黄承浩
博士，现任厦门大学公共卫生学院副教授

电子邮件: huangchenghao@xmu.edu.cn
工作地址：厦门大学翔安校区国家传染病诊断试剂与疫苗工程技术研究中心（椭圆楼）312室
工作电话：


学习经历
2012.8-2013.3 访问**** 哈佛大学医学院布里格姆妇女医院
2008.9-2014.12 博士 厦门大学


主要研究方向
溶瘤病毒与肿瘤治疗
肿瘤的免疫调节及免疫治疗研究
肿瘤致癌机制研究


代表性论文
1.Lin, C.#, Ren, W.#, Luo, Y., Li, S., Chang, Y., Li, L., Xiong, D., Huang, X., Xu, Z., Yu, Z., Wang, Y., Zhang, J., Huang, C.* and Xia, N.* Intratumoral Delivery of a PD-1-blocking scFv encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade. Cancer Immunol Res, doi:10.1158/2326-6066.CIR-19-0628 (2020). (*Co-correspondence)
2.Luo, Y.#, Lin, C.#, Zou, Y., Ju, F., Ren, W., Lin, Y., Wang, Y., Huang, X., Liu, H., Yu, Z., Liu, P., Tan, G., Yuan, Q., Zhang, J., Huang, C.* and Xia, N.* Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens. Oncoimmunology 9, **, doi:10.1080/**X.2020. ** (2020). (*Co-correspondence)
3.Lin, M.#, Huang, C. #, Ren, W., Chen, J., Xia, N. and Zhong, S. Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration. Oxid Med Cell Longev, **, doi:10.1155/2020/** (2020). (#Co-first author)
4.Luo, Y.#, Lin, C.#, Ren, W., Ju, F., Xu, Z., Liu, H., Yu, Z., Chen, J., Zhang, J., Liu, P.*, Huang, C.* and Xia, N. Intravenous Injections of a Rationally Selected Oncolytic Herpes Virus as a Potent Virotherapy for Hepatocellular Carcinoma. Mol Ther Oncolytics 15, 153-165, doi:10.1016/j.omto.2019.09.004 (2019). (*Co-correspondence)
5.Huang, C., Zhang, Y. and Zhong, S. Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer. Oxidative Medicine and Cellular Longevity 2019, 1-9, doi:10.1155/2019/** (2019).
6.Zhang, T. Y., Chen, H. Y., Cao, J. L., Xiong, H. L., Mo, X. B., Li, T. L., Kang, X. Z., Zhao, J. H., Yin, B., Zhao, X., Huang, C. H., Yuan, Q., Xue, D., Xia, N. S. and Yuan, Y. A. Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction. Nat Commun 10, 3192, doi:10.1038/s41467-019-11173-1 (2019).
7.Zou, Y., Luo, Y., Zhang, J., Xia, N., Tan, G. and Huang, C. Bibliometric analysis of oncolytic virus research, 2000 to 2018. Medicine (Baltimore) 98, e16817, doi:10.1097/MD.6817 (2019).
8.He, C., Qiu, Y., Han, P., Chen, Y., Zhang, L., Yuan, Q., Zhang, T., Cheng, T., Yuan, L., Huang, C.,Zhang, S., Yin, Z., Peng, X. E., Liang, D., Lin, X., Lin, Y., Lin, Z. and Xia, N. ER stress regulating protein phosphatase 2A-B56gamma, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death Dis 9, 762, doi:10.1038/s41419-018-0787-3 (2018).
9.Chen, Q., Qiu, S., Li, H., Lin, C., Luo, Y., Ren, W., Zou, Y., Wang, Y., Xia, N. and Huang, C. A novel approach for rapid high-throughput selection of recombinant functional rat monoclonal antibodies. BMC Immunol 19, 35, doi:10.1186/s12865-018-0274-8 (2018).
10.Yi, Y.#, Huang, C.#, Zhang, Y., Tian, S., Lei, J., Chen, S., Shi, G., Wu, Z., Xia, N. and Zhong, S. Exploring a common mechanism of alcohol-induced deregulation of RNA Pol III genes in liver and breast cells. Gene 626, 309-318, doi:10.1016/j.gene.2017.05.048 (2017). (#Co-first author)
11.Luo, Y.#, Xiong, D.#, Li, H. H., Qiu, S. P., Lin, C. L., Chen, Q., Huang, C. H.*, Yuan, Q., Zhang, J. and Xia, N. S.* Development of an HSV-1 neutralization test with a glycoprotein D specific antibody for measurement of neutralizing antibody titer in human sera. Virol J 13, 44, doi:10.1186/s12985-016-0508-4 (2016). (*Co-correspondence)
12.Lin, C., Li, H., Hao, M., Xiong, D., Luo, Y., Huang, C.*, Yuan, Q., Zhang, J. and Xia, N.* Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells. Sci Rep 6, 34531, doi:10.1038/srep34531 (2016). (*Co-correspondence)
13.Yuan, Q., Song, L. W., Liu, C. J., Li, Z., Liu, P. G., Huang, C. H., Yan, Y., Ge, S. X., Wang, Y. B., Peng, C. Y., Zhang, J., Kao, J. H., Chen, D. S., Chen, P. J. and Xia, N. S. Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients. Gut 62, 182-184, doi:10.1136/gutjnl-2012-302656 (2013).
14.Huang, C. H.#, Yuan, Q.#, Chen, P. J., Zhang, Y. L., Chen, C. R., Zheng, Q. B., Yeh, S. H., Yu, H., Xue, Y., Chen, Y. X., Liu, P. G., Ge, S. X., Zhang, J. and Xia, N. S. Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors. J Hepatol 57, 720-729, doi:10.1016/j.jhep.2012.05.009 (2012).
15.Geng, X.#, Huang, C.#, Qin, Y., McCombs, J. E., Yuan, Q., Harry, B. L., Palmer, A. E., Xia, N. S. and Xue, D. Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. Proc Natl Acad Sci U S A 109, 18471-18476, doi:10.1073/pnas. (2012). (#Co-first author)
16.Yuan, Q., Ou, S. H., Chen, C. R., Ge, S. X., Pei, B., Chen, Q. R., Yan, Q., Lin, Y. C., Ni, H. Y., Huang, C. H., Yeo, A. E., Shih, J. W., Zhang, J. and Xia, N. S. Molecular characteristics of occult hepatitis B virus from blood donors in southeast China. J Clin Microbiol 48, 357-362, doi:10.1128/JCM.01781-09 (2010).



主持课题
1. 国家科技重大专项，2018ZX**-001，HBV特异性B细胞应答规律及抗体基因克隆，2018/01-2020/06，172.4万元，在研，子课题负责人，主持
2. 国家自然科学基金面上项目，**，HBx BH3结构域在HBV复制和肝癌转化中的作用及机制研究，2016/01-2019/12，60万元，已结题，主持

获奖和荣誉
曾获得2014年厦门市科学技术进步一等奖，2017年福建省科学技术进步二等奖。