任欢教学教授、博士生导师


renh@sustech.edu.cn
生物楼514
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个人简介任欢，南方科技大学医学院教学教授，博士生导师。1991年获医学学士学位，1997年获免疫学硕士学位。2001-2005年在英国利物浦大学医学院工作并获得博士学位，2009年哈尔滨医科大学药学博士后出站。2006-2018年在哈尔滨医科大学担任免疫学教研室主任、教授、博士生导师，省级领军人才梯队学术带头人。目前担任中国免疫学会理事，中华医学核心期刊《国际免疫学》副主编；国家自然基金、波兰国家自然基金、国家教育部学位点论文评审专家。多年来一直从事医学免疫学教学和科研工作。主讲本科生与研究生课程《医学免疫学》、《肿瘤免疫学》、《临床免疫及诊断》《分子免疫学及进展》、《Medical Immunology》等。作为主编、副主编或参编医学免疫学教材和参考书10部；主编或参编中英文学术专著9部。主持完成多项国家自然基金面上项目以及重大研究计划培育项目等科研课题，获得教育部提名科技进步一等奖、黑龙江省科技进步二等奖、世界卫生组织奖学金等奖励。已培养硕士生45人、博士生10人、出站博士后4人。任欢课题组采用生物医学实验、生物信息学、临床医学、生物物理及数学模型等多学科研究方法，以肿瘤生物免疫与靶向治疗基础与应用研究为主要方向。重点关注恶性肿瘤多分子靶标诊断、肿瘤免疫微环境在诊疗中的作用，以及建立体外药物筛选检测平台和肿瘤疫苗研发等。近年来在国际学术期刊包括 Nuclear Acid Research, Neuro-oncology, Cell Death & Differentiation, Mol Cancer Ther, Oncotarget, BMC Immuology 等发表论文50多篇。
研究领域任欢课题组采用生物医学实验、生物信息学、临床医学、生物物理及数学模型等多学科研究方法，以肿瘤生物免疫与靶向治疗基础与应用研究为主要方向。重点关注恶性肿瘤多分子靶标诊断、肿瘤免疫微环境在诊疗中的作用，以及建立体外药物筛选检测平台和肿瘤疫苗研发等。

教育背景1986-1991年 中国医科大学 医学士学位
1994-1997年 哈尔滨医科大学 免疫学硕士学位
2000-2003年 哈尔滨医科大学 免疫学博士学位
2001-2005年 英国利物浦大学医学院 神经学博士学位



工作经历1991年6月-1994年9月 哈尔滨市第一医院神经内科 临床护师
1997年6月-2019年1月 哈尔滨医科大学 基础医学院免疫学教研室讲师、副教授（2002年）、教授（2005年）
2001年4月-2001年10月 英国牛津布鲁克斯学院细胞生物学系，世界卫生组织访问****
2001年10月-2004年10月 英国利物浦大学医学院神经学系 兼职研究员
2006年6月-2019年1月 哈尔滨医科大学基础医学院免疫学教研室主任；黑龙江省级领军人才梯队（免疫学）带头人（2008-2019）
2007年12月-2009年12月 哈尔滨医科大学 药理学博士后工作流动站 博士后
2015年04-2015年10月 美国加州大学圣地亚哥分校 访问教授
2019年1月-至今 南方科技大学 医学院 教学教授



获奖情况及荣誉巨噬细胞M1/M2型极性转化对肝转移瘤微循环构建的作用与机制；国家自然科学基金 面上项目（NSFC-**）2019-2022
抑癌基因缺失下EGFR活化通过调控微环境适变介导胶质母细胞瘤恶性发展，国家自然科学基金面上项目（NSFC-**）2015-2018
EGFR 过表达协同PTEN 缺失介导的免疫炎性网络促进胶质母细胞瘤恶性进展的分子机制，国家自然科学基金重大研究计划培育计划（NSFC-**）2013-2015
解析GBM 基于EGFR/PI3K 信号通路多模式靶向治疗靶标的研究，国家自然科学基金 面上项目（NSFC-**）2008-2010
恶性脑肿瘤分子靶标的确立及分子机制研究——恶性脑胶质瘤分子亚型分类与靶向治疗的基础与临床应用研究，黑龙江省自然科学基金 重点项目（ZD200804-01）2009-2011
基于EGFR/PI3K信号转导通路恶性胶质母细胞瘤靶向治疗分子靶标的研究，教育部科技发展中心高等学校博士学科点专项科研基金（006）2009-2011
实验性自身免疫性葡萄膜视网膜炎（EAU）恢复期神经组织-免疫细胞交互作用及其相关机制，教育部“春晖计划”（ Z**）2011-2012
恶性脑胶质瘤基于EGFR/PI3K信号转导通路分子亚型分类的研究，中国博士后 特别资助（）2007-2010
肿瘤生物治疗的基础与应用系列性研究。2006年教育部提名国家科技进步一等奖（自然科学类，第三）
恶性脑胶质瘤细胞PDGFR/EGFR信号转导通路上抗肿瘤靶点的作用及相互作用。哈尔滨市科技进步二等奖（2010年第一）、黑龙江省科技进步二等奖（2011年第一）
CIK体外增殖及体内外抗肿瘤活性的实验研究。《中国肿瘤生物治疗》杂志创刊20周年优秀论文一等奖（2015年 第一作者）



杂志编委会成员主要学术兼职:
中国免疫学会 第六届、第七届（现任）理事
黑龙江省生物信息学会 监事
《国际免疫学杂志》 第七届、第八届（现任）副总编辑
《哈尔滨医科大学学报》 编委
国家自然科学基金委员会 评审专家
国家教育部学位与研究生教育评估中心 评审专家
波兰国家自然科学基金评审专家
Neuro-oncology, PloS One, Cancer letters, BMC cancer, etc. 审稿专家



