性别：男
职称：副研究员
学历：博士
电话：
传真：
电子邮件:jiang_zhiwu@gibh.ac.cn
通讯地址广州市科学城开源大道190号
简历：
2016.07至今中国科学院广州生物医药与健康研究院，副研究员
2013/09-2016/06
中国科学院广州生物医药与健康研究院，细胞生物学，理学博士
2012/07-2013/09
中国科学院广州生物医药与健康研究院，研究实习员
2009/09-2012/07
汕头大学，免疫学，医学硕士
2005/09-2009/07
烟台大学，生物技术，理学学士
研究领域：
1. 肿瘤免疫治疗研究：靶向肝癌的新型嵌合抗原受体T细胞研发和临床前评估2. B急性髓性淋巴细胞白血病的异质性和耐药机制研究
3. 人源化小鼠研究：肿瘤病人来源的异种移植模型（PDX）、肝脏人源化小鼠模型
承担科研项目情况：
社会任职：
获奖及荣誉：
代表论著：
1. （2017年）第十九届中国专利优秀奖、专利名称：一种免疫缺陷小鼠模型的建立方法、专利号：CN9.9、主要发明人（第三）2. （2017年）第四届广东省专利优秀奖、专利名称：一种免疫缺陷小鼠模型的建立方法、专利号：CN9.9、主要发明人（第三）
承担项目情况
1. 国家自然科学基金-面上项目、“构建用于评估临床前免疫治疗效果的肝癌人源化小鼠模型”、2018-2021年、国家级拨款/80（万元）、项目负责人
2. 广东省自然科学基金-博士启动项目、“CD34阳性/阴性的B-ALL起始细胞群的异质性耐药机制研究”、2017-2019年、广东省拨款/10（万元）、项目负责人
3. 广州市科技计划项目（一般项目）、“新型人源化肝脏小鼠模型的构建及其应用”、2019-2021年、广州市拨款/20（万元）、项目负责人
期刊论文发表
第一作者论文：
1. Zhiwu Jiang#, Xiaofeng Jiang#, Suimin Chen, Yunxin Lai, Xinru Wei, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubing Liang, Qifa Liu, MuyunPeng, Fenglei Yu, JiangyuWeng, Xin Du, Duanqing Pei, Pentao Liu, Yao Yao, Ping Xue, Peng Li*., Anti-GPC3 CAR T cells suppress the growth of tumour cells in patient-derived xenografts of hepatocellular carcinoma. Front. Immunol. 11 January 2017.（IF=5.511）
2. Zhiwu Jiang#; Manman Deng#; Xinru Wei; Wei Ye; Yiren Xiao; Simiao Lin; Suna Wang; Baiheng Li; Xin Liu; Gong Zhang; Peilong Lai; Jianyu Weng; Donghai Wu; Haijia Chen; Wei Wei; Yuguo Ma; Yangqiu Li; Pentao Liu; Xin Du; Duanqing Pei; Yao Yao; Bing Xu*; Peng Li*.Heterogeneity of CD34 and CD38 expression in adult acute B lymphoblastic leukemia cells is reversible and not hierarchically organized. J Hematol Oncol. 2016 Sep 22;9(1):94. （IF=7.333）
3. Deng M#, Zha J#, Jiang Zhiwu#, Jia X, Shi Y, Li Peng, Chen XL, Fang Z, Du Z, Xu B. Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia. J Transl Med. 2018 Feb 28;16(1):47. （IF=4.197）
4. Zhiwu Jiang#, Wu D, Ye W, Weng J, Lai P, Shi P, Guo X, Huang G, Deng Q, Tang Y, Zhao H, Cui S, Lin S, Wang S, Li B, Wu Q, Li Y, Liu P, Pei D, Du X, Yao Y, Li P. Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia. Oncotarget. 2017 Nov 15;8(63):106382-106392. （IF=5.168）
5. Wei Ye#, Zhiwu Jiang #, Xiaoyun Lu, Xiaomei Ren, Manman Deng, Shouheng Lin, Yiren Xiao, Simiao Lin, Suna Wang, Baiheng Li, Yi Zheng, Peilong Lai, Jianyu Weng, Donghai Wu, Yuguo Ma, Xudong Chen, Zhesheng Wen, Yaoyu Chen, Xiaoyan Feng, Yangqiu Li, Pentao Liu, Xin Du, Duanqing Pei, Yao Yao, Bing Xu, Ke Ding*, Peng Li*.GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways. Oncotarget. July 28, 2016. （IF=5.168）
