贺云娇研究助理教授


heyj@sustech.edu.cn
第二科研楼317
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个人简介南方科技大学医学院研究助理教授，于2013年从香港理工大学获得博士学位，之后先后于香港理工大学和南方科技大学从事博士后研究工作。主要研究方向为结构生物学、糖生物化学等。
教育背景1999.9-2003.6 武汉大学，药学专业，学士
2003.9-2006.6 武汉大学，药物化学，硕士
2009.1-2013.10 香港理工大学，生物化学与分子生物学专业，博士



工作经历2006.07-2008.08 上海药明康德新药开发有限公司 药物合成研究员
2013.10-2014.07 香港理工大学，研究助理
2014.07-2016.07 香港理工大学，博士后
2016.09-2019.05 南方科技大学，博士后



近年代表文章(1) Shuai Wu #,Yunjiao He#,Xianxiu Qiu,Wenchao Yang,Wenchao Liu,Xiaohua Li,Yan Li,Han-Ming Shen,Renxiao Wang, Zhenyu Yue,YanxiangZhao*. TargetingthepotentBeclin1-UVRAGcoiled-coilinteractionwithdesignedpeptidesenhances autophagyandendolysosomaltrafficking. Proc Natl Acad Sci ,2018 Jun 19;115(25):E5669-E5678. (Co-first author)
(2) Pan, Xuehua#;He, Yunjiao#; Chen, Tianfeng; Chan, Kin-Fai; Zhao, Yanxiang*, Modified Penicillin Molecule with Carbapenem- Like Stereochemistry Specifically Inhibits Class C beta-Lactamases. Antimicrobial Agents and Chemotherapy, 2017.12, 61(12). (Co-first author)
(3) Pan, Xuehua;He, Yunjiao; Lei, Jinping; Huang, Xuhui; Zhao, Yanxiang*，Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis. Journal of Biological Chemistry, 2017.3, 292(10): 4022~4033.
(4) Pan, Xuehua; Wong, Wai-Ting;He, Yunjiao; Jiang, Yongwen; Zhao, Yanxiang*. Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 2014.8.26, 53(33): 5414~5423.
(5) Teng H.;He Yunjiao.; Wu L.; Su J.; Feng X.; Qiu G.; Liang S.; Hu X*. AgeneralandfacilesyntheticapproachtoN-alpha-Bocureidoalaninederivatives. Synlett, 2006, (6): 877~880.
(6) He Y, Lei J, Pan X, Huang X and Zhao Y. “Novel intermediates in the active site of Class A β-lactamase reveal critical factors that coordinate the catalytic water molecule for nucleophilic attack on β-lactam acyl adduct”. Scientific reports, 2019（Accepted）


专利：
(1) Patent: . Xianming Hu, Hanbing Teng, Yunjiao He. A Facile Synthetic Approach to Na-Boc Ureidoalanine Derivatives.
(2) Patent number：3.9，潘雪华，贺云娇，陈建辉，赵燕湘，C类β-内酰胺酶抑制剂及其制备方法和应用。
(3) United States Patent Application , Zhao, Yanxiang, WU, Shuai, Yang, Wenchao, HE, Yunjiao, LI, Xiaohua, Qiu, Xianxiu, Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation.