彭广敦，男，研究员，博士生导师，1980年生
简历：
2009年毕业于中国科学院上海生物化学与细胞生物学研究所，获得博士学位；在美国加州大学洛杉矶分校从事博士后研究；回国后在中国科学院上海生物化学与细胞生物学先后担任助理研究员、副研究员。2018年9月入职中国科学院广州生物医药与健康研究院，担任研究员、课题组长、博士生导师。

研究领域：
主要研究多能干细胞的时空动态分子图谱以及转化应用
一：高通量自动化单细胞测序技术解析体内干细胞的功能分群与异质性，重绘干细胞的发育起源与命运特化机制；
二：原位空间转录组技术解析空间功能特异的干细胞转录组特征，构建哺乳动物多能干细胞高分辨率的时空动态分子谱系；
三：新型组织干细胞用于体外器官重建与功能修复
承担科研项目情况：
国家重点研发计划重点专项
中国科学院战略性先导科技专项
国家自然科学基金面上项目
广东省自然科学基金****项目
国际干细胞学会（ISSCR）会员
获奖及荣誉：
Sanofi-SIBS 2017 Distinguished Young Faculty
ISSCR 2017 Poster Award and Travel Award
代表论著：

1. Peng, G*., Cui, G., Ke, J. and Jing, N. (2020) Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annu Rev Genomics Hum Genet,doi: 10.1146/annurev-genom-120219-083220
2. Kim, H.J., Osteil, P., Humphrey, S.J., Cinghu, S., Oldfield, A.J., Patrick, E., Wilkie, E.E., Peng, G., Suo, S., Jothi, R., Tam, P.P.L. and Yang, P. (2020) Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning. Nucleic Acids Res48,1828-1842.
3. Zhang, K., Yu, F., Zhu, J., Han, S., Chen, J., Wu, X., Chen, Y., Shen, T., Liao, J., Guo, W., Yang, X., Wang, R., Qian, Y., Yang, J., Cheng, L., Zhao, Y., Hui, C.C., Li, J., Peng, G., He, S., Jing, N. and Tang, K. (2020) Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation. Cell Rep 31,107521.
4. He, D.D., Tang, X.T., Dong, W., Cui, G., Peng, G., Yin, X., Chen, Y., Jing, N. and Zhou, B.O. (2020) C-KIT Expression Distinguishes Fetal from Postnatal Skeletal Progenitors. Stem Cell Reports doi: 10.1016/j.stemcr.2020.03.001
5. Peng G*, Suo S, Cui G, Yu F, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han JJ*, Jing N* (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature,572:528–532
6. Niu Y, Sun N, Li C, Lei Y, Huang Z, Wu J, Si C, Dai X, Liu C, Wei J, Liu L, Feng S, Kang Y, Si W, Wang H, Zhang E, Zhao L, Li Z, Luo X, Cui G, Peng G, Izpisúa Belmonte JC, Ji W, Tan T (2019) Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science,366: doi:10.1126/science.aaw5754
7. Cui G, Jing N, Peng G* (2019) Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo’. Journal of Molecular Cell Biology,doi:10.1093/jmcb/mjz101
8. Yang X, Hu B, Liao J, Qiao Y, Chen Y, Qian Y, Feng S, Yu F, Dong J, Hou Y, Xu H, Wang R, Peng G, Li J, Tang F, Jing N (2019) Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development. Cell Research,29: 911–926
9. Zhou Y, Wang X, Song M, He Z, Cui G, Peng G, Dieterich C, Antebi A, Jing N, Shen Y (2019) A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing. Nature Communications,10: 4827
10. Yu W, Ma X, Xu J, Heumüller AW, Fei Z, Feng X, Wang X, Liu K, Li J, Cui G, Peng G, Ji H, Li J, Jing N, Song H, Lin Z, Zhao Y, Wang Z, Zhou B, Zhang L (2019) VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genetics,15: e**
11. Song W, Wang R, Jiang W, Yin Q, Peng G, Yang R, Yu QC, Chen J, Li J, Cheung TH, Jing N, Zeng YA (2019) Hormones induce the formation of luminal-derived basal cells in the mammary gland. Cell Research,29: 206–220
12. Cheng S, Pei Y, He L, Peng G, Reinius B, Tam PPL, Jing N, Deng Q (2019) Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development. Cell Reports,26: 2593–2607.e3
13. Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H*, Zhou B* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nature Genetics,51: 728–738
14. Osteil P, Studdert JB, Goh HN, Wilkie EE, Fan X, Khoo PL, Peng G, Salehin N, Knowles H, Han JJ, Jing N, Fossat N, Tam PPL (2019) Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells. Development,146, doi:10.1242/dev.172858
15. Xue Y, Liu D, Cui G, Ding Y, Ai D, Gao S, Zhang Y, Suo S, Wang X, Lv P, Zhou C, Li Y, Chen X, Peng G, Jing N, Han JJ, Liu F (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports,27: 1567–1578.e5
16. Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ (2018) Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation. Cell Stem Cell,23: 586–598.e8
17. Peng G, Han JJ (2018) Regulatory network characterization in development: challenges and opportunities. F1000Res,7:
18. Cui G, Suo S, Wang R, Qian Y, Han JJ, Peng G*, Tam PPL*, Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Dev Growth Differ,60: 463–472
19. Christodoulou N, Kyprianou C, Weberling A, Wang R, Cui G, Peng G, Jing N, Zernicka-Goetz M (2018) Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation. Nature Cell Biology, 20: 1278–1289
20. Sibbritt, T., Ip, C. K., Khoo, P. L., Wilkie, E., Jones, V., Sun, J. Q. J., Shen, J. X., Peng, G., Han, J. J., Jing, N., Osteil, P., Ramialison, M., Tam, P. P. L., and Fossat, N. (2018). A gene regulatory network anchored by LIM homeobox 1 (LHX1) for embryonic head development. Genesis 56: e23246
21. Liu C, Wang, R, He Z, Osteil P, Yang X, Chen J, Peng G, Tam P, Jing N (2018), Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells. Stem Cell Reports 11, 43-57.
22. Yang X, Hu B, Hou Y, Qiao Y,, Wang R, Chen Y, Qian Y, Feng S, Chen J, Liu C, Peng G, Tang F and Jing N (2018). Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages. Cell Research 28(5):593-596.
23. Han, X#, Luo, S#, Peng G#, Lu, JY, Cui G, Liu L, Yan P, Yin Y, Liu W, Wang R, Chang Z, Na J, Jing N*, and Shen X* (2018). Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development. Journal of Molecular Cell Biology.10:175-178.