陈毅歆，博士，副教授
CHEN Yixin，Ph.D.，Associate Prof.
国家传染病诊断试剂与疫苗工程技术研究中心 单抗组 组长
办公室：厦门大学翔安校区椭圆楼321室
E-mail: yxchen2008@xmu.edu.cn
2008年厦门大学博士毕业，2009年至今任职厦门大学生命科学学院助理教授、副教授，2011年至今兼职厦门大学公共卫生学院。
研究领域（Research Area)
针对流感病毒、肠道病毒、EB病毒和疱疹病毒等人类病毒性传染病的病原体开展分子病毒学与免疫学研究，基于小鼠、大鼠和兔单克隆抗体技术研究病原体靶标蛋白的B细胞表位、抗原性、免疫原性及生物学功能等，为研制病原体的疫苗、治疗性药物和诊断试剂提供支持。 我们还涉及癌症研究，主要是开发新型溶瘤病毒用于癌症治疗和发现新型肿瘤特异性抗体用于癌症的诊断和治疗。
Our group is dedicated to study the molecular virology and immunology of human pathogens, such as influenza virus, enterovirus, Epstein-Barr virus and herpes virus. We are focused to apply monoclonal antibody techniques to investigate the B cell epitope, antigenicity, immunogenicity, and biological functions of target viral proteins. Our primary goals are to develop vaccine, therapeutic agents and diagnostic kit against specific viruses. We also get involved with cancer research, including the development of oncolytic virus for cancer therapy and the establishment of novel tumor-specific antibodies for cancer diagnosis and therapy.