6. Deng M#, Jiang Zhiwu#, Li Y, Zhou Y, Li J, Wang X, Yao Y, Wang W, Li Peng*, Xu B*. Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models. Oncotarget. 2016 May 17. doi: 10.18632/oncotarget.9413. （IF=5.168）
7. W Ye#; Zhiwu Jiang#; Y Xiao; S Lin; B Jia; Y Li; Z Huang; J Li; F Feng; S Li; H Yao; Z Liu; S Cao; L Xu; Y Li; D Wu; L Zeng; M Zhong; P Liu; Z Wen; B Xu; Y Yao; Y Lai, D Pei*; Peng Li*;. Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments. Journal of Hematology & Oncology. 2015 May 29;8:59. doi: 10.1186/s13045-015-0156-y. （IF=7.333）
8. Wei Li#, Zhiwu Jiang#, Tianzhong Li, Xinru Wei, Yi Zheng, Donghai Wu, Lijian Yang, Shaohua Chen, Bing Xu, Mei Zhong, Jue Jiang, Yufeng Hu, Hexiu Su, Minjie Zhang, Xiaojun Huang, Suxia Geng, Jianyu Weng, Xin Du, Pentao Liu, Yangqiu Li, Hudan Liu, Yao Yao（通讯） and Peng Li（通讯）. Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes. Molecular Cancer. 2015 14:26. doi:10.1186/s12943-014-0285-x.. （IF= 7.776）
9. Zhiwu Jiang, Di Wu, Shouheng Lin and Peng Li., CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia. Biomarker Research. 2016 4:23.
非第一/通讯作者论文：
1. Zhang Kun; Zhang Ludi; Liu Wenming; Ma Xiaolong; Cen Jin; Sun Zhen; Wang Chenhua; Feng Sisi; Zhang Zhengtao; Yue Liyun; Sun Lulu; Zhu Zhenfeng; Chen Xiaotao; Feng Anqi; Wu Jiaying; Jiang Zhiwu; Li Peng; Cheng Xin; Gao Dong; Peng Luying; Hui Lijian,. InVitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity. Cell Stem Cell. 2018 Oct 30. IF=23.29
2. Chen X, Lai P, Wang Y, He C, Wu S, Huang X, Geng S, Luo C, Ling W, Zeng L, Li Peng, Jiang Zhiwu, Weng J, Du X. Emerging role of C5a/C5aR IL-17A axis in cGVHD. Am J Transl Res. 2018 Jul 15;10(7):2148-2157. eCollection 2018. （IF=3.061）
3. Weng J, Lai P, Qin L, Lai Y, Jiang Z, Luo C, Huang X, Wu S, Shao D, Deng C, Huang L, Lu Z, Zhou M, Zeng L, Chen D, Wang Y, Chen X, Geng S, Robert W, Tang Z, He C, Li P, Du X. A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia. J Hematol Oncol. 2018 Feb 20;11(1):25.
4. Shi P, Zhang L, Chen K, Jiang Z, Deng M, Zha J, Guo X, Li P, Xu B. Low-dose decitabine enhances chidamide-induced apoptosis in adult acute lymphoblast leukemia, especially for p16-deleted patients through DNA damage. Pharmacogenomics. 2017 Aug;18(13):1259-1270.
5. Zhang L, Zhou Y, Chen K, Shi P, Li Y, Deng M, Jiang Z, Wang X, Li P, Xu B. The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells. Target Oncol. 2017 Oct;12(5):677-687.
