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广州医科大学生物化学与分子生物学导师教师师资介绍简介-李志远

本站小编 Free考研考试/2021-05-31


李志远, 男,研究员,博士生导师,1965年生。
简历:
1997年获中南大学药理学博士学位
2000年获得日本德岛大学(Tokushima University)博士学位
2000-2002年 在美国范德堡大学(Vanderbilt University)药理学系从事博士后
2002-2007年 在美国圣路易斯大学(Saint Louis University)医学院从事助理教授
2007年-至今 在中国科学院广州生物医药与健康研究院担任研究员
研究领域:
1、细胞膜离子通道蛋白的研究
2、P2X受体的结构与功能研究
3、干细胞的神经分化与电生理研究

代表论著:
1.Deng S, Hou G, Xue Z, Zhang L, Zhou Y, Liu C, Liu Y, Li Z *, Vitamin E isomer -tocopherol enhances the ef?ciency of neural stem cell differentiation via L-type calcium channel, Neuroscience Letters. (2014) 585C:166-170.
2.Jie Y, Zhang L, Xu H, Gao C, Ma W, Li Z, Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement. Neurosci Lett. (2014) 582C:1-5.
3.Zhang L, Xu H, Jie Y, Gao C, Chen W, Yin S, Samways DS, Li Z, Involvement of Ectodomain Leu 214 in ATP Binding and Channel Desensitization of the P2X4 Receptor. Biochemistry. (2014) 53(18): 3012-3019.
4.Chen W, Liu J, Zhang L, Xu H, Guo X, Deng S, Liu L, Yu D, Chen Y, Li Z, Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique. Scientific Reports. . (2014) 4:5404.
5.Long Y, Chen W, Lin Z, Sun H, Xia M, Zheng W, Li Z, Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol. . (2014) 737C: 202-209.
6.Samways DS, Li Z, Egan TM. Principles and properties of ion flow in P2X receptors. Front Cell Neurosci. (2014) 8: 6
7.Liang X, Xu H, Xu T, Liu J, Li Z. Identification of an Intrasubunit Interaction between His33 and Ser345 in the Rat P2X2 Receptor. PloS One (2013) 6;8(8): e70629. doi: 10.1371/journal.pone.**.
8.Li C, Long Y, Lin Z, Jie Y, Xiao Y, Yang L, Sun J, Ren Y, Chen L, Li Z.New strategy for high throughput screening of anti-influenza virus m2 ion channel inhibitors. Current Pharmacology Design. (2013) 19 (28): 5146-55.
9.Long Y, Lin Z, Xia M, Zheng W,LiZ. Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride. Toxicology and Applied Pharmacology 267 (2013) 155–166.
10.Samways DS, Migita K, Li Z, Egan TM. Principles and properties of ion flow in P2X receptors. (2013) Frontiers in Cellular Neuroscience. 8f16-ede35c613a45.
11.Su H, Wang L, CaiJ, Yuan Q, Yang X, Yao X, Wong W, Huang W, Li Z, Wan J, Wang Y, Pei P, So K, Qin D, Wu W.Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle. (2013) Stem Cell Research11, 529–539
12.Hu X, Chen D, Cui Y, Li Z, Huang J. Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10. (2013) Scientific Reports. Dec 5;3:3423doi: 10.1038/srep03423.
13.Pan A, Li M, Gao J, Xue Z, Li Z,Yuan X, Luo D, Luo X, Yan X. Experimental Epidural Hematoma Causes Cerebral Infarction and Activates Neocortical Glial and Neuronal Genesis in Adult Guinea Pigs. (2013) Journal of neuroscience research, 91(2): 249-261.
14.Lu D, He L, Xiang W, Ai W, Cao Y,Wang X, Pan A, Luo X, Li Z, Yan X. Somal and Dendritic Development of Human CA3 Pyramidal Neurons From Midgestation to Middle Childhood: A Quantitative Golgi Study. (2013) The Anatomical Record, 296(1): 123-132.
15.Su H, Wang L, Huang W, Qin D, CaiJ, Yao X, FengC, Li Z, Wang Y, So K, Pan G, Wu W, Pei D.Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells. (2013) Stem Cell Research10, 338–348


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