代表性论文 (Selected Publications) ^# Co-first author，^* Corresponding author
Wang, G., Chen, R., Huang, P., Hong, J., Cao, J., Wu, Q., Lin, L., Han, Q., Chen, Y*., Xia, N. Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo. Antiviral research. 2021 Feb;186:105014.
Wang, G., Huang, P., Hong, J., Fu, R., Wu, Q., Chen, R., Lin, L., Han, Q., Chen, H., Chen, Y*., Xia, N. Establishment of a rapid ELISPOT assay for influenza virus titration and neutralizing antibody detection. Journal of Medical Virology. 2020 Jul 4. 2020;1–10.
Shen C, Zhang M, Chen Y, Zhang L, Wang G, Chen J, Chen S, Li Z, Wei F, Chen J, Yang K, Guo S, Wang Y, Zheng Q, Yu H, Luo W, Zhang J, Chen H, Chen Y*, Xia N. An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency. Theranostics. 2019 Jan 1;9(1):210-231.
Chen J, Yang K, Zhang M*, Shen C, Chen J, Wang G, Huang S, Zhang M, Xiong H, Chen H, Chen Y*, Xia N. Rapid identification of imported influenza viruses at Xiamen International Airport via an active surveillance program. Clinical Microbiology and Infection, 2018 Mar;24(3):289-294.
Woo PCY #, Lau SKP #, Chen Y #, Wong EYM, Chan KH, Chen H, Zhang L, Xia N, Yuen KY. Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin. Emerging Microbes & Infections. 2018 Mar 7;7(1):18.
Lin Q #, Li T #, Chen Y #, Lau SY, Wei M, Zhang Y, Zhang Z, Yao Q, Li J, Li Z, Wang D, Zheng Q, Yu H, Gu Y, Zhang J, Chen H, Li S, Xia N. Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. Journal of Virology. 2018 Aug 16;92(17).
Shen C, Chen J, Li R, Zhang M, Wang G, Stegalkina S, Zhang L, Chen J, Cao J, Bi X, Anderson SF, Alefantis T, Zhang M, Cai X, Yang K, Zheng Q, Fang M, Yu H, Luo W, Zheng Z, Yuan Q, Zhang J, Wai-Kuo Shih J, Kleanthous H, Chen H, Chen Y*, Xia N*. A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses. Science Translational Medicine. 2017 Oct 18;9(412).
Chen Y #, Chan KH, Hong C, Kang Y, Ge S, Chen H, Wong EY, Joseph S, Patteril NG, Wernery U, Xia N, Lau SK, Woo PC. A highly specific rapid antigen detection assay for on-site diagnosis of MERS. Journal of Infection. 2016 Jul;73(1):82-4.
Zhang P #, Chen Y #, Zeng Y #, Shen C, Li R, Guo Z, Li S, Zheng Q, Chu C, Wang Z, Zheng Z, Tian R, Ge S, Zhang X, Xia NS, Liu G, Chen X. Virus-mimetic nanovesicles as a versatile antigen-delivery system. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6129-38.
Chen Y #, Chan KH, Kang Y, Chen H, Luk HK, Poon RW, Chan JF, Yuen KY, Xia N, Lau SK, Woo PC. A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus. Emerging Microbes & Infections. 2015 Apr;4(4):e26.
Gui X, Li R, Zhang X, Shen C, Yu H, Guo X, Kang Y, Chen J, Chen H, Chen Y*, Xia N*. An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2. Virology, 2014, 464-465:11-20.
Gui X, Ge P, Wang X, Yang K, Yu H, Zhao Q, Chen Y*, Xia N*. Identification of a highly conserved and surface exposed B-cell epitope on the nucleoprotein of influenza A virus. Journal of Medical Virology, 2014, 86:995-1002.
Chen Y #, Li C #, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen P-J, Zhang J, Xia N. Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity. Vaccine, 2013, 31:425-30.
Wu WL, Lau SY, Chen Y #, Wang G, Mok BW, Wen X, Wang P, Song W, Lin T, Chan KH, Yuen KY, Chen H. The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses. Antiviral Research, 2012, 93:144-153.
Chen Y #, Zheng Q #, Yang K, Zen F, Lau S-Y, Wu WL, Huang S, Zhang J, Chen H, Xia N. Serological survey of antibodies to influenza A viruses on a group of people without a history of influenza vaccination. Clinical Microbiology and Infection, 2011, 17:1347-1349.
Zheng Q, Xia L, Wu WL, Zheng Z, Huo Y, Wu J, Liu Y, Yu H, Chen Y, Lau SY, Chen H, Luo W, Xia N. Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses. Antimicrobial Agents and Chemotherapy, 2011, 55:1349-1357.
Chen Y #, Xu F, Gui X, Yang K, Wu X, Zheng Q, Ge S, Yuan Q, Yeo AET, Zhang J, Guan Y, Chen H, Xia N. A rapid test for the detection of influenza A virus including pandemic influenza A/H1N1 2009. Journal of Virological Methods, 2009, 167:100-102.
Chen Y #, Qin K #, Wu WL, Li G, Zhang J, Du H, Ng MH, Shih JWK, Peiris JSM, Guan Y, Chen H, and Xia N. Broad Cross-Protection against H5N1 Avian Influenza Virus Infection by Means of Monoclonal Antibodies that Map to Conserved Viral Epitopes. Journal of Infectious Diseases, 2009, 199:49-58.
WL Wu #, Chen Y #, Wang P, Song W, Lau SY, Rayner JM, Smith GJD, Webster RG, Peiris JSM, Lin T, Xia N, Guan Y and Chen H. Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. Journal of Virology, 2008, 82:1798-1807.
Chen Y #, F Xu, X Fan, H Luo, S Ge, Q Zheng, N Xia, H Chen, Y Guan, and J Zhang. Evaluation of a rapid test for detection of H5N1 avian influenza virus. Journal of Virological Methods, 2008, 154:213-215.

授权发明专利 (Patents)