近年代表文章Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, Lu F, Liu N, Yu M, Peng S, Wang Y, Zhao D, Zhao Y, Ren H, Cheng Z, Dong S, Lu F, Zhang W. Exogenous H2S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD+-SIRT3 pathway in cardiac tissues of db/db mice. Am J Physiol Endocrinol Metab. 2019;317(2):E284-E297
Sun Q, Pei C, Li Q, Dong T, Dong Y, Xing W, Zhou P, Gong Y, Zhen Z, Gao Y, Xiao Y, Su J, Ren H*. Up-regulation of MSH6 is associated with temozolomide resistance in human glioblastoma. Biochem Biophys Res Commun. 2018; 496 (4): 1040-1046.
Sun CH, Zou MY, Li L, Li DX, Ma YJ, Xia W, Wu LJ*, Ren H* Association study between inwardly rectifying potassium channels 2.1 and 4.1 and autism spectrum disorders. Life Sciences 2018; 213: 183
Jiao H, Ren H* The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain–Barré syndrome Drug Des Devel Ther 2018 6;12: 3817
Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W. Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice. J Mol Med (Berl). 2018;96(3-4):281-299
Teng YQ, DongYC, Liu ZY, Zou Y, Xie H，Zhao Y，Su J，Cao FL, Jin H*, Ren H*. DNA methylation-mediated caspase-8 down-regulation is highly relevant to anti-apoptosis activity and human malignant glioma grade. Int J Mol Med 2017; 39: 725-733
He X, Ren H*. Non-inflammasome forming NLRC3 suppresses tumorigenesis in the gut. J Xiangya Med 2017; 2: 64 (Editorial invited)
Xing WJ, Xiao Y, Lu XL, Li X*, Karin M*, Ren H*. GFI1 down-regulation promotes inflammation linked-metastasis of colorectal cancer. Cell Death & Differentiation 2017; 24 (5): 729-743
Lijie Sun, Yan Li, Xiuzhi Jia, Qi Wang, Weihua Zhang, Jingtao Wang, Hongwei Xu, Lihua Wang*, Dekai Zhang* and Huan Ren* Neuroprotection by IFN-g via astrocyte-secreted IL-6 in acute neuroinflammation. Oncotarget 2017; 8(25):40065-40078
Junwei Han , Siyao Liu , Zeguo Sun , Yunpeng Zhang , Fan Zhang , Chunlong Zhang , Desi Shang , Haixiu Yang , Fei Su , Yanjun Xu , Chunquan Li , Huan Ren* and Xia Li*. LncRNAs2Pathways: Identifying the pathways influenced by a set of interested lncRNAs based on global network propagation method. Scientific Reports 2017; 7: 46566
Liu ZY, Han L, Dong YC, Tan YL, Li YS, Zhao ML, Xie H, Ju HY, Wang H, Zhao Y, Zheng QF, Wang QX, Su J, Fang C, Fu SB, Jiang T, Liu JR, Li X*, Kang CS*, Ren H*. EGFRvIII/integrin β3 interactions in hypoxic and vitronectin-enriching microenvironment promote GBM progression and metastasis. Oncotarget 2016 Jan 26; 7(4):4680-94.
Xie H, Yang JF, Xing WJ, Dong YC, Ren H*. Nuclear EGFRvIII Resists Hypoxic Microenvironment Induced Apoptosis via Recruiting ERK1/2 Nuclear Translocation. Biochem Biophys Res Commun. 2016; 5; 470 (2):466-72.
Ju H, Xing W, Yang J, Zheng Y, Jia X, Zhang B, Ren H*. An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model. BMC Immunol. 2016; 17 (1): 31
Liu CD, Wang Q, Zong DK, Pei SC, Yan Y, Yan ML, Sun LL, Hao YY, Mao M, Xing WJ, Ren H, Ai J. Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion. Neurobiol Aging. 2016;45:76-87.
Tian L, Li L, Xing W, Li R, Pei C, Dong X, Fu Y, Gu C, Guo X, Jia Y, Wang G, Wang J, Li B, Ren H*, Xu H*. IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition. Scientific Reports 2015 Jul 23; 5: 12357.
Yang J, Xu Z, Sui M, Han J, Sun L, Jia X, Zhang H, Han C, Jin X, Gao F, Liu Y, Li Y, Cao J, Ling H, Zhang F*, Ren H*. Co-Positivity for Anti-dsDNA, -Nucleosome and -Histone Antibodies in Lupus Nephritis Is Indicative of High Serum Levels and Severe Nephropathy. PLoS One. 2015 Oct 14; 10 (10): e**
Dong H, Tian L, Li R, Pei C, Fu Y, Dong X, Xia F, Wang C, Li W, Guo X, Gu C, Li B, Liu A, Ren H, Wang C, Xu H. IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy. Oncogene. 2015 Oct 16;34 (42):5363-71
Zheng QF , Han L , Dong YC , Tian J, Huang W, Liu ZY, Jia XZ, Jiang T, Zhang JN, Li X*, Kang CS* and Ren H*. JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma. Neuro-Oncol 2014; 16 (9):1229-43.
Chang L, Su J, Jia X, Ren H*. Treating malignant glioma in Chinese patients: update on temozolomide. Onco Targets Ther.2014; 7:235-244 (invited review)
Jin H, Zhang X, Su J, Teng Y, Ren H*, Yang L*. RNA interference-mediated knockdown of translationally controlled tumor protein induces apoptosis and inhibits growth and invasion in glioma cells. Mol Med Rep. 2015 Nov;12(5):6617-25
Jia X, Li J, Shi D, Zhao Y, Dong Y, Ju H, Yang J, Sun J, Li X*, Ren H*. Grouping annotations on the subcellular layered interactome demonstrates enhanced autophagy activity in a recurrent experimental autoimmune uveitis T cell line. PLoS One. 2014; 9 (8):e104404.
