李少伟，博士 LI Shaowei, Ph.D.
教授，博士生导师 Professor
结构疫苗学(Structural Vaccinology)
电话：+86-
传真：+86-
E-mail：shaowei@xmu.edu.cn


简历 (Education and Work experience)：
1998年，厦门大学生物化学专业，学士学位；
2003年，厦门大学生化与分子生物学/动物学专业，博士学位；
2003年，厦门大学生命科学学院讲师；
2006年，厦门大学生命科学学院副教授；
2011年，厦门大学生命科学学院/公共卫生学院教授、博士生导师。
B.S. Biochemistry, Xiamen University, 1998
Ph.D.Biochemistry&Molecular Biology/Zoology, Xiamen University, 2003
Lecturer,School of Life Sciences, Xiamen University, 2003
AssociateProfessor, School of Life Sciences, Xiamen University, 2006
Professor,School of Life Sciences/School of Public Health, Xiamen University, 2011


研究领域 (Research Area)：
·基因工程疫苗研究与开发
·重要传染病病毒免疫表位的结构和功能研究
·基于结构的分子模拟和分子设计
·Research and development of recombinant human vaccine
·Structural basis and functional implication for underlying immune epitopes of key infectious viruses
·Structure-based molecular simulation and rational design for vaccine


代表性论文(Selected Publications)(* Corresponding author)：
1.Longfa Xu#, Qingbing Zheng#, Rui Zhu#, Zhichao Yin#, Hai Yu#, Yu Lin, Yuanyuan Wu, Maozhou He, Yang Huang, Yichao Jiang, Hui Sun, Zhenghui Zha, Hongwei Yang, Qiongzi Huang, Dongqing Zhang, Zhenqin Chen, Xiangzhong Ye, Jinle Han, Lisheng Yang, Che Liu, Yuqiong Que, Mujin Fang, Ying Gu, Jun Zhang, Wenxin Luo, Z. Hong Zhou*, Shaowei Li*, Tong Cheng*, Ningshao Xia*. Cryo-EM Structures Reveal Basis of Receptor-Initiated Coxsackievirus Uncoating with Implications for Therapeutic Antibody Development. Cell Host Microbe, 2021, S1931-3128(21)00001-9.
2.He, Maozhou#; Xu, Longfa#; Zheng, Qingbing#; Zhu, Rui#; Yin, Zhichao#; Zha, Zhenghui; Lin, Yu; Yang, Lisheng; Huang, Yang; Ye, Xiangzhong; Li, Shuxuan; Hou, Wangheng; Wu, Yangtao; Han, Jinle; Liu, Dongxiao; Li, Zekai; Chen, Zhenqin; Yu, Hai; Que, Yuqiong; Wang, Yingbin; Yan, Xiaodong; Zhang, Jun; Gu, Ying; Zhou, Z. Hong*; Cheng, Tong*; Li, Shaowei*; Xia, Ningshao*; Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16, Cell Host & Microbe, 2020, 27(2): 249-261.
3.Daning Wang#; Xinlin Liu#; Minxi Wei#;Ciying Qian; Shuo Song; Jie Chen; Zhiping Wang; Qin Xu; Yurou Yang; Maozhou He; Xin Chi; Shiwen Huang; Tingting Li; Zhibo Kong; Qingbing Zheng; Hai Yu; Yingbin Wang; Qinjian Zhao; Jun Zhang; Ningshao Xia*;Ying Gu*& Shaowei Li*;Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles., Nature Communications, 2020, 11(1):2841.
4.Wei Wang#;Qingbing Zheng#; Dequan Pan#; Hai Yu#; Wenkun Fu, Jian Liu, Maozhou He, Rui Zhu, Yuze Cai, Yang Huang, Zhenghui Zha, Zhenqin Chen, Xiangzhong Ye, Jinle Han, Yuqiong Que, Ting Wu, Jun Zhang, Shaowei Li*;Hua Zhu*;Z. Hong Zhou*;Tong Cheng*and Ningshao Xia*;Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nature Microbiology, 2020,5(12) :1542-1552.
5.Qingbing Zheng#; Rui Zhu#; Longfa Xu#; Maozhou He#; Xiaodong Yan#; Dongxiao Liu; Zhichao Yin; Yangtao Wu; Yongchao Li; Lisheng Yang; Wangheng Hou; Shuxuan Li; Zizhen Li; Zhenqin Chen; Zhihai Li; Hai Yu; Ying Gu; Jun Zhang; Timothy S Baker; Z Hong Zhou; Barney S Graham*; Tong Cheng*; Shaowei Li*; Ningshao Xia*; Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization , Nature Microbiology, 2019, 4(1): 124-133.
