防研究
4、人工智能在疾病诊断中的应用

杂志编委会成员目前他担任Association for Molecular Pathology及American Society of Clinical Pathology学会会员，《American Journal of Pathology》、《Archive of Pathology》、《Journal of Molecular Pathology》等杂志审稿人。



近年代表文章论著：
Zhuge, W. Zhang. Principles of molecular biology inMolecular Diagnosis of Skin Diseases(M. Murphy, ed). Humana Press (2011).
学术论文：
Ying Liu, Zhangzhang Lan, Fang Zhao, Shuangchuan Zhang, Wenyong Zhang. Analysis of a Chinese pedigree with familial chylomicronemia syndrome reveals two novel LPL mutations by whole-exome sequencing. Frontiers in Genetics2020 Jul 17;11:741.
Min Li; Haitao Jia; Qiuqin Qian; Peng Wen; Chuan Chen; Yaqiong Hua; Kai Wang; Wenyong Zhang; Feng Shi. Genomic Characterization of High-Recurrence Risk Papillary Thyroid Carcinoma in Southern Chinese populations. Diagnostic Pathology2020 15:49.
Luan H, Jiang X, Ji F, Lan Z, Cai Z, Zhang W. CPVA: a web-based metabolomic tool for chromatographic peak visualization and annotation.Bioinformatics. 2020 Mar 18. pii: btaa200.
Ou J, Yang C, Cui X, Chen C, Ye S, Zhang C, Wang K, Chen J, Zhang Q, Qian C, Fang G, Zhang W.Successful pregnancy after prenatal diagnosis by NGS for a carrier of complex chromosome rearrangements.Reprod Biol Endocrinol. 2020 Feb 29;18(1):15.
Geng Q, Cui X, Zhang Y, Zhang L, Zhang C, Wang K, Chen J, Zhu Q, Xie J, Xu Z, Liu Y, Zhang M, Ding L, Zhang W, Yang C. Screening of Triploid with Low-coverage Whole-genome Sequencing by A Single-nucleotide Polymorphism-based Test in Miscarriage TissueJ Assist Reprod Genet. 2019 Dec;36(12):2525-2531.
Luo A, Cheng D, Yuan S, Li H, Du J, Zhang Y, Yang C, Lin G,Zhang W, Tan YQ. Maternal interchromosomal insertional translocation leading to 1q43-q44 deletion and duplication in two siblings. Mol Cytogenet. 2018 Apr 4;11:24 (共同通讯作者).
T. Huang, J. Zhuge,W. Zhang. Sensitive detection of BRAF V600E mutation by Amplification Refractory Mutation System (ARMS)-PCR. Biomarker Research 2013; 1:3.
Li Z, Cai X, Cai CL, Wang J,Zhang W, Petersen BE, Yang FC, Xu M. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011 Oct 27;118(17):4509-18.
L. Varricchio, E. Masselli, E. Alfani,W. Zhang, R. Hoffman, AR Migliaccio. The dominant negative b isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells. Blood 2011, 118(2): 425-36.
J. Zhuge,W. Zhang. Sensitive detection of MPLW515L/K mutations by amplification refractory mutation system (ARMS)-PCR. Clinica Chimica Acta 2010; 411:122-123.
W. Zhang, D. Jones. Predictors of primary imatinib resistance in chronic myeloid leukemia are distinct from those in secondary resistance. J Clin Oncology. 2009; 27: 3642-3649.
W. Zhang, D. López-Terrada. Molecular monitoring of 8p11 myeloproliferative syndrome in an infant. J Pediatr Hematol Oncol 2009;31:879-883.
Wenyong W. Zhang, Jorge E. Cortes, Hui Yao, Li Zhang, Neelima G. Reddy, Elias Jabbour, Hagop M. Kantarjian, and Dan Jones.Predictors of Primary Imatinib Resistance in Chronic Myelogenous Leukemia Are Distinct From Those in Secondary Imatinib Resistance.J Clin Oncology. 2009 Aug 1;27(22):3642-9
W. Wang, E. Mayordomo,W. Zhang, V. S. Hernandez, D. Tuvin, L. Garcia, D. C. Lev, A. J. F. Lazar, D. López-Terrada. Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in Clear Cell Sarcoma (Melanoma of Soft Parts). Modern Pathology 2009; 22:1201-1209.
Z. Chen,W. Zhang, D. Ho. Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'. JAIDS 2008; 47: 412-421.
Y. Huang, Z. Chen,W. Zhang, D. Gurner, Y. Song, D. Gardiner, D. D. Ho. Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant. JAIDS 2008; 47: 403-411.
Y. Huang, A. Chen, X. Li, Z. Chen,W. Zhang, Y. Song, D. Gurner, D. Gardiner, S. Basu, D. D. Ho and M. Tsuji. Enhancement of HIV DNA vaccine immunogenicity by the NK T cell ligand, -galactosylceramide. Vaccine 2008; 26:1807-1816.
W. Zhang, J. Versalovic. Expanding the diagnostic capabilities of molecular microbiology by genomic methods. Journal of Molecular Diagnostics 2007; 9(5): 572-573.
W. Zhang, J. E. Dahlberg, W. Tam. MicroRNAs in tumorigenesis: a primer for pathologists. American Journal of Pathology 2007; 171(3):728-738.
W. Zhang, H. Syed. Mammary small cell carcinoma with dimorphic phenotype. Breast Journal 2007; 13(5): 529-530.
L. Zhang, W. Yu, T. He, J. Yu, R. E. Caffrey, E. A. Dalmasso, S. Fu, T. Pham, J. Mei, J. J. Ho,W. Zhang, P. Lopez, D. D. Ho. Contribution of human {alpha}-Defensin-1, -2 and -3 to the anti-HIV-1 activity of CD8 antiviral factor. Science 2002; 298:995-1000.
B. Stibrková, J. Majewski, I. Sebesta,W. Zhang, J. Ott, S. Kmoch. Familial juvenile hyperuricemic nephropathy: localization of the gene on chromosome 16p11.2-and evidence for genetic heterogeneity. Am. J. Human Genetics 2000; 66:1989-1994