Li Y, Xu J, Ju H, Xiao Y, Chen H, Lv J, Shao T, Bai J, Zhang Y, Wang L, Wang X, Ren H*, Li X* A network-based, integrative approach to identify genes with aberrant co-methylationincolorectalcancer. Mol Biosyst. 2014;10 (2):180- 90
Hu MH, Zheng QF, Jia XZ, Li Y, Dong YC, Wang CY, Lin QY, Zhang FY, Zhao RB, Xu HW, Zhou JH, Yuan HP, Zhang WH, Ren H*. Neuroprotection effect of Interleukin-17 secreted by reactive astrocytes is emerged from a high-level IL-17-containing environment during acute neuroinflammation. Clin Exp Immunol 2014;175 (2):268-84 (cover story)
Li Y, Xu J, Chen H, Bai J, Li S, Zhao Z, Shao T, Jiang T, Ren H*, Kang C*, Li X*. Comprehensive analysis of the functional microRNA–mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. Nucleic Acids Res. 2013 Dec 1; 41(22):e203
Sui M, Lin Q, Xu Z, Han X, Xie R, Jia X, Guo X, Zhang W, Guan X, Ren H*. Simultaneous positivity for anti-DNA, anti-nucleosome and anti-histone antibodies is a marker for more severe lupus nephritis. J Clin Immunol. 2013;33 (2):378-87
Xing WJ, Zou Y, Han QL, Dong YC, Deng ZL, Lv XH, Jiang T, Ren H*. Effects of EGFR and PTEN gene expressions on the inhibition of U87MG glioblastoma cell proliferation induced by protein kinase inhibitors. Clin Exp Pharmacol Physiol. 2013;40 (1):13-21
Pei C, Chen H, Jia X, Yan L, Zou Y, Jiang C, Jin H, Kang C, Jiang T, Ren H*. A high frequency of MSH6 G268A polymorphism and survival association in glioblastoma. Int J Neurosci 2013; 123 (2):114-20.
Xiao Y, Fan H, Zhang Y, Xing W, Ping Y, Zhao H, Xu C, Li Y, Wang L, Li F, Hu J, Huang T, Lv Y, Ren H*, Li X*. Systematic identification of core transcription factors mediating dysregulated links bridging inflammatory bowel diseases and colorectal. PLoS One.2013; 8 (12):e83495.
Jia X, Hu M, Lin Q, Ren H Association of the IRF5 rs** polymorphism with rheumatoid arthritis: a meta-analysis. Rheumatol Int. 2013;33 (11):2757-61
Shi M, Huang R, Pei C, Jia X, Jiang C, Ren H* TP53 codon 72 polymorphism and glioma risk: A meta-analysis, Oncology Letters. 2012; 3(3):599-606.
Dong Y, Han Q, Zou Y, Deng Z, Lu X, Wang X, Zhang W, Jin H, Su J, Jiang T, Ren H*. Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells. Mol Cell Biochem. 2012; 370 (1-2):89-102.
He S, Wang C, Dong H, Xia F, Zhou H, Jiang X, Pei C, Ren H, Li H, Li R, Xu H. Immune-related GTPase M1 (IRGM1) regulates neuronal autophagy in a mouse model of stroke. Autophagy2012;8 (11):1621-7.
Xiao Y, Guan J, Ping Y, Xu C, Huang T, Zhao H, Fan H, Li Y, Lv Y, Zhao T, Dong Y, Ren H, Li X. Prioritizing cancer-related key miRNA-target interactions by integrative genomics. Nucleic Acids Res. 2012; 40 (16):7653-65.
Xu J, Li CX, Lv JY, Li YS, Xiao Y, Shao TT, Huo X, Li X, Zou Y, Han QL, Li X*, Wang LH*, Ren H*. Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA Target-Dysregulated Network: Case Study of Prostate Cancer. Mol Cancer Ther. 2011; 10 (10):1857-66.
Dong Y, Jia L, Wang X, Tan X, Xu J, Deng Z, Jiang T, Rainov NG, Li B, Ren H*. Selective inhibition on PDGFR by imatinib elicits sustained activation of ERK and downstream receptor signaling in malignant glioma cells. Int J Oncol. 2011; 38 (2):555-69.
Jia X, Hu M, Wang C, Wang C, Zhang F, Han Q, Zhao R, Huang Q, Xu H, Yuan H, Ren H*. Coordinated gene expression of Th17- and Treg-associated molecules correlated with resolution of the monophasic experimental autoimmune uveitis. Mol Vis. 2011; 7:1493-507.
Li X, Wang Q, Zheng Y, Lv S, Ning S, Sun J, Huang T, Zheng Q, Ren H, Xu J, Wang X, Li Y. Prioritizing human cancer microRNAs based on genes' functional consistency between microRNA and cancer. Nucleic Acids Res. 2011; 39 (22):e153.