6.Zheng, Qingbing#; Jiang, Jie#; He, Maozhou#; Zheng, Zizheng#; Yu, Hai; Li, Tingting; Xue, Wenhui; Tang, Zimin; Ying, Dong; Li, Zekai; Song, Shuo; Liu, Xinlin; Wang, Kaihang; Zhang, Zhiqing; Wang, Daning; Wang, Yingbin; Yan, Xiaodong; Zhao, Qinjian; Zhang, Jun; Gu, Ying*; Li, Shaowei*; Xia, Ningshao*; Viral neutralization by antibody-imposed physical disruption, Proceedings of the National Academy of Sciences, 2019, 116(52): 26933-26940.
7.Li Zhihai#; Song Shuo#; He Maozhou#; Wang Daning; Shi Jingjie; Liu Xinlin; Li Yunbing; Chi Xin; Wei Shuangping; Yang Yurou; Wang Zhiping; Li Jinjin; Qian Huilian; Yu Hai; Zheng Qingbing; Yan Xiaodong; Zhao Qinjian; Zhang Jun; Gu Ying*; Li Shaowei*; Xia Ningshao*; Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity., Nature Communications, 2018, 9(1): 0-5360.
8.Li, Zhihai#; Wang, Daning#; Gu, Ying#; Song, Shuo; He, Maozhou; Shi, Jingjie; Liu, Xinlin; Wei, Shuangping; Li, Jinjin; Yu, Hai; Zheng, Qingbing; Yan, Xiaodong; Baker, Timothy S.; Zhang, Jun; McLellan, Jason S.*; Li, Shaowei*; Xia, Ningshao*; Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus, MBio, 2017, 8(5).
9.Zhu Rui#; Xu Longfa#; Zheng Qingbing#; Cui Yanxiang#; Li Shaowei#; He Maozhou; Yin Zhichao; Liu Dongxiao; Li Shuxuan; Li Zizhen; Chen Zhenqin; Yu Hai; Que Yuqiong; Liu Che; Kong Zhibo; Zhang Jun; Baker Timothy S; Yan Xiaodong*; Hong Zhou Z*; Cheng Tong*; Xia Ningshao*; Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Science Advances, 2018, 4(9): 0-eaat7459.
10.Xu, Longfa#; Zheng, Qingbing#; Li, Shaowei#; He, Maozhou; Wu, Yangtao; Li, Yongchao; Zhu, Rui; Yu, Hai; Hong, Qiyang; Jiang, Jie; Li, Zizhen; Li, Shuxuan; Zhao, Huan; Yang, Lisheng; Hou, Wangheng; Wang, Wei; Ye, Xiangzhong; Zhang, Jun; Baker, Timothy S.; Cheng, Tong*; Zhou, Z. Hong; Yan, Xiaodong*; Xia, Ningshao*; Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody, Nature communications, 2017, 11;8(1):505.
11.Lizhi Zhou#; Hai Yu#; Kaihang Wang; Tingting Chen; Yue Ma; Yang Huang; Jiajia Li; Liqin Liu; Yuqian Li; Zhibo Kong; Qingbing Zheng; Yingbin Wang; Ying Gu; Ningshao Xia and Shaowei Li*; Genome re-sequencing and reannotation of the Escherichia coli ER2566 strain and transcriptome sequencing under overexpression conditions, BMC Genomics, 2020, 21(1):407.
12.Chen, Tingting#; Wang, Kaihang#; Chi, Xin; Zhou, Lizhi; Li, Jiajia; Liu, Liqin; Zheng, Qingbing; Wang, Yingbin; Yu, Hai; Gu, Ying; Zhang, Jun; Li, Shaowei*; Xia, Ningshao; Construction of a bacterial surface display system based on outer membrane protein F , Microbial Cell Factories, 2019, 18: 0-70.




荣誉、奖励及参加学术团体的情况(Honors and award)：

入选2020国家百千****才工程、教育部新世纪优秀人才、Nature Biotechnology 评选的2016年度全球转化研究者TOP20（大陆****首次入选），荣获国家科技进步二等奖、国家技术发明二等奖、中国专利金奖、2020第二十三届中国科协求是****成果转化奖和中国药学会-赛诺菲青年生物药物奖等奖励。主持国家自然科学海峡联合基金、国家863计划、重大新药创制重大科技专项等项目。近5年（2016-2020）在结构疫苗学领域发表SCI论文49篇，获得授权发明专利29项（22项为第一发明人，12项国际授权），为主研制出戊肝疫苗、宫颈癌疫苗、艾滋诊断试剂等新药。参与编写2020年出版的《当代疫苗学》（第二版），担任第九届中国药学会生化与生物技术药物专业委员会委员、中生药协重组药物分会候选副秘书长、《国际生物制品学杂志》编委和厦门市生物化学与分子生物学学会理事等。