6. Xiao Y, Jiang Zhiwu, Li Y, Ye W, Jia B, Zhang M, Xu Y, Wu D, Lai L, Chen Y, Chang Y, Huang X, Liu H, Qing G, Liu P, Li Y, Xu B, Zhong M, Yao Y, Pei D（通讯）, Peng Li（通讯）. ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells. Haematologica. 2015 Jan 30. pii: haematol.2014.118612. [Epub ahead of print]
7. Yiren Xiao, Xinru Wei, Zhiwu Jiang, Xiangmeng Wang, Wei, Xin Liu, Minjie Zhang, Yan Xu, Donghai Wu, Liangxue Lai, Huihui Yao, Zixia Liu, Su Cao, Pentao Liu, Bing Xu, Yangqiu Li, Yao Yao, Duanqing Pei（通讯） and Peng Li（通讯）. Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells. Journal of Hematology & Oncology. J Hematol Oncol. 2015 Feb 6;8(1):7. [Epub ahead of print].
8. Wang G, Li R, Zhiwu Jiang, Gu L, Chen Y, Dai J, Li K. Influenza Virus Induces Inflammatory Response in Mouse Primary Cortical Neurons with Limited Viral Replication. Biomed Res Int. 2016;2016:**. doi: 10.1155/2016/**.
9. Song J, Zhong J, Guo X , Zhang Q, Jiang Zhiwu, Chen Y, Zou Q, Yang H, Huang J. Li X,Li P, Pei D, Lai L.aJiao , Xiaoping Li3Generation of RAG 1 and 2 deficient rabbits by embryo microinjection of TALENs, Cell Research. 2013, 2013 Aug;23(8)
10. Zhao H, Shi P, Deng M, Jiang Zhiwu, Li Y, Kannappan V, Wang W, Peng Li, Xu B. Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption. Oncotarget. 2016 Nov 19. doi: 10.18632/oncotarget.13454.
11. Yin Li, Kai Chen, Yong Zhou, Yiren Xiao, Manman Deng, Zhiwu Jiang, Wei Ye, Xiangmeng Wang, Xinru Wei, Jie Li, Jiabao Liang, Zhongxin Zheng, Yao Yao, Weiguang Wang, Peng Li*, Bing Xu*. A New Strategy to Target Acute Myeloid Leukemia Stem and Progenitor Cells Using Chidamide, a Histone Deacetylase Inhibitor. Current Cancer Drug Targets. 2015;15(6):493-503.
12. Li WZ, Wang GF, Zhang Heng, Shen Yanqin, Dai Jianping, Wu Liqi, Zhou Jianxiang, Jiang Zhiwu, Li Kangsheng, Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition. Vet Res, 2012. 43: p.
13. Zeng J, Wang G, Li W, Zhang D, Chen X, Xin G, Jiang, Zhiwu, Li K. Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes. Virol J. 2013 May 21;10:157. doi: 10.1186/1743-422X-10-157.
14. Yang, Song，Kuang, Ye，Li, Hongbo，Liu, Yuehong，Hui, Xiaoyan，Li, Peng，Jiang, Zhiwu，Zhou, Yulai，Wang, Yu，Xu, Aimin，Li, Shiwu，Liu, Pentao，Wu, Donghai(*) ，Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1' site ，PLos One，2013，8（9）：1-11.
15. 邓漫漫; 蒋治武; 李洁; 陈凯; 李鹏; 周淑芸; 徐兵、Disulfiram联合铜对B淋巴细胞白血病细胞株增殖与凋亡影响机制探讨、中华肿瘤防治杂志, 11期, pp 840-845, 2015.
16. 周健祥,王革非,蒋治武,曾俊,苏芸,李康生. 流感病毒诱导小鼠胶质细胞的细胞因子级联反应[J]. 中国免疫学杂志. 2012(01)
17. 蒋治武,王革非,周健祥,陈小璇,许燕璇,苏芸,李康生. 流感病毒感染小鼠星形胶质细胞诱导GDNF转录水平上调[J]. 中国热带医学. 2012(06)
18. 谢泽锋,苏芸,蒋治武,许燕璇,辛岗,李康生. LPS预激神经胶质细胞培养上清对神经元的影响[J]. 中国热带医学. 2012(06)
会议论文发表
1. Jiang, Zhiwu; Deng, Manman; Xu, Bing; Li, Peng. NO HIERARCHICAL HETEROGENEITY IN ADULT B-ALL LYMPHOID NEOPLASIA. 44th ISEH, 2015/9/17-2015/9/19, p S70, Kyoto, JAPAN, 2015/9.
