许永， 男，研究员，博士生导师，1975年生
简历：
1998.9 – 2001.7 硕士， 辽宁师范大学化学系
2001.9 – 2004.7 博士， 药物发现与设计中心，中国科学院上海药物研究所
2004.8 – 2006.5 博士后，生命有机国家重点实验室，中国科学院上海有机化学研究所
2006.6 – 2011.8 博士后，结构生物学与药物发现中心，美国Van Andel研究所
2011.9 – 至今 研究员，中国科学院广州生物医药与健康研究院，中科院****
研究领域：
运用计算生物学、药物化学和结构生物学等方法研究生物大分子的结构与功能以及生物大分子与小分子间的相互作用，在此基础上针对重要靶标进行药物分子设计研究。
代表论著：
在国际期刊Nature，Science，Nature Medicine，Nature Structural & Molecular Biology，Cell Research，Science Signaling，Journal of Medicinal Chemistry等杂志上发表论40余篇。
发表论文
1. Wang, J.; Zou, J.X.; Xue, X.; Cai, D.; Zhang, Y.; Duan, Z.; Xiang, Q.; Yang, J.C.; Louie, M.C.; Borowsky, A.D.; Gao, A.C,; Evans, C.P.; Lam, K.S.; Xu, J.; Kung, H.J.; Evans, R.M.; Xu, Y.*; Chen, H.W.*; ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016, 22: 488-496. (highlighted by Nature, Nature Review Urology)
2. Zheng, S.; Tang, Q.; He, J.; Du, S.; Xu, S.; Wang, C.; Xu, Y.; Lin, F.; VFFDT: A New Software for Preparing AMBER Force Field Parameters for Metal-Containing Molecular Systems. J Chem Inf Model. 2016, 56: 811-818.
3. Wang, Z.; Bian, H.; Bartual, S.G.; Du, W.; Luo, J.; Zhao, H.; Zhang, S.; Mo, C.; Zhou, Y.; Xu, Y.; Tu, Z.; Ren, X; Lu, X.; Brekken, R.A.; Yao, L.; Bullock, A.N.; Su, J.; Ding, K.; Structure-Based Design of Tetrahydroisoquinoline-7-Carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem. 2016, May 24. [Epub ahead of print]
4. Song, Y.; Xue, X.; Wu, X.; Wang, R.; Xing, Y.; Yan, W.; Zhou, Y.; Qian, C-N.; Zhang, Y.; Xu, Y.*; Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. Eur J Med Chem, 2016, 116, 13-26.
5. Xue, X.; Zhang, Y.; Liu, Z.; Song, M.; Xing, Y.; Xiang, Q.; Wang, Z.; Tu, Z.; Zhou, Y.; Ding, K.; Xu, Y. Discovery of benzo[cd]indol-2(1H)-ones as potent and specific BET bromodomain inhibitors: structure-based virtual screening, optimization, and biological evaluation. J Med Chem, 2016, 59, 1565-1579.
6. Zhao, X.; Zhang, Z. W.; Cui, W.; Chen, S. W.; Zhou, Y.; Dong, J. H.; Jie, Y. L.; Wan, J. T.; Xu, Y.; Hu, W. H. Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus. Medchemcomm, 2015, 6, 727-731.
7. Zhang, Y.; Luo, X. Y.; Wu, D. H.; Xu, Y. ROR nuclear receptors: structures, related diseases, and drug discovery. Acta Pharmacol Sin, 2015, 36, 71-87.
8. Xu, S.; Mao, L.; Ding, P.; Zhuang, X.; Zhou, Y.; Yu, L.; Liu, Y.; Nie, T.; Xu, T.; Xu, Y.; Liu, J.; Smaill, J.; Ren, X.; Wu, D.; Ding, K. 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor gamma and promote the browning of white adipose. Bioorg Med Chem, 2015, 23, 3751-3760.
9. Xu, P.; Wang, J.; Xu, Y.; Chu, H.; Shen, H.; Zhang, D.; Zhao, M.; Liu, J.; Li, G. Binding modes and interaction mechanism between different base pairs and methylene blue trihydrate: a quantum mechanics study. Adv Exp Med Biol, 2015, 827, 187-203.
10. Xu, P.; Wang, J.; Xu, Y.; Chu, H.; Liu, J.; Zhao, M.; Zhang, D.; Mao, Y.; Li, B.; Ding, Y.; Li, G. Advancement of polarizable force field and its use for molecular modeling and design. Adv Exp Med Biol, 2015, 827, 19-32.
11. Wu, X.; Xu, P.; Wang, J.; Xu, Y.; Fu, T.; Zhao, M.; Zhang, D.; Liu, J.; Shen, H.; Xiu, Z.; Li, G. Theoretical studies on the folding mechanisms for different DNA G-quadruplexes. Adv Exp Med Biol, 2015, 827, 123-141.
12. Wu, X.; Xu, P.; Wang, J.; Xu, Y.; Fu, T.; Zhang, D.; Zhao, M.; Liu, J.; Shen, H.; Xiu, Z.; Li, G. Folding mechanisms of Trefoil Knot proteins studied by molecular dynamics simulations and Go-model. Adv Exp Med Biol, 2015, 827, 93-110.
13. Liu, T.; Wang, B.; Guo, J.; Zhou, Y.; Julius, M.; Njire, M.; Cao, Y.; Wu, T.; Liu, Z.; Wang, C.; Xu, Y.; Zhang, T. Role of folP1 and folP2 genes in the action of sulfamethoxazole and trimethoprim against mycobacteria. J Microbiol Biotechnol, 2015, 25, 1559-1567.