Chen Yixin, Shen Chenguang, Chen Junyu, Wang Guosong, Zhang Mengya, Xia Ningshao. Broad-spectrum monoclonal anti-flu B antibody and uses thereof. Australian Patent No.: , 2018.12.06
陈毅歆，桂勋，吴兴容，黄德党，郑清炳，夏宁邵。甲型流感病毒核衣壳蛋白的抗原表位及其用途。中国发明专利号：ZL6.5，2018.2.9
程通，徐龙发，杨立生，陈毅歆，杜海莲，张军，夏宁邵。肠道病毒71 型的VP2 抗原的中和表位多肽及其用途。中国发明专利号：ZL7.4, 2018.5.4
罗文新，霍永庭，李善伟，崔传佳，陈毅歆，夏宁邵。特异结合高致病性禽流感病毒的抗体。中国发明专利号：ZL9.4，2017.9.8
Yuan Quan, Zhang Tianying, Luo Wenxin, Chen Yixin, Zhang Jun, Xia Ningshao. Poly-peptides and antibodies for treating HBV infection and related diseases. United States Patent No.:US**B2, 2017.9.5
Yixin Chen, Qingbing Zheng, Rui Li, Chenguang Shen, Shaojun Ke, Wenxin Luo, Honglin Chen, Ningshao Xia. Broad-spectrum monoclonal antibody recognizing HA1 domain of hemagglutinin of influenza virus. United States Patent no.: US**B2, 2017.5.16
Chen Yixin，Luo Wenxin，Zhang Jun，Xia Ningshao，Guan Yi，Chen Honglin. Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof (8G9), European Patent No.: EP**B1，2016.10.12
Yixin Chen，Wenxin Luo，Jun Zhang，Ningshao Xia，Yi Guan，Honglin Chen. Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof (13D4), European Patent No.: EP**A1，2016.3.16
葛胜祥，徐飞海，翁祖星，程通，何德磊，陈毅歆，陈自敏，夏宁邵。肠道病毒71型的中和表位多肽及其用途。中国发明专利号：ZL4.9，2015.4.8
陈毅歆，罗文新，张军，夏宁邵，陈鸿霖，管轶。H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途(8G9)。中国发明专利号：ZL0.0，2015.1.21
罗文新，陈毅歆，宋慧娟, 陈瑛炜，陈鸿霖, 张军，夏宁邵。H5亚型禽流感病毒保守中和表位模拟肽及其用途。中国发明专利号：ZL2.5，2015.1.14
罗文新，陈毅歆，郑振华,李国强, 陈鸿霖, 张军，夏宁邵。H5亚型禽流感病毒血凝素蛋白的人源化抗体及其用途。中国发明专利号：ZL5.X，2015.1.7
Chen Yixin, Luo Wenxin, Zhang Jun, Xia Ningshao, Guan Yi, Chen Honglin. Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof (13D4). United States Patent No.: US**B2, 2013.12.10
罗文新，陈瑛炜，王明桥，陈毅歆，张军，夏宁邵。H5亚型禽流感病毒中和表位模拟肽及其用途。中国发明专利号：ZL 5.5，2013.7.3
陈毅歆，罗文新，张军，夏宁邵，管轶，陈鸿霖. 特异性结合H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途 (13D4). 中国发明专利号：ZL9.6，2013.5.1
夏宁邵，张军，葛胜祥，陈毅歆，罗文新。一种H5亚型禽流感病毒血凝素蛋白的单克隆抗体，其制备方法及其用途。中国发明专利号：ZL 8.X，2009.4.1

奖励（Honors and Awards）
(1) 2020年全国抗击新冠肺炎疫情先进集体奖
(2) 2017年福建省科技进步二等奖（排名第一）
(3) 2017年厦门市科技进步二等奖（排名第一）
(4) 2015 求是杰出科技成就集体奖
(5) 2014福建省科技进步奖一等奖（排名第三）
(6) 2014厦门市科技进步奖二等奖（排名第三）
(7) 2014厦门市科技进步奖三等奖（排名第八）
(8) 2003北京市科技进步三等奖（排名第六）


主持项目 (Grants)
国家重点研发计划项目，生物大分子胞内递送系统的研究(2020YFC**)，2020-2021
国家自然科学基金专项项目，基于减毒流感病毒载体的流感和新冠肺炎通用疫苗的免疫保护机制研究(**），2021.1-2021.12
国家自然科学基金面上项目，CDCA3调控伪狂犬病毒溶瘤疗效的分子机制研究(**），2021-2024
福建省科技重大专项项目，新型冠状病毒候选疫苗及质量控制方法研究(2020YZ014001)，2020-2021
国家自然科学基金面上项目，甲型流感病毒血凝素头部区跨亚型广谱中和抗体的作用机制研究(**)，2019-2022
国家重点研发计划子课题，重要突发急性和烈性传染病临床生物安全关键设备创制(2018YFC**)，2018-2021
国家自然科学基金面上项目，基于广谱中和单抗的通用型流感疫苗设计及其结构基础研究(**)，2017-2020
国家自然科学基金面上项目，人肠道病毒71型构象性中和表位的确定及其诱导抗病毒免疫保护应答机制研究(**)，2014-2017
通用型流感疫苗—鉴定针对季节性流感病毒的交叉中和性单克隆抗体的合作研究计划，赛诺菲巴斯德公司，2013-2017
新药创制国家重大专项子课题，H5N1禽流感病毒广谱治疗性单克隆抗体临床前研究(2011ZX09102-009-12)，2011-2017
福建省科技重大专项项目，系列肿瘤相关免疫诊断试剂高活性的关键原料的研制及产业化(2011YZ0002-1)，2011-2016
国家863计划子课题，抗体研发关键技术及产品研发(2012AA02A307)，2012-2016
厦门市科技项目，H5N1禽流感病毒广谱治疗性单克隆抗体临床前研究(3502Z**)，2012-2013
国家自然科学基金青年项目，H5N1禽流感病毒血凝素广谱中和表位的结构研究(**)，2010-2012