2. Jiang, Zhiwu; Deng, Manman; Lu, Yi; Xu, Bing; Li, Peng. Heterogeneity of CD34 and CD38 expression in adult acute B lymphoblastic leukemia cells is reversible and not hierarchically organized. 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), 2015/4/18-2015/4/22, Philadelphia, PA, 2015/8/1.
3. Li, Peng; Jiang, Zhiwu., Identification of growth factors that promote the proliferation and drug resistance of human primary acute B lymphoblastic cells. AACR 107th, CANCER RESEARCH, 76: 14: 5201
4. Li Lin, Xu Na, Jiang Zhiwu, Lu Qisi, Zhou Xuan, Lu Ziyuan, Huang Jixian, Li Yuling, He Bolin, Pan Chengyun, Li Peng and Liu Xiaoli., EphB4/ephrinB2 ephrinB1 Interaction Mediated Chronic Myelogenous Leukemia Mesenchymal Stromal Cells Osteogenic Differentiation in Vitro and In Vivo. Blood 2016 128:1901; : 58th ASH
5. Xu, B; Li, Y; Chen, K; Zhou, Y; Xiao, YR; Deng, MM; Jiang, ZW; Ye, W ; Wei, XR; Wang, XM; Li, J; Liang, JB; Zheng, ZX; Yao, Y; Wang, WG; Li, P., A New Strategy to Target Acute Myeloid Leukemia Stem and Progenitor Cells Using Chidamide, a Histone Deacetylase Inhibitor. 57th ASH, BLOOD, 126: 23
6. Xu, B ; Deng, MM; Jiang, ZW; Li, J; Chen, K; Li, P., Role of Mitochondrial Apoptotic Pathway in Disulfiram/Copper Mixture-Induced Cell Apoptosis in Human B-Lineage Acute Lymphoblastic Leukemia in Vitro. 57th ASH, BLOOD, 126: 23
专利申请
1. “一种检测嵌合抗原受体T细胞对肝癌细胞抑制作用的方法”、李鹏、蒋治武、吴迪、林思妙、秦乐、李柏衡、王素娜、吴绮婷、陈冬梅、姚瑶、专利号：CN3.8，已受理；
2. “一种原代细胞的培养方法”、李鹏，蒋治武，林思妙，叶未，姚瑶、专利号：一种人原代细胞培养基及其应用、PCT/CN2015/079846、已进入国家阶段；
3. “一种原代B细胞急性淋系白血病细胞的体外培养方法”、李鹏, 蒋治武, 林思妙, 魏新茹、专利号：2.7、专利受理。
4. “一种评估小鼠免疫缺陷程度的方法”、李鹏，叶未，肖毅仁，蒋治武，林思妙，姚瑶，王素娜，李柏衡、专利号：CN9.3、受理阶段；
5. “一种免疫缺陷小鼠模型的建立方法”、李鹏，刘志新，蒋治武，王素娜，钟梅，贾蓓、专利号：CN9.9，已授权；
6. “一种使BCL11B蛋白降解的方法”、李鹏, 李田忠,蒋治武,吴东海、专利号：CN8.7、已授权；（授权公告日：2015.01.21）
7. “一种扩增脐带血造血干细胞的细胞因子及其培养基”、李鹏, 肖毅仁,蒋治武,赖允鑫,姚瑶、专利号：CN5.0、已授权；（授权公告日：2016.06.29）
8. “一种人体造血干细胞分化培养方法”、李鹏, 李巍,蒋治武、专利号：CN4.2、已授权；（授权公告日：2016.06.15）
