姓名：何俊
性别：男
职称：研究员
学历：博士
电话：
传真：
电子邮件:he_jun@gibh.ac.cn
通讯地址广州市科学城开源大道190号

简历：

2018 中科院广州生物医药与健康研究院 研究员2016-2018 Senior Scientist, UCB Pharma
2013-2016 Post-doctoral Research Fellow, the Francis Crick Institute. Supervisor: Dr. John Diffley, FRS
2012-2013 Post-doctoral Scientist, The Institute of Cancer Research, London. Supervisor: Dr David Barford, FRS
2008-2012 PhD at The Institute of Cancer Research, London. Supervisors: Dr David Barford FRS and Dr Ed Morris
2002-2006 理学学士 清华大学 生物科学

研究领域：

综合低温冷冻电镜技术和X射线晶体学技术等多种结构生物学研究手段，在多尺度上来研究生物系统的高分辨率构造。主要研究方向为调控细胞命运调控因子的结构与功能的关系，以及细胞命运转变分子机制的探索。

承担科研项目情况：

社会任职：

获奖及荣誉：

2013 Chairman’s Prize for Best PhD, the Institute of Cancer Research
2012 Chinese Government Award for outstanding students abroad

代表论著：

Frigola, J.*, He, J.*, Kinkeilin, K., Pye, V., Renault, L., Douglas, M., Remus, D., Cherepanov, P., Costa, A., Diffley, J.F.X. (2017). Cdt1 stabilises an open MCM ring for helicase loading. Nat. Commun, 8, 15720.He, J.*, Chao, W.C.*, Zhang, Z., Yang, J., Cronin, N., & Barford, D. (2013). Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Molecular cell, 50(5):649-60.
da Fonseca, P. C., He, J., & Morris, E. P. (2012). Molecular model of the human 26S proteasome. Molecular cell, 46(1), 54-66.
He, J.*, Kulkarni, K.*, da Fonseca, P. C., Krutauz, D., Glickman, M. H., Barford, D., & Morris, E. P. (2012). The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings. Structure, 20(3), 513-521.