Zheng H, Liu J, Liu C, Lu F, Zhao Y, Jin Z, Ren H, Leng X, Jia J, Hu G, Dong S, Zhong X, Li H, Yang B, Xu C, Zhang W. Calcium-sensing receptor activating phosphorylation of PKCδ translocation on mitochondria to induce cardiomyocyte apoptosis during ischemia/reperfusion. Mol Cell Biochem. 2011; 358 (1-2):335-43.
Xing WJ, Kong FJ, Li GW, Qiao K, Zhang WH, Zhang L, Bai SZ, Xi YH, Li HX, Tian Y, Ren H, Wu LY, Wang R, Xu CQ. Calcium-sensing receptors induce apoptosis during simulated ischaemia-reperfusion in Buffalo rat liver cells. Clin Exp Pharmacol Physiol. 2011; 38 (9):605-12.
Lu FH, Tian Z, Zhang WH, Zhao YJ, Li HL, Ren H, Zheng HS, Liu C, Hu GX, Tian Y, Yang BF, Wang R, Xu CQ. Calcium-sensing receptors regulate cardiomyocyte Ca2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation. J Biomed Sci. 2010;17; 17: 50.
Dong S, Teng Z, Lu FH, Zhao YJ, Li H, Ren H, Chen H, Pan ZW, Lv YJ, Yang BF, Tian Y, Xu CQ, Zhang WH. Post-conditioning protects cardiomyocytes from apoptosis via interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk. Mol Cell Biochem. 2010; 341(1-2):195-206.
Lu F, Tian Z, Zhang W, Zhao Y, Bai S, Ren H, Chen H, Yu X, Wang J, Wang L, Li H, Pan Z, Tian Y, Yang B, Wang R, Xu C. Calcium-sensing receptors induce apoptosis in rat cardiomyocytes via plasmic reticulum pathway during hypoxia/reoxygenation. Basic Clin Pharmacol Toxicol. 2010;106 (5):396-405.
Ren H*, Tan XQ, Dong YC, Giese A, Rainov NG. Differential effect of imatinib and synergism of combination treatment with chemotherapeutic agents in malignant glioma cells. Basic Clin Pharmacol Toxicol. 2009;104:241-252
Zhang Wei, Qiu Xiao-guang, Chen Bao-shi, Li Shou-wei, Cui Yun, Ren Huan and Jiang Tao. Antiangiogenic therapy with bevacizumab in recurrent malignant gliomas: analysis of the response and core pathway aberrations. Chin Med J 2009; 122 (11):1250-1254.
Li SW, Qiu XG, Chen BS, Zhang W, Ren H, Wang ZC, Jiang T. Prognostic factors influencing clinical outcomes of glioblastoma multiforme. Chin Med J 2009;122 (11):1245-9
Ren H*, Yang BF, Rainov NG. Receptor tyrosine kinases as therapeutic targets for malignant glioma. Rev Recent Clin Trials 2007; 2 (2) 87-101 (invited review)
Ren H, Giese A, Walker C, Pazmany L, Pelech S, Rainov NG Biological activity of the receptor tyrosine kinase inhibitor Imatinib mesylate (STI571) in malignant glioma. Neuro-Oncology 2004; 335: ET-20
Rainov NG, Ren H. Clinical trials with retrovirus mediated gene therapy--what have we learned? J Neurooncol. 2003 Dec; 65 (3): 227-36.
Rainov NG, Ren H. Gene therapy for human malignant brain tumors. Cancer J. 2003 May-Jun; 9 (3): 180-8.
Ren H, Boulikas T, Soling A, Warnke PC, Rainov NG. Immunogene therapy of recurrent glioblastoma multiforme with a liposomally encapsulated replication-incompetent Semliki forest virus vector carrying the human interleukin-12 gene--a phase I/II clinical protocol. J Neurooncol. 2003 Aug-Sep; 64(1-2): 147-54.
Rainov NG,Ren H. Oncolytic viruses for treatment of malignant brian tumors. Acta Neurochir Suppl. 2003; 88:113-23