性别：男
职称：研究员
学历：博士
电话：
传真：
电子邮件:liu_xingguo@gibh.ac.cn
通讯地址广州市开源大道190号
简历：
2002年-2006年：清华大学生物科学与技术系，博士1998年-2002年：山东大学生命科学学院，学士
2007年-2010年: Thomas Jefferson University, 博士后
2010年－至今： 中国科学院广州生物医药与健康研究院 研究员
·8个国际杂志编委
·亚洲线粒体研究与医学学会常务理事
研究领域：
·干细胞命运调控中的核与线粒体等细胞器重塑·人类线粒体疾病的病理与干细胞治疗
承担科研项目情况：
社会任职：
获奖及荣誉：
·国家自然科学“杰出青年“基金·国家重点研发计划首席科学家
·国家自然科学优秀青年基金
·****奖励计划青年学者
·2016年干细胞青年研究员奖
·广东省特支计划－科技创新“领军人才”
·广东省自然科学杰出青年基金获得者（首届）
·国际生物物理学会 "2011YoungBioenergeticistaward"
·中国科学院广州教育基地优秀研究生导师
·中国科学院广州分院优秀青年科学家
·臻溪生命科学优秀教育工作者奖教金
代表论著：
1. Ying, Z., Xiang G., Zheng, L., …& Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 28(6):935-945.2. Ying, Z., Chen K., Zheng L., …& Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1): 220-226.
3. Li, L., Chen, K., Wang, T., ……Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2(9):882-892.
4. Guo, J., Duan, L., He, X.,……Liu, X*. (2021). A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome. Advanced Science Mar 08 online, DOI: 10.1002/advs..
5. Li, S., Guo, J., Ying, Z., ... & Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model.Hepatology,61(5):1730-1739.
6. Wu, Y., Chen, K., Xing, G., …& Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances, 5(11): eaax7525。
7. Chen, K., Long, Q., Xing, G., …Pei, D*& Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal, 39(1): e99165 (F1000 recommendation)
8. Xiang, G., Yang, L., Long, Q., …& Liu, X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy, 13(9): 1543-1555.
9. Zhou, Y., Long, Q., Wu, H., …& Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy, 16(3):562-574. (Cover Story)
10. Chen, K., Long, Q., Wang, T., … Liu, X* & Pei, D*. (2016) Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Reports,17(11): 1641-1656. (co-corresponding author)
11. Yang, L., Lin, X., Tang, H.,....Liu, X*. (2020). Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell 19(9):e13206.
12. Yang, L., Long, Q., Liu, J., ... & Liu, X*. (2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA.Cellular and Molecular Life Sciences, 72(13):2585-2598.
13. Bao, F., Shi, H., Gao, M.,…& Liu, X*. (2018). Polybrene induces neural degeneration by bidirectional Ca2+ influx dependent mitochondrial and ER-mitochondrial dynamics. Cell Death & Disease, 9(10): 966.
14. Li, L., Chen, K., Wu, Y., …& Liu, X*. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death Disease, 8(10): e3107.
15. Lin, Y., Xiao, M., Chen, H., Meng, Y., Zhao, N., Yang, L., Tang, H., Wang, J., Liu, X*, Zhu, Y.*, Zhuang, S.*. (2019). A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death & Disease, 10(7):528. (co-corresponding author)
16. Wu, Y., Chen, K., Liu, X., ... & Liu, X*. (2015). Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming.Stem Cells, 34(1): 83-92.
17. Yang, L., Tang, H., Lin, X....& Liu, X*. (2020) OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. Frontiers in Cell and Developmental Biology, 8: 180.
18. Long, Q., Zhao, D., Fan, W., ... Wang X* & Liu, X*. (2015). Modeling of Mitochondrial Donut Formation.Biophysical Journal,109(5), 892-899. (co-corresponding author)
19. Bao, F., Shi, H., Long, Q., …& Liu, X*. (2016). Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration. CNS Neuroscience & Therapeutics, 22(8), 648-660. (Cover Story)
20. Liu, W., Long, Q., Chen, K., ... & Liu, X*. (2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation.Biochemical and Biophysical Research Communications,431(4), 767-771.
21. Liu, X., Weaver, D., Shirihai, O., & Hajnóczky, G. (2009). Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics. The EMBO Journal,28(20), 3074-3089. (F1000 recommendation)
22. Liu, X., & Hajnoczky, G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress. Cell Death & Differentiation,18(10), 1561-1572. (F1000 recommendation)
23. Weaver, D., Eisner, V., Liu, X., … & Hajnóczky, G. (2014). Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion.Molecular Cell,54(5), 870-878. (